Pharmaceutical nanotechnology最新文献_第3页

Lipids Fortified Nano Phytopharmaceuticals: A Breakthrough Approach in Delivering Bio-actives for Improved Therapeutic Efficacy. 脂质强化纳米植物药：提供生物活性物质以提高疗效的突破性方法。

Pharmaceutical nanotechnology Pub Date : 2025-01-01 DOI: 10.2174/0122117385277686231127050723

Sunny Shah, Harshida Chauhan, Hardik Madhu, Dhaval Mori, Moinuddin Soniwala, Sudarshan Singh, Bhupendra Prajapati

{"title":"Lipids Fortified Nano Phytopharmaceuticals: A Breakthrough Approach in Delivering Bio-actives for Improved Therapeutic Efficacy.","authors":"Sunny Shah, Harshida Chauhan, Hardik Madhu, Dhaval Mori, Moinuddin Soniwala, Sudarshan Singh, Bhupendra Prajapati","doi":"10.2174/0122117385277686231127050723","DOIUrl":"10.2174/0122117385277686231127050723","url":null,"abstract":"Phytopharmaceuticals, derived from natural sources, manifest tremendous potential for therapeutic applications. Nevertheless, effective delivery of these bio-actives presents significant challenges. A breakthrough in fortifying phytopharmaceuticals within phosphatidylcholine is a promising remedy to overcome solubility, permeability, and other related drawbacks. This intrinsic lipid, which is obtained from both natural and synthetic sources, confers numerous benefits, encompassing heightened solubility, augmented bioavailability, and enhanced stability. The conjugation of phytopharmaceuticals with phosphatidylcholine enables improved dermal permeation, absorption, targeted distribution, and the possibility of synergistic results, eventually improving therapeutic efficacy. Additionally, the use of phytopharmaceuticals enriched with phosphatidylcholine presents a promising route for overcoming the limitations imposed by conventional delivery techniques, encouraging more effective treatments. The review provides a thorough analysis of phosphatidylcholine- incorporated phytopharmaceuticals as nanomedicine with variables that significantly affect their therapeutic efficacy. Moreover, the review elaborates on how phosphatidylcholine improves solubility, permeability, and tissue distribution and boosts the potential of phytopharmaceuticals. Further, the review underscores the significance of nano-formulation strategies, analytical methodologies, and forthcoming prospects to propel this field forward. Furthermore, the review emphasizes the potential inherent in this innovative approach while highlighting the importance of additional research endeavors and collaborative initiatives to unlock the therapeutic benefits of phosphatidylcholinefortified phytopharmaceuticals, enhancing patient well-being.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"70-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Lipid-based Carriers for Systematic Utilization in the Pharmaceutical and Biomedical Sciences: A Review. 新出现的脂质载体在制药和生物医学中的系统应用：综述。

Pharmaceutical nanotechnology Pub Date : 2025-01-01 DOI: 10.2174/0122117385268268231204061938

Prakash N Kendre, Dhiraj R Kayande, Ajinkya K Pote, Sanagmeshwar B Kanthale, Bhupendra G Prajapati, Yuvraj Kendre, Shirish Jain

{"title":"Emerging Lipid-based Carriers for Systematic Utilization in the Pharmaceutical and Biomedical Sciences: A Review.","authors":"Prakash N Kendre, Dhiraj R Kayande, Ajinkya K Pote, Sanagmeshwar B Kanthale, Bhupendra G Prajapati, Yuvraj Kendre, Shirish Jain","doi":"10.2174/0122117385268268231204061938","DOIUrl":"10.2174/0122117385268268231204061938","url":null,"abstract":"Emerging lipid-based carriers are revolutionizing drug delivery in the pharmaceutical and biomedical sciences. These innovative carriers harness the unique properties of lipids to improve the solubility, stability, and targeted delivery of therapeutic agents, ushering in a new era of precision medicine. Lipid- based carriers, such as liposomes, lipid nanoparticles, and solid lipid nanoparticles, offer several advantages. They can encapsulate both hydrophilic and hydrophobic drugs, enabling the delivery of a wide range of compounds. Additionally, lipids are biocompatible and biodegradable, minimizing the risk of toxicity. Their ability to mimic cell membranes allows for enhanced cellular uptake and controlled release, optimizing drug efficacy while minimizing side effects. Furthermore, lipid-based carriers are ideal for delivering drugs to specific sites within the body. By modifying the lipid composition, surface charge, and size, researchers can tailor these carriers to target tumours, inflamed tissues, or specific cells, improving therapeutic outcomes and reducing systemic toxicity. In summary, emerging lipid-based carriers are poised to transform pharmaceutical and biomedical sciences by addressing critical challenges in drug delivery. These carriers enhance drug stability, bioavailability, and targeted delivery, offering the potential to revolutionize the treatment of various diseases and improve patient outcomes. As research in this field continues to advance, we can expect even more sophisticated lipid-based carrier systems to emerge, further expanding the possibilities for precision medicine. This review focuses on the contribution of lipid carriers in the pharmaceutical and biomedical sciences.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"2-21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Lipid-based Nanoformulations for Targeting Brain through Non-invasive Nasal Route. 通过无创鼻腔途径靶向脑部的脂基纳米制剂综述

