Nutritional Neuroscience最新文献_第2页

Immunonutrition: future perspective in neurodegenerative disorders. 免疫营养：神经退行性疾病的未来前景。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-07-01 Epub Date: 2024-11-19 DOI: 10.1080/1028415X.2024.2425565

Carmen María Claro-Cala, Fernando Rivero-Pino, María Torrecillas-López, Víctor Jimenez-Gonzalez, Sergio Montserrat-de la Paz

{"title":"Immunonutrition: future perspective in neurodegenerative disorders.","authors":"Carmen María Claro-Cala, Fernando Rivero-Pino, María Torrecillas-López, Víctor Jimenez-Gonzalez, Sergio Montserrat-de la Paz","doi":"10.1080/1028415X.2024.2425565","DOIUrl":"10.1080/1028415X.2024.2425565","url":null,"abstract":"The relevance of lifestyle, including diet and exercise, has been associated with improved learning and memory capacity, delayed age-related cognitive decline, and a reduced risk of neurodegeneration. Most neurodegenerative diseases are defined as complex multifactorial disorders in which genetic and environmental factors greatly contribute to their onset. Although inflammatory cells produce reactive oxygen species (ROS), oxidative stress itself might exert pro-inflammatory effects and an uncontrolled response could lead to a state of chronic inflammation. Anti-inflammatory dietary approaches unify the disciplines of nutrition, immunity, and neurology. Personalized dietary interventions will be developed based on an individual's genetic makeup, metabolic profile, and gut microbiota composition, thanks to advances in genomics, metabolomics, and microbiome research. The relevance of dietary patterns in decreasing inflammation relies on the role of specific antioxidant nutrients, which might contribute to a decrease in the levels of ROS. This review aims to summarize recent advancements in neuroscience and immunology that have revealed the crucial role that diet and the immune system play in brain function and disease progression. Nutrition influences the immune system, and in turn, the immune system impacts neurological health. This bidirectional relationship suggests that targeted nutritional interventions could modulate immune responses to delay or mitigate the progression of neurodegenerative diseases potentially. This approach focuses on the use of specific nutrients and dietary components that influence the immune system and inflammatory pathway. Key elements of immunonutrition include omega-3 fatty acids, antioxidants, vitamins and various bioactive compounds found in foods.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"807-818"},"PeriodicalIF":3.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effect of Kaempferol through modulation of autophagy. 山奈酚通过调节自噬的神经保护作用。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-06-30 DOI: 10.1080/1028415X.2025.2524702

Razieh Moalefshahri, Seyed Isaac Hashemy, Hossein Hosseini, Amirhossein Sahebkar

{"title":"Neuroprotective effect of Kaempferol through modulation of autophagy.","authors":"Razieh Moalefshahri, Seyed Isaac Hashemy, Hossein Hosseini, Amirhossein Sahebkar","doi":"10.1080/1028415X.2025.2524702","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2524702","url":null,"abstract":"Objective: Autophagy is a critical cellular mechanism that ensures the breakdown of damaged or unnecessary components. This process helps ensure cellular health by maintaining cellular balance, protecting cells from stress, and providing an alternative energy source during metabolic stress. Disruptions in autophagy have been linked to neurological disorders.Method: In this review, the neuroprotective effects of Kaempferol through autophagy modulation are elaborated. Methods: An electronic search in scientific databases was performed to find relevant studies exploring the neuroprotective effects of kaempferol mediated via modulation of autophagy.Results: Kaempferol, a natural flavonoid found in fruits, vegetables, and plant-based products like tea, has been shown to demonstrate a variety of health-promoting properties, including antimicrobial, antioxidant, and antiinflammatory effects. This review summarizes the current understanding of how Kaempferol modulates autophagy and discusses its potential impact on various neurological disorders, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, ischemic stroke, and depression. Studies increasingly indicate that Kaempferol could be a vital factor in maintaining neural health by influencing autophagy mechanisms.Conclusion: Numerous studies have established Kaempferol's neuroprotective potential through autophagy regulation, which suggests opprotunities for potential therapeutic applications.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astaxanthin as an adjunct therapy in Alzheimer's disease and multiple sclerosis: neuroprotective mechanisms and future perspective. 虾青素作为阿尔茨海默病和多发性硬化症的辅助治疗：神经保护机制和未来展望。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-06-29 DOI: 10.1080/1028415X.2025.2516620

Farzane Rezaei Yazdi, Fatemeh Taghizadeh, Soraya Parvari, Parinaz Javanbakht, Sina Mojaverrostami, Davood Zarini, Iraj Ragerdi Kashani

