Nutritional Neuroscience最新文献_第2页

Advanced strategies for enhancing the neuroprotective potential of curcumin: delivery systems and mechanistic insights in neurodegenerative disorders.

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-03 DOI: 10.1080/1028415X.2025.2472773

Pratikeswar Panda, Shreyashree Mohanty, Sangita Ranee Gouda, Tirtha Chandan Baral, Abhijit Mohanty, Jyotirmay Nayak, Rajaram Mohapatra

{"title":"Advanced strategies for enhancing the neuroprotective potential of curcumin: delivery systems and mechanistic insights in neurodegenerative disorders.","authors":"Pratikeswar Panda, Shreyashree Mohanty, Sangita Ranee Gouda, Tirtha Chandan Baral, Abhijit Mohanty, Jyotirmay Nayak, Rajaram Mohapatra","doi":"10.1080/1028415X.2025.2472773","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2472773","url":null,"abstract":"Background: Curcumin, a polyphenolic compound derived from Curcuma longa, exhibits significant neuroprotective potential due to its diverse pharmacological properties.Objective: This review explores curcumin's role in modulating key pathological mechanisms underlying neurodegenerative disorders such as Alzheimer's, Parkinson's diseases, Amyotrophic Lateral Sclerosis, Huntington's Disease and Prion Disease.Methods: A comprehensive analysis of curcumin's molecular interactions, including its effects on amyloid-beta (Aβ) aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress, and metal-induced neurotoxicity, was conducted. Additionally, strategies to overcome its low bioavailability and blood-brain barrier (BBB) permeability were evaluated.Results: Curcumin inhibits Aβ aggregation and promotes disaggregation, reducing amyloid plaque formation in Alzheimer's disease. It modulates glial cell activity, attenuating neuroinflammation and fostering a neuroprotective environment. By interacting with tau proteins, curcumin prevents hyperphosphorylation and neurofibrillary tangle formation. As a potent antioxidant, it scavenges reactive oxygen species, mitigating oxidative stress-related neuronal damage. Its metal-chelating properties further diminish neurotoxicity by sequestering iron and copper ions. Despite its limited bioavailability and BBB permeability, curcumin's therapeutic efficacy can be enhanced using nanocarriers such as nanoparticles, liposomes, and micelles, which improve solubility, stability, and brain penetration.Conclusion: Curcumin's multifaceted neuroprotective mechanisms make it a promising candidate for preventing or slowing neurodegenerative disease progression. Advanced drug delivery systems hold potential for overcoming its pharmacokinetic limitations, paving the way for future clinical applications.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-26"},"PeriodicalIF":3.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal vitamin D levels and infant cognitive, motor, language and social-emotional development at 6 and 9 months of age. 产前维生素 D 水平与婴儿 6 个月和 9 个月大时的认知、运动、语言和社会情感发育。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-06-19 DOI: 10.1080/1028415X.2024.2366649

Dolat Singh Shekhawat, Kuldeep Singh, Pratibha Singh, Varuna Vyas, Shoban Babu Varthya, Praveen Sharma

{"title":"Prenatal vitamin D levels and infant cognitive, motor, language and social-emotional development at 6 and 9 months of age.","authors":"Dolat Singh Shekhawat, Kuldeep Singh, Pratibha Singh, Varuna Vyas, Shoban Babu Varthya, Praveen Sharma","doi":"10.1080/1028415X.2024.2366649","DOIUrl":"10.1080/1028415X.2024.2366649","url":null,"abstract":"Aim: Vitamin D is involved in several processes related to the development of neuronal and non-neuronal cells. There is a possible link between maternal vitamin D status in pregnancy and delayed neurocognitive development in the offspring. The aim of the study was to explore the association of maternal and cord blood vitamin D levels with infants' neurodevelopment at 6 and 9 months of age.Methodology: A cohort study was conducted in western Rajasthan, India. Maternal and cord blood samples were collected at the time of delivery. Serum 25(OH)-vitamin D levels were measured in both. Infant neurodevelopment was assessed at 6 and 9 months of age in six domains namely cognitive, receptive language, expressive language, fine motor, gross motor and social-emotional using the Bayley Scale of Infant Development- III (BSID-III).Results: A total of 175 mother-child pairs were enrolled. Among the mothers taking part in this study, 7.3% had deficient and 59.09% had insufficient levels of serum 25(OH) vitamin D during the third trimester of their pregnancy. Maternal and cord blood serum 25-OH vitamin D levels were 18.86 ± 8.53 ng/mL and 17.39 ± 8.87 ng/mL, respectively, and there was a significant correlation (r = 0.9778, p = 0.000) between levels of vitamin D. Based on the repeated measures ANOVA, post hoc Tukey's HSD test, maternal vitamin D levels had a significant relationship (p = 0.047) to the cognitive development of infants at 6 months of age. Furthermore, cord serum vitamin D levels showed a significant association (p = 0.023 and p = 0.010) with the social-emotional development of the infant at the age of 6 and 9 months.Conclusion: Maternal and cord serum 25-OH vitamin D deficiency was significantly associated with the cognitive and social-emotional development of infants.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"263-272"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folic acid and autism: updated evidences. 叶酸与自闭症：最新证据。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-07-05 DOI: 10.1080/1028415X.2024.2367855

