Otolaryngology- Head and Neck Surgery最新文献

{"title":"Elevated Body Mass Index Aggravates Histopathological Changes and Postoperative Recurrence Risk in Nasal Polyps.","authors":"Sijie Jiang, Liyuan Liu, Hua Zhang, Zhihai Xie, Shaobing Xie, Weihong Jiang","doi":"10.1002/ohn.1285","DOIUrl":"https://doi.org/10.1002/ohn.1285","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the association between body mass index (BMI) and histopathological features and postoperative recurrence risk of chronic rhinosinusitis with nasal polyps (CRSwNP).</p><p><strong>Study design: </strong>A retrospective clinical study.</p><p><strong>Setting: </strong>Recurrent group and nonrecurrent group.</p><p><strong>Methods: </strong>We recruited CRSwNP patients who underwent functional endoscopic sinus surgery and classified them into three groups based on BMI: normal weight, overweight, and obesity. All patients were followed for 3 years and divided into recurrence and nonrecurrence groups. The histopathological features and the impact of BMI on the risk of postoperative recurrence were analyzed through comparative analysis.</p><p><strong>Results: </strong>A total of 577 CRSwNP patients completed the follow-up, with 197 experiencing postoperative recurrence. Recurrence rates, tissue eosinophil counts, and interleukin (IL)-5 and IL-17A expression levels were significantly higher in the overweight and obesity groups compared to the normal weight group. Additionally, within the overweight and obesity groups, patients with recurrence had elevated tissue eosinophil counts and IL-5 and IL-17A levels compared to the other two groups. Notably, tissues collected during revision surgery showed increased eosinophil counts, IL-5 and IL-17A levels compared to baseline, particularly in obese patients. Both logistic regression analyses and Kaplan-Meier curves indicated that overweight and obesity were associated with an increased risk of CRSwNP recurrence.</p><p><strong>Conclusion: </strong>Elevated BMI presented significant impacts on the histopathological changes and the risk of postoperative recurrence in CRSwNP patients. Overweight and obesity aggravated tissue eosinophil infiltration, and IL-5 and IL-17A expressions contributing to the recurrent mechanisms of CRSwNP.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic Factors Influencing Operative Time and Extent of Surgery in the Management of Cholesteatoma.","authors":"Connor S Dedeker, J Dylan Johnson, Anthony A Mangino, Matthew L Bush, Nathan D Cass","doi":"10.1002/ohn.1294","DOIUrl":"https://doi.org/10.1002/ohn.1294","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to evaluate how various sociodemographic factors such as rurality, age, race, body mass index, and sex affect the surgical management of cholesteatoma. Canal wall-down (CWD) tympanomastoidectomy and longer surgical times were used as potential proxies for increased severity of disease.</p><p><strong>Study design: </strong>Retrospective.</p><p><strong>Setting: </strong>A tertiary academic center.</p><p><strong>Methods: </strong>All patients who underwent primary tympanomastoidectomy for cholesteatoma at the University of Kentucky from January 2008 through September 2023 were reviewed in this study. The rurality of the patient's home county was defined as metro, rural, or very rural as delineated by Rural-Urban Continuum Codes. Unadjusted and adjusted linear and logistic regression models were used to assess differences in the rate of CWD procedure and surgical times, respectively, across sociodemographic variables.</p><p><strong>Results: </strong>A total of 604 patients were included in the study. Male sex and increased age were positively and inversely correlated with length of surgery, respectively, in the adjusted models. No significant difference was found in the rate of CWD procedures in rural or very rural patients compared to metro (P = .989). No significant difference was found in surgical time in rural or very rural patients compared to metro (P = .885).</p><p><strong>Conclusion: </strong>Age and sex were significant predictors of surgical time, while no associations were found between any sociodemographic factor and type of tympanomastoidectomy. No significant association was found between rurality and the 2 proxies used. Our findings refute the thinking that patients requiring surgery for cholesteatoma from socioeconomically and educationally disadvantaged areas require longer or more involved surgeries.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of Dysphagia in Pediatric Patients With Vocal Fold Immobility.","authors":"Rachel Georgopoulos, Khashayar Arianpour, Samantha Anne","doi":"10.1002/ohn.1281","DOIUrl":"https://doi.org/10.1002/ohn.1281","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to determine the incidence and prognosis of dysphagia in pediatric patients with true vocal fold (TVF) immobility or hypomobility.</p><p><strong>Study design: </strong>A single-center retrospective chart review.</p><p><strong>Setting: </strong>A single-institution tertiary-care center.