Otolaryngology- Head and Neck Surgery最新文献

{"title":"Demographics and Trends in Outpatient Surgery for Laryngeal Cancer: 2016-2021.","authors":"Jason H Lee, Jamie W Lewis, James D Warren, Alia Tayara, Thanh-Huyen Vu, Anne C Kane","doi":"10.1002/ohn.1198","DOIUrl":"10.1002/ohn.1198","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the utilization patterns of outpatient laryngoscopic excision procedures for laryngeal cancer in the United States, examining procedural costs and patient demographics to identify disparities in healthcare access.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>National Ambulatory Surgery Sample database of major ambulatory surgeries in the United States, 2016-2021.</p><p><strong>Methods: </strong>Encounters for endoscopic resection of laryngeal cancers were identified focusing on patient demographics and procedural costs. Analysis was performed regarding trends over time.</p><p><strong>Results: </strong>Of 11,371 encounters in 2016-2021, patients were mostly male (82.6%), White (75.3%), and living in metropolitan areas with greater than 1 million residents (54.1%), with an even distribution between income quartiles. Predictors of utilization at urban teaching hospitals progressively decreased in patients residing in smaller metropolitan areas (250-999,000 residents (odds ratio [OR] = 0.451, P ≤ .0001) and 50-249,000 residents (OR = 0.193, P ≤ .0001). Higher utilization was found in non-White patients (Black [OR = 1.673, P = .0075], Hispanic [OR = 1.752, P = .0118]), and those with patients with higher income (2nd quartile [OR = 1.411, P = .0058], 3rd quartile [OR = 2.017, P ≤ .0001], and 4th quartile [OR = 4.422, P < .0001]). These findings were consistent on multivariate analysis, however belonging to a racial minority lost significance (Black patients [P = .0508], Hispanic [P = .3008]).</p><p><strong>Conclusion: </strong>There are existing disparities in endoscopic resection of laryngeal cancers. Our findings add to the literature underscoring the importance of expanding access to minimally invasive laryngeal preserving surgical treatment.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1664-1675"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Timing of Primary Radiosurgical Treatment of Growing Vestibular Schwannoma: Insights From Salvage Microsurgery Outcomes.","authors":"John P Marinelli, Hans A Herberg, Lindsay S Moore, Kristen L Yancey, Emily Kay-Rivest, Garrett G Casale, Allison Durham, Karl R Khandalavala, Morten Lund-Johansen, Nikitha Kosaraju, Christine M Lohse, Neil S Patel, Richard K Gurgel, Seilesh C Babu, John G Golfinos, J Thomas Roland, Jacob B Hunter, J Walter Kutz, Peter L Santa Maria, Michael J Link, Øystein V Tveiten, Matthew L Carlson","doi":"10.1002/ohn.1161","DOIUrl":"10.1002/ohn.1161","url":null,"abstract":"<p><strong>Objective: </strong>Limited evidence guides the optimal timing of treatment after the detection of tumor growth during the observation of sporadic vestibular schwannoma (VS). The current work aimed to inform the timing of radiosurgical intervention based on an analysis of patient outcomes among those who ultimately failed stereotactic radiosurgery (SRS) and underwent salvage microsurgery.</p><p><strong>Study design: </strong>A historical cohort study.</p><p><strong>Setting: </strong>Seven centers across the United States and Norway.</p><p><strong>Methods: </strong>Adults with sporadic VS who underwent salvage microsurgery following failed primary SRS were included. The primary outcome of interest was the association between tumor size at the time of primary SRS and the ability to achieve gross total resection (GTR) and maintain postoperative House-Brackmann (HB) facial nerve grade I at the last follow-up after salvage microsurgery.</p><p><strong>Results: </strong>Among 96 patients, the median (interquartile range [IQR]) cerebellopontine angle (CPA) tumor size at primary SRS was 14.5 mm (10.0-19.0). Each 1-mm increase in CPA tumor size at the time of primary SRS was associated with a 13% increased likelihood of near-total/subtotal resection or most recent postoperative HB grade >I (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.05-1.21, P = .001), with an optimal tumor size threshold to distinguish this outcome of 12 mm of CPA extension (c-index 0.73). Similarly, for each 1-mm increase in CPA tumor size at the time of primary SRS, a 9% increase in any postoperative complication with salvage microsurgery was observed (OR 1.09, 95% CI 1.02-1.15, P = .009).