Pharmaceutical nanotechnology Pub Date : 2025-01-01 DOI: 10.2174/0122117385293436240321090218

Nirvesh Chaudhri, Vaibhav Rastogi, Anurag Verma

{"title":"A Review on Lipid-based Nanoformulations for Targeting Brain through Non-invasive Nasal Route.","authors":"Nirvesh Chaudhri, Vaibhav Rastogi, Anurag Verma","doi":"10.2174/0122117385293436240321090218","DOIUrl":"10.2174/0122117385293436240321090218","url":null,"abstract":"The nasal method for administering nanoformulations to the brain has been examined and proven successful by prior investigators. For the treatment of central nervous system (CNS) disorders such as neuropsychiatric, depression, Alzheimer and anxiety, intranasal administration has become more popular for delivering drugs to the brain. This method offers direct transport through neuronal pathways. The lipid-based nanocarriers like nanostructured lipid carriers (NLC) appear more favorable than other nanosystems for brain administration. The nanostructured lipid carriers (NLC) system can quickly transform into a gelling system to facilitate easy administration into the nasal passages. The various compatibility studies showed that the other lipid structured-based formulations may not work well for various reasons, including a low drug filing capacity; during storage, the formulation showed changes in the solid lipid structures, which gives a chance of medication ejection. Formulations containing NLC can minimize these problems by improving drug solubility and permeation rate by incorporating a ratio of liquid lipids with solid lipids, resulting in improved stability during storage and drug bioavailability because of the higher drug loading capacity. This review aimed to find and emphasize research on lipid-based nanocarrier formulations that have advanced the treatment of central nervous system illnesses using nasal passages to reach the targeted area's drug molecules.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"143-154"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering the Emerging Prospects of Lipid-based Nanoparticulate Vehicles in Lung Cancer Management: A Recent Perspective. 揭示脂质纳米颗粒载体在肺癌治疗中的新前景：最新视角。

Pharmaceutical nanotechnology Pub Date : 2025-01-01 DOI: 10.2174/0122117385286781240228060152

Dhruv Sanjay Gupta, Divya Suares

{"title":"Uncovering the Emerging Prospects of Lipid-based Nanoparticulate Vehicles in Lung Cancer Management: A Recent Perspective.","authors":"Dhruv Sanjay Gupta, Divya Suares","doi":"10.2174/0122117385286781240228060152","DOIUrl":"10.2174/0122117385286781240228060152","url":null,"abstract":"Lung cancer, a leading cause of cancer-related deaths globally, is gaining research interest more than ever before. Owing to the burden of pathogenesis on the quality of life of patients and subsequently the healthcare system, research efforts focus on its management and amelioration. In an effort to improve bioavailability, enhance stability, minimize adverse effects and reduce the incidence of resistance, nanotechnological platforms have been harnessed for drug delivery and improving treatment outcomes. Lipid nanoparticles, in particular, offer an interesting clinical opportunity with respect to the delivery of a variety of agents. These include synthetic chemotherapeutic agents, immunotherapeutic molecules, as well as phytoconstituents with promising anticancer benefits. In addition to this, these systems are being studied for their usage in conjunction with other treatment strategies. However, their applications remain limited owing to a number of challenges, chiefly clinical translation. There is a need to address the scalability of such technologies, in order to improve accessibility. The authors aim to offer a comprehensive understanding of the evolution of lipid nanoparticles and their application in lung cancer, the interplay of disease pathways and their mechanism of action and the potential for delivery of a variety of agents. Additionally, a discussion with respect to results from preclinical studies has also been provided. The authors have also provided a well-rounded insight into the limitations and future perspectives. While the possibilities are endless, there is a need to undertake focused research to expedite clinical translation and offer avenues for wider applications in disease management.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"155-170"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Spanlastics as a Novel Carrier for Drug Delivery: A Review. 揭秘作为新型载体的跨膜药物输送：综述。

Pharmaceutical nanotechnology Pub Date : 2025-01-01 DOI: 10.2174/0122117385286921240103113543

