Pharmaceutical nanotechnology最新文献_第4页

Chromatography and Spectroscopic Technique-based Rapid Characterization of Nano-carrier Pharmaceuticals. 基于色谱和光谱技术的纳米载体药物快速表征。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/0122117385319695240911115239

Shamim Shamim, Tarmeen Ali

{"title":"Chromatography and Spectroscopic Technique-based Rapid Characterization of Nano-carrier Pharmaceuticals.","authors":"Shamim Shamim, Tarmeen Ali","doi":"10.2174/0122117385319695240911115239","DOIUrl":"10.2174/0122117385319695240911115239","url":null,"abstract":"A nanocarrier is a novel colloidal system whose particle size ranges between 1-100 nm. It is extensively utilized in drug delivery and various other sectors, such as the pharmaceutical, food, and dairy industries. The nanocarrier systems, including solid lipid nanoparticles, micelles, liposomes, and other encapsulated compounds, have improved stability, solubility, bioavailability, and quality. Nanocarriers offer therapeutic effectiveness with low toxicity because of their biocompatibility and ability to cross body barriers. Various analytical techniques, such as chromatography and spectroscopy, are crucial in qualitative and quantitative analysis of nanocarrier-based formulations. Molecular identification and drug content determination require chromatographic techniques, particularly HPLC. Spectroscopic techniques such as LC-MS, NMR, GC-MS, CE-MS, Raman, and IR are used to analyze the interaction and molecular structure of the sample. Nanocarriers have several benefits but face various challenges like stability, drug loading, regulatory standards, and biocompatibility. Future surface engineering and nanocarrier design advancements could improve targeted drug delivery and sustained diagnostic applications, significantly impacting healthcare.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"178-192"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle Carriers for Drug Delivery: An Updated Review. 纳米颗粒药物递送载体：最新综述。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/0122117385340986241208123048

Somayeh Hajipour, Alireza Ghiasvand

引用次数: 0

Network Pharmacology and Optimization of β-Sitosterol-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design for Enhanced Solubility and Sustained Drug Release in Diabetes. 利用Box-Behnken设计优化β-谷甾醇负载固体脂质纳米颗粒的网络药理学和优化，以提高糖尿病患者的溶解度和持续药物释放。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/0122117385321110241110170903

Ramsha Aslam, Varsha Tiwari, Prashant Upadhyay, Abhishek Tiwari

{"title":"Network Pharmacology and Optimization of β-Sitosterol-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design for Enhanced Solubility and Sustained Drug Release in Diabetes.","authors":"Ramsha Aslam, Varsha Tiwari, Prashant Upadhyay, Abhishek Tiwari","doi":"10.2174/0122117385321110241110170903","DOIUrl":"10.2174/0122117385321110241110170903","url":null,"abstract":"Introduction: The pharmaceutical industry has paid a lot of attention to solid lipid nanoparticles (SLN) because they show promising drug delivery vehicles.Methods: This work aimed to design and optimize the SLN of β-sitosterol, a hydrophobic drug, to improve solubility and sustained action. An ultrasonication technique after melting was used to design SLN using a randomized response surface Box-Behnken design (BBD). Network pharmacology analysis was performed to explore the interactions between genes. According to the findings, Compritol ATO 888 was the most soluble at a drug: lipid ratio of 1:3. Particle size, PDI, zeta, and entrapment efficiency (EE) were observed as 168.83nm, 0.231 -28.9 Mv, and 68.29%, respectively. The optimized formulation did not undergo any chemical changes, as depicted through DSC. The in vitro drug release investigation showed that the SLN released the drug continuously for 28 hours. Scanning Electron Microscopy (SEM) revealed homogenous, spherical particles.Results and discussion: The antidiabetic potential of the formulation was assessed through the potential of glucose uptake by yeast, and the α-amylase inhibitory assay revealed its significant antidiabetic potential when compared with that of the standard drug metformin. The network pharmacology of β-sitosterol demonstrated gene interaction with hexokinase, phosphoglucomutases, glucose-6- phosphate dehydrogenase, hexose-6-phosphate dehydrogenase, and glutathione disulfide reductase.Conclusion: The β-sitosterol-loaded SLN generated by BBD was found to be a potential method for improving drug solubility with sustained drug release and was found to be long-term storage stable.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"521-536"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silk Fibroin Hydrogels: Cutting-edge Developments and Future Directions. 丝素蛋白水凝胶：前沿发展和未来方向。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/0122117385339249241102165029

Govindaraj Sabarees, Ganesan Padmini Tamilarasi, Jayaraman Rajangam, Veerachamy Alagarsamy, Viswas Raja Solomon

