Nutritional Neuroscience最新文献

{"title":"Probiotics, psychobiotics, and postbiotics: a therapeutic modality for the management of schizophrenia.","authors":"Sumel Ashique, Debasmita Paul, Biplab Debnath, Dinesh Kumar Chellappan, Joy Das, Utpal Bhui, Mohhammad Ramzan, Neha Sharma, Bimlesh Kumar, Sathvik Belagodu Sridhar, Uttam Prasad Panigrahy, Md Sadique Hussain","doi":"10.1080/1028415X.2025.2560658","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2560658","url":null,"abstract":"<p><p>Schizophrenia is a debilitating, chronic neuropsychiatric disorder, a multifactorial disorder combining genetic, neurodevelopmental, immunological, and environmental factors. Common antipsychotic treatments may be effective against positive symptoms, but still lack when dealing with negative symptoms, cognitive defects, and side effects of medication. Recent innovations show how the gut-brain axis is an important modulator of neuropsychiatric health, identifying microbial dysbiosis as a cause of schizophrenia. This review examines the therapeutic potential of such treatments of probiotics, psychobiots, and postbiotics as an adjunctive or alternative treatment targeting the way of modulating neuroinflammation, neurotransmitter synthesis, experience, and maintenance of blood-brain barrier integrity. Probiotics, which are live beneficial microbes, have immunomodulatory and neuroactive effects; psychobiotics, a subclass that has specific mental effects, modify stress-response systems and neurotrophic factors. Postbiotics, consisting in turn of microbial metabolism like short-chain fatty acids, present improved safety and stability with anti-inflammatory and antioxidant functions. Available clinical and preclinical evidence suggests the ability of these agents to attenuate the symptoms of schizophrenia and cognitive impairment, as well as to increase the tolerability of treatment. Regarding the conclusive presumptions, however, strain-specific variability and inconsistent methodologies confined by the sparse large-scale trials limit them. New technologies of nanocarrier systems, artificial intelligence, and personalized microbiome profiling might provide the best precision of the therapy. In this review, pitfalls in mechanistic insights, progress reports on translational studies, and future research prospects are deconstructively examined to support microbiota-based interventions as promising paradigms of holistic schizophrenia management.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-27"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of safflower oil supplementation on sciatic nerve crush injury in rats.","authors":"Qin Li, Yuting Wang, Songyi Wei, Juan Liu, Jun Wang","doi":"10.1080/1028415X.2025.2506461","DOIUrl":"10.1080/1028415X.2025.2506461","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the effect of safflower oil (SO), a high-quality edible oil derived from seeds of <i>Carthamus tinctorius L</i>. possessing multiple bioactivities, on rats that underwent sciatic nerve crush (SNC) to induce peripheral nerve injury (PNI).</p><p><strong>Methods: </strong>Sprague-Dawley rats were randomly divided into 4 groups with 10 mice in each group: sham, SNC model, SNC + SO 100 mg/kg, and SNC + SO 300 mg/kg. The sciatic function index (SFI) was monitored for evaluation of sciatic nerve function. Bilateral gastrocnemius muscles were isolated to measure the gastrocnemius muscle mass ratio. Tissue sections of sciatic nerve and gastrocnemius muscle were stained with hematoxylin and eosin for histopathological observations. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, malondialdehyde (MDA), and superoxide dismutase (SOD), and expression of myelin basic protein(MBP) and β₃-tubulin were detected in damaged nerves.</p><p><strong>Results: </strong>SO supplementation increased the SFI scores, improved the histopathological features of damaged nerves, and enhanced muscle mass and fiber diameters of affected gastrocnemius muscle in SNC rats. SNC-enhanced levels of TNF-α, IL-1β and MDA in damaged nerves were reduced, while SNC-inhibited SOD activity was increased by SO supplementation. Nerve expression of MBP and β₃-tubulin was upregulated in SO-supplemented SNC rats.</p><p><strong>Conclusion: </strong>Date suggested that SO could improve nerve function, attenuate neuroinflammation and oxidative stress, and might accelerate peripheral nerve regeneration after injury in SNC rats, thus being a promising dietary adjuvant for PNI treatment.