</p><p><strong>Conclusion: </strong>Corroborated by size threshold surveillance data informing the timing of primary microsurgical resection, the current study suggests that VS outcomes are optimized when primary radiosurgical intervention is undertaken on growing tumors when they harbor 10-15 mm of cerebellopontine angle extension or less.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1717-1724"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Unilateral, Asymmetric, and Bilateral Tinnitus in Military Personnel and Its Impact on Disability.","authors":"Kristofer G Andren, John P Marinelli, Samuel A Spear, Samrita Thapa, Emily J Thielman, Isaac D Erbele, Kelly M Reavis","doi":"10.1002/ohn.1153","DOIUrl":"10.1002/ohn.1153","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to describe the prevalence of unilateral, asymmetric, and bilateral tinnitus by severity of tinnitus across hearing sensitivity within the Noise Outcomes In Service members Epidemiology (NOISE) Study cohort.</p><p><strong>Study design: </strong>A cross-sectional study.</p><p><strong>Setting: </strong>Multi-institutional tertiary referral centers.</p><p><strong>Methods: </strong>Behavioral audiometric testing, tinnitus history, and tinnitus severity were described cross-sectionally. Tinnitus severity was assessed by the Tinnitus Functional Index (TFI). The WHO Disability Assessment Schedule (WHODAS) 2.0 was used to capture functional deficits.</p><p><strong>Results: </strong>Tinnitus prevalence within the NOISE cohort was 46% (644/1387). Among those with tinnitus, the mean age was 36.1 years (standard deviation = 9.7), and 86% (553/644) were male, reflecting the predominantly male composition of the overall study population. The majority (85%) had normal hearing, and the remaining (15%) had mild-to-moderate sensorineural hearing loss. Bilateral tinnitus was the most prevalent (54%), followed by asymmetric (35%) and unilateral (11%). Severe tinnitus was reported in 24%, moderate in 38%, and no/mild in 38%. Compared to those with normal hearing, subjects with mild-to-moderate hearing loss had a higher prevalence of tinnitus (odds ratio (OR) = 2.4, 95% confidence interval [CI]: 1.6-3.7), higher TFI scores (mean difference = 14.1, 95% CI: 9.4-18.7), and a higher proportion reporting severe versus mild tinnitus (OR = 3.7, 95% CI: 2.0-6.9). In individuals with mild-to-moderate hearing loss, the highest TFI and WHODAS scores were associated with bilateral tinnitus (49.0 and 28.2, respectively).</p><p><strong>Conclusion: </strong>Tinnitus is prevalent in people with military service history, both in those with and without sensorineural hearing loss. However, tinnitus had a greater impact on daily functioning among those with sensorineural hearing loss.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1608-1616"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Targeted Congenital Cytomegalovirus Screening Model Using a Customized Electronic Medical Record Dashboard Report.","authors":"Meryl B Kravitz, Dhvanii K Raval, Juan Lin, Stelby Augustine, Mahindra Ramdhanie, Suzette O Oyeku, Sheri L Nemerofsky, Michel N Nassar","doi":"10.1002/ohn.1175","DOIUrl":"10.1002/ohn.1175","url":null,"abstract":"<p><strong>Objective: </strong>Targeted congenital Cytomegalovirus (cCMV) screening in newborns has been proposed to identify neonates who could benefit from early diagnosis and intervention. Oftentimes, implementation of targeted screening is variable and left to the discretion of individual institutions. This study investigates the utility of a centralized electronic medical record (EMR) dashboard to improve compliance of targeted screening in the inpatient setting.</p><p><strong>Study design: </strong>Single center prospective feasibility study SETTING: Tertiary medical center METHODS: A targeted cCMV screening dashboard report was generated weekly using an EMR system. The dashboard screened all births in a large multi-site medical center for failed neonatal hearing screens and specific high-risk diagnoses associated with cCMV. Eligible patients requiring further hearing screening or cCMV testing were communicated to inpatient units. Log-binomial regression analyses were utilized to assess provider-led cCMV screening performance after the introduction of weekly reports.