{"title":"Astaxanthin as an adjunct therapy in Alzheimer's disease and multiple sclerosis: neuroprotective mechanisms and future perspective.","authors":"Farzane Rezaei Yazdi, Fatemeh Taghizadeh, Soraya Parvari, Parinaz Javanbakht, Sina Mojaverrostami, Davood Zarini, Iraj Ragerdi Kashani","doi":"10.1080/1028415X.2025.2516620","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2516620","url":null,"abstract":"Background: Alzheimer's disease (AD) and Multiple sclerosis (MS) are progressive neurodegenerative conditions. AD is characterized by neuroinflammation, plaques, tangles, and synaptic loss, while MS involves inflammatory demyelination. Although AD and MS have different pathogenesis, they may share some neurodegenerative mechanisms, so similar therapeutic strategies could potentially be effective for both. Research suggests that natural substances such as carotenoids may be beneficial for neurological disorders. Notably, Astaxanthin (AXT) has demonstrated promising effects as an adjunct therapy.Methods: In this review, we aimed to shed light on the effects of AXT on MS and AD by searching published articles from inception to 1 August 2024, in the Scopus, Google Scholar, PubMed, and PubMed/Medline databases.Results: The therapeutic effects of AXT in neurodegenerative disorders are associated with its antioxidant, anti-inflammatory, anti-apoptotic, and neuroplasticity improvement properties. Literature have confirmed that AXT can positively impact AD by modulating anti-inflammatory and pro-inflammatory cytokines, mitochondrial function, amyloid beta production, and microglial activation, which collectively leads to memory and learning enhancement. Additionally, AXT has demonstrated advantages in MS by reducing demyelination and preserving nerve functions through its effects on pro- and anti-inflammatory cytokines, as well as promoting the differentiation of oligodendrocyte precursors into mature oligodendrocytes.Conclusion: AXT, as a promising versatile adjunctive neuroprotective therapy, can influence multiple recovery pathways rather than focusing on a single target or mechanism. According to the results of preclinical studies, we can recommend assessing AXT effects in clinical trials of AD and MS.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-25"},"PeriodicalIF":3.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different dietary compositions alter pubertal onset in Wistar rats. 不同的饮食成分改变了Wistar大鼠的青春期。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-06-27 DOI: 10.1080/1028415X.2025.2522454

Harsh Shah, Nehareeka Dan, Ankita Salunke, A V Ramachandran, Parth Pandya

{"title":"Different dietary compositions alter pubertal onset in Wistar rats.","authors":"Harsh Shah, Nehareeka Dan, Ankita Salunke, A V Ramachandran, Parth Pandya","doi":"10.1080/1028415X.2025.2522454","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2522454","url":null,"abstract":"Introduction: Puberty is a crucial developmental phase influenced by neuroendocrine signals involving various neuropeptides and hormones. The impact of various diet combinations on the initiation of puberty in female rats was studied, along with the crosstalk between hypothalamic neuropeptides that might influence it.Methods: Weaned female Wistar rats were segregated into five groups and given different diets for a duration of 21 d. The diet included high-fat, high-carbohydrate, high-protein, cafeteria diet and standard chow. Throughout the 21-day period, body weight, vaginal opening and blood samples were recorded. Post sacrifice parameters like hormonal analysis, gene expression, protein expression and Immunolocalization were performed.Results: The High Fat Diet (HFD), High carbohydrate Diet (HCD), and Cafeteria diet (CafD) groups exhibited early vaginal opening, increased body weight, elevated somatic indices, and Follicle-stimulating Hormone (FSH), Luteinizing Hormone (LH), and estradiol levels were elevated in regards to the control group. Gene expression analysis showed upregulation of Kiss1, Kiss1r, Pomc, Lep, Lepr, and Gnrh, while Npy, Agrp, and Mkrn3 were downregulated. Protein expression studies confirmed the increased levels of KISS1, KISS1R, LEPR, and POMC, particularly in the HFD and HCD groups. Histone acetylation analysis revealed higher global acetylation in the hypothalamus of HFD and HCD groups.Discussion: This study highlights the significant role of dietary composition in modulating pubertal onset through the neuroendocrine pathways. These findings suggest that high-fat and high-carbohydrate diets expedite puberty by altering the expression of key hypothalamic neuropeptides and hormones. This underscores the importance of nutrition in reproductive development and its broad implications for adolescent health.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin C reduces the loss of retinal ganglion cells in chronic glaucoma by inhibiting neuroinflammation. 维生素C通过抑制神经炎症减少慢性青光眼视网膜神经节细胞的损失。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-06-23 DOI: 10.1080/1028415X.2025.2509337

