Otolaryngology- Head and Neck Surgery最新文献

{"title":"Platelet-Rich Plasma for Rhinitis Medicamentosa: A Promising Histopathological Study in an Animal Model.","authors":"Kamil Gokce Tulaci, Salih Yayman, Erhan Arslan, Hasan Canakci, Tugba Tulaci, Gülay Turan, Omer Hizli, Hasmet Yazici","doi":"10.1002/ohn.1303","DOIUrl":"https://doi.org/10.1002/ohn.1303","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether platelet-rich plasma (PRP) has an efficacy on histopathologic changes in rhinitis medicamentosa (RM) in a rat model.</p><p><strong>Study design: </strong>Experimental animal study.</p><p><strong>Setting: </strong>University animal laboratory.</p><p><strong>Methods: </strong>Forty Wistar albino rats were randomly assigned to five groups to assess the effects of various treatments on RM. Group 1 received intranasal normal saline solution (NSS) for 60 days and served as the negative control. Group 2 was administered intranasal oxymetazoline for 60 consecutive days to induce RM. After decapitation, histopathological evaluation confirmed the development of RM in group 2. The remaining three groups were then similarly treated with oxymetazoline for 60 days. Following this period, group-specific treatments were applied for an additional 15 days: group 3 received NSS, group 4 was treated with intranasal corticosteroids, and group 5 received intranasal PRP. Nasal mucosal samples were harvested and subjected to histopathological evaluation to determine treatment-related changes.</p><p><strong>Results: </strong>Intranasal PRP treatment significantly reduced submucosal edema and improved submucosal gland degeneration (SGD) scores in the nasal mucosa. Moreover, PRP treatment led to a greater reduction in total histopathological score compared to steroid treatment (P = .007).</p><p><strong>Conclusion: </strong>This study demonstrated that PRP administration effectively ameliorates submucosal edema, SGD, and total histopathologic score in experimentally induced RM. Given that PRP is an autologous product with a low risk of side effects, it may serve as a promising alternative to steroids in the treatment of RM.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Gender Differences: Training, Practice, and Family Dynamics Among Fellowship-Trained Neurotologists.","authors":"Nadia L Samaha, Maria Armache, Wassim Najjar, Rachel Stemme, Wendy Chen, Leila J Mady, Tiffany P Hwa","doi":"10.1002/ohn.1296","DOIUrl":"https://doi.org/10.1002/ohn.1296","url":null,"abstract":"<p><strong>Objective: </strong>To characterize and examine gender differences in training paths, practice patterns, family dynamics, and career trajectories in the field of neurotology.</p><p><strong>Study design: </strong>Cross-sectional survey.</p><p><strong>Setting: </strong>Research Electronic Data Capture (RedCap) Framework.</p><p><strong>Methods: </strong>A survey was created and distributed electronically to fellowship-trained neurotologists in the United States who were identified via publicly available information. Descriptive, univariate, and multivariate statistics were performed.</p><p><strong>Results: </strong>Of the 223 neurotologists invited, 80 (35.8%) responded. Most participants were male (77.5%, n = 62), white (77.5%, n = 62), and aged 41 years or older (81.2%, n = 65). Training and practice patterns showed no significant gender differences. However, women were more likely to have a physician spouse (55.6% vs 25.8%, P = .02), have their first child post-fellowship (55.6% vs 24.2%, P = .007), rely on professional childcare (47.1% vs 22.6%, P = .05), and reduce work hours due to childcare needs (22.2% vs 6.45%, P = .05). Men were more likely to rely on their spouse as the primary caretaker (48.4% vs 5.9%, P = .001). Having a physician spouse was associated with post-fellowship childbearing (48.1% vs 28.9%, P = .041) and increased use of professional childcare (44.3% vs 30.1%, P = .05), regardless of gender.</p><p><strong>Conclusion: </strong>Although training and practice patterns were similar across genders, significant differences in family structure, childbearing, and caretaking roles suggest that women in neurotology may face unique challenges that could influence their career progression.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Severe Obesity and Pediatric Obstructive Apnea-A Retrospective Case Series.","authors":"Tyler A Durham, Basir S Mansoor, Stephen R Chorney, Ron B Mitchell, Alex Najjar, Romaine F Johnson","doi":"10.1002/ohn.1295","DOIUrl":"https://doi.org/10.1002/ohn.1295","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of severe obesity on the severity of pediatric obstructive sleep apnea (OSA).</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Setting: </strong>Tertiary stand-alone pediatric hospital.