{"title":"Silk Fibroin Hydrogels: Cutting-edge Developments and Future Directions.","authors":"Govindaraj Sabarees, Ganesan Padmini Tamilarasi, Jayaraman Rajangam, Veerachamy Alagarsamy, Viswas Raja Solomon","doi":"10.2174/0122117385339249241102165029","DOIUrl":"10.2174/0122117385339249241102165029","url":null,"abstract":"The exploration of hydrogel materials has gained significant attention due to the ongoing period of collaborative interdisciplinary advancements. Silk fibroin (SF) possesses remarkable attributes, such as less immunogenicity, sterilization efficacy, processability without chemical crosslinkers, excellent biocompatibility, low immunogenicity, non-toxicity, mechanical strength, thermal stability, non-carcinogenicity, and adjustable biodegradability make it a highly valuable biomaterial. Silk fibroin hydrogel (SFH), a versatile biomaterial, has garnered significant attention due to its unique properties. Its biocompatibility, tunable mechanical properties, water retention capacity, and bioactive nature offer a unique combination of features that can effectively promote tissue regeneration and enhance wound healing. The utilization of SF for hydrogel production presents a valuable opportunity to leverage natural resources and promote eco-friendly production practices. With their exceptional properties and versatile applications in biomedicine, silk protein- based hydrogels hold promise for various research fields. This review aims to discuss the potential properties and recent advancements in the application of SF-based hydrogels for preclinical skin wound healing.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"484-508"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparations, Applications, Patents, and Marketed Formulations of Nanoemulsions - A Comprehensive Review. 纳米乳剂的制备、应用、专利和上市配方 - 全面回顾。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/0122117385325186240912110731

Mansi Chauhan, Rupa Mazumder, Anjna Rani, Rashmi Mishra, Rashmi Saxena Pal

{"title":"Preparations, Applications, Patents, and Marketed Formulations of Nanoemulsions - A Comprehensive Review.","authors":"Mansi Chauhan, Rupa Mazumder, Anjna Rani, Rashmi Mishra, Rashmi Saxena Pal","doi":"10.2174/0122117385325186240912110731","DOIUrl":"10.2174/0122117385325186240912110731","url":null,"abstract":"Nanoemulsions have emerged as versatile colloidal dispersions with promising applications in various fields, including pharmaceuticals, food, and cosmetics. These nano-sized emulsions, stabilized by surfactants, offer unique advantages such as enhanced ingredient penetration efficacy and versatile dosage forms. This article provides an extensive overview of nanoemulsions, covering their composition, methods of preparation, and applications in drug delivery, the food industry, and cosmetics. Various high-energy and low-energy methods for nanoemulsion preparation are discussed, along with their advantages and limitations. Additionally, the article highlights the potential of nanoemulsions in improving drug bioavailability, stability, and therapeutic efficacy, especially in oral, topical, parenteral, intranasal, ocular, and pulmonary drug delivery. Furthermore, nanoemulsions are explored as carriers for encapsulating flavoring agents, nutraceuticals, and natural preservatives in the food industry, as well as their use in cosmetic formulations. Current clinical trials involving nanoemulsions and recent patents in the field are also summarized, providing insights into ongoing research and development efforts. Lastly, a selection of marketed nanoemulsion formulations is presented, showcasing their practical applications and commercial availability. Overall, nanoemulsions hold great promise as effective delivery systems with broad applications across various industries.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"78-93"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Enhanced Scrutiny of Mechanistic and Translational Approaches to Extinguish Cancer Hypoxia. 加强对消除癌症缺氧的机制和转化方法的审查。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/0122117385328105241216042016

