Andrew Meci, F Jeffrey Lorenz, Neerav Goyal, David Goldenberg
{"title":"Elevated Risk of Thyroid Malignancy in Biological Males Taking Estrogen Hormone Therapy.","authors":"Andrew Meci, F Jeffrey Lorenz, Neerav Goyal, David Goldenberg","doi":"10.1002/ohn.1128","DOIUrl":"https://doi.org/10.1002/ohn.1128","url":null,"abstract":"<p><strong>Objective: </strong>The role of estrogen in developing thyroid malignancy is poorly understood. Epidemiological studies have shown exogenous estrogen is associated with increased risk in females. Still, no studies to date have investigated this association among biological males undergoing estrogen hormone therapy.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>TriNetX Research Network.</p><p><strong>Methods: </strong>Biologically male patients prescribed estrogen with at least 5 years of follow-up were queried from the database. Rates of diagnosis of malignant neoplasm of the thyroid gland within 5 years of estrogen hormone therapy prescription were determined, and statistics were conducted within the TriNetX platform.</p><p><strong>Results: </strong>We identified 6394 biologically male patients from 65 health care organizations prescribed estrogen hormone treatment. The average age was 44.4 years. When balanced for demographic factors as well as known risk factors for thyroid malignancy, the estrogen treatment cohort had a 0.64% risk for diagnosis of thyroid malignancy within 5 years, compared to a 0.27% risk among patients not taking estrogen (relative risk: 2.35, 95% confidence interval: 1.34-4.15, P = .002).</p><p><strong>Conclusion: </strong>We found a higher risk of developing thyroid cancer in biologically male patients prescribed estrogen hormone therapy. This is the first association found between estrogen and thyroid malignancy in this group.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jamil Hayden, Emily R Youner, Ross Rosen, Chelsea N Cleveland, De'Andre A Warren, Sarah Mowry, Todd D Otteson, Maroun Semaan
{"title":"Assessing the Impact of Vaccination Status on Meningitis Risk Post Cochlear Implantation.","authors":"Jamil Hayden, Emily R Youner, Ross Rosen, Chelsea N Cleveland, De'Andre A Warren, Sarah Mowry, Todd D Otteson, Maroun Semaan","doi":"10.1002/ohn.1115","DOIUrl":"https://doi.org/10.1002/ohn.1115","url":null,"abstract":"<p><strong>Objective: </strong>To better understand the protective benefit of pneumococcal vaccines on rates of meningitis after cochlear implantation.</p><p><strong>Study design: </strong>Retrospective large database review.</p><p><strong>Setting: </strong>Several studies have shown that cochlear implantation increases the incidence of bacterial meningitis, mostly due to pneumococcal meningitis. However, there are no studies that have demonstrated that pneumococcal vaccination is associated with a decreased risk of meningitis among cochlear implant recipients.</p><p><strong>Methods: </strong>TriNetX, an electronic medical record database, was queried for incidence of meningitis after cochlear implantation, with and without pneumococcal vaccination.</p><p><strong>Results: </strong>There are a total of 35,434 patients in the TriNetX database who have received a cochlear implant. Of these patients, 9803 patients (27.7%) had coding sufficient to assess their immunization status and were included in our study. Of the patients in our study, 9264 patients (93.7%) had evidence of receiving a PCV immunization, while 539 (5.5%) were found to be under vaccinated. A total of 258 patients in our study had an episode of meningitis after cochlear implantation, translating to an overall rate of 2.6%. The vaccinated group demonstrated a significantly lower incidence of meningitis (2.5%, n = 236) compared to the under-vaccinated group (4.1%, n = 22) (relative risk: 1.60; confidence interval (1.0441, 2.4586); P < .0310).</p><p><strong>Conclusion: </strong>Our study provides evidence that pneumococcal vaccination is associated with a significantly lower rate of bacterial meningitis after cochlear implantation. Meningitis is a potentially life-threatening complication. Better adherence to pneumococcal vaccination guidelines pre- and post-CI is critical to reducing the feared risk of bacterial meningitis after cochlear implantation.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikhila Raol, Prasanth Pattisapu, Allison K Ikeda, Jane Lowers, Stephanie Joe, Jennifer J Shin