Cristiane Vasconcelos, Ingrid Schweigert Perry, Carmem Gottfried, Rudimar Riesgo, Kamila Castro

{"title":"Folic acid and autism: updated evidences.","authors":"Cristiane Vasconcelos, Ingrid Schweigert Perry, Carmem Gottfried, Rudimar Riesgo, Kamila Castro","doi":"10.1080/1028415X.2024.2367855","DOIUrl":"10.1080/1028415X.2024.2367855","url":null,"abstract":"Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that impairs communication, socialization, and behavior. The association of ASD with folic acid has been investigated due to the importance of this vitamin for neurological health. This study is an update of the publication 'Folic acid and autism: What do we know?' and aims to systematically review studies examining the relationship between folic acid and ASD. The search resulted in 2,389 studies on folic acid and ASD, which were selected by two reviewers based on their titles and abstracts. Studies meeting the inclusion criteria were fully read. The 52 included studies involved 10,429 individuals diagnosed with ASD and assessed the intake of vitamin B6, folic acid, and vitamin B12; serum levels of these vitamins, homocysteine, and methionine; therapeutic interventions using folic acid; and the association between maternal exposure to this vitamin and the risk of ASD. The evidence of insufficient folic acid intake in most individuals with ASD remains consistent in this update. No association was found between maternal exposure to folic acid and the risk of ASD in their children. Despite observed improvements in communication, socialization, and behavior in individuals with ASD following folic acid interventions, it is crucial to consider the individuality and complexity of ASD. Given the relevance of the topic, there remains a need for more high-quality research and clinical trials characterized by rigorous methodological designs.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"273-307"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin and macular carotenoids and relations to academic achievement among school-aged children. 学龄儿童的皮肤和黄斑类胡萝卜素及其与学习成绩的关系。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-07-11 DOI: 10.1080/1028415X.2024.2370175

Laura M Rosok, Corinne N Cannavale, Shelby A Keye, Hannah D Holscher, Lisa Renzi-Hammond, Naiman A Khan

{"title":"Skin and macular carotenoids and relations to academic achievement among school-aged children.","authors":"Laura M Rosok, Corinne N Cannavale, Shelby A Keye, Hannah D Holscher, Lisa Renzi-Hammond, Naiman A Khan","doi":"10.1080/1028415X.2024.2370175","DOIUrl":"10.1080/1028415X.2024.2370175","url":null,"abstract":"Objectives: Carotenoids are plant pigments that accumulate in human tissue (e.g. macula and skin) and can serve as biomarkers for diet quality; however, knowledge on skin and macular carotenoids in relation to cognition in children is limited. This study aimed to address this gap by assessing links between skin and macular carotenoids and academic achievement in school-aged children.Methods: Children 7-12 years old (n = 81) participated in a crosssectional study. Skin and macular carotenoids were measured with reflection spectroscopy and heterochromatic flicker photometry, respectively. Academic achievement was measured using Woodcock-Johnson IV (WJ-IV). Body Mass Index was calculated using height and weight measurements, demographic information was collected using a family demographics and pediatric health history questionnaire, and carotenoid intake was assessed using 7-day diet records.Results: Skin carotenoids were not related to macular pigment (r = 0.08, p = 0.22). Adjusting for age, sex, BMI percentile, household income, and total carotenoid consumption (mg/1000kcal), skin carotenoids were predictive of math (β = 0.27, p = 0.02), broad math (β = 0.36, p < 0.01) and math calculation (β = 0.38, p < 0.01). Skin carotenoids displayed trending relationships with broad reading (β = 0.23, p = 0.05) and reading fluency (β = 0.22, p = 0.07). There were no significant associations between macular pigment and academic achievement (all β's ≤ 0.07, all p's ≥ 0.56).Discussion: Skin carotenoids were positively associated with academic abilities in children, while macular carotenoids did not display this relationship. Future interventions examining prospective effects of changes in carotenoids in different tissues on childhood academic achievement are warranted.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"308-320"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the acute impact of rosemary consumption on brain activity in healthy volunteers. 研究食用迷迭香对健康志愿者大脑活动的急性影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-07-06 DOI: 10.1080/1028415X.2024.2370729