</p><p><strong>Methods: </strong>Consecutive children with obesity (≥95th percentile body mass index [BMI]) who underwent full-night polysomnography between January 2021 and December 2021 were analyzed. Patients were categorized into obesity (≥95th percentile BMI and <120% of the 95th percentile) and severe obesity (≥120% of the 95th percentile BMI). The association between severe obesity and severe OSA was assessed using multiple logistic regression.</p><p><strong>Results: </strong>The study included 282 patients with a median age of 9.2 years (interquartile range 5.9-12.3), 63% male, and 65% Hispanic. In total, 53% were severely obese. Severely obese children had a higher prevalence of severe OSA (53% vs 33%, P < .001) and very severe OSA (apnea-hypopnea index ≥ 24; 24% vs 11%, P = .006). Multiple logistic regression revealed that severe obesity was associated with severe OSA (adjusted odds ratio [aOR] = 3.44; 95% confidence interval [CI], 1.82-6.53; P < .001) after adjusting for age, sex, and tonsillar hypertrophy. Among 170 patients who underwent posttonsillectomy polysomnography, 29% exhibited residual OSA, with 19% having residual severe OSA. Class 3 severe obesity was associated with residual OSA (aOR = 4.05, 95% CI = 1.09-15.00).</p><p><strong>Conclusion: </strong>Children with severe obesity face substantial sleep disturbances and a heightened risk of residual OSA following adenotonsillectomy.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review of Tongue Tie Publications: Exponential Rise in Publications Without Exponential Increase in Evidence.","authors":"Annie R Thornton, Emily A Montgomery, M Elise Graham, Charles A Riley, Claire M Lawlor","doi":"10.1002/ohn.1264","DOIUrl":"https://doi.org/10.1002/ohn.1264","url":null,"abstract":"<p><strong>Objective: </strong>Ankyloglossia and lingual frenotomy in young children and infants remains an area of debate, with a body of research with poor quality-but increasing number-of studies, a trend that has continued into the present day. To systematically review the published literature to identify the number, type, and quality of studies on the evaluation, diagnosis, and treatment of ankyloglossia.</p><p><strong>Data sources: </strong>In this Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review, a literature search of PubMed, Embase, and Ovid MEDLINE was conducted in 2024 using keywords related to ankyloglossia and frenotomy.</p><p><strong>Review methods: </strong>Studies from 2017 to 2024 were assessed by two independent reviewers. Articles were included if they focused on ankyloglossia in children and in the English language.</p><p><strong>Results: </strong>Overall, 462 articles were included for full-text extraction, of which cohort studies were the most common (179, 38.7%), and randomized controlled trials (RCTs; 13, 2.8%) were among the least common. Studies on different frenotomy techniques were common, despite no evidence suggesting that no intervention may be superior. There was an overall lack of study endpoints with objective measures such as breastfeeding duration or infant growth rates postprocedure. Despite the presence of several classification systems for ankyloglossia, none of those described in the literature focuses primarily on function as opposed to appearance or other factors.</p><p><strong>Conclusion: </strong>This systematic review provides an update demonstrating the continued exponential rise of publications focused on ankyloglossia and lingual frenotomy without a rise in evidence clarifying the controversies surrounding these important topics. Future studies in this area should be quality RCTs with meaningful outcome measures.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency Ablation as a Palliative Treatment for Advanced Primary Papillary Thyroid Carcinoma Ineligible for Surgery.","authors":"Dongbin Ahn, Ji Hye Kwak, Sung Jae Heo","doi":"10.1002/ohn.1307","DOIUrl":"https://doi.org/10.1002/ohn.1307","url":null,"abstract":"","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Trials Comparing Inferior Turbinoplasty Techniques for Nasal Obstruction: A Meta-analysis.","authors":"Macario Camacho, Yoseph A Kram, Forrest D Craig, Sungjin A Song, Edward T Chang, Victor Certal, Jason L Acevedo, Scott E Brietzke, Nolan N Jones","doi":"10.1002/ohn.1269","DOIUrl":"https://doi.org/10.1002/ohn.1269","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to systematically review the international literature for randomized trials presenting subjective, long-term outcomes (1-3 years) for nasal obstruction treated with inferior turbinoplasties, followed by a meta-analysis.</p><p><strong>Data sources: </strong>PubMed/MEDLINE and 5 other databases.</p><p><strong>Review methods: </strong>Two authors searched through October 27, 2024.</p><p><strong>Results: </strong>Four randomized trials with 2874 patients provided outcomes after bilateral inferior turbinoplasties. At 2 years, the microdebrider visual analog scale (VAS) values reduced 81.7% from 8.2 ± 1.4 to 1.5 ± 0.7, the submucosal resection reduced 82.4% from 8.5 ± 1.0 to 1.5 ± 0.6, outfracturing reduced 82.8% from 8.7 ± 1.1 to 1.5 ± 0.7, and radiofrequency ablation increased 8.1% from 7.4 ± 1.0 to 8.0 ± 1.4. At 3 years, the microdebrider VAS values reduced 80.5% from 8.2 ± 1.4 to 1.6 ± 0.8, the submucosal resection reduced 82.4% from 8.5 ± 1.0 to 1.5 ± 0.7, outfracturing reduced 82.8% from 8.7 ± 1.1 to 1.5 ± 0.8, and radiofrequency ablation increased 12.2% from 7.4 ± 1.0 to 8.3 ± 1.4.