{"title":"Evidence-Based Medicine in Otolaryngology Part 17: A Qualitative Research Primer.","authors":"Nikhila Raol, Prasanth Pattisapu, Allison K Ikeda, Jane Lowers, Stephanie Joe, Jennifer J Shin","doi":"10.1002/ohn.1120","DOIUrl":"https://doi.org/10.1002/ohn.1120","url":null,"abstract":"<p><p>As qualitative data analysis becomes more frequently applied within the fields of medicine and surgery, it is beneficial to expand our knowledge of the utility, methodology, and interpretation of these techniques. While qualitative research serves a distinct purpose and differs from quantitative research, both can be approached with diligence, with careful techniques that are similarly maintained and respected. In advance of this installment in the Evidence-Based Medicine in Otolaryngology series, we presented a comparison between qualitative and quantitative methods. To provide additional understanding of the specifics of qualitative research, this article presents further insights into qualitative research applications, theories, data collection methods, sources of and approaches to bias, and methods which support rigorous results.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raymond J So, Kimberley S Noij, Jiangxia Wang, Jonathan Walsh, Christine G Gourin, Carolyn M Jenks
{"title":"National and Regional Trends in Congenital Cytomegalovirus Infection From 1998 to 2019.","authors":"Raymond J So, Kimberley S Noij, Jiangxia Wang, Jonathan Walsh, Christine G Gourin, Carolyn M Jenks","doi":"10.1002/ohn.1107","DOIUrl":"https://doi.org/10.1002/ohn.1107","url":null,"abstract":"<p><strong>Objective: </strong>To analyze temporal changes and to assess the possible effect of newborn hearing screening (NBHS) programs on changes in congenital cytomegalovirus (cCMV) diagnostic rates in the United States.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>National Inpatient Sample (NIS) database.</p><p><strong>Methods: </strong>Neonates with cCMV infection were identified using discharge data from the NIS database from 1998 to 2019. Neonates with cCMV infection were identified via International Classification of Diseases codes and categorized as asymptomatic versus symptomatic and with or without hearing loss. Linear regression and interrupted time series analyses were conducted to analyze changes in diagnostic rates over time. Interrupted analyses were based on the timing of NBHS implementation in geographic regions.</p><p><strong>Results: </strong>Per 1,000,000 live births, the estimated total number of cCMV diagnoses increased from 109 in 1998 to 250 in 2019 (the estimated annual increase per 1,000,000 live births is 6.89 ([95% confidence interval, 5.43-8.35], P < .001). Diagnosis of cCMV with hearing loss showed a significant annual increase during this time (0.87 [0.51-1.22], P < .001), and within this group, diagnosis of both asymptomatic (0.18 [0.03-0.32], P = .02) and symptomatic (0.68 [0.37-0.99], P < .001) cases increased significantly. Compared to pre-NBHS, the rate of increase in cCMV diagnosis was significantly higher post-NBHS implementation in the Northeast (P < .001) and South (P = .008).</p><p><strong>Conclusion: </strong>Implementation of state NBHS programs correlated with increasing diagnosis rates of cCMV, though cCMV education and awareness may be contributing. cCMV continues to be underdiagnosed in a large national database.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Avraham E Adelman, Akshay Tangutur, Alfredo S Archilla, Gennadiy Vengerovich