Aynur Muduroglu-Kirmizibekmez, Ceren Cati, Alparslan Onder, Sevcan Aydin, Ihsan Kara

{"title":"Investigation of the acute impact of rosemary consumption on brain activity in healthy volunteers.","authors":"Aynur Muduroglu-Kirmizibekmez, Ceren Cati, Alparslan Onder, Sevcan Aydin, Ihsan Kara","doi":"10.1080/1028415X.2024.2370729","DOIUrl":"10.1080/1028415X.2024.2370729","url":null,"abstract":"Objectives: Rosmarinus officinalis L. (rosemary) is a fragrant plant of the mint family, broadly known as a nourishment flavoring agent; it is additionally utilized in conventional people cures for its anti-inflammatory, diuretic, and antibacterial properties. Intense cognitive impacts from devouring plant-based flavonoids can be measured with electroencephalography (EEG), which records unconstrained brain movement. Brain activity can be evaluated amid independent states or whereas performing attentional assignments. This study aimed to determine the impact of rosemary consumption on cognitive consequences.Methods: Twenty volunteers took part in the study. EEG was taken for each volunteer twice, before drinking rosemary extract and around one hour after drinking it. EEG information was recorded with a Micromed recording framework inspecting rate of 512 Hz. EEG signals were prepared to be utilized in EEGLAB, an open-source toolbox within the MATLAB environment. The information obtained after the EEG recording was compared with the preliminary EEG information.Results: The signal's power spectral density in theta, delta, and beta frequency bands modestly increased in males and females. Even though there was a significant increase in power at the alpha frequency band in both sexes, this increment was not specific channel-wise.Discussion: The obtained data are consistent with the expected results and similar studies conducted, suggesting that the consumption of rosemary is beneficial for cognitive function in the short term. It is anticipated that forthcoming long-term studies will support the existing data.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"321-332"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of the Prime Diet Quality Score (PDQS) with depression and anxiety symptoms: the Isfahan functional disorders (ISFUN) cohort study. 首要饮食质量评分 (PDQS) 与抑郁和焦虑症状的关系：伊斯法罕功能性失调（ISFUN）队列研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-07-10 DOI: 10.1080/1028415X.2024.2372190

Fahimeh Haghighatdoost, Awat Feizi, Parisa Hajihashemi, Hassan Shahoon, Alireza Ani, Hamidreza Roohafza, Peyman Adibi

{"title":"The association of the Prime Diet Quality Score (PDQS) with depression and anxiety symptoms: the Isfahan functional disorders (ISFUN) cohort study.","authors":"Fahimeh Haghighatdoost, Awat Feizi, Parisa Hajihashemi, Hassan Shahoon, Alireza Ani, Hamidreza Roohafza, Peyman Adibi","doi":"10.1080/1028415X.2024.2372190","DOIUrl":"10.1080/1028415X.2024.2372190","url":null,"abstract":"Background: Due to scarce epidemiologic data regarding the Prime Diet Quality Score (PDQS) and mental health disorders, this study aimed to investigate the association of PDQS with depression and anxiety symptoms in Iranian adults.Methods: This cross-sectional analysis was performed using the baseline data collected for the Isfahan functional disorders (ISFUN) cohort study. ISFUN was established in 2017 and enrolled apparently healthy adults, aged 18-65 years in Isfahan, Iran. Information on usual dietary intakes was collected using a validated Dish-based, 106-item food frequency questionnaire. The severity of depression and anxiety was assessed using a validated Iranian version of the Hospital Anxiety and Depression Scale.Results: A total number of1892 participants were enrolled in the present study. In total, 54.50% of subjects were female. In the fully adjusted model, participants with PDQS lower than median compared with those with PDQS higher than median had higher risk of depression (OR = 1.62; 95% CI: 1.11, 2.37) and anxiety (OR: 1.57; 95% CI: 1.08, 2.27). In stratified analysis by sex, males with PDQS lower than median compared with those with PDQS higher than median had greater risk for depressive (OR: 1.57) and anxiety symptoms (OR = 1.52). However, in females, no significant association was found between PDQS and odds of depression, and anxiety in the fully adjusted model.Conclusion: We found evidence indicating a significant inverse association between PDQS and depression and anxiety symptoms among Iranian adults. Further studies, in particular with prospective design, are required to confirm these findings.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"360-369"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dietary riboflavin intake and cognitive decline in older adults: a cross-sectional analysis. 老年人膳食核黄素摄入量与认知能力下降之间的关系：横断面分析。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-07-16 DOI: 10.1080/1028415X.2024.2375171

