Nutritional Neuroscience最新文献

{"title":"Prebiotic-based banana snacks (<i>Musa sapientum</i> L.) alleviate cognitive impairment by reducing brain inflammation, apoptosis, microglial activation, and dendritic spine loss in obese rats.","authors":"Piangkwan Sa-Nguanmoo, Nattayaporn Apaijai, Hiranya Pintana, Titikorn Chunchai, Busarin Arunsak, Aphisek Kongkaew, Wasana Pratchayasakul, Sakamon Devahastin, Nipon Chattipakorn, Siriporn C Chattipakorn","doi":"10.1080/1028415X.2026.2632672","DOIUrl":"10.1080/1028415X.2026.2632672","url":null,"abstract":"<p><strong>Objectives: </strong>Prebiotics may reduce adiposity and inflammation, improving cognitive function in obese rats, mediated by modulation of the gut-brain axis. Banana-based snacks are promising prebiotic foods. However, their effects on gut microbiota, inflammation, brain reactive oxygen species (ROS) production, microglial morphology, dendritic spine density, and cognitive function remain underexplored in high-fat diet (HFD)-induced obese rats.</p><p><strong>Methods: </strong>Seventy-two male rats were maintained on either a normal diet (ND) or a HFD for 16-weeks. At week 13, ND-fed rats were subdivided into six groups (<i>n</i> = 6/group) receiving either a vehicle (NDV, 10.5 mL/kg/day twice daily), prebiotic snacks from bananas at ripening stages 2-5 (NDS2-5, 7.47 g in water, 10.5 mL/kg/day twice daily), or inulin (NDI, 2 g/kg/day in water, 10.5 mL/kg/day twice daily). HFD-fed rats were similarly subdivided into six groups (<i>n</i> = 6/group) with either a vehicle (HFV), banana-based prebiotic snacks (HFS2-5), or inulin (HFI), administered for four weeks at the same doses as the ND-fed rats.</p><p><strong>Results: </strong>HFD-fed rats exhibited both obesity and insulin resistance, gut dysbiosis, inflammation, and cognitive impairment. However, rats receiving inulin or banana-based prebiotics from all ripening stages exhibited improved cognitive function by reducing gut dysbiosis, oxidative stress, inflammation, brain ROS, apoptosis, dendritic spine loss, and microglial activation.</p><p><strong>Conclusions: </strong>Prebiotic banana snacks from all ripening stages may protect against HFD-induced cognitive impairment by enhancing gut health and reducing inflammation and oxidative stress, potentially via the gut-brain axis. These findings support their potential use as functional foods to promote both cognitive and metabolic health.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1136-1152"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egg intake and the risk of glioma and head and neck cancers: a systematic review and dose-response meta-analysis of observational studies.","authors":"Mohammad Amin Mohammadi, Ali Kosari, Gholamreza Askari, Omid Sadeghi","doi":"10.1080/1028415X.2026.2628827","DOIUrl":"10.1080/1028415X.2026.2628827","url":null,"abstract":"<p><p>Findings on the relationship between egg consumption and risk of glioma and head and neck cancer (HNC) are conflicting. A 2019 meta-analysis reported no significant association between egg intake and glioma risk. However, several eligible articles have been published since the release of that meta-analysis. In addition, there is no evidence of a dose-response relationship in this regard. Also, we found no meta-analysis investigating the association between egg intake and HNC. Therefore, we aimed to conduct a comprehensive meta-analysis to summarize current evidence on the relationship between egg consumption and the risk of glioma and HNC. We systematically searched PubMed, Scopus, Web of Sciences, and Google Scholar until August 2024, for observational studies that reported the association between egg consumption and the risk of glioma and HNC. In total, eleven studies, including seven studies on glioma and four studies on HNC, were included in the current meta-analysis. These studies included 1,274,437 participants with 4199 cases of glioma and 3164 cases of HNC. The meta-analysis was performed using a random-effects model. We found that egg consumption was associated with a reduced risk of glioma, particularly in Eastern populations (i.e. Asian populations) (RR: 0.51, 95% CI: 0.35-0.73). Additionally, in the non-linear dose-response analysis, egg consumption above 50 grams per day (>1 egg/day) gradually increased the risk of HNC. In conclusion, we found a significant inverse association between egg and glioma risk among Eastern populations and a positive association between egg intake and HNC risk in the dosages of >50 grams per day.