Elevated Body Mass Index Aggravates Histopathological Changes and Postoperative Recurrence Risk in Nasal Polyps.

IF 2.6 3区医学 Q1 OTORHINOLARYNGOLOGY

Otolaryngology- Head and Neck Surgery Pub Date : 2025-05-05 DOI:10.1002/ohn.1285

Sijie Jiang, Liyuan Liu, Hua Zhang, Zhihai Xie, Shaobing Xie, Weihong Jiang

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引用次数: 0

Abstract

Objective: This study aimed to investigate the association between body mass index (BMI) and histopathological features and postoperative recurrence risk of chronic rhinosinusitis with nasal polyps (CRSwNP).

Study design: A retrospective clinical study.

Setting: Recurrent group and nonrecurrent group.

Methods: We recruited CRSwNP patients who underwent functional endoscopic sinus surgery and classified them into three groups based on BMI: normal weight, overweight, and obesity. All patients were followed for 3 years and divided into recurrence and nonrecurrence groups. The histopathological features and the impact of BMI on the risk of postoperative recurrence were analyzed through comparative analysis.

Results: A total of 577 CRSwNP patients completed the follow-up, with 197 experiencing postoperative recurrence. Recurrence rates, tissue eosinophil counts, and interleukin (IL)-5 and IL-17A expression levels were significantly higher in the overweight and obesity groups compared to the normal weight group. Additionally, within the overweight and obesity groups, patients with recurrence had elevated tissue eosinophil counts and IL-5 and IL-17A levels compared to the other two groups. Notably, tissues collected during revision surgery showed increased eosinophil counts, IL-5 and IL-17A levels compared to baseline, particularly in obese patients. Both logistic regression analyses and Kaplan-Meier curves indicated that overweight and obesity were associated with an increased risk of CRSwNP recurrence.

Conclusion: Elevated BMI presented significant impacts on the histopathological changes and the risk of postoperative recurrence in CRSwNP patients. Overweight and obesity aggravated tissue eosinophil infiltration, and IL-5 and IL-17A expressions contributing to the recurrent mechanisms of CRSwNP.

查看原文本刊更多论文

体重指数升高加重鼻息肉的组织病理改变和术后复发风险。

目的：探讨慢性鼻窦炎合并鼻息肉（CRSwNP）患者体重指数（BMI）与组织病理学特征及术后复发风险的关系。研究设计：回顾性临床研究。设置：复发组和非复发组。方法：我们招募了接受功能性内窥镜鼻窦手术的CRSwNP患者，并根据BMI将其分为三组：正常体重、超重和肥胖。随访3年，分为复发组和非复发组。通过对比分析，分析组织病理学特征及BMI对术后复发风险的影响。结果：共577例CRSwNP患者完成随访，197例术后复发。与正常体重组相比，超重和肥胖组的复发率、组织嗜酸性粒细胞计数、白细胞介素(IL)-5和IL- 17a表达水平显著升高。此外，在超重和肥胖组中，与其他两组相比，复发患者的组织嗜酸性粒细胞计数和IL-5和IL-17A水平升高。值得注意的是，翻修手术期间收集的组织显示，与基线相比，嗜酸性粒细胞计数、IL-5和IL-17A水平增加，尤其是在肥胖患者中。logistic回归分析和Kaplan-Meier曲线均表明，超重和肥胖与CRSwNP复发风险增加相关。结论：BMI升高对CRSwNP患者的组织病理改变及术后复发风险有显著影响。超重和肥胖加重了组织嗜酸性粒细胞浸润，IL-5和IL-17A的表达参与了CRSwNP的复发机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

6.70

自引率

2.90%

发文量

250

审稿时长

2-4 weeks

期刊介绍： Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.