Kai Zhang, Tianyi Cai, Yu Han, Zhaoxuan Gu, Rui Hu, Zhengyan Hou, Xiaoqi Yu, Yafang Gao, Min Gao, Tianzhou Liu, Yixin Zhang

{"title":"Association between dietary riboflavin intake and cognitive decline in older adults: a cross-sectional analysis.","authors":"Kai Zhang, Tianyi Cai, Yu Han, Zhaoxuan Gu, Rui Hu, Zhengyan Hou, Xiaoqi Yu, Yafang Gao, Min Gao, Tianzhou Liu, Yixin Zhang","doi":"10.1080/1028415X.2024.2375171","DOIUrl":"10.1080/1028415X.2024.2375171","url":null,"abstract":"Background: Research exploring the link between dietary riboflavin intake and cognitive decline in this demographic is limited. Our aim was to examine the association between riboflavin intake levels and cognitive decline.Methods: The National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2014 were utilized in this cross-sectional analysis. The Consortium to Establish a Registry for Alzheimer's Disease test Word Learning delayed recall trial (DR), Digit Symbol Substitution Test (DSST), Animal Fluency Test(AFT) and Z test were used to evaluate cognitive performance. Multivariate logistic regression, restricted cubic spline and subgroup analysis were performed to evaluate the associations between riboflavin intake and cognitive decline.Results: The study included a total of 2255 patients, with 47.9% being male. The incidence of cognitive decline was 23.8%. After adjusting for all selected covariates, we found that high riboflavin intake was associated with a lower risk of cognitive impairment in adults in the United States. When riboflavin intake was used as a Categorical variable, compared to those with the lowest intake, the odds ratio (OR) of individuals with the highest riboflavin intake for DR test, AFT test, DSST test and Z test were 0.73 (95% CI: 0.53~1), 0.68(95% CI: 0.49-0.96),0.53(95% CI: 0.37-0.77) and 0.56(95% CI: 0.39-0.8). The study also found an L-shaped association between riboflavin intake and cognitive decline, with an inflection point at approximately 2.984 mg/d.Conclusions: Our cross-sectional study in a nationwide sample of American old adults suggests that dietary riboflavin intake was negative associated with cognitive decline.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"384-393"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between plant and animal protein intake with depression, anxiety, and stress. 植物蛋白和动物蛋白摄入量与抑郁、焦虑和压力之间的关系。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-07-09 DOI: 10.1080/1028415X.2024.2372194

Bita Forootani, Bahareh Sasanfar, Amin Salehi-Abargouei, Masoud Mirzaei

{"title":"The association between plant and animal protein intake with depression, anxiety, and stress.","authors":"Bita Forootani, Bahareh Sasanfar, Amin Salehi-Abargouei, Masoud Mirzaei","doi":"10.1080/1028415X.2024.2372194","DOIUrl":"10.1080/1028415X.2024.2372194","url":null,"abstract":"Background: Recent evidence suggests that diet composition is a key biological factor related to the development of depressive disorders. The present study was conducted to investigate the animal and plant protein intake and their replacement in association with depression, anxiety, and stress in Iranian adults.Method: In this cross-sectional study, the dietary intake of 7169 subjects were assessed using a validated food frequency questionnaire. The depression, anxiety, and stress Scale - 21 (DASS-21) questionnaire was used to psychological disorders. Logistic regression was used to obtain odds ratios for depression, anxiety, and stress across quintiles of animal and plant protein.Results: The participants' age range was 20-69 years. Individuals with the highest animal protein consumption had a lower chance for developing depression compared to those with the lowest intakes (OR = 0.73, 95%CI: 0.59-0.90; Ptrend < 0.01). Results also showed a significant association between animal protein intake and anxiety, such that subjects in the highest quintile of animal protein intake had 24% lower odds for anxiety compared to those in the lowest quintile (p < 0.05). We found a significant association between highest quintiles of animal protein intake and a 40% lower risk for stress among female individuals (Ptrend = 0.05). The multivariable-adjusted non-linear analyses also revealed that the replacement of plant protein with animal protein was significantly associated with the likelihood of depression and anxiety (P < 0.05).Conclusion: Animal protein intake might lower the odds of depression and anxiety particularly. Future prospective investigations are proposed to confirm these findings.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"370-383"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy as a window of opportunity for dementia prevention: a narrative review. 怀孕是预防痴呆症的机会之窗：叙述性综述。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-07-06 DOI: 10.1080/1028415X.2024.2371727