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1097-1110"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Ficus deltoidea</i> preserves neuronal-glial ultrastructure and attenuates neuroinflammation in an Alzheimer's disease-like rat model.","authors":"Michael Ayuba, Che Mohd Nasril Che Mohd Nassir, Hafizah Abdul Hamid, Zaw Myo Hein, Bukar Alhaji Modu, Mohamad Aris Mohd Moklas, Muhammad Zulfadli Mehat","doi":"10.1080/1028415X.2026.2717205","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2717205","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by β-amyloid (Aβ) plaques, hyperphosphorylated tau tangles, cognitive decline, neuroinflammation, and neuronal-glial dysfunction, yet effective disease-modifying therapies remain unavailable. Increasing evidence suggests that preservation of neuronal and glial integrity is critical for mitigating disease progression. In the present study, we investigated the neuroprotective effects of <i>Ficus deltoidea</i> Jack (FD) in a D-galactose and aluminum chloride (D-gal/AlCl₃)-induced rat model of AD-like neurodegeneration. Adult male Wistar rats were treated with FD (50, 100, and 200 mg/kg) for ten weeks and assessed for cognitive performance, cortical neuronal integrity, hippocampal ultrastructure, and neuroinflammatory signaling. FD treatment significantly improved spatial learning and memory in the Morris water maze without affecting locomotor activity. Histopathological analysis demonstrated dose-dependent preservation of pyramidal neurons in prefrontal cortex and hippocampal layers II (<i>p</i> < 0.0001), III (<i>p</i> < 0.0001), and V (<i>p</i> < 0.0001), with the highest dose of FD producing neuronal viability comparable to donepezil. Importantly, transmission electron microscopy demonstrated that FD markedly preserved the ultrastructural integrity of hippocampal microglia and astrocytes, maintaining mitochondrial morphology, rough endoplasmic reticulum organization, and myelin integrity. Consistent with these structural effects, FD significantly suppressed neuroinflammatory cytokine expression (IL-1β, IL-6, and TNF-α) in the prefrontal cortex. Collectively, this study provides the first integrated ultrastructural and molecular evidence that FD confers multi-level neuroprotection across the cortical-hippocampal axis by preserving neuronal-glial architecture and attenuating neuroinflammation. These findings highlight FD as a promising multi-target natural candidate for mitigating neurodegenerative processes associated with AD.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-18"},"PeriodicalIF":3.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erucic acid arbitrates neuroprotection in streptozotocin-induced memory deficit via improving oxidative stress/neuroinflammatory indicators/cholinergic activity in rodents.","authors":"Nadeem Sayyed, Muhammad Afzal, Misbahuddin Rafeeq, Asma B Omer, Fahad A Al-Abbasi, Shakilur Rahman, Mohammed Al-Zharani, Sami I Alzarea, Imran Kazmi","doi":"10.1080/1028415X.2026.2718394","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2718394","url":null,"abstract":"<p><strong>Background: </strong>Erucic acid (EA), a monounsaturated omega-9 fatty acid derived from Raphanus sativus L. seeds, has antioxidant and anti-inflammatory properties. This study investigated its neuroprotective effects against streptozotocin (STZ)-induced diabetes-associated cognitive dysfunction in rats.</p><p><strong>Methods: </strong>Male Wistar rats were randomly assigned to five groups: normal control, STZ control (60 mg/kg), STZ + EA (10 mg/kg), STZ + EA (20 mg/kg), and EA (20 mg/kg) per se. EA was administered orally for 38 days. Blood glucose and body weight were measured before STZ administration and at the end of the study. Cognitive function was assessed using the Y-maze and Morris water maze (MWM). Cholinergic function, oxidative stress, neurotransmitters, inflammatory mediators, apoptosis, and cellular energy status were evaluated biochemically, and hippocampal histopathology was performed.