Arun Radhakrishnan, Nikhitha K Shanmukhan, Linda Christabel S

{"title":"An Enhanced Scrutiny of Mechanistic and Translational Approaches to Extinguish Cancer Hypoxia.","authors":"Arun Radhakrishnan, Nikhitha K Shanmukhan, Linda Christabel S","doi":"10.2174/0122117385328105241216042016","DOIUrl":"10.2174/0122117385328105241216042016","url":null,"abstract":"Cancer continues to pose a formidable challenge in global health due to its incidence and increasing resistance to conventional therapies. A key factor driving this resistance is tumor hypoxia, characterized by reduced oxygen levels within cancer cells. This hypoxic environment triggers a variety of adaptive mechanisms, significantly compromising the efficacy of cancer treatments. Notably, hypoxia promotes metastasis and reshapes the tumor microenvironment (TME), thereby aggravating treatment resistance. Central to this process are hypoxia-inducible factors (HIFs), which mediate cellular adaptations such as metabolic shifts and enhanced survival pathways. These adaptations render therapies like chemotherapy, radiotherapy, and photodynamic therapy (PDT) less effective. Additionally, hypoxia-induced vascular irregularities further impede drug delivery, amplifying the therapeutic challenge. This review provides a comprehensive examination of the roles of hypoxia in cancer, its contributions to drug resistance, and its interplay with apoptosis and autophagy. By evaluating novel mechanistic and translational approaches to target hypoxia, this study highlights the potential to improve therapeutic outcomes and offers insights into overcoming treatment resistance in cancer.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"362-376"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer Therapy with Polymeric Nanocarriers and the Transition to Targeted Cancer Therapy: Advances and Future Directions. 高分子纳米载体的癌症治疗和向靶向癌症治疗的过渡：进展和未来方向。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/0122117385350610250112112855

Panagiotis Theodosis-Nobelos, Elina N Kitiri, Melina Christou, Maria Pantelidou, Maria Rikkou-Kalourkoti

{"title":"Cancer Therapy with Polymeric Nanocarriers and the Transition to Targeted Cancer Therapy: Advances and Future Directions.","authors":"Panagiotis Theodosis-Nobelos, Elina N Kitiri, Melina Christou, Maria Pantelidou, Maria Rikkou-Kalourkoti","doi":"10.2174/0122117385350610250112112855","DOIUrl":"10.2174/0122117385350610250112112855","url":null,"abstract":"The development of targeted cancer therapies has become crucial in addressing the limitations of conventional chemotherapy, particularly its lack of specificity and severe side effects. Polymeric nanocarriers have emerged as a transformative solution, providing enhanced drug solubility, selective targeting, and controlled release of therapeutics. This review discusses recent advances in polymeric nanocarriers, emphasizing their capacity to incorporate multiple drugs and optimize delivery through both active and passive targeting strategies, and especially the transition to targeted cancer therapy through the various applied methods in the field. Mechanisms such as the enhanced permeability and retention (EPR) effect for passive targeting, and the use of ligands, peptides, and proteins for active targeting, are explored in depth. Furthermore, the potential of these nanocarriers to improve therapeutic outcomes through targeting specific cellular and subcellular sites, including the nucleus, mitochondria, and endoplasmic reticulum, is examined. These innovations pave the way for the development of safer and more effective cancer treatments with the potential to enhance clinical outcomes.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"469-483"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium Nanoliposome Improves Glycemic Control in a Mouse Diabetes Mellitus Model. 钙纳米脂质体改善小鼠糖尿病模型的血糖控制。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/0122117385407218250621220813

Parhan, Rachmat Mauludin, Kusnandar Anggadiredja

{"title":"Calcium Nanoliposome Improves Glycemic Control in a Mouse Diabetes Mellitus Model.","authors":"Parhan, Rachmat Mauludin, Kusnandar Anggadiredja","doi":"10.2174/0122117385407218250621220813","DOIUrl":"10.2174/0122117385407218250621220813","url":null,"abstract":"Introduction: Intracellular calcium in pancreatic beta cells plays a crucial role in insulin synthesis and secretion. Diabetes impairs this calcium-mediated action, necessitating an effective delivery system such as liposomes to facilitate calcium uptake.Methods: Calcium lactate nanoliposomes (6.25 mg/mL) were prepared via the thin-film hydration method using lecithin and cholesterol as bilayer lipids. Their glucose-lowering efficacy was tested in hyperglycemic mice induced by oral glucose (1 g/kg) and intraperitoneal streptozotocin (45 mg/kg). Pancreatic calcium levels were measured using X-ray fluorescence to verify calcium delivery to beta cells.Results: The nanoliposomes exhibited a diameter of 172.1 nm, zeta potential of -53.45 mV, polydispersity index of 0.203, and pH 7.2. Entrapment efficiency was 93.42%, with stable pH and particle size over six cycles. Treatment with calcium nanoliposomes significantly reduced blood glucose levels in both diabetic and glucose-loaded mice. Pancreatic calcium concentrations were higher in animals receiving calcium nanoliposomes compared to controls.Discussion: Calcium nanoliposomes induced a significant glucose reduction relative to controls (empty liposomes, distilled water, and calcium in distilled water). Encapsulation within liposomal vesicles enhanced calcium delivery to pancreatic beta cells, increasing intracellular calcium and stimulating insulin production and release. This was corroborated by elevated pancreatic calcium levels observed via X-ray fluorescence in treated animals.Conclusion: Calcium nanoliposomes effectively improve glycemic control in diabetic and glucosechallenged animal models by enhancing calcium delivery to pancreatic beta cells.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"152-166"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: A Comprehensive Review of Nanomaterials as Potential Weapons against Multidrug-resistant Staphylococcus aureus. 纳米材料作为耐多药金黄色葡萄球菌潜在武器的综合综述。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/2211738514999260106142359