Zhenni Mou, Yunfan Zheng, Xiaochen Wang, Sisi Tan, Jingchang Yuan, Hong Li

{"title":"Vitamin C reduces the loss of retinal ganglion cells in chronic glaucoma by inhibiting neuroinflammation.","authors":"Zhenni Mou, Yunfan Zheng, Xiaochen Wang, Sisi Tan, Jingchang Yuan, Hong Li","doi":"10.1080/1028415X.2025.2509337","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2509337","url":null,"abstract":"Recent studies have revealed that glaucoma is a neurodegenerative disorder characterized by the degeneration of retinal ganglion cells (RGCs). Neuroinflammation is a significant cause of RGC loss. Vitamin C (Vit C) has been shown to inhibit neuroinflammation in other diseases; however, its effects in glaucoma are yet to be determined. This study aimed to investigate the neuroprotective effects of Vit C on RGCs in glaucoma and the underlying mechanisms. Our findings indicate that Vit C treatment protects against elevated intraocular pressure (IOP)-induced loss of RGCs and thinning of retinal thickness in a chronic ocular hypertension model. Further studies revealed that Vit C reduces the overexpression of glial cells by inhibiting the TLR4/cleaved-caspase-8/NLRP3/cleaved-caspase-1 pathway, thereby alleviating neuroinflammation. Additionally, Vit C was found to inhibit the activation of the Bax/Bcl-2/cleaved-caspase-3 pathway, thus reducing RGC apoptosis. In conclusion, Vit C demonstrates neuroprotective effects in chronic glaucoma, potentially through its roles in reducing neuroinflammation and inhibiting apoptosis, suggesting its therapeutic potential for glaucoma.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary total antioxidant capacity associated with nutritional status and clinical condition of patients with multiple sclerosis. 膳食总抗氧化能力与多发性硬化症患者营养状况和临床状况的关系

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-06-15 DOI: 10.1080/1028415X.2025.2516627

Fernanda Nunes Maia, Bruna Yhang da Costa Silva, Renan Souto Pereira, Larissa da Silva Albuquerque, Vitor Wagner de Sousa Lacerda, José Artur Costa D'Almeida, Maria Luisa Pereira de Melo

{"title":"Dietary total antioxidant capacity associated with nutritional status and clinical condition of patients with multiple sclerosis.","authors":"Fernanda Nunes Maia, Bruna Yhang da Costa Silva, Renan Souto Pereira, Larissa da Silva Albuquerque, Vitor Wagner de Sousa Lacerda, José Artur Costa D'Almeida, Maria Luisa Pereira de Melo","doi":"10.1080/1028415X.2025.2516627","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2516627","url":null,"abstract":"Objective: To identify dietary total antioxidant capacity (DTAC) in people with MS (PwMS) and evaluate its interrelation with nutritional status and disease progression.Methods: Cross-sectional, quantitative study with 127 patients with MS recruited from the Interdisciplinary Center for Assistance, Research and Teaching in Neuroimmunology (CIAPEN) (Fortaleza, Ceará, Brazil). The clinical parameters were clinical phenotype, the expanded disability status scale (EDSS), the medical research council (MRC) muscle scale, and Magnetic Resonance Imaging (MRI) evaluation. Weight and height measurements were obtained to calculate the body mass index (BMI), waist circumference (WC) and estimate body fat percentage (BF%). The DTAC was estimated using food intake data from the 24DR and the intake of antioxidant supplements.Results: As for the nutritional status, it was found that 48 (37.80%) and 64 (50.39%) had excess adiposity according to the BMI and BF%, respectively, and 67 (53.60%) had elevated WC. Higher DTAC was associated with higher WC (r = 0.192, p = 0.032) and BF% (r = 0.246, p = 0.005); and higher intake of energy (r = 0.418, p < 0.001). There was no association between the clinical phenotype of the disease, the EDSS, the presence of visible lesions and the DTAC tertiles. However, in the unadjusted model, it was observed that the second tertile of DTAC reduced by 64% (OR = 0.36; 95% CI: 0.14-0.96) the individual's chance of having lower muscle strength, assessed by the MRC muscle scale.Conclusion: Healthy nutrition, especially sufficient intake of dietary antioxidants, should be encouraged in PwMS.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-9"},"PeriodicalIF":3.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary plant-derived lectins induce oxidative stress, metabolic dysfunction, apoptosis and neuroinflammation in mice brain. 膳食植物源性凝集素可诱导小鼠脑氧化应激、代谢功能障碍、细胞凋亡和神经炎症。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-06-13 DOI: 10.1080/1028415X.2025.2516619