</p><p><strong>Results: </strong>From July 1, 2021, to December 31, 2022, 5,866 newborns were screened by the dashboard. Nine-hundred and eighteen newborns (15.6%) were eligible for testing. Nearly 75% (n = 687) of newborns were tested by inpatient teams prior to report generation. The remaining 25% (n = 231) of eligible newborns were identified by the report but not yet tested by inpatient teams, and subsequently tested. Three of the newborns tested positive for CMV. The rate of eligible newborns appropriately identified by the inpatient teams increased over time (log-binomial regression coefficient 0.0215, P < .01).</p><p><strong>Conclusion: </strong>An EMR dashboard to guide targeted cCMV screening can improve testing compliance. This model is promising for large-scale cCMV screening.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1768-1773"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communication of Voice-Related Complications in Thyroidectomy: A Qualitative Analysis.","authors":"Derek D Kao, Catherine B Jensen, Elizabeth Bacon, Norman D Hogikyan, Benjamin R Roman, Susan C Pitt","doi":"10.1002/ohn.1162","DOIUrl":"10.1002/ohn.1162","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to characterize patient-surgeon discussions of voice-related complications during thyroidectomy for low-risk thyroid cancer.</p><p><strong>Study design: </strong>A qualitative study.</p><p><strong>Setting: </strong>Three academic medical centers.</p><p><strong>Methods: </strong>Pre-operative clinic visits between 14 surgeons (6 otolaryngologists and 8 endocrine surgeons) and 49 patients with low-risk (cT1-2, N0) thyroid cancer were audio-recorded and transcribed. Qualitative analysis was used to evaluate surgeon counseling strategies and patient concerns related to voice.</p><p><strong>Results: </strong>Patients aged from 20 to 77 years old were predominantly female (77.6%) and white (89.9%). Surgeons presented risk with negative framing and numerical percentages (1%-4%) and/or qualified the risk as \"low\" or \"small\" for a lobectomy, but a \"much bigger deal\" for bilateral nerve injury in total thyroidectomy. At a minimum, surgeons referred to voice dysfunction as \"voice change.\" Some further described \"hoarseness\" or the \"inability to project voice.\" Other surgeons imitated what voice dysfunction would sound like. A few surgeons probed the importance of voice to a patient's life. One surgeon imparted that having a voice-related complication \"can be really emotional.\" Patients responded with varying degrees of concern about voice changes after surgery, from feeling \"super concerned … about losing [their] voice\" to feeling \"ok\" with it \"as long as [they're] around to deal with it.\"</p><p><strong>Conclusion: </strong>Significant variability exists in how surgeons describe and set expectations about voice-related complications. The degree to which patients value voice-related outcomes differed based on their occupation and hobbies, but this was tempered by their cancer diagnosis. Further research is needed to identify optimal disclosure of voice-related risks and expectations.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1560-1569"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Prescribing Patterns: A Systematic Review of Chronic Opioid Prescriptions After Head and Neck Cancer Surgeries.","authors":"Sabin Karki, Brooke Stephanian, Mirian Ramirez, Michael G Moore, David A Campbell, Diane W Chen, Michael W Sim, Jessica A Yesensky, Avinash Mantravadi, Janice L Farlow","doi":"10.1002/ohn.1165","DOIUrl":"10.1002/ohn.1165","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to review opioid prescribing changes for pain management in head and neck cancer (HNC) surgery patients, given the recent focus on Enhanced Recovery After Surgery protocols.</p><p><strong>Data sources: </strong>MEDLINE, Embase, and CENTRAL, covering 1998 to 2023.</p><p><strong>Review methods: </strong>We selected studies that evaluated opioid prescribing patterns post-major HNC surgery in various settings, including tertiary care hospitals and community hospitals. Primary outcomes considered were prevalence and patterns of opioid use post-surgery, as well as related outcomes such as chronic use and side effects.