Bhargav Devliya, Bimalkumar Patel, Shreya J Chauhan, Hitesh D Patel

{"title":"Corrigendum to: A Comprehensive Review of Nanomaterials as Potential Weapons against Multidrug-resistant Staphylococcus aureus.","authors":"Bhargav Devliya, Bimalkumar Patel, Shreya J Chauhan, Hitesh D Patel","doi":"10.2174/2211738514999260106142359","DOIUrl":"10.2174/2211738514999260106142359","url":null,"abstract":"In the article, titled \"A Comprehensive Review of Nanomaterials as Potential Weapons against Multidrug-Resistant Staphylococcus aureus,\" published in Pharmaceutical Nanotechnology [1], the citation for Figure 4 was inadvertently omitted in the original version of the manuscript. This omission has now been corrected. The details of the correction are as follows: Original: Nanomaterial-based approaches show promise for efficient, economical point-of-care diagnostics due to their inherent antimicrobial activity and ability to bind pathogens, facilitating improved detection methods. Nanoparticles offer intrinsic benefits such as size, high surface area, morphology, simplicity of surface modification, and unique optical, electromagnetic, mechanical, and chemical capabilities. Aside from improved antimicrobial action, the features of metal-based NPs allow them to be used as diagnostics agents for microbial infections [29, 156]. Fig. (5) depicts several ways for bioimaging S. aureus using colorimetric, fluorescent, magnetic NPs, and surface-enhanced Raman scattering approaches. Corrected: Nanomaterial-based approaches show promise for efficient, economical point-of-care diagnostics due to their inherent antimicrobial activity and ability to bind pathogens, facilitating improved detection methods. Nanoparticles offer intrinsic benefits such as size, high surface area, morphology, simplicity of surface modification, and unique optical, electromagnetic, mechanical, and chemical capabilities. Aside from improved antimicrobial action, the features of metal-based NPs allow them to be used as diagnostics agents for microbial infections [29, 156]. Fig. (4 and 5) depicts several ways for bioimaging S. aureus using colorimetric, fluorescent, magnetic NPs, and surface-enhanced Raman scattering approaches. We regret the error and apologize to the readers. The original article can be found online at: https://www.eurekaselect.com/article/141225.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":"14 1","pages":"167"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Nanoemulsion-based Gel of Betulin for the Treatment of Psoriasis-Like Skin Inflammation in a Small Animal Model. 小动物模型中治疗牛皮癣样皮肤炎症的纳米乳脂凝胶的研制。

Pharmaceutical nanotechnology Pub Date : 2026-01-01 DOI: 10.2174/0122117385336297241210053845

Dev Prakash, Anjali Chaudhary

{"title":"Development of Nanoemulsion-based Gel of Betulin for the Treatment of Psoriasis-Like Skin Inflammation in a Small Animal Model.","authors":"Dev Prakash, Anjali Chaudhary","doi":"10.2174/0122117385336297241210053845","DOIUrl":"10.2174/0122117385336297241210053845","url":null,"abstract":"Introduction/ Background: This study aimed to introduce a gel (NEG) formulation containing betulin-loaded nanoemulsions for topical psoriasis treatment.Materials and methods: The prepared nanoemulsions were optimized for smaller particle size and higher drug content using a response surface methodology that exhibited uniform distribution and high drug loading (21.17±3.55%).Results: The gel demonstrated skin-compatible pH and good spreadability. The developed gel showed slower release compared to nanoemulsion. In vivo pharmacokinetics demonstrated elevated AUC (55835.1 μg/cm2.h) and extended Tmax (720 min) for the gel than NE, indicating extended skin retention. Improved skin hydration (35%) and lipid content (28%) were observed, along with significant reductions in PASI scores and cytokine levels.Discussion: Provided with enhanced skin retention, improved hydration, and lipid content, along with significant therapeutic efficacy in psoriasis treatment, betulin-loaded nanoemulsion gel demonstrated prolonged drug release and notably reduced PASI scores and cytokine levels, highlighting its effectiveness against psoriasis.Conclusion: This highlights the promising potential of NEG for topical psoriasis management.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":"537-554"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0