</p><p><strong>Methods: </strong>A total of 89 pediatric patients diagnosed with vocal fold hypo/immobility with a modified barium swallow (MBS) performed were examined. Patient demographic information and etiology of vocal fold immobility as well as laterality were reviewed. Changes in MBS findings over time were assessed.</p><p><strong>Results: </strong>A total of 89 pediatric patients were identified with a mean follow-up of 35.4 months. The most common etiology of TVF hypo/immobility was cardiothoracic surgery (58.4%).Immobility was observed in 80.6% of patients. Patients with unilateral disease were more likely to present with dysphonia than bilateral disease (40.3% vs 9.1%, odds ratio [OR] 6.75, 95% confidence interval [CI] 1.77-44.5, P = .01). MBS results did not vary statistically with respect to laterality, hypomobility versus immobility, or etiology. Of the 33 children who demonstrated aspiration on their initial MBS, 48.5% demonstrated complete resolution over median of 10.5 weeks. Rates of recovery differed only with respect to hypomobility versus immobility (87.5% vs 33.3%, OR 14.0, 95% CI 2.01-286, P = .0133).</p><p><strong>Conclusion: </strong>Based on the study results, about half of pediatric patients with vocal fold hypo/immobility will have resolution of dysphagia at about 10.5 weeks. This may helpful when deciding on when to obtain follow up imaging/exam on pediatric patients with dysphagia. The only factor that confers improved prognosis is hypomobility when compared to complete immobility.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Calvarial Osteoradionecrosis After Treatment of Cutaneous Malignancy: A Systematic Review.","authors":"Siyuan Pang, Elizabeth Concannon, Martin Higgins, Katharine Drummond, Peter Gearing, Maxim Devine, Albert Tiong, Anand Ramakrishnan, Carly Fox","doi":"10.1002/ohn.1290","DOIUrl":"https://doi.org/10.1002/ohn.1290","url":null,"abstract":"<p><strong>Objective: </strong>Osteoradionecrosis (ORN) is a recognized complication of radiotherapy. However, calvarial ORN (ORNC) following treatment for cutaneous malignancies is poorly understood. Shedding light on the limited evidence to date, this study aims to summarize existing evidence and highlight the research gaps.</p><p><strong>Data sources: </strong>PubMed and Embase.</p><p><strong>Review methods: </strong>A systematic search of PubMed and Embase was conducted up to May 2024, using relevant keywords to identify papers on ORNC. Data on the definition, incidence, risk factors, radiotherapy parameters, diagnostic methods, and management strategies were collected.</p><p><strong>Results: </strong>Twenty articles reporting on 42 ORNC patients were identified, revealing relatively poor data quality. There remains no consensus on a definition of ORNC. Patient- and disease-related risk factors have been inconsistently documented. No conclusion could be reached regarding thresholds for radiation dose delivery, as only seven studies reported the total radiation dose, with a mean of 58.9 Gy. Twenty-five (60%) cases managed with wound care and antibiotics demonstrated a spectrum of success rates, while 90% of surgically managed ORNC wounds healed at various follow-up points, ranging from 6 weeks to 9 years.</p><p><strong>Conclusion: </strong>This study proposes an ORNC-specific definition and reporting standard through comparison with mandibular ORN. This will help generate valuable data, guiding the development of an ORNC-specific treatment protocol and clinical decision-making in managing this debilitating side effect of radiotherapy.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Benign Paroxysmal Positional Vertigo Modified by Diuretics-A Population-Level Case-Control Study.","authors":"Marwin Li, Rebecca C Chiffer, Hongyan Li","doi":"10.1002/ohn.1282","DOIUrl":"https://doi.org/10.1002/ohn.1282","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to characterize diuretic use among patients with and without benign paroxysmal positional vertigo (BPPV) using a population-level database.</p><p><strong>Study design: </strong>A case-control study.</p><p><strong>Setting: </strong>TriNetX US Collaborative Network.</p><p><strong>Methods: </strong>Subjects with ≥1 hospital visit between 2019 and 2024 were queried and stratified by age (18-44, 45-64, and 65+ years) and sex. Each cohort was then divided into those with/without BPPV. Patients with head trauma, middle/inner ear surgery, central vertigo, or migraine were excluded. The prevalence of diuretic use and vitamin D deficiency of each case cohort was compared against the control cohort of the same age/sex using Chi-square analysis. This stratification and analysis were repeated for patients with a vestibular disorder, as well as those with/without Ménière's disease (MD).</p><p><strong>Results: </strong>Diuretic use was significantly more common in case cohorts than in control cohorts in the general population. In vestibular patients, thiazide and carbonic anhydrase inhibitor (CAI) use were more common in control cohorts, and loop use was less common. In MD patients, thiazide and loop use were more common in control cohorts, and CAI use did not differ significantly. In patients without MD, CAI use also did not differ, while thiazide and loop use were less common in control cohorts.