Nutritional Neuroscience最新文献

{"title":"Preclinical study of red dragon fruit (<i>Hylocereus polyrhizus</i>) betacyanins in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis.","authors":"Claudia Pena, Madison K Sinar, Lilia A Koza, Nicole Boehler, Emma Buechler, Alec C Smith, Allie McGarr, Angela N Baybayon-Grandgeorge, McKenna Spaeth Herda, Sydney Jaques, Daniel A Linseman","doi":"10.1080/1028415X.2026.2661760","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2661760","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by loss of cortical and spinal motor neurons, oxidative stress, neuroinflammation, and mitochondrial dysfunction. Betacyanins, betalain pigments found in red dragon fruit and beetroot, display powerful anti-inflammatory and free-radical scavenging properties which may help ameliorate ALS pathology and slow disease progression. The present study characterized the therapeutic effects of a betacyanin-rich red <u>d</u>ragon <u>f</u>ruit <u>e</u>xtract (DFE) in the G93A mutant hSOD1 transgenic mouse model of ALS. Mice were treated orally with 5% (v/v) DFE in drinking water <i>ad libitum</i>, from disease onset until end-stage. DFE treatment had a statistically significant effect on survival, with an approximate 13-day extension of median lifespan in the treated G93A mutant hSOD1 group. Treatment with DFE also significantly preserved muscle strength and endurance, as assessed by grip strength and rotarod behavioral testing. This was associated with a modest but statistically significant preservation of gastrocnemius muscle weight in the DFE-treated group. Histopathological analyses demonstrated improvements in NMJ size and complexity, an increase in surviving spinal cord motor neurons, and a reduction in spinal cord astrogliosis in G93A mutant hSOD1 mice treated with DFE, when compared to their untreated mutant littermates. Overall, these findings indicate that DFE, or purified betacyanin compounds, should be investigated further as potential therapeutic agents for patients with SOD1-related ALS. Additional preclinical studies in non-SOD1 models of ALS will need to be completed to determine the potential benefit of betacyanin compounds in sporadic ALS.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean and western diets differentially modulate cellular aging, oxidative stress, and inflammation in rats: a randomized control trial.","authors":"Mehmet Mustafa Tilekli, Nilüfer Acar Tek","doi":"10.1080/1028415X.2026.2661074","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2661074","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the effects of Mediterranean and Western diet models on telomere length, oxidative stress, inflammatory markers, and total hippocampal cell count in rats.</p><p><strong>Methods: </strong>Twenty-one male Sprague - Dawley rats (8 weeks old) were randomly assigned to Control, Mediterranean, and Western diet groups (n = 7 per group). Following an eight-week specific dietary intervention, telomere lengths were measured by PCR, biochemical parameters (oxidative stress and inflammation) by ELISA and colorimetric methods, and hippocampal cell counts using the isotropic fractionator.</p><p><strong>Results: </strong>The Western diet group exhibited significantly higher body weight and BMI compared to other groups (<i>p</i> < 0.05). Telomere length was significantly longer in the Mediterranean diet group compared to the Western diet group (<i>p</i> < 0.05). Regarding inflammatory markers, TNF- α levels were significantly higher, whereas IL- 10 levels were significantly lower in the Western diet group compared to the Mediterranean group. Additionally, hippocampal cell counts were significantly reduced in the Western diet group. Dietary intake of omega- 3 and resveratrol was positively associated with telomere length.</p><p><strong>Discussion: </strong>The Mediterranean diet appears to protect telomere integrity and hippocampal cell survival by mitigating oxidative stress and inflammation. Conversely, the Western diet accelerates molecular aging markers. These findings highlight the translational potential of dietary composition in modulating cellular senescence.