</p><p><strong>Results: </strong>Of 1278 abstracts, 24 studies involving 17,027 patients from the United States, China, and Canada met inclusion criteria. Quality was assessed using the MINORS scale, with an average score of 9.9 for non-comparative studies and 20.0 for comparative studies. Persistent opioid use post-surgery, defined as ongoing prescriptions 90 days after treatment, was noted in 15.4% to 64% of patients. Two studies reported adverse events, with up to 16% of patients experiencing side effects. Risk factors for chronic use included preoperative opioid use, tobacco use, higher cancer stage, adjuvant treatment, and demographic factors. Correlations were found between larger opioid prescriptions and shorter survival in advanced cancers. There was notable variability in patient-reported pain control.</p><p><strong>Conclusion: </strong>Persistent opioid use post-HNC surgery is common, with variable efficacy and risk of adverse effects. Tailoring pain management to individual risk factors and focusing on multimodal analgesia could reduce the risks of continued opioid use. Future prospective studies are required to identify optimal pain management strategies.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1512-1520"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Class III Congenital Middle Ear Anomalies: Refining the Teunissen-Cremers Classification Based on Stapes Suprastructure Viability.","authors":"Eun-Kyeong Yeon, Sang Heun Kim, Sumin Yi, Jin Woong Choi","doi":"10.1002/ohn.1158","DOIUrl":"10.1002/ohn.1158","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the surgical outcomes of partial ossicular replacement prosthesis (PORP) and total ossicular replacement prosthesis (TORP) in class III congenital middle ear anomalies (CMEAs) based on stapes suprastructure integrity and to propose a refined Teunissen-Cremers classification.</p><p><strong>Study design: </strong>A retrospective cohort study.</p><p><strong>Setting: </strong>A tertiary academic medical center.</p><p><strong>Methods: </strong>Forty-nine ears from 46 patients with class III CMEAs who underwent ossiculoplasty from 2012 to 2024 were included. Patients were categorized into the viable suprastructure group (26 ears), with intact or mildly dysplastic suprastructures requiring PORP, and the non-viable suprastructure group (23 ears), with severely dysplastic or absent suprastructures requiring TORP. Exclusion criteria included revision surgeries, other types of CMEAs, and a follow-up period of <6 months.</p><p><strong>Results: </strong>Preoperative demographics and hearing thresholds were comparable between groups. Postoperative air-bone gap (ABG) closure within 10 dB was significantly more frequent in the viable group (80.8%) compared to that in the non-viable group (52.2%, P = .033). ABG closure within 20 dB was achieved in 100% of the viable group and 91.3% of the non-viable group (P = .215). Postoperative complications, including sensorineural hearing loss and prosthesis extrusion, were similar between groups (P > .05).</p><p><strong>Conclusions: </strong>Ossiculoplasty with PORP in viable cases demonstrated better ABG closure compared to TORP in non-viable cases. Further investigation is warranted to determine the influence of baseline hearing differences on these outcomes. A refined Teunissen-Cremers classification, subdividing class IIIa into IIIa1 (viable) and IIIa2 (non-viable) based on stapes suprastructure integrity, may improve prosthesis selection and prognostic assessment.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1711-1716"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Routine Plain Film Imaging Post Cochlear Implantation.","authors":"Ali Kouhi, Alireza Sharifi, Nikolas H Blevins","doi":"10.1002/ohn.1144","DOIUrl":"10.1002/ohn.1144","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate the efficacy of routine post-op X-ray in cochlear implantation patients.</p><p><strong>Study design: </strong>Retrospective chart review study.</p><p><strong>Setting: </strong>Primary or revision cochlear implant patients who had routine postoperative X-ray (XR) or had planned postoperative computed tomography (CT) due to clinical concerns for array malposition.