{"title":"Microbiological Profiles and Patterns of Resistance in Patients With Sinus Infections After Endoscopic Sinus Surgery.","authors":"Avraham E Adelman, Akshay Tangutur, Alfredo S Archilla, Gennadiy Vengerovich","doi":"10.1002/ohn.1122","DOIUrl":"https://doi.org/10.1002/ohn.1122","url":null,"abstract":"<p><strong>Objective: </strong>Identify common pathogens and antibiotic resistances in chronic rhinosinusitis patients post-endoscopic sinus surgery presenting with an active sinus infection.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Setting: </strong>Single-institution rhinology private practice in Southeast Florida.</p><p><strong>Methods: </strong>Recorded postoperative endoscopically-guided sinus cultures from symptomatic patients with purulent drainage on endoscopy from August 2020 to December 2023. When available, pre- or intraoperatively cultured organisms were collected.</p><p><strong>Results: </strong>Of 125 patients, 50.4% were female with a mean age of 51.0. In 34.4% of patients that underwent revision surgery, 76% had nasal polyps and 26.4% had asthma. Of 301 cultures, 264 (87.7%) were positive, 53 (17.6%) were polymicrobial, and 37 (12.3%) were negative. Of 351 total isolates, 165 (47%) were Gram-negative, 125 (35.6%) Gram-positive, 14 (4%) fungi, and 10 (2.8%) anaerobic. 46.9% of postoperative organisms were not cultured preoperatively. Gram-negative bacteria included Enterobacteriaceae (17.7%), Pseudomonas spp. (10.5%), Serratia spp. (5.1%). Gram-positive bacteria included Methicillin-sensitive Staphylococcus aureus (MSSA, 17.1%) and Methicillin-resistant S. aureus (MRSA, 8%). Antibiotic resistances included MSSA to penicillins (52.8%) and clindamycin (32.8%), and MRSA resistance to quinolones (53.6%) and clindamycin (35.7%). Enterobacteriaceae were 42% resistant to amoxicillin-clavulanate and 37.1% to penicillins, while Pseudomonas aeruginosa was 17.7% resistant to quinolones.</p><p><strong>Conclusion: </strong>A cohort of chronic rhinosinusitis patients post-sinus surgery grew a large proportion of Gram-negative organisms and significant Staphylococcal penicillin and Gram-negative amoxicillin-clavulanate resistance. Our findings indicate the benefit of culturing patients with this patient presentation. If cultures cannot be obtained, we suggest broad-spectrum antibiotics that consider wide Gram-negative coverage and local antibiotic resistance patterns.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro R Marrero-Gonzalez, Douglas P Nanu, Shaun A Nguyen, Emily A Brennan, William Greer Albergotti, Bhisham S Chera, Jennifer L Harper, John M Kaczmar, Alexandra E Kejner, Jason G Newman, Judith M Skoner, Evan M Graboyes
{"title":"Disparities in Survival of Head and Neck Cancer in the Hispanic Population: Systematic-Review and Meta-analysis.","authors":"Alejandro R Marrero-Gonzalez, Douglas P Nanu, Shaun A Nguyen, Emily A Brennan, William Greer Albergotti, Bhisham S Chera, Jennifer L Harper, John M Kaczmar, Alexandra E Kejner, Jason G Newman, Judith M Skoner, Evan M Graboyes","doi":"10.1002/ohn.1113","DOIUrl":"https://doi.org/10.1002/ohn.1113","url":null,"abstract":"<p><strong>Objective: </strong>The Hispanic health paradox (HHP), the observation that Hispanic people in the United States often experience better health outcomes than non-Hispanic people despite having worse prognostic factors, has not been evaluated for patients with head and neck squamous cell carcinoma (HNSCC), a malignancy with marked racial disparities in outcomes. The objective of this study is to evaluate the HHP within the context of HNSCC.</p><p><strong>Data sources: </strong>CINAHL, PubMed, and Scopus.</p><p><strong>Review methods: </strong>Studies that compared survival between Hispanic and non-Hispanic patients with HNSCC in the United States were included. Meta-analysis of adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) was conducted to compare overall survival (OS) and cancer-specific survival (CSS) between Hispanic white (HW) and non-Hispanic white (NHW) patients with HNSCC.</p><p><strong>Results: </strong>Of 2106 unique abstracts reviewed, 25 studies were included in the systematic review and 22 in the meta-analysis. Among the 657,185 patients in the meta-analysis, 6.9% (95% CI: 5.8%-8.3%) were of Hispanic ethnicity. HW patients had improved OS relative to NHW patients (aHR = 0.90, 95% CI: 0.86-0.94) among the 17 studies reporting OS and improved CSS relative to NHW patients (aHR = 0.87, 95% CI: 0.80-0.94) among the 4 studies reporting this outcome.