</p><p><strong>Results: </strong>EA treatment significantly reduced hyperglycemia and attenuated diabetes-induced body weight loss. EA improved spontaneous alternation in the Y-maze and spatial learning and memory in the MWM, reducing escape latency and increasing target-quadrant time. EA decreased acetylcholinesterase activity while increasing choline acetyltransferase activity, restored antioxidant defenses, and reduced MDA, ROS, and NO levels. It also normalized neurotransmitter levels, suppressed TNF-α, IL-1β, IL-6, NF-κB, and caspase-3, increased IL-10, and improved the ATP/ADP ratio. Histopathology demonstrated preservation of hippocampal neuronal architecture.</p><p><strong>Conclusions: </strong>EA ameliorated diabetes-associated cognitive dysfunction by improving learning and memory, preserving cholinergic neurotransmission, reducing oxidative stress and neuroinflammation, inhibiting neuronal apoptosis, and restoring cellular energy metabolism. These findings support the therapeutic potential of EA for managing cognitive impairment associated with diabetes.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-23"},"PeriodicalIF":3.1,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148830962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective role of L-methylfolate, vitamin B₂, and vitamin D₃ in modulating neurobehavioural and epigenetic outcomes of chronic stress.","authors":"Muhammad Nouman Zahid Magray, Laiba Taufiq, Saleha Bari, Naila Naz","doi":"10.1080/1028415X.2026.2718400","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2718400","url":null,"abstract":"<p><p>Chronic stress is a key risk factor for depression, while conventional antidepressants, though effective, often are associated with adverse effects. Nutritional approaches such as L-methylfolate, vitamin B₂, and vitamin D₃ offer safer alternatives by supporting neurotransmitter synthesis, one-carbon metabolism, and stress regulation. This study examined the preventive effects of a multivitamin combination in a chronic unpredictable mild stress (CUMS) rat model. Male and female Sprague Dawley rats were divided into control, CUMS + saline, or CUMS + multivitamin groups and treated for 21 days. Behavioural tests, cortical morphometry, neurotransmitter receptor expression, hepatic folate levels, DNA methylation, and METTL3 expression were assessed, alongside serum cortisol and biochemical markers of liver and kidney function. CUMS induced depressive-like behaviours, elevated cortisol, impaired organ function, reduced cortical thickness, and downregulated serotonergic, dopaminergic, and adrenergic receptors. Multivitamin supplementation restored behaviour, normalized cortisol and organ function, preserved cortical integrity and hepatic methylation, and upregulated METTL3. These findings highlight multivitamins as functional food-based strategies for the prevention of depression-like behaviour.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-19"},"PeriodicalIF":3.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary casein source modulates water intake and anxiety- and cognition-related behaviors in C57BL/6J male mice.","authors":"Atsushi Toyoda, Hideaki Nishizawa, Chiho Kozawa, Hyeran Jang, Takamitsu Tsukahara","doi":"10.1080/1028415X.2026.2719754","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2719754","url":null,"abstract":"<p><strong>Introduction: </strong>Semi-purified diets are commonly used in animal studies to improve experimental reproducibility. However, the composition of these diets often differs, particularly in ingredient sources such as casein, and the influence of these compositional differences on physiological and behavioral phenotypes remains unclear. Therefore, this study aimed to compare commonly used semi-purified diets and to test whether ingredient-level variation influences physiological and behavioral outcomes in mice.</p><p><strong>Methods: </strong>Male C57BL/6J mice were fed semi-purified diets based on the AIN-93G or an OpenStandard diet (OSD), the latter containing inulin. Each diet was formulated using either lactic acid casein or mineral acid casein and administered for 114 days. Feed intake, water intake, body weight, tissue weight, and various behavioral tests were assessed.