</p><p><strong>Conclusion: </strong>All diuretics may alter the risk of BPPV. Their influences can be favorable or unfavorable, depending on the individual patient's medical history. Their effects might relate more directly to the efficacy of each diuretic class rather than their specific mechanisms of action.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-acetylcysteine for the Prevention of Cisplatin-Induced Hearing Loss: A Systematic Review and Meta-analysis.","authors":"Jaime Plane, Thamiris D D Cabral, Renata M Knoll, João E P Conrado, Bruno D V Vendramini, David H Jung","doi":"10.1002/ohn.1272","DOIUrl":"https://doi.org/10.1002/ohn.1272","url":null,"abstract":"<p><strong>Objective: </strong>Cisplatin is an effective antineoplastic drug used worldwide in the treatment of various malignancies. However, it is associated with side effects, including cisplatin-induced hearing loss (CIHL). N-acetylcysteine (NAC) has been suggested as a promising drug to prevent or reduce cisplatin-derived ototoxicity. To evaluate the evidence supporting the efficacy of NAC in preventing CIHL, we conducted a systematic review and meta-analysis of the literature.</p><p><strong>Data sources: </strong>A systematic search was conducted on PubMed, Embase, Web of Science, Clinicaltrials.gov, and Cochrane Library.</p><p><strong>Review methods: </strong>Articles reporting the administration of systemic or transtympanic injection of NAC for CIHL prevention were considered. The outcomes of interest included the presence of hearing loss events and changes in hearing thresholds at 0.5 through 12 kHz following cisplatin treatment.</p><p><strong>Results: </strong>A total of 7 studies involving 217 patients met inclusion criteria. Of these patients, 175 received systemic administration of NAC, and the remaining received transtympanic injection of NAC. No significant differences were found in CIHL prevention between the use of either systemic or transtympanic NAC administration compared to placebo (risk ratio [RR] 0.80; 95% confidence interval [CI] 0.54-1.19; P = .28, and RR 0.89; 95% CI 0.51-1.54; P = .67, respectively). No significant differences were found at 0.5 to 8 kHz between groups. Qualitative analyses suggested a tendency to otoprotection in ultra-high frequencies (10 and 12 kHz).</p><p><strong>Conclusion: </strong>Our findings suggest that, regardless of administration route, current published evidence does not show that NAC is effective in preventing CIHL in the standard clinical audiogram range. Further studies with larger samples are needed to confirm our findings.</p><p><strong>Level of evidence: </strong>I.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Columellar Lengthening in Bilateral Nasal Cleft Deformities With a Sliding Flap Cheilorhinoplasty.","authors":"Robert M Frederick, William Dougherty, Eric Dobratz","doi":"10.1002/ohn.1299","DOIUrl":"https://doi.org/10.1002/ohn.1299","url":null,"abstract":"<p><p>A characteristic short columella and decreased nasal projection is common in patients with bilateral cleft lip and palate following primary repair. The main disadvantage of the previously described secondary columellar lengthening procedures is the cosmetically undesirable \"banking\" of forked flaps in the nasal sill. We introduce a modified sliding flap cheilorhinoplasty that involves the recruitment of soft tissue adjacent to lip scars to achieve adequate columellar lengthening without the aforementioned banking of forked flaps. The end result is simultaneous columellar lengthening and lip scar revision.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Extranodal Extension Grading in Laryngeal Squamous Cell Carcinoma.","authors":"Hakan Kara, Levent Aydemir, Melek Büyük, Erol Bozbora, Kübra Özkaya Toraman, Saim Pamuk, Kağan Avcı, Comert Sen, Said Sonmez, Murat Ulusan, Bora Basaran, Musa Altun, Erkan Kıyak","doi":"10.1002/ohn.1297","DOIUrl":"https://doi.org/10.1002/ohn.1297","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective was to investigate the effect of extra-nodal extension (ENE) grading on the survival of pN-positive patients with laryngeal squamous cell carcinoma (LSCC).</p><p><strong>Study design: </strong>A retrospective cohort study.</p><p><strong>Setting: </strong>A tertiary referral center.</p><p><strong>Methods: </strong>The patients with LSCC were retrospectively reviewed. The histopathological slides of patients were re-examined, and ENE was graded. Survival analyses were performed.</p><p><strong>Results: </strong>Seventy-six patients were enrolled in this study. The average age of patients was 61.29 years. 3-year overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) rates were 69.7%, 73.7%, and 73.7%, respectively. ENE grading had no statistically significant impact on survival rates.