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-13"},"PeriodicalIF":3.6,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin E on cerebrovascular function: a systematic review.","authors":"Sarah Jansen, Coralie J Graham, Dean E Mills, Edward S Bliss","doi":"10.1080/1028415X.2026.2655229","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2655229","url":null,"abstract":"<p><p><b>Objectives:</b> Cerebrovascular function declines with normal ageing, and the antioxidant and anti-inflammatory properties of Vitamin E may maintain or improve this. The aim of this systematic review is to evaluate the effect of vitamin E on cerebrovascular function in both pre-clinical and clinical populations.<b>Methods:</b> Six databases (PubMed, MEDLINE, Web of Science, Scopus, ScienceDirect, and CINAHL) were searched in 2024 using keywords such as 'vitamin E', tocopherol, tocotrienol, 'cerebrovascular function', and related medical subject heading terms.<b>Results:</b> Of the 335 records returned, no clinical studies were identified. Ten pre-clinical studies met the inclusion criteria and were included for analysis. Due to heterogeneity in study designs and outcomes, a meta-analysis was not performed. Across animal models of cerebral ischaemia and haemorrhagic hypoperfusion, vitamin E supplementation improved cerebral blood flow, reduced intracranial pressure, and enhanced cerebrovascular responsiveness, thus reflecting improved cerebrovascular function. Furthermore, studies examining platelet aggregation reported delayed thrombus formation, likely mediated by reduced oxidative stress and improved endothelial function and nitric oxide bioavailability. However, with heterogeneous outcomes from pre-clinical studies and a lack of clinical studies, the translatability of data to the effect of chronic consumption on cerebrovascular function in humans is limited.<b>Discussion:</b> Pre-clinical data suggest that the antioxidant capacity of vitamin E and its regulatory effect on platelet aggregation may improve cerebrovascular function. However, the absence of clinical data limits translation to human populations. Future well-designed studies in older adults are warranted to determine whether vitamin E supplementation can preserve or improve cerebrovascular function throughout the ageing process.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-15"},"PeriodicalIF":3.6,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of eating behavior in patients with migraine: a case-control study.","authors":"Alaa Elmazny, Ahmed Yehia Ismaeel, Mona Hussein, Diana Khedr, Azza Elashiry, Mennat-Allah Tarek, Ahmed Dahshan, Amira Hassan, Omar Ashraf Ibrahim, Mohamed Wagdy, Mohammad A Farrag, Doaa Lotfy Abd El Baky, Rehab Magdy","doi":"10.1080/1028415X.2025.2572081","DOIUrl":"10.1080/1028415X.2025.2572081","url":null,"abstract":"<p><strong>Background: </strong>Altered eating behaviors may precede the onset of full-scale eating disorders. Given the link between eating disorders and migraine, it is critical to identify individuals with migraine with altered eating behaviors. Therefore, this study aimed to investigate eating behaviors in a sample of migraine patients and to examine their potential associations with migraine frequency and related disability.</p><p><strong>Methods: </strong>Adult patients diagnosed with migraine (n = 531) were asked to report their monthly migraine days (MMDs), complete the Headache Impact Test-6 (HIT-6), and answer the Adult Eating Behavior Questionnaire (AEBQ). A group of healthy controls (n = 1062) was also asked to answered AEBQ.</p><p><strong>Results: </strong>Migraine patients had a significantly lower score in the enjoyment of food compared to controls (<i>P</i> = 0.037), whereas they had significantly higher scores in hunger and satiety responsiveness compared to controls (<i>P</i> values < 0.001 and 0.008, respectively). There were no statistically significant differences between patients and controls in terms of scores for food fussiness, food responsiveness, emotional overeating, slowness in eating, and emotional undereating. There were statistically significant negative correlations between MMDs and both enjoyment of food and food responsiveness scores (<i>P</i> = 0.006 and 0.032, respectively). A statistically significant positive correlation was found between HIT-6 total scores and satiety responsiveness scores (<i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>Altered eating habits are frequently reported among individuals with migraine, adding to the migraine burden. Health professionals, therefore, need to consider these eating behaviors to foster more tailored nutrition interventions for patients with migraine, aiming at improving their quality of life.