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1233-1242"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin C reduces the loss of retinal ganglion cells in chronic glaucoma by inhibiting neuroinflammation.","authors":"Zhenni Mou, Yunfan Zheng, Xiaochen Wang, Sisi Tan, Jingchang Yuan, Hong Li","doi":"10.1080/1028415X.2025.2509337","DOIUrl":"10.1080/1028415X.2025.2509337","url":null,"abstract":"<p><p>Recent studies have revealed that glaucoma is a neurodegenerative disorder characterized by the degeneration of retinal ganglion cells (RGCs). Neuroinflammation is a significant cause of RGC loss. Vitamin C (Vit C) has been shown to inhibit neuroinflammation in other diseases; however, its effects in glaucoma are yet to be determined. This study aimed to investigate the neuroprotective effects of Vit C on RGCs in glaucoma and the underlying mechanisms. Our findings indicate that Vit C treatment protects against elevated intraocular pressure (IOP)-induced loss of RGCs and thinning of retinal thickness in a chronic ocular hypertension model. Further studies revealed that Vit C reduces the overexpression of glial cells by inhibiting the TLR4/cleaved-caspase-8/NLRP3/cleaved-caspase-1 pathway, thereby alleviating neuroinflammation. Additionally, Vit C was found to inhibit the activation of the Bax/Bcl-2/cleaved-caspase-3 pathway, thus reducing RGC apoptosis. In conclusion, Vit C demonstrates neuroprotective effects in chronic glaucoma, potentially through its roles in reducing neuroinflammation and inhibiting apoptosis, suggesting its therapeutic potential for glaucoma.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1315-1333"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect and mechanism of Saikosaponin A against oxidative damage in cochlear hair cells <i>in vitro</i>.","authors":"Haolei Zhang, Guangli Wu, Kaifeng Dong","doi":"10.1080/1028415X.2025.2559872","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2559872","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the protective effect and underlying mechanism of Saikosaponin A (SSA) against oxidative stress-induced damage in mouse cochlear hair cells (HEI-OC1).</p><p><strong>Methods: </strong>An oxidative stress model was established by treating HEI-OC1 cells with 50 mU/mL glucose oxidase (GO). Cells were divided into four groups: Control, GO, Control + SSA, and GO + SSA (1 μM SSA). Cell viability was assessed using the CCK-8 assay, and apoptosis was evaluated by flow cytometry and by analyzing expression of BAX, BCL-2, and cleaved CASPASE-3. Oxidative stress levels were assessed via malondialdehyde (MDA), reactive oxygen species (ROS), and glutathione peroxidase (GSH-Px). mRNA levels of Ptgs2 (COX-2), Nos2 (iNOS), Hmox1 (HO-1), and Sod1 (SOD1) were detected by qRT-PCR. Protein expression of KEAP1, NFE2, and phosphorylated NFE2 was examined by western blot, including analysis of nuclear translocation. All experiments were independently performed in triplicate.</p><p><strong>Results: </strong>SSA increased cell viability by approximately 40% (<i>P</i> < 0.01) and reduced apoptotic rate by 70% (<i>P</i> < 0.001) in GO-treated HEI-OC1 cells. SSA also decreased MDA and ROS levels and restored GSH-Px activity (<i>P</i> < 0.01). Moreover, SSA downregulated Ptgs2 and Nos2 <i>expression</i>, while upregulating Hmox1 and Sod1. At the protein level, SSA suppressed KEAP1 expression, enhanced NFE2 and p-NFE2 levels, and promoted NFE2 nuclear translocation.</p><p><strong>Conclusion: </strong>SSA alleviates GO-induced oxidative stress and apoptosis in HEI-OC1 cells by activating the KEAP1/NFE2 signaling pathway. These findings support the potential application of SSA in protecting cochlear hair cells from oxidative damage, warranting further <i>in vivo</i> investigation.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":3.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual role of dietary tryptophan on memory regulation in male albino wistar rats - synergistic modulation of serotonergic signaling and kynurenine pathway.","authors":"Huma Ikram, Shahla Perveen, Darakhshan J Haleem","doi":"10.1080/1028415X.2025.2565703","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2565703","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the impact of tryptophan metabolism on synaptic plasticity, neurogenesis, and memory consolidation using a combined biochemical and behavioral approach.