</p><p><strong>Conclusion: </strong>In this systematic review, evaluating data at 2 and 3 years after inferior turbinoplasties, the procedures that removed tissue or outfractured had approximately 80% improvement in the VAS, while techniques that did not remove tissue or outfracture tended to have a recurrence of their nasal obstruction. Additional research is needed.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient's Perspective and Change in Quality of Life After Stapes Surgery: A Multicenter Prospective Trial.","authors":"Maaike Jellema, Esther E Blijleven, Joeri Buwalda, Raphael J B Hemler, Huib F van Waegeningh, Robert J Stokroos, Inge Wegner, Henricus G X M Thomeer","doi":"10.1002/ohn.1298","DOIUrl":"https://doi.org/10.1002/ohn.1298","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated outcomes of stapes surgery in otosclerosis patients by assessing audiometric results and health-related quality of life (HRQOL) using the Dutch Stapesplasty Outcome Test-25 (SPOT-25) questionnaire. Additionally, the role of SPOT-25 in preoperative decision-making and as a follow-up tool was explored.</p><p><strong>Study design: </strong>A prospective, multicenter cohort study.</p><p><strong>Setting: </strong>One tertiary academic medical center and 3 secondary referral centers.</p><p><strong>Methods: </strong>Data from 115 adult patients undergoing primary stapes surgery was analyzed. Audiometric outcomes were measured using pure-tone audiometry results and word recognition score (WRS). HRQOL was assessed using SPOT-25, Glasgow Health Status Questionnaire, and Glasgow Benefit Inventory. Pre- and postoperative outcomes were compared, and correlations between pure-tone audiometry results, WRS, and HRQOL were analyzed. Outcomes were compared between patients receiving 0.4 and 0.6 mm diameter pistons, and the impact of preoperative pure-tone audiometry results was analyzed.</p><p><strong>Results: </strong>Significant postoperative improvements were observed in all audiometric measures (mean air conduction gain of 22 dB and air-bone gap (ABG) improvement of 18 dB). HRQOL also improved significantly (mean SPOT-25 score improved from 48 to 27). The 0.6 mm piston group had a significantly smaller postoperative ABG than the 0.4 mm group. Patients with a preoperative ABG ≤ 15 dB had a mean SPOT-25 gain of 19 (SD 22), whereas those with a preoperative ABG > 15 dB had a gain of 21 (SD 18).</p><p><strong>Conclusion: </strong>Stapes surgery significantly improves hearing and HRQOL. The SPOT-25 is a valuable tool for evaluating HRQOL and may assist in preoperative decision-making in patients with varying hearing impairments.</p><p><strong>Level of evidence: </strong>III.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Cochlear Nerve Deficiency in Unilateral Pediatric Auditory Neuropathy Spectrum Disorder.","authors":"Samuel P O'Rourke, Teresa G Vos, Lisa R Park, Shannon Culbertson, Kevin D Brown","doi":"10.1002/ohn.1289","DOIUrl":"https://doi.org/10.1002/ohn.1289","url":null,"abstract":"<p><strong>Objective: </strong>Determine the incidence of cochlear nerve deficiency in pediatric subjects with auditory neuropathy spectrum disorder in the setting of single-sided deafness.</p><p><strong>Study design: </strong>Retrospective chart review of pediatric subjects with single-sided deafness.</p><p><strong>Setting: </strong>Single tertiary care institution from January 2014 to October 2019.</p><p><strong>Methods: </strong>Subjects with unilateral severe-to-profound hearing loss were included if they had both magnetic resonance imaging and auditory brainstem response testing available. The incidence of auditory neuropathy spectrum disorder was assessed based on auditory brainstem response testing, and the incidence of cochlear nerve deficiency was determined from imaging review by a neurotologist. Mean pure tone audiometry at 500, 1000, and 2000 Hz of subjects within the auditory neuropathy spectrum disorder population was calculated.</p><p><strong>Results: </strong>In total, 103 pediatric subjects were included. The incidence of auditory neuropathy spectrum disorder in this population was 30% (31 subjects). Within this group, 77.4% had cochlear nerve deficiency on imaging (24 subjects) and 22.6% (7 subjects) had normal cochlear nerves. Of the abnormal cochlear nerves, 18 nerves were aplastic and 6 hypoplastic. In subjects with auditory neuropathy spectrum disorder, there was no statistically significant difference in mean pure tone audiometry (P = .579) between ears with normal and deficient cochlear nerves.