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"458-465"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145346120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of cytotoxic effects of food additives on brain tissue.","authors":"Fatemeh Karimi, Farzad Sadri, Azam Soleimani, Sara Azhdari, Samira Karbasi, Seyede Fatemeh Hosseini","doi":"10.1080/1028415X.2025.2573225","DOIUrl":"10.1080/1028415X.2025.2573225","url":null,"abstract":"<p><strong>Objectives: </strong>This review aims to evaluate the impact of food additives on brain tissue, focusing on oxidative stress-related mechanisms and their role in neurodegeneration.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted using PubMed, Scopus, Web of Science, ScienceDirect, and Springer, covering studies published up to 2025.</p><p><strong>Results: </strong>Multiple studies indicate that food additives contribute to oxidative stress, leading to a decrease in glutathione (GSH) levels and superoxide dismutase (SOD) activity, while increasing malondialdehyde (MDA) concentrations in brain tissue. These biochemical changes are associated with inflammation and cellular damage.</p><p><strong>Discussion: </strong>Findings suggest that certain food additives contribute to oxidative stress and other neurotoxic mechanisms, leading to cellular and molecular alterations in neural tissue, including functionally relevant brain regions. Further research is warranted to elucidate their long-term biological effects and inform regulatory decision-making.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"476-497"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of olive oil and its phenolic compounds on neuroinflammation: a systematic review.","authors":"Alessandro Medoro, Giovanni Scapagnini, Frank B Hu, Sergio Davinelli","doi":"10.1080/1028415X.2025.2572080","DOIUrl":"10.1080/1028415X.2025.2572080","url":null,"abstract":"<p><strong>Objectives: </strong>Neuroinflammation contributes to the pathogenesis of multiple neurological and neurodegenerative diseases but is also involved in non-degenerative conditions such as aging, sleep disorders, depression, and metabolic dysfunctions. Among dietary factors with potential neuroprotective activity, olive oil and its phenolic compounds have attracted interest for their anti-inflammatory properties. This systematic review aimed to assess the effects of olive oil and its main phenolic compounds on neuroinflammation in preclinical in vivo studies.</p><p><strong>Methods: </strong>A systematic search was conducted using PubMed, Scopus, and Web of Science to identify controlled in vivo studies evaluating the impact of olive oil or its phenolic compounds on neuroinflammatory markers. Thirty-two studies met the inclusion criteria and were critically analyzed for experimental model, type of intervention, and neuroinflammation-related outcomes.</p><p><strong>Results: </strong>Olive oil, particularly extra-virgin olive oil (EVOO) rich in phenolic compounds, showed anti-inflammatory effects in several models, although results were inconsistent. In contrast, phenolic compounds such as hydroxytyrosol, oleuropein, oleacein, and oleocanthal more consistently reduced glial activation and pro-inflammatory cytokines across diverse experimental paradigms. Hydroxytyrosol emerged as the most frequently studied and effective compound.</p><p><strong>Discussion: </strong>The preclinical evidence supports the anti-neuroinflammatory potential of olive oil and its phenolic compounds, though the variability in experimental design, compound characterization, and outcome measures limits translational interpretation. While isolated compounds demonstrated more robust effects than whole oil, high doses and lack of pharmacokinetic data raise questions about clinical relevance. Future research should address these limitations and evaluate the neuroimmune effects of olive oil-derived compounds in human studies.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"437-457"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct serum micronutrient metabolic profiles in Parkinson's disease patients with diabetes mellitus: associations with motor and non-motor symptoms.","authors":"Tingting Feng, Tayier Tuersong, Xiaobei Wang, Peishan Li, Shuying Shang, Pengbo Yang, Yue Pan, Xinling Yang","doi":"10.1080/1028415X.2025.2598568","DOIUrl":"10.1080/1028415X.2025.2598568","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a common neurodegenerative disease, and its pathogenesis may be related to abnormal metabolism of micronutrients.