</p><p><strong>Results: </strong>Mineral-acid casein was associated with higher total water intake than lactic-acid casein across diet formulations. In contrast, lactic-acid casein was associated with a higher recognition index in the novel object recognition test and longer center-zone time in the elevated plus maze than mineral-acid casein. OSD increased cecum weight compared with AIN-93G.</p><p><strong>Conclusions: </strong>These findings suggest that dietary casein source is associated with differences in water intake and selected behavioral outcomes in mice, with mineral-acid casein increasing water intake and lactic-acid casein improving memory performance. The choice of protein source in semi-purified diets should be considered when designing nutritional and behavioral experiments.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":3.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of medium-chain triglyceride with and without ketogenic diet in the management of drug-resistant epilepsy: a systematic review.","authors":"Marta Pellizzari, Larissa De Clauser, Susan Mir-Majidi, Alessandro Leone, Pierangelo Veggiotti, Roberto Previtali, Sara Olivotto, Simona Bertoli, Ramona De Amicis","doi":"10.1080/1028415X.2026.2720527","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2720527","url":null,"abstract":"<p><strong>Background: </strong>Ketogenic dietary therapies, including the medium-chain triglyceride ketogenic diet (MCT KD), are established non-pharmacological treatments for drug-resistant epilepsy (DRE). MCTs may also exert antiseizure effects partly independent of ketosis. This review evaluated the effectiveness, tolerability, safety, and adherence of MCT-based interventions used with or without a ketogenic diet.</p><p><strong>Methods: </strong>PubMed, Web of Science, Scopus, and the Cochrane Library were searched from inception to April 2025. Randomized controlled trials (RCTs) and cohort studies in patients with DRE were included. Methodological quality was assessed using Joanna Briggs Institute tools and certainty of evidence using GRADE. Owing to substantial heterogeneity, findings were synthesized using a structured Synthesis Without Meta-analysis approach.</p><p><strong>Results: </strong>Twelve studies were included: three RCTs and nine observational studies. One paediatric RCT found no clear difference in seizure outcomes between MCT KD and the classical ketogenic diet (CKD), despite higher ketone levels with CKD; however, equivalence was not established. A small paediatric crossover trial suggested possible benefit from a C10-enriched KD, while a small adult RCT indicated a possible therapeutic signal from MCT supplementation. Observational studies generally reported improvement from baseline but were limited by methodological weaknesses. Gastrointestinal adverse events were common but often manageable. Certainty of evidence was low to very low.</p><p><strong>Conclusion: </strong>MCT-based interventions may offer a flexible option for DRE. Low-certainty evidence suggests that MCT KD may achieve seizure outcomes similar to CKD, but equivalence remains unproven. Evidence for MCT supplementation without a strict KD is very uncertain.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-22"},"PeriodicalIF":3.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of anti-inflammatory diets based on complementary and alternative medicine in multiple sclerosis: a systematic review and meta-analysis of clinical trials.","authors":"Amir Reza Moravejolahkami, Vida Nazari, Fatemeh Zare Hossein Abadi, Masoud Mohammadnezhad","doi":"10.1080/1028415X.2026.2717197","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2717197","url":null,"abstract":"<p><strong>Background: </strong>The role of diet in modulating inflammation has garnered attention, particularly regarding anti-inflammatory dietary interventions rooted in complementary medicine. The present study examined the clinical manifestations through which anti-inflammatory diets may influence MS, providing insights for clinician researchers.</p><p><strong>Methods: </strong>A thorough search was performed in Scopus, MEDLINE (PubMed), ScienceDirect, EMBASE, Google Scholar, Central Cochrane Library, and the Web of Science, covering trials published until December 2025. Random-effects models were used to analyze the quantitative data through STATA₁₄.