</p><p><strong>Conclusion: </strong>HW people with HNSCC exhibit improved survival relative to NHW people with HNSCC, supporting the HHP in the context of HNSCC. Research is needed to understand the underlying mechanisms, which could provide insights into improving outcomes for all patients with HNSCC.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Otolaryngology Resident Education: Beyond Procedural Case Logs-A 10-Year Single Institutional Review.","authors":"Pauline P Huynh, Benjamin D Malkin, Kevin H Wang","doi":"10.1002/ohn.1082","DOIUrl":"https://doi.org/10.1002/ohn.1082","url":null,"abstract":"<p><strong>Objective: </strong>To quantify the otolaryngologic diagnoses encountered in outpatient clinics by otolaryngology-head and neck surgery (OHNS) residents during their 5 years of postgraduate training.</p><p><strong>Methods: </strong>This is a retrospective review at a single institution following 5 consecutive graduating resident cohorts throughout their training. The electronic health record was queried for OHNS clinic encounters from 2013 through 2022 during which the resident physicians were included as the visit provider or assistant to an attending physician. Diagnoses were sorted into categories as adapted from the Accreditation Council for Graduate Medical Education OHNS Milestones 2.0.</p><p><strong>Results: </strong>From 2013 to 2022, 10 residents participated in 25,447 unique clinic encounters, averaging 2544 total clinic encounters per resident. Of these, 13,957 (54.8%) listed the resident as a visit provider. The most frequently coded categories included otologic diseases (25.3%), head and neck neoplasms (14.8%), and rhinologic diseases (10.8%). Most frequently coded diagnoses included postoperative care, benign subcutaneous masses, ear infections, cerumen impaction, and maxillofacial fractures.</p><p><strong>Discussion: </strong>To our knowledge, this is the first study to quantify the OHNS resident clinic experience. Additional data from other institutions is needed to better evaluate clinical competency regarding these nonprocedural facets in residency training.</p><p><strong>Implications for practice: </strong>As OHNS residency training continues to evolve, it is important to evaluate the outpatient clinical experience and ensure it reflects educational needs, including adequate exposure to a range of otolaryngologic diagnoses and conditions to prepare trainees for independent practice.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Derek J Vos, Sara W Liu, Khashayar Arianpour, Peter J Ciolek, Brandon L Prendes, Michael A Fritz
{"title":"Iliac Crest Bone Graft and Fascia Lata Free Flap for Rescue of Mandibular Osteoradionecrosis.","authors":"Derek J Vos, Sara W Liu, Khashayar Arianpour, Peter J Ciolek, Brandon L Prendes, Michael A Fritz","doi":"10.1002/ohn.1125","DOIUrl":"https://doi.org/10.1002/ohn.1125","url":null,"abstract":"<p><strong>Objective: </strong>Describe the use, indications, and outcomes of iliac crest bone graft (ICBG) with concomitant anterolateral thigh fascia lata (ALTFL) rescue flap for the management of mandibular osteoradionecrosis (ORN).</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Setting: </strong>Single institution.</p><p><strong>Methods: </strong>Retrospective chart review of patients who underwent ICBG with ALTFL rescue flap for mandibular ORN between 2011 and 2023.