</p><p><strong>Methods: </strong>All images were reviewed, and those were considered abnormal if there was a bent tip, kinking, incomplete insertion, or if the electrode array didn't follow the expected cochlear curvature. Postoperative CT scans were performed in patients with abnormal postoperation X-ray, or if there were abnormal surgical findings encountered during insertion which raised the suspicion for suboptimal placement.</p><p><strong>Results: </strong>A total of 195 patients with a mean age of 64.8 ± 18.9 years were included. XRs were performed in 188 patients and others had CT scan from the beginning. Only 2 out of 188 patients had abnormal findings on XR, which showed malposition of the electrode in one patient and a tip fold over and incomplete insertion in the other one. Both patients with abnormal findings had labyrinthitis ossificans. The patient with tip fold over ultimately underwent re-implantation. Another patient with incomplete insertion had required extended basal turn drilling during implantation, and no additional measures were taken.</p><p><strong>Conclusion: </strong>Routine XR findings did not provide the reason for additional intervention, and its benefit for patients without demonstrable cochlear abnormalities was minimal. Post-op XR can be informative in selected high risk patients, but CT imaging is a reasonable alternative to better define anatomic array location in patients particularly at risk.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1682-1691"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipopolysaccharide Causes Acquired CFTR Dysfunction in Murine Nasal Airways.","authors":"Jessica W Grayson, T Graham Norwood, Shaoyan Zhang, Daniel Skinner, Do-Yeon Cho, Bradford A Woodworth","doi":"10.1002/ohn.1143","DOIUrl":"10.1002/ohn.1143","url":null,"abstract":"<p><strong>Objective: </strong>Cystic fibrosis (CF) is a clinical entity defined by aberrant chloride (Cl^-) ion transport causing downstream effects on mucociliary clearance (MCC) in sinonasal epithelia. Inducible deficiencies in transepithelial Cl^- transport via CF transmembrane conductance regulator (CFTR) has been theorized to be a driving process in recalcitrant chronic rhinosinusitis (CRS) in patients without CF. We have previously identified that brief exposures to bacterial lipopolysaccharide (LPS) in mammalian cells induces an acquired dysfunction of CFTR in vitro and in vivo. The objective of the current study is to evaluate whether LPS generates a model of acquired CFTR dysfunction murine nasal airways.</p><p><strong>Study design: </strong>Basic science.</p><p><strong>Setting: </strong>Laboratory.</p><p><strong>Methods: </strong>CFTR^+/+ murine nasal airways were irrigated with 2 µg/mL LPS or control vehicle twice daily for 1 week and transepithelial Cl^- transport assessed with the nasal potential difference (NPD) assay. Histopathologic evaluation included the number of lymphoid aggregates, as well as the epithelial and subepithelial heights.</p><p><strong>Results: </strong>Transepithelial Cl^- secretion by NPD was markedly reduced in mice exposed to LPS (in mV, -0.14 ± 7.7 vs control, -6.98 ± 7.15, P < .05), while amiloride-sensitive voltage was preserved (6.38 ± 5.09 vs control, 7.36 ± 2.87, P = .99). Histopathology demonstrated significantly higher lymphoid aggregates per high-power field (2.3 ± 0.9 vs 1.1 ± 0.7, control, P < .01) and increased epithelial height (in µm, 40.88 ± 13.9 vs control, 25.32 ± 6.26, P < .05).</p><p><strong>Conclusion: </strong>Twice daily irrigation with LPS in murine nasal airways over 1 week led to acquired defects in transepithelial Cl^- transport. This animal model provides an excellent means to test the contributions of acquired CFTR dysfunction to CRS and test CFTR correctors and potentiators that might improve MCC.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1774-1780"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding \"Thyroid Radiofrequency Ablation- Thermal Effects on Recurrent Laryngeal Nerve Using Continuous Intraoperative Neuromonitoring Animal Model\".","authors":"Catherine F Sinclair, Vaninder Dhillon, Steven Hodak, Jennifer Kuo, Kepal Patel, Jonathon Russell, Ralph P Tufano","doi":"10.1002/ohn.1130","DOIUrl":"10.1002/ohn.1130","url":null,"abstract":"","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1805-1806"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}