The Importance of Extranodal Extension Grading in Laryngeal Squamous Cell Carcinoma.

IF 2.6 3区医学 Q1 OTORHINOLARYNGOLOGY

Otolaryngology- Head and Neck Surgery Pub Date : 2025-05-05 DOI:10.1002/ohn.1297

Hakan Kara, Levent Aydemir, Melek Büyük, Erol Bozbora, Kübra Özkaya Toraman, Saim Pamuk, Kağan Avcı, Comert Sen, Said Sonmez, Murat Ulusan, Bora Basaran, Musa Altun, Erkan Kıyak

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Abstract

Objective: The primary objective was to investigate the effect of extra-nodal extension (ENE) grading on the survival of pN-positive patients with laryngeal squamous cell carcinoma (LSCC).

Study design: A retrospective cohort study.

Setting: A tertiary referral center.

Methods: The patients with LSCC were retrospectively reviewed. The histopathological slides of patients were re-examined, and ENE was graded. Survival analyses were performed.

Results: Seventy-six patients were enrolled in this study. The average age of patients was 61.29 years. 3-year overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) rates were 69.7%, 73.7%, and 73.7%, respectively. ENE grading had no statistically significant impact on survival rates.

Conclusion: While the presence of ENE in more than 4 lymph nodes, lymph node density (LND) greater than 0.2, poor histologic differentiation, and not receiving chemotherapy were identified as independent poor prognosticators in LSCC, the study did not show any effect of ENE grading on survival rates.

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结外扩展分级在喉鳞癌中的重要性。

目的：主要目的是研究淋巴结外延伸（ENE）分级对pn阳性喉鳞癌（LSCC）患者生存的影响。研究设计：回顾性队列研究。环境：三级转诊中心。方法：对LSCC患者进行回顾性分析。重新检查患者的组织病理切片，并对ENE进行分级。进行生存分析。结果：76例患者入组。患者平均年龄61.29岁。3年总生存率（OS）、疾病特异性生存率（DSS）和无病生存率（DFS）分别为69.7%、73.7%和73.7%。ENE分级对生存率没有统计学上的显著影响。结论：虽然ENE存在于4个以上淋巴结，淋巴结密度（LND）大于0.2，组织学分化差，未接受化疗被确定为LSCC的独立不良预后因素，但研究并未显示ENE分级对生存率的任何影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

6.70

自引率

2.90%

发文量

250

审稿时长

2-4 weeks

期刊介绍： Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.