</p><p><strong>Method: </strong>This study included 316 PD patients who visited the Second Affiliated Hospital of Xinjiang Medical University from January 2021 to December 2023. Patients were divided into two groups: those with both PD and diabetes mellitus(PD-DM group), and those with PD without DM(PD-NDM group). Inductively coupled plasma-mass spectrometry was employed to determine the levels of micronutrients, including calcium (Ca), magnesium (Mg), and iron (Fe), in serum samples. Next, demographic characteristics, clinical parameters, and micronutrient differences were compared between the two groups. Furthermore, the correlation between micronutrients and the progression of PD, as well as motor and non-motor symptoms, was analyzed. Finally, logistic regression was used to investigate the factors influencing PD with DM.</p><p><strong>Result: </strong>The PD-DM group had higher serum Ca(2.27 ± 0.14 vs 2.22 ± 0.12) and lower Mg (0.83 ± 0.08 vs 0.89 ± 0.06) and Fe (14.28 ± 5.13 vs 16.45 ± 6.81) than the PD-NDM group (<i>P</i> < 0.05). Ca levels were negatively correlated with age of onset, UPDRS-I, and non-motor symptoms. Mg levels correlated with UPDRS score and substantia nigra echo area(<i>P</i> < 0.05). Logistic regression identified high Ca, low Mg, and low Fe as independent predictors of PD with DM (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Patients with PD and DM exhibit distinct micronutrient metabolic abnormalities, notably higher Ca and lower Mg and Fe levels.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"427-436"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the potency of naturally derived Virgin coconut oil in modulating chronic restraint stress-induced spatial learning and memory.","authors":"Rucha Dafale, Shobha U Kamath, Gitika Bhasin, Vasanthalaxmi K, Ujjal Bose, Ramesh Babu, Dhiren Punja, Amith Bharadwaj, Manjula S D","doi":"10.1080/1028415X.2025.2573226","DOIUrl":"10.1080/1028415X.2025.2573226","url":null,"abstract":"<p><strong>Background and objectives: </strong>Stress in day-to-day life affects the body system differently by altering homeostasis and biological processes. The foremost sign of chronic stress-induced disorders is reflected in behavioral activity. Chronic stress affects the brain negatively, it modulates neurobehavioral activity and impairs the associated activities like learning, memory, and cognition. Emerging evidence suggests that virgin coconut oil (VCO), is an abundant source of natural antioxidants with anti-inflammatory, antidepressant, and neuroprotective potential. However, VCO's efficacy in ameliorating chronic restraint stress-induced abnormal changes is rarely understood. Hence, we aimed to evaluate VCO's neuroprotective potential in attenuating chronic restraint stress-induced neurobehavioral and biochemical alteration in rats.</p><p><strong>Methods: </strong>A total of eighteen male Wistar rats were allocated into three groups (<i>n</i> = 6/group): Control (C) - saline (5 ml/kg/21 days), Stress (S) - restraint stress (6hrs/day/21 days), and Test (S + VCO) (6 hrs/day+5 ml/kg VCO for 21 days). The behavioral (Radial arm maze (RAM)) and biochemical (corticosterone (CORT)), reduced glutathione (GSH), and malonaldehyde (MDA) parameters were analyzed to determine the neuroprotective effect of VCO.</p><p><strong>Results: </strong>The VCO-treated group has shown a significant increase in the percentage of correct choice entries and a reduction in error entries, highlighting an improvement in working and reference memory. Moreover, there was a substantial elevation in GSH, and a reduction in MDA and CORT levels, indicating a potent antioxidant activity of VCO. Additionally, significant body weight gain and reduced adrenal gland weight were noted in VCO-treated rats.</p><p><strong>Conclusions: </strong>Our findings signify that VCO has therapeutic potential to improve spatial learning memory and antioxidant status in chronic restraint stress rats.Schematic depiction of the protective effect of virgin coconut oil on chronic restraint stress rats.