</p><p><strong>Methods: </strong>We treated male Albino Wistar rats with different doses of tryptophan for 4 weeks followed by weekly assessment of memory performance through Morris Water Maze (MWM) and Novel Object Recognition (NOR) tests. High-performance liquid chromatography (HPLC) was used to quantify serotonin and metabolites in hippocampus, while kynurenine in plasma samples.</p><p><strong>Results: </strong>Our findings reveal that low dose of tryptophan improved learning and memory in rats while high dose significantly impaired spatial and recognition memory, correlating with reduced serotonin and increased kynurenic acid levels. Conversely, tryptophan supplementation at high dose was also accompanied by increased Interleukin-6 (IL-6), Interleukin-1β (IL-1β) and Tumor Necrosis Factor-α (TNF-α) expression in brain.</p><p><strong>Discussion: </strong>These results highlight the dual role of tryptophan in memory regulation - through serotonergic signaling and kynurenine pathway modulation - providing potential therapeutic targets for memory-related disorders such as Alzheimer's and Parkinson's-related dementia.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-15"},"PeriodicalIF":3.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoconstituents of Indian mustard honey impart antidepressant activity in reserpine-induced depressed condition through activation of TrkB/CREB/BDNF pathway in hippocampus.","authors":"Saakshi Saini, Viney Kumar, Samrat Chauhan, Rajat Saini, Partho Biswas, Tiyasa Pathak, Thakur Gurjeet Singh, Surendra Kumar Saini, Kaushik Ghosh, Prabhat Kumar, Partha Roy","doi":"10.1080/1028415X.2025.2554363","DOIUrl":"10.1080/1028415X.2025.2554363","url":null,"abstract":"<p><strong>Objective: </strong>Depression is a global health issue, with traditional antidepressants raising safety concerns. Indian mustard honey (MH) offers a potential alternative due to its health benefits, though its antidepressant effects remain unexplored. This study investigates the neuroprotective and antidepressant effects of MH in HT-22 cells <i>in vitro</i> and in Wistar rats <i>in vivo</i>.</p><p><strong>Methods: </strong>Chemical constituents of MH were identified using liquid chromatography-mass spectrometry (LC-MS). Effects of MH on phosphorylated tyrosine kinase receptor B (p-TrkB), brain-derived neurotropic factor (BDNF) and phosphorylated cyclic AMP-dependent response element-binding protein (p-CREB) were assessed in reserpine-treated HT-22 cells and rat models. Antidepressant effects in rats were evaluated using forced swim, tail suspension and locomotor activity tests, along with hippocampal histopathology and molecular analyses.</p><p><strong>Results: </strong>MH profiling identified key polyphenols with antioxidant properties. In HT-22 cells, MH showed neuroprotection at 60 mg/mL (<i>p</i> < 0.001), and upregulated p-TrkB, BDNF, and p-CREB (<i>p</i> < 0.001) against reserpine-induced oxidative stress. In rats, compared to fluoxetine, MH at 1 g/kg BW increased locomotor activity by ∼2.3 fold and reduced immobility by ∼50% and 25% in the tail suspension and forced swim tests (<i>p</i> < 0.001), respectively, showing comparable/ better antidepressant effects. It also preserved hippocampal architecture and upregulated p-TrkB, BDNF, and p-CREB (<i>p</i> < 0.001) levels compared to reserpine-treated rats.</p><p><strong>Discussions: </strong>MH demonstrated antioxidant, neuroprotective and antidepressant activities in <i>in vitro</i> and <i>in vivo</i> models, suggesting therapeutic potential. However, further studies on additional pathways, including β-catenin/Wnt, MAPK/ERK, along with pharmacokinetics, are essential before recommending MH as an antidepressant agent.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of American ginseng <i>(Panax quinquefolius)</i> extract on human neurocognitive function: a review.","authors":"Lynne Bell, Pascale Fança-Berthon, Romain Le Cozannet, David Ferguson, Andrew Scholey, Claire Williams","doi":"10.1080/1028415X.2025.2555921","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2555921","url":null,"abstract":"<p><p>Compared with <i>Panax ginseng</i> (Asian ginseng), <i>Panax quinquefolius</i> (American ginseng) has received relatively little research attention. Nevertheless, across several clinical trials a common finding is that <i>P. quinquefolius</i> extracts improve aspects of mood, mental fatigue, and cognitive function. This review details the findings from double-blind, randomized, controlled clinical trials which included assessment of cognitive