Dipanjan Karati, Swarupananda Mukherjee, Bhupendra G Prajapati

{"title":"Unveiling Spanlastics as a Novel Carrier for Drug Delivery: A Review.","authors":"Dipanjan Karati, Swarupananda Mukherjee, Bhupendra G Prajapati","doi":"10.2174/0122117385286921240103113543","DOIUrl":"10.2174/0122117385286921240103113543","url":null,"abstract":"Innovative colloidal preparations that can alter the pharmacological properties of drugs have been made possible by the advancement of nanotechnology. Recent advances in the sciences of the nanoscale have led to the creation of new methods for treating illnesses. Developments in nanotechnology may lessen the side effects of medicine by using effective and regulated drug delivery methods. A promising drug delivery vehicle is spanlastics, an elastic nanovesicle that can transport a variety of drug compounds. Spanlastics have expanded the growing interest in many types of administrative pathways. Using this special type of vesicular carriers, medications intended for topical, nasal, ocular, and trans-ungual treatments are delivered to specific areas. Their elastic and malleable structure allows them to fit into skin pores, making them ideal for transdermal distribution. Spanlastic is composed of non-ionic surfactants or combinations of surfactants. Numerous studies have demonstrated how spanlastics significantly improve, drug bioavailability, therapeutic effectiveness, and reduce medication toxicity. The several vesicular systems, composition and structure of spanlastics, benefits of spanlastics over alternative drug delivery methods, and the process of drug penetration via skin are all summarized in this paper. Additionally, it provides an overview of the many medications that may be treated using spanlastic vesicles. The primary benefits of these formulations were associated with their surface properties, as a variety of proteins might be linked to the look. For instance, procedure assessment and gold nanoparticles were employed as biomarkers for different biomolecules, which included tumor label detection. Anticipate further advancements in the customization and combining of spanlastic vesicles with appropriate zeta potential to transport therapeutic compounds to specific areas for enhanced disease treatment.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"133-142"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle Carriers for Drug Delivery: An Updated Review. 纳米颗粒药物递送载体：最新综述。

Pharmaceutical nanotechnology Pub Date : 2024-12-30 DOI: 10.2174/0122117385340986241208123048

Somayeh Hajipour, Alireza Ghiasvand

引用次数: 0

A Comprehensive Review of Strategies of Topical Niosomes and Their Synergistic Effect for Enhanced Therapeutic Outcomes 外用Niosomes策略及其协同作用对提高治疗效果的综合综述。

Pharmaceutical nanotechnology Pub Date : 2024-12-30 DOI: 10.2174/0122117385345369241212071947

N Bharathi Sai Thilagam, V P Karthik, R Gnanasambandan, C Sowmya

{"title":"A Comprehensive Review of Strategies of Topical Niosomes and Their Synergistic Effect for Enhanced Therapeutic Outcomes","authors":"N Bharathi Sai Thilagam, V P Karthik, R Gnanasambandan, C Sowmya","doi":"10.2174/0122117385345369241212071947","DOIUrl":"10.2174/0122117385345369241212071947","url":null,"abstract":"The review aims to assess the potential of niosomes-nonionic surfactant-based vesicular systems-as carriers for topical and transdermal drug delivery. Niosomes enable targeted and controlled drug release while minimizing systemic toxicity. The investigation centers on their structure, stability, and capacity to entrap both hydrophilic and lipophilic drugs, as well as their use in managing various dermatological and systemic disorders. Recent studies have examined the formulation of niosomes, particularly highlighting the roles of nonionic surfactants and cholesterol in enhancing the stability and entrapment efficiency of these vesicles. Research on permeability enhancers has been reviewed for their ability to work together to improve drug transport and bioavailability. It also provides a detailed discussion on the use of niosomes in treating various dermatological conditions, as well as their applications in systemic diseases, with a particular focus on co-delivery systems in cancer therapies. Niosomes exhibit efficacy in drug delivery by providing an increase in penetration through the stratum corneum, targeting hydrophilic and lipophilic drugs for dermatological and systemic applications. The Development of niosomal therapy has expanded into immunization, antiinflammatory treatments, and the control of pigmentation. Permeability enhancers further increase their efficacy, bioavailability, and tissue localization. Anticancer treatment using niosomes for codelivery of agents demonstrates synergistic effects with reduced side effects. Niosomes have tremendous potential in advancing topical and transdermal drug delivery, offering controlled, targeted release and improved patient outcomes. With optimized fabrication and comprehensive toxicity evaluation, niosomes can potentially revolutionize topical therapies, making them safer, more effective, and patient-friendly for a range of next-generation treatment options across dermatology and beyond.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Nanoemulsion-Based Gel of Betulin for the Treatment of Psoriasis-Like Skin Inflammation in a Small Animal Model. 小动物模型中治疗牛皮癣样皮肤炎症的纳米乳脂凝胶的研制。