Nikoloz Zhgenti, Otar Bibilashvili, George Burjanadze, Mariam Shengelia, Marine Koshoridze, Elene Davitashvili, Nana Koshoridze

{"title":"Dietary plant-derived lectins induce oxidative stress, metabolic dysfunction, apoptosis and neuroinflammation in mice brain.","authors":"Nikoloz Zhgenti, Otar Bibilashvili, George Burjanadze, Mariam Shengelia, Marine Koshoridze, Elene Davitashvili, Nana Koshoridze","doi":"10.1080/1028415X.2025.2516619","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2516619","url":null,"abstract":"Background: Lectins are carbohydrate-binding proteins found in plants and animals. While they serve essential biological functions, certain plant-derived lectins-especially from legumes-may exert neurotoxic effects through the gut-brain axis. The growing intake of raw plant-based foods, including lectin-rich sprouts, raises safety concerns.Objective: To evaluate the neurotoxic potential of a galactose-specific lectin (BS-Gal) isolated from bean sprouts, with a focus on oxidative stress, energy metabolism, and neuroinflammation in mice.Methods: Mice were chronically administered BS-Gal orally. Brain regions (substantia nigra, cerebellum, brainstem) were analyzed for oxidative markers, metabolic enzymes, apoptotic signals, and inflammatory mediators using biochemical assays and immunoblotting.Results: BS-Gal significantly increased hydrogen peroxide, nitric oxide, and malondialdehyde levels, alongside reduced antioxidant enzyme activities, indicating oxidative damage. Glycolytic and citric acid cycle enzymes were suppressed, suggesting disrupted cellular metabolism. Apoptotic analysis revealed elevated pro-apoptotic markers (Bad, Bax) and reduced anti-apoptotic proteins (Bcl-2, Bcl-xL). Neuroinflammation was evident via NF-κB activation, increased proinflammatory cytokines (TNF-α, IL-6, IL-1β), and decreased anti-inflammatory markers (IκB-α, IL-4, IL-10, TGF-β).Conclusion: Chronic oral exposure to BS-Gal induces oxidative stress, metabolic dysfunction, and neuroinflammation in key mouse brain regions. These findings suggest potential neurotoxic risks associated with dietary intake of lectin-rich plant foods like bean sprouts.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-13"},"PeriodicalIF":3.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eicosapentaenoic acid alleviates fibromyalgia-like pain by modulating microglia, astrocytes, and toll-Like receptor 4 signaling in the mice cerebellum. 二十碳五烯酸通过调节小鼠小脑中的小胶质细胞、星形胶质细胞和toll样受体4信号传导来减轻纤维肌痛样疼痛。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-06-11 DOI: 10.1080/1028415X.2025.2518210

I-Han Hsiao, Hsin-Cheng Hsu, I-Ying Lin, Kai-Ting Chuang, Yi-Wen Lin

{"title":"Eicosapentaenoic acid alleviates fibromyalgia-like pain by modulating microglia, astrocytes, and toll-Like receptor 4 signaling in the mice cerebellum.","authors":"I-Han Hsiao, Hsin-Cheng Hsu, I-Ying Lin, Kai-Ting Chuang, Yi-Wen Lin","doi":"10.1080/1028415X.2025.2518210","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2518210","url":null,"abstract":"Fibromyalgia (FM) is a widespread systemic pain disorder often accompanied by symptoms such as insomnia, mania, obesity, and depression. FM is difficult to diagnose and, therefore, cannot be effectively treated with current medical approaches. After prolonged suffering, FM patients frequently seek help from chronic pain physicians and psychiatrists. Eicosapentaenoic acid (EPA), derived from fish oil, is a common nutritional therapy for pain. While EPA is a documented fatty acid for depression treatment, its role in FM management is less established. In this study, we investigated the effects of EPA on FM pain and its potential mechanisms involving microglia/astrocytes and toll-like receptor 4 (TLR4) pathways in the cerebellum of mice. We found that intermittent cold stress (ICS) effectively induced FM-like pain in mice. Pain was evaluated using von Frey and Hargraves' tests to assess mechanical (2.01 ± 0.11 g) and thermal (4.09 ± 0.34 s) sensitivity. Nociceptive responses were alleviated by oral EPA administration (3.68 ± 0.13 g and 7.89 ± 0.3 s). EPA levels were lower in FM mice but increased following oral intake. Our findings revealed elevated levels of microglia/astrocyte markers and neurotransmitters such as HMGB1 and S100B in the cerebellum 5-7 (CB5-7) of FM mice. Similarly, TLR4 and related nociceptive signals were upregulated in the FM group. Notably, oral EPA effectively reduced these pain-related substances in CB5-7. Our results suggest that EPA can treat FM by modulating microglia/astrocyte activity and TLR4 signaling, highlighting its potential as a therapeutic target in FM management.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":3.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a single 10-hour daytime fasting intervention on mood and appetite in female adults with and without obesity: a real-world feasibility trial. 单次10小时日间禁食干预对有或无肥胖的成年女性情绪和食欲的影响：一项现实世界的可行性试验。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-06-10 DOI: 10.1080/1028415X.2025.2514490