</p><p><strong>Conclusion: </strong>While the presence of ENE in more than 4 lymph nodes, lymph node density (LND) greater than 0.2, poor histologic differentiation, and not receiving chemotherapy were identified as independent poor prognosticators in LSCC, the study did not show any effect of ENE grading on survival rates.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking Pleomorphic Adenoma Incidence Trends Over 47 Years: A Population-Based Study.","authors":"Katelyn S Rourk, Ghazal S Daher, Jenna R Schwartz, Hawa M Ali, Anne K Shurtz, Kendall K Tasche, Daniel L Price, Kathryn M Van Abel, Linda X Yin, Eric J Moore","doi":"10.1002/ohn.1292","DOIUrl":"https://doi.org/10.1002/ohn.1292","url":null,"abstract":"<p><strong>Objective: </strong>To (1) track the incidence of pleomorphic adenomas (PAs) and (2) compare demographic and treatment trends in PAs over the last five decades in a single county.</p><p><strong>Study design: </strong>Retrospective cohort of all patients with a pathologic diagnosis of nonrecurrent PA from January 1976 to December 2022.</p><p><strong>Setting: </strong>Olmsted County, Minnesota.</p><p><strong>Methods: </strong>Incidence was calculated per 100,000 persons/year and age and sex-adjusted to the US 2020 census data. Incidence trends were identified using Poisson rate regression models. Changes in clinical features of diagnosis were evaluated using Spearman rank correlation coefficient tests, Wilcoxon rank sum tests, and Kruskal-Wallis tests.</p><p><strong>Results: </strong>In total, 251 patients with PA were identified. The median age at diagnosis was 50.0 years with a slight female predominance (1.24:1). The adjusted incidence during this period is 4.79/100,000 person-years, increasing from 2.50 in 1976 to 1979 to 5.73/100,000 persons/year in 2020 to 2022. Less extensive surgery, including partial and superficial parotidectomies, increased significantly from 1976 to 2022, whereas total parotidectomies decreased (P < .0001). The number of patients who presented with an incidental imaging finding increased during this time period (P < .001), as did the age at diagnosis (45-51 years, P = .05) CONCLUSION: The average annual incidence of PAs in Olmsted County from 1976 to 2022 is higher than reported US estimates and has increased over the last five decades. The percentage of patients who presented with incidental imaging findings increased over this period, as did the age at diagnosis. These findings highlight modern imaging techniques and an aging population more willing to seek workup and treatment of a benign parotid mass.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Digestive Enzymes in Patients With Reflux-Induced Chronic Cough.","authors":"Jerome R Lechien, Nathalie De Vos, Sven Saussez","doi":"10.1002/ohn.1283","DOIUrl":"https://doi.org/10.1002/ohn.1283","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the presence and clinical value of salivary elastase, pepsin, trypsin, cholesterol, and bile salts in the development of laryngopharyngeal reflux disease-related chronic cough (LPRD-CC).</p><p><strong>Study design: </strong>Prospective controlled study.</p><p><strong>Setting: </strong>University hospital study.</p><p><strong>Methods: </strong>Patients with LPRD at the 24-hour hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring were recruited from two European hospitals. Symptoms and findings were evaluated with the reflux symptom score (RSS), quality-of-life RSS (QoL-RSS), and the reflux sign assessment (RSA) at baseline and following 3 months of treatment. Pepsin, trypsin, elastase, cholesterol, and bile acids were measured in the saliva of patients. Clinical presentation and enzyme patterns were compared between patients with LPRD-CC versus patients without chronic cough. Predictive values of digestive enzymes on clinical patterns were assessed.</p><p><strong>Results: </strong>Of the 104 recruited patients, 54 had LPRD-CC and 50 did not. Patients with chronic cough demonstrated significantly lower pharyngeal upright reflux events but higher RSS compared to those without chronic cough. The CC group demonstrated significant reduction of RSS (164.4 ± 104.5 vs 105.1 ± 103.2) and RSA (27.7 ± 6.6 vs 21.6 ± 8.1) following treatment. RSS (78.4 ± 51.3 vs 50.2 ± 49.7) and RSA (24.8 ± 7.9 vs 21.5 ± 10.3) were similarly reduced in the non-CC group. The chronic cough group maintained significantly higher scores in otolaryngological RSS (P = .033), respiratory RSS (P = .036), overall RSS (P = .035), and RSS quality of life (RSS-QoL) (P = .007). Salivary elastase demonstrated moderate correlation with both chronic cough presence (r_s = 0.325) and RSS (r_s = 0.353), while salivary bile salts correlated strongly with RSS-QoL (r_s = 0.564). In patients with chronic cough, esophageal acid exposure time showed a significant negative correlation with salivary pH (r_s = -0.443).</p><p><strong>Conclusion: </strong>LPRD patients with chronic cough demonstrated higher symptom severity than those without, with salivary elastase and bile salts as potential predictors of clinical findings.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}