</p><p><strong>Conclusion: </strong>There is a high incidence of auditory neuropathy spectrum disorder in pediatric subjects with single-sided deafness, and the majority of ears with auditory neuropathy spectrum disorder also demonstrated cochlear nerve deficiency on imaging. It is imperative to pursue a thorough audiologic and radiographic work-up in this population to fully assess nerve status.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Daily Device Use and Subjective Hearing Abilities in Pediatric Cochlear Implant Users.","authors":"Lacey Magee, Mihika Thapliyal, Andrea D Warner-Czyz, Samantha Anne","doi":"10.1002/ohn.1277","DOIUrl":"https://doi.org/10.1002/ohn.1277","url":null,"abstract":"<p><strong>Objective: </strong>Increased hours of cochlear implant (CI) use have been shown to improve auditory and speech recognition outcomes in children with hearing loss. However, the impact of hours of CI use over time on patient-reported functional hearing skills is unknown. Increased duration of CI use, measured by hearing hour percentage (HHP), will coincide with improved long-term subjective hearing abilities, assessed by Speech, Spatial, and Qualities of Hearing (SSQ) questionnaire.</p><p><strong>Study design: </strong>Retrospective chart review from 2013 to 2023.</p><p><strong>Setting: </strong>Pediatric CI recipients with at least 18 months of CI use at a single institution.</p><p><strong>Methods: </strong>Demographic characteristics and audiology history were collected, and HHP was calculated. Changes in SSQ scores over time and HHP were correlated utilizing Spearman's rank correlation.</p><p><strong>Results: </strong>Of 104 patients reviewed, 24 patients (54% female) met inclusion criteria. Median age at implantation was 6.0 years (4-7.25, Q1-Q3), and median duration of CI experience was 33 months (24.5-60.3, Q1-Q3). In patients with at least two SSQ measures postoperatively, a significant positive correlation emerged between average HHP and change in SSQ score from first to most recent test (r = 0.63, P = .01). Of patients with a preimplantation SSQ score, there was a significant positive correlation between average HHP and change in SSQ from pre-CI to most recent test (r = 0.68, P = .04).</p><p><strong>Conclusion: </strong>Higher average HHP corresponded to a greater increase in SSQ scores in pediatric CI users over time, suggesting that increased hours of CI use may improve patient-reported outcomes in long-term hearing ability.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor Hypoxia and CD8⁺ T-Cell Infiltration in Patients With Advanced Laryngeal Cancer.","authors":"Joshua D Smith, Elizabeth Gensterblum-Miller, David W A Forner, Pratyusha Yalamanchi, Marisa R Buchakjian, Steven B Chinn, Andrew G Shuman, Keith A Casper, Kelly M Malloy, Chaz L Stucken, Scott A Mclean, Michelle L Mierzwa, Jennifer Shah, Paul L Swiecicki, Francis P Worden, Mark E P Prince, Matthew E Spector, J Chad Brenner, Molly E Heft Neal","doi":"10.1002/ohn.1291","DOIUrl":"https://doi.org/10.1002/ohn.1291","url":null,"abstract":"<p><strong>Objective: </strong>We assessed correlations between tumor carbonic anhydrase IX (CAIX) staining, as a marker of tumor hypoxia, and CD8⁺ T-cell infiltration in a cohort of patients with advanced laryngeal squamous cell carcinoma undergoing a bioselection approach for definitive treatment.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Tertiary care hospital.</p><p><strong>Methods: </strong>Patients with stage III to IV laryngeal squamous cell carcinoma treated under a bioselection paradigm were included. Immunohistochemistry for CD8⁺ T-cells and CAIX was performed. Nonparametric tests and Kaplan-Meier survival analyses were used to compare tumor CAIX status by clinicopathologic variables and CD8⁺ T-cell infiltration and to evaluate the role of CAIX and combination CAIX/tumor infiltrating lymphocytes (TIL) category on survival.</p><p><strong>Results: </strong>Our cohort included 92 patients (n = 68 [73.9%] supraglottic). No difference in CAIX staining was seen by tumor subsite, stage, and response to induction chemotherapy (all P > .05). Thirteen (14.1%) tumors were CAIX-positive and showed significantly lower CD8⁺ T-cell infiltration than CAIX-negative tumors (18 [0-62] vs 32 [0-399], P = .028). Combination CAIX/TIL category was significantly associated with the likelihood of response (CAIX-/TIL[high] were less likely to respond) and in the group of responders, was predictive of a higher degree of tumor shrinkage (>80%).</p><p><strong>Conclusion: </strong>CAIX staining correlates with reduced CD8⁺ T-cell infiltration in patients with advanced laryngeal squamous cell carcinoma undergoing bioselection. The combination CAIX/TIL category is associated with the likelihood and degree of response to induction. The utility of CAIX status and other combination immune and hypoxia signatures as a biomarker of induction response and survival merits prospective evaluation.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}