聚合纳米片:一种用于局部治疗的多功能纳米载体平台。

Q2 Pharmacology, Toxicology and Pharmaceutics
Devesh U Kapoor, Mansi Gaur, Hetal Hingalajia, Sudarshan Singh, Bhupendra G Prajapati
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引用次数: 0

摘要

聚合物纳米片提供了一个有前途的和适应性强的纳米载体平台,用于局部应用,包括靶向给药。这些生物相容性聚合物基的圆盘状纳米结构因其封装各种治疗药物的特殊能力而引起了人们的兴趣。将治疗和诊断结合为一个单一系统的治疗学概念是吸引人的核心。聚合物纳米片提供了精确和更少的不良反应,提供了这些药物的调节和延长释放。它们还为跟踪治疗效果提供了完美的基础。选择具有生物相容性和定制释放机制的聚合物材料是有效实现聚合物纳米片的关键。最近的临床前和临床研究已经证明了靶向治疗干预的有效性。然而,在实际应用中存在障碍和限制,需要更多的研究来充分发挥其潜力。因此,聚合物纳米片提供了控制药物释放和同时诊断能力,使其成为局部治疗的灵活可行的途径。它们的进步有机会改善治疗效果;然而,需要更多的研究来妥善解决障碍并发挥其治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polymeric Nano-discs: A Versatile Nanocarrier Platform for Delivering Topical Theranostics.

Polymeric nano-discs offer a promising and adaptable nanocarrier platform for topical applications involving the targeted administration of drugs. These biocompatible polymer-based, disc-shaped, nanoscale structures have drawn interest due to their exceptional capacity to encapsulate a diverse range of theranostics. Theranostics, the concept of combining treatments and diagnostics into a single system, is the core of attraction. Precision and fewer adverse effects are provided by the regulated and prolonged release of these drugs made possible by polymeric nano-discs. They also offer the perfect foundation for keeping track of the effectiveness of treatments. The selection of polymeric materials that provide biocompatibility and customized release mechanisms is critical to effectively implementing polymeric nano-discs. Recent pre-clinical and clinical research has demonstrated efficacy in targeted therapeutic interventions. Nevertheless, there are obstacles and restrictions in real-world implementation, and more study is necessary to fully realize their potential. Hence polymeric nano-discs offer controlled drug release and simultaneous diagnostic capabilities, making them a flexible and viable path forward for topical theranostics. Their advancement has opportunities for improved treatment results; however, more study is needed to properly resolve obstacles and realize their therapeutic potential.

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来源期刊
Pharmaceutical nanotechnology
Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.20
自引率
0.00%
发文量
46
期刊介绍: Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.
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