Pharmaceutical nanotechnology Pub Date : 2024-12-30 DOI: 10.2174/0122117385336297241210053845

Dev Prakash, Anjali Chaudhari

{"title":"Development of Nanoemulsion-Based Gel of Betulin for the Treatment of Psoriasis-Like Skin Inflammation in a Small Animal Model.","authors":"Dev Prakash, Anjali Chaudhari","doi":"10.2174/0122117385336297241210053845","DOIUrl":"https://doi.org/10.2174/0122117385336297241210053845","url":null,"abstract":"Introduction/ Background: This study aimed to introduce a gel (NEG) formulation containing betulin-loaded nanoemulsions for topical psoriasis treatment.Materials and methods: The prepared nanoemulsions were optimized for smaller particle size and higher drug content using a response surface methodology that exhibited uniform distribution and high drug loading (21.17±3.55%).Results: The gel demonstrated skin-compatible pH and good spreadability. The developed gel showed slower release compared to nanoemulsion. In vivo pharmacokinetics demonstrated elevated AUC (55835.1 μg/cm2.h) and extended Tmax (720 min) for the gel than NE, indicating extended skin retention. Improved skin hydration (35%) and lipid content (28%) were observed, along with significant reductions in PASI scores and cytokine levels.Discussion: Provided with enhanced skin retention, improved hydration, and lipid content, along with significant therapeutic efficacy in psoriasis treatment, betulin-loaded nanoemulsion gel demonstrated prolonged drug release and notably reduced PASI scores and cytokine levels, highlighting its effectiveness against psoriasis.Conclusion: This highlights the promising potential of NEG for topical psoriasis management.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WITHDRAWN: Formulation of Benzoyl Peroxide Microsponge-based Transdermal Gel for Acne Infection and Its Evaluation 撤回：过氧化苯甲酰微海绵基痤疮感染透皮凝胶的配方及评价

Pharmaceutical nanotechnology Pub Date : 2024-12-30 DOI: 10.2174/2211738511666230908162410

Samali S Raut, Neha R Singh, Bhushan R Rane, Ashish S Jain

{"title":"WITHDRAWN: Formulation of Benzoyl Peroxide Microsponge-based Transdermal Gel for Acne Infection and Its Evaluation","authors":"Samali S Raut, Neha R Singh, Bhushan R Rane, Ashish S Jain","doi":"10.2174/2211738511666230908162410","DOIUrl":"10.2174/2211738511666230908162410","url":null,"abstract":"Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn from the journal Pharmaceutical Nanotechnology.Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/pages/editorial-policies-mainBentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10570859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Enhanced Scrutiny of Mechanistic and Translational Approaches to Extinguish Cancer Hypoxia. 加强对消除癌症缺氧的机制和转化方法的审查。

Pharmaceutical nanotechnology Pub Date : 2024-12-26 DOI: 10.2174/0122117385328105241216042016

Arun Radhakrishnan, Nikhitha K Shanmukhan, Linda Christabel S

{"title":"An Enhanced Scrutiny of Mechanistic and Translational Approaches to Extinguish Cancer Hypoxia.","authors":"Arun Radhakrishnan, Nikhitha K Shanmukhan, Linda Christabel S","doi":"10.2174/0122117385328105241216042016","DOIUrl":"https://doi.org/10.2174/0122117385328105241216042016","url":null,"abstract":"Cancer continues to pose a formidable challenge in global health due to its incidence and increasing resistance to conventional therapies. A key factor driving this resistance is tumor hypoxia, characterized by reduced oxygen levels within cancer cells. This hypoxic environment triggers a variety of adaptive mechanisms, significantly compromising the efficacy of cancer treatments. Notably, hypoxia promotes metastasis and reshapes the tumor microenvironment (TME), thereby aggravating treatment resistance. Central to this process are hypoxia-inducible factors (HIFs), which mediate cellular adaptations such as metabolic shifts and enhanced survival pathways. These adaptations render therapies like chemotherapy, radiotherapy, and photodynamic therapy (PDT) less effective. Additionally, hypoxia-induced vascular irregularities further impede drug delivery, amplifying the therapeutic challenge. This review provides a comprehensive examination of the roles of hypoxia in cancer, its contributions to drug resistance, and its interplay with apoptosis and autophagy. By evaluating novel mechanistic and translational approaches to target hypoxia, this study highlights the potential to improve therapeutic outcomes and offers insights into overcoming treatment resistance in cancer.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0