{"title":"西印度榆树叶提取物纳米研磨提高其体外生物活性","authors":"Yuda Prasetya Nugraha, Juniar Kalpika Resmi, Muhammad Luthfi Shidik, Rachmat Mauludin, Muhamad Insanu, Sophi Damayanti, Benny Permana, Siti Farah Rahmawati, Neng Fisheri Kurniati, Nizar Happyana, Ade Danova, Heni Rachmawati","doi":"10.2174/0122117385338502250417020845","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Guazuma ulmifolia or mutamba has been traditionally used for many years as a slimming agent. Various studies reported the antihyperlipidemic activity of mutamba leaves extract due to its flavonoid content.</p><p><strong>Objective: </strong>This research was conducted to improve the bioactivity of mutamba leaves extract by applying ball-milling technology.</p><p><strong>Methods: </strong>Unground dried mutamba leaves were extracted in ethanol 40%. The resulting extract (ME) was nano-milled and characterized for its physicochemical parameters. The ball milling process was optimized by performing in various durations, ball and powder ratios, and rotation speed.</p><p><strong>Results: </strong>The optimized process of ball milling produced nano-extract (NanoME) with a particle size of 492,57±55,96 nm, confirmed with particle size and SEM. Compared with ME, the crystallinity and thermal behavior of NanoME did not change by particle size reduction. The reduction of particle size also did not improve the HMG-CoA reductase inhibitor activity. ME and NanoME showed comparable activity compared to Pravastatin. However, the bioactivities of NanoME, including DPPH antioxidant activities, improved 8-fold compared to ME.</p><p><strong>Conclusion: </strong>The improvement of these activities was attributed to the increase in their flavonoid content. This study emphasizes the role of particle size reduction or nano-extract preparation in increasing the biological activity of plant extracts.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nano Milling Application of Mutamba (West Indian Elm) Leaves Extract to Enhance its In vitro Bioactivity.\",\"authors\":\"Yuda Prasetya Nugraha, Juniar Kalpika Resmi, Muhammad Luthfi Shidik, Rachmat Mauludin, Muhamad Insanu, Sophi Damayanti, Benny Permana, Siti Farah Rahmawati, Neng Fisheri Kurniati, Nizar Happyana, Ade Danova, Heni Rachmawati\",\"doi\":\"10.2174/0122117385338502250417020845\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Guazuma ulmifolia or mutamba has been traditionally used for many years as a slimming agent. Various studies reported the antihyperlipidemic activity of mutamba leaves extract due to its flavonoid content.</p><p><strong>Objective: </strong>This research was conducted to improve the bioactivity of mutamba leaves extract by applying ball-milling technology.</p><p><strong>Methods: </strong>Unground dried mutamba leaves were extracted in ethanol 40%. The resulting extract (ME) was nano-milled and characterized for its physicochemical parameters. The ball milling process was optimized by performing in various durations, ball and powder ratios, and rotation speed.</p><p><strong>Results: </strong>The optimized process of ball milling produced nano-extract (NanoME) with a particle size of 492,57±55,96 nm, confirmed with particle size and SEM. Compared with ME, the crystallinity and thermal behavior of NanoME did not change by particle size reduction. The reduction of particle size also did not improve the HMG-CoA reductase inhibitor activity. ME and NanoME showed comparable activity compared to Pravastatin. However, the bioactivities of NanoME, including DPPH antioxidant activities, improved 8-fold compared to ME.</p><p><strong>Conclusion: </strong>The improvement of these activities was attributed to the increase in their flavonoid content. This study emphasizes the role of particle size reduction or nano-extract preparation in increasing the biological activity of plant extracts.</p>\",\"PeriodicalId\":19774,\"journal\":{\"name\":\"Pharmaceutical nanotechnology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutical nanotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0122117385338502250417020845\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical nanotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0122117385338502250417020845","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Nano Milling Application of Mutamba (West Indian Elm) Leaves Extract to Enhance its In vitro Bioactivity.
Background: Guazuma ulmifolia or mutamba has been traditionally used for many years as a slimming agent. Various studies reported the antihyperlipidemic activity of mutamba leaves extract due to its flavonoid content.
Objective: This research was conducted to improve the bioactivity of mutamba leaves extract by applying ball-milling technology.
Methods: Unground dried mutamba leaves were extracted in ethanol 40%. The resulting extract (ME) was nano-milled and characterized for its physicochemical parameters. The ball milling process was optimized by performing in various durations, ball and powder ratios, and rotation speed.
Results: The optimized process of ball milling produced nano-extract (NanoME) with a particle size of 492,57±55,96 nm, confirmed with particle size and SEM. Compared with ME, the crystallinity and thermal behavior of NanoME did not change by particle size reduction. The reduction of particle size also did not improve the HMG-CoA reductase inhibitor activity. ME and NanoME showed comparable activity compared to Pravastatin. However, the bioactivities of NanoME, including DPPH antioxidant activities, improved 8-fold compared to ME.
Conclusion: The improvement of these activities was attributed to the increase in their flavonoid content. This study emphasizes the role of particle size reduction or nano-extract preparation in increasing the biological activity of plant extracts.
期刊介绍：
Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.
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