Jenneffer Rayane Braga Tibaes, Gabriela Barbosa Fagundes, Lais Bhering Martins, Ana Maria Dos Santos Rodrigues, Alexandre Camargo Campos, Leticia Maria de Souza Cordeiro, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira

{"title":"Effects of a single 10-hour daytime fasting intervention on mood and appetite in female adults with and without obesity: a real-world feasibility trial.","authors":"Jenneffer Rayane Braga Tibaes, Gabriela Barbosa Fagundes, Lais Bhering Martins, Ana Maria Dos Santos Rodrigues, Alexandre Camargo Campos, Leticia Maria de Souza Cordeiro, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira","doi":"10.1080/1028415X.2025.2514490","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2514490","url":null,"abstract":"Objective: Comparison of the effect of acute daytime fasting on mood, satiety, and neurotrophic factors in females with (OB) and without obesity (N-OB).Methods: Non-randomized single-arm feasibility trial. Data were collected at an outpatient clinic and from real-world settings. Participants were evaluated after 10 h of nocturnal fasting (T1) and following a 10-hour diurnal fasting period (T2) after consuming a standardized breakfast. Mood, subjective feelings of satiety, food cravings, and neurotrophic factors brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell line-derived neurotrophic factor (GDNF) were assessed.Results: Fifty-four participants were enrolled in the study [mean age 31 (SD 9)]. One participant from the OB group dropped out before T2, leaving 53 participants (N-OB: n = 29, OB: n = 24). Both groups experienced increased hunger and decreased satiety and fullness after T2. Females with obesity had a greater increase in hunger (p = 0.02). Depression and anger symptoms increased in the OB group, whereas fatigue increased in the N-OB group after T2. NGF increased slightly in the N-OB group after T2, while BDNF and GDNF remained unchanged.Conclusion: Daytime fasting during daily activities affects mood and eating behavior, especially in females with obesity. Fasting interventions should be tailored to individual needs, considering these differential effects.Trial registration: ClinicalTrials.gov identifier: NCT03532672.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-14"},"PeriodicalIF":3.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant potential of Carica Papaya fruit extract and diet: behavioral and physiological effects in mice models. 番木瓜果实提取物和饮食的抗抑郁潜力：小鼠模型的行为和生理影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-06-02 DOI: 10.1080/1028415X.2025.2509750

Tejinder Kaur, Varinder Singh, Richa Shri

{"title":"Antidepressant potential of Carica Papaya fruit extract and diet: behavioral and physiological effects in mice models.","authors":"Tejinder Kaur, Varinder Singh, Richa Shri","doi":"10.1080/1028415X.2025.2509750","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2509750","url":null,"abstract":"Carica papaya is a popular fruit valued for its nutritive and diverse medicinal activities. Traditionally, it is used for its varied effects, including those on the central nervous system. The present study investigated the effect of hydroethanolic extract and diet enriched with papaya fruit on depression-like behavior in mice. The extract was standardized with respect to total phenolics, total carbohydrate and total protein contents. The antidepressant effects of the extract and enriched diet (standard diet augmented with 5% w/w papaya pulp powder) were evaluated using the forced swim test (FST) and tail suspension test (TST) in mice. The effect of diet on physiological parameters of the mice was also studied to determine any adverse effects. The extract was found to contain appreciable levels of phenols, carbohydrates and proteins. The extract showed dose-dependent antidepressant activity, as evident by a decrease in the immobility time in the FST and TST. Pre-treatment with the test diet for one month also produced significant antidepressant-like and a reduction in body weight in animals. The results revealed significant antidepressant activity of Carica papaya fruit extract and diet in mice. Since diet is a keystone for well-being, the incorporation of papaya in the diet, after detailed investigation, may prove beneficial in the prevention of depression.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-8"},"PeriodicalIF":3.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0