</p><p><strong>Results: </strong>After analyzing 246 entries, we found 10 Randomized Controlled Trials (RCTs) with a total of 332 participants, who had an average disease duration of 8.7 years. The combined effect size revealed a decrease in fatigue severity (Weighted Mean Difference [WMD] = -7.10; 95% Confidence Interval [CI] = -13.61, -0.59; <i>P</i> = 0.032) and an increase in physical health score (WMD = 2.59; 95% Confidence Interval [CI] = 0.17, 5.00; <i>P</i> = 0.036).</p><p><strong>Conclusion: </strong>Anti-inflammatory diets may improve MS clinical manifestations, especially fatigue and disability; therefore, more research is needed to confirm the present findings.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-16"},"PeriodicalIF":3.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schisandrin A, a dietary lignan from Schisandra chinensis, ameliorates cognitive deficits in AlCl₃/D-galactose-treated mice.","authors":"Jing-Su Xue, Min Niu, Xiao-Yue Song, Xiang-Min Deng","doi":"10.1080/1028415X.2026.2714516","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2714516","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited disease-modifying therapies. Chronic aluminum exposure, a well-recognized environmental risk factor, exacerbates AD pathogenesis by driving oxidative stress and neuroinflammation. Schisandrin A (SchA), a bioactive lignan from the medicinal and edible plant Schisandra chinensis, exhibits promising antioxidant and anti-inflammatory properties, yet its nutritional relevance for AD intervention remains undefined. This study evaluated SchA's neuroprotective potential in an AlCl₃/D-galactose-induced cognitive impairment model. We found that SchA significantly ameliorated learning and memory impairments in Morris water maze, novel object recognition, open field and Y-maze tests, alleviated neuronal damage in the hippocampus and cortex, and reduced cerebral amyloid-β (Aβ) production in AlCl₃/D-galactose-treated mice. Mechanistically, SchA mitigated neuroinflammation via inhibiting the IKK/NF-κB/iNOS pathway, and alleviated oxidative stress through activating the Nrf2/HO-1 axis. Our findings demonstrate that SchA exerts neuroprotective effects in AlCl₃/D-galactose-treated mice, accompanied by modulation of inflammatory and oxidative-stress-related signalling, supporting its potential as a nutritional intervention for AD.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-14"},"PeriodicalIF":3.1,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luteolin and neurodegenerative disease modulation: linking molecular mechanisms, neurotransmission, and pharmacokinetics.","authors":"Shivani Chib, Shaurabh Shukla, Kajal Sharma, Randhir Singh","doi":"10.1080/1028415X.2026.2700760","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2700760","url":null,"abstract":"<p><p>Neurodegenerative disorders arise from the convergence of oxidative stress, neuroinflammation, synaptic dysfunction, mitochondrial failure, and dysregulated cell death, highlighting the need for therapeutic agents capable of coordinated, multi-target modulation. Luteolin (3',4',5,7-tetrahydroxyflavone), a dietary flavonoid widely present in edible and medicinal plants, has emerged as a promising neuroactive compound with pleiotropic biological actions. Rather than focusing on isolated outcomes, this review presents an integrated summary of how luteolin orchestrates interconnected signaling networks, with receptor-level neuromodulation and neuroimmune regulation to preserve neuronal integrity. Particular emphasis is placed on pathway convergence, cross-talk, and system-level neuroprotection across models of Alzheimer's disease, Parkinson's disease, and related disorders. In parallel, pharmacokinetic behavior, metabolite activity, and emerging delivery strategies are examined in relation to mechanistic efficacy. By linking molecular signaling, neurotransmission and therapeutic feasibility within a unified framework, this review offers a refined perspective on role of luteolin in neurodegenerative disease modulation.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-18"},"PeriodicalIF":3.1,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}