Lauren K Hand, Matthew K Taylor, Debra K Sullivan, Catherine F Siengsukon, Jill K Morris, Laura E Martin, Holly R Hull

{"title":"Pregnancy as a window of opportunity for dementia prevention: a narrative review.","authors":"Lauren K Hand, Matthew K Taylor, Debra K Sullivan, Catherine F Siengsukon, Jill K Morris, Laura E Martin, Holly R Hull","doi":"10.1080/1028415X.2024.2371727","DOIUrl":"10.1080/1028415X.2024.2371727","url":null,"abstract":"Dementia is a debilitating condition with a disproportionate impact on women. While sex differences in longevity contribute to the disparity, the role of the female sex as a biological variable in disease progression is not yet fully elucidated. Metabolic dysfunctions are drivers of dementia etiology, and cardiometabolic diseases are among the most influential modifiable risk factors. Pregnancy is a time of enhanced vulnerability for metabolic disorders. Many dementia risk factors, such as hypertension or blood glucose dysregulation, often emerge for the first time in pregnancy. While such cardiometabolic complications in pregnancy pose a risk to the health trajectory of a woman, increasing her odds of developing type 2 diabetes or chronic hypertension, it is not fully understood how this relates to her risk for dementia. Furthermore, structural and functional changes in the maternal brain have been reported during pregnancy suggesting it is a time of neuroplasticity for the mother. Therefore, pregnancy may be a window of opportunity to optimize metabolic health and support the maternal brain. Healthy dietary patterns are known to reduce the risk of cardiometabolic diseases and have been linked to dementia prevention, yet interventions targeting cognitive function in late life have largely been unsuccessful. Earlier interventions are needed to address the underlying metabolic dysfunctions and potentially reduce the risk of dementia, and pregnancy offers an ideal opportunity to intervene. This review discusses current evidence regarding maternal brain health and the potential window of opportunity in pregnancy to use diet to address neurological health disparities for women.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"347-359"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal protein malnutrition decreases neuron numbers in the parahippocampal region but not prefrontal cortex in adult rats. 产前蛋白质营养不良会减少成年大鼠海马旁区的神经元数量，但不会减少前额叶皮层的神经元数量。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-08-01 DOI: 10.1080/1028415X.2024.2371256

A C Amaral, J P Lister, J W Rueckemann, M W Wojnarowicz, J A McGaughy, D J Mokler, J R Galler, D L Rosene, R J Rushmore

{"title":"Prenatal protein malnutrition decreases neuron numbers in the parahippocampal region but not prefrontal cortex in adult rats.","authors":"A C Amaral, J P Lister, J W Rueckemann, M W Wojnarowicz, J A McGaughy, D J Mokler, J R Galler, D L Rosene, R J Rushmore","doi":"10.1080/1028415X.2024.2371256","DOIUrl":"10.1080/1028415X.2024.2371256","url":null,"abstract":"Objective: Prenatal protein malnutrition produces anatomical and functional changes in the developing brain that persist despite immediate postnatal nutritional rehabilitation. Brain networks of prenatally malnourished animals show diminished activation of prefrontal areas and an increased activation of hippocampal regions during an attentional task [1]. While a reduction in cell number has been documented in hippocampal subfield CA1, nothing is known about changes in neuron numbers in the prefrontal or parahippocampal cortices.Methods: In the present study, we used unbiased stereology to investigate the effect of prenatal protein malnutrition on the neuron numbers in the medial prefrontal cortex and the cortices of the parahippocampal region that comprise the larger functional network.Results: Results show that prenatal protein malnutrition does not cause changes in the neuronal population in the medial prefrontal cortex of adult rats, indicating that the decrease in functional activation during attentional tasks is not due to a reduction in the number of neurons. Results also show that prenatal protein malnutrition is associated with a reduction in neuron numbers in specific parahippocampal subregions: the medial entorhinal cortex and presubiculum.Discussion: The affected regions along with CA1 comprise a tightly interconnected circuit, suggesting that prenatal malnutrition confers a vulnerability to specific hippocampal circuits. These findings are consistent with the idea that prenatal protein malnutrition produces a reorganization of structural and functional networks, which may underlie observed alterations in attentional processes and capabilities.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"333-346"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0