</p><p><strong>Results: </strong>Twenty-three patients (mean age 66.5 years, 73.9% male) with mandibular ORN underwent ICBG at the time of ATLFL. Patients failed prior antibiotic therapy (78.3%), hyperbaric oxygen therapy (39.1%), and/or pentoxifylline/tocopherol (34.8%). The most common mandibular subsites included the body (91.3%) and the angle (60.9%). All patients underwent concurrent ICBG with ALTFL to augment cortical height of retained mandible (<1 cm following debridement of ORN to healthy, bleeding bone). Following the ALTFL rescue flap with ICBG, the median length of stay was 3 days. There was 1 episode of flap failure noted at follow-up, requiring additional ALTFL procedure. No other major complications were reported at the reconstructed site. There were no complications associated with ICBG harvest, with all patients ambulating at the time of discharge. The mean clinical follow-up length was 20 months. Mandibular stability, based on radiographic features and clinical symptoms, was maintained in the majority of patients. Mandibular height was restored to an average of 1.9 cm, with a mean radiographic follow-up length of 16.8 months. A subset of patients (n = 4, 17.4%) experienced a flare in ORN symptoms following this procedure and required additional mandibular debridement with antibiotic therapy. One such patient required segmental mandibulectomy with osteocutaneous free flap reconstruction; however, all other patients exhibited radiographic and clinical arrest of symptoms for the follow-up period of 6.5 to 61.7 months.</p><p><strong>Conclusion: </strong>In patients undergoing ALTFL rescue flap for mandibular ORN, ICBG appears to supplement mandibular height and strength in patients with limited remaining mandibular bone height following debridement, with successful arrest of clinical and radiographic disease progression, low morbidity, and abbreviated hospital stays.</p><p><strong>Level of evidence: </strong>Level 4.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ebraheem Albazee, Hamad Alajmi, Ali Aldoukhi, Abeer Waleed Alali
{"title":"Endoscopic Versus Microscopic Stapedotomy: A Systematic Review and Meta-analysis of Randomized Controlled Trials.","authors":"Ebraheem Albazee, Hamad Alajmi, Ali Aldoukhi, Abeer Waleed Alali","doi":"10.1002/ohn.1109","DOIUrl":"https://doi.org/10.1002/ohn.1109","url":null,"abstract":"<p><strong>Objective: </strong>To compare the safety and efficacy of endoscopic versus microscopic stapedotomy in patients with otosclerosis.</p><p><strong>Data sources: </strong>PubMed, Embase, Web of Science, Scopus, Google Scholar, and CENTRAL.</p><p><strong>Review methods: </strong>Eligible randomized controlled trials (RCTs) were assessed for bias using Cochrane's instrument. The specific outcomes included the mean duration of surgery, the mean gain in air-bone gap (ABG), and the rates of chorda tympani nerve (CTN) injury, CTN manipulation, facial nerve (FN) injury, tympanic membrane (TM) perforation, dysgeusia, dizziness, and pain score. Continuous data were analyzed using mean difference (MD) or standardized mean difference (SMD), and dichotomous data with risk ratio (RR), with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Eleven RCTs with 515 patients were analyzed. There was no significant difference between both groups in the mean duration of surgery (MD = -10.42, 95% CI [-26.26, 5.43]), mean gain in ABG (MD = 1.04, 95% CI [-0.48, 2.57]), CTN injury (RR = 0.46, 95% CI [0.20, 1.04]), FN injury (RR = 1.00, 95% CI [0.11, 9.27]), TM perforation (RR = 0.99, 95% CI [0.23, 4.25]), and dizziness (RR = 0.79, 95% CI [0.41, 1.53]). However, endoscopic stapedotomy significantly reduced the need for CTN manipulation (RR = 0.58, 95% CI [0.35, 0.96]), dysgeusia (RR = 0.33, 95% CI [0.19, 0.57]), and pain score (SMD = -1.59, 95% CI [-2.22, -0.97]).</p><p><strong>Conclusion: </strong>Endoscopic stapedotomy significantly reduces dysgeusia, CTN manipulation, and pain compared to microscopic stapedotomy, with similar surgery durations, audiometric gains, and comparable risks of CTN injury, TM perforation, FN injury, and dizziness.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter to Editor Regarding \"Taste Disorders After Middle Ear Surgery: Chorda Tympani Nerve Injury and Quality of Life\".","authors":"Blandine Lafargue, Grégoire D'andréa, Roxane Fabre, Abdallah Alshukry, Clair Vandersteen, Nicolas Guevara","doi":"10.1002/ohn.1116","DOIUrl":"https://doi.org/10.1002/ohn.1116","url":null,"abstract":"","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}