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"498-514"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fruits and vegetables mitigate cognitive impairment in mice with high-fat diet-induced obesity: a pilot study.","authors":"Weimin Guo, Barbara Shukitt-Hale, Dayong Wu, Lijun Li, Simin Nikbin Meydani","doi":"10.1080/1028415X.2025.2572546","DOIUrl":"10.1080/1028415X.2025.2572546","url":null,"abstract":"<p><strong>Objectives: </strong>The rising prevalence of cognitive decline linked to obesity is becoming a significant public health issue. Epidemiological studies indicate that a higher intake of fruits and vegetables (F&V) may be associated with a lower risk of cognitive impairment, although the evidence for the causal relationship is lacking. This study examined whether F&V supplementation could prevent cognitive decline in mice with high-fat diet-induced obesity.</p><p><strong>Methods: </strong>Male C57BL/6J mice (6 weeks old) were randomly assigned to one of five diet groups (12 mice per group): low fat (LF, 10% kcal fat) diet, or high fat (HF0, 45% kcal fat) diet supplemented with 0% (HF0), 5% (HF5), 10% (HF10), or 15% (HF15) of a mixture of F&V (wt/wt). These levels of supplementation correspond to approximately 0, 3, 5-7, or 8-9 servings of F&V per day for humans, respectively. The novel object recognition test was performed after mice consumed the respective diets for 17 weeks.</p><p><strong>Results: </strong>Mice fed the Western-style HF diet spent less time exploring the novel object, indicating significant cognitive impairment compared to the LF group. Conversely, F&V supplementation alleviated the HF diet-induced cognitive deficits in a dose-dependent manner.</p><p><strong>Discussion: </strong>The results from this pilot study suggest the causal link between F&V intake and the prevention of cognition impairment caused by a Western-style high-fat diet, establishing a foundation for further investigation into the protective effects of F&V consumption on obesity-related cognitive decline. Additional research is required to better understand the underlying mechanisms.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"466-475"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145346123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Lactobacillus</i> yogurts alleviate anxious- and depressive-like effects in CUMS mice via multiple pathways and regulating gut-brain axis.","authors":"Chunyang Zheng, Song Wei, Fulei Liu, Haiyan Lv, Yang Sun","doi":"10.1080/1028415X.2025.2574961","DOIUrl":"10.1080/1028415X.2025.2574961","url":null,"abstract":"<p><p><b>Background:</b> Current researches suggest that the microbiota-gut-brain axis plays a critical role in modulating human cognition and emotion, particularly in the context of psychiatric disorders. Probiotic fermented dairy products have been shown to regulate gut microbiota composition and alleviate depressive symptoms; however, the underlying mechanism and associated metabolic pathways remain unclear.<b>Methods:</b> In this study, we compared the effects of probiotics (Lactobacillus reuteri and Lactobacillus bulgaricus) fermented yogurt on chronic unpredictable mild stress (CUMS)-induced anxious and depressive-like symptoms in mice, as well as discussed potential mechanisms.<b>Results:</b> Behavioral tests revealed that both L. reuteri and L. bulgaricus fermented yogurt significantly alleviated these symptoms. We also observed that Lactobacillus fermented yogurt exerted an overall neuroprotective effect in the hippocampus and helped maintain normal cerebral activity. L. reuteri and L. bulgaricus fermented yogurts were also observed to ameliorate the levels of monoamine neurotransmitters and inflammatory cytokines via inhibiting the activation of the NF-κB pathway accompanied by elevating the CREB-BDNF pathway.<b>Conclusion:</b> Our findings suggest that L. reuteri and L. bulgaricus fermented yogurts may modulate gut microbiota composition and host metabolism, thereby performing neuroprotective effects and ameliorating depressive behaviors in mice by at least partially microbiota-gut-brain axis. These findings have important implications for understanding the antidepressant mechanisms of fermented dairy products that target the intestinal microbiota and provide a promising new way for the development of novel treatments for depression.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"515-544"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}