performance, fatigue, or mood, individually or in combination. Limited fatigue benefits were observed in cancer patients at high doses (2000mg). The most notable effects at lower doses (100mg-400 mg) included enhancement of attentional and working memory performance in healthy adults and in Schizophrenia patients. Several studies also highlighted potential mechanisms underlying the cognitive effects of <i>P. quinquefolius</i>. These include increased activation of frontoparietal neural circuits and, in the context of the gut-brain axis, alterations of the human gut microbiome composition. The effects are also consistent with cholinergic modulation. Such effects suggest that <i>P. quinquefolius</i> extract may have benefits to everyday cognitive function.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-11"},"PeriodicalIF":3.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of blackcurrant juice on pre-frontal cortical haemodynamics and cognition in healthy young adults.","authors":"Anthony W Watson, Arjan Scheepens, David O Kennedy, Crystal F Haskell-Ramsay","doi":"10.1080/1028415X.2025.2538062","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2538062","url":null,"abstract":"<p><strong>Background: </strong>Evidence from randomised controlled trials demonstrates the modulatory effects of polyphenol consumption on the vascular system including improvements to cortical blood flow (CBF), microvascular blood flow, and large artery plasticity. Polyphenol-rich blackcurrants have been shown to inhibit monoamine oxidase, modulate brainwave spectral activity and modulate peripheral blood flow. This study assessed whether blackcurrant consumption can modulate blood flow in the shallow pre-frontal cortex, as measured using near infrared spectroscopy, during rest and under cognitive demand.</p><p><strong>Methods: </strong>A randomised double blind, placebo-controlled balanced cross over design was used to assess the efficacy of a cold pressed blackcurrant juice drink (Blackadder cultivar, Neuroberry, Plant and Food Research Ltd.) standardised at 500 mg of total polyphenols upon attention and working memory and prefrontal cortical haemodynamics at rest and during cognitive load in 20 healthy young adults aged 18-35 years, following a 60-minute absorption period.</p><p><strong>Results: </strong>Consumption of the Blackadder juice extract resulted in significant acute modulations of pre-frontal cortex haemodynamics during resting absorption and cognitive task performance as indicated by a decrease in deoxygenated haemoglobin [F(1,19) = 5.70, <i>p</i> = 0.027] and an increase in left hemisphere oxygenated haemoglobin during task performance [F(1.88,33.83) = 7.70, <i>p</i> = 0.002]. No effects on cognition were observed in this sample of healthy young adults.</p><p><strong>Conclusion: </strong>Results from this trial outline the ability of a blackcurrant juice extract to increase cerebral blood flow during cognitive demand in healthy young adults. The effects of the juice extract in addition to other types of blackcurrant extracts upon acute and chronic brain function and blood flow deserve further investigation.<b>Trial registration:</b>ClinicalTrials.gov identifier: NCT01540123.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-15"},"PeriodicalIF":3.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of diet-derived short chain fatty acids with Parkinson's disease: a systematic review and meta-analysis.","authors":"Ke An, Yi Qu, Jingyi Li, Danlei Wang, Zhijuan Mao, Zheng Xue","doi":"10.1080/1028415X.2025.2558119","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2558119","url":null,"abstract":"<p><strong>Objectives: </strong>As extensively researched metabolites, short chain fatty acids (SCFAs) undergo significant alterations in individuals with Parkinson's disease (PD). This meta-analysis was conducted to (1) explore the relationship between SCFAs and PD, and (2) provide evidence for the metabolic mechanisms underlying PD pathogenesis.</p><p><strong>Methods: </strong>A systematic search of four electronic databases (PubMed, Embase, Web of Science and Cochrane Library) was conducted up to February 29, 2024. The Agency of Healthcare Research and Quality (AHRQ) criteria were used for quality evaluation. Forest plots were used to display the results of the meta-analysis, and publication bias was assessed using funnel plots, Begg's tests and Egger's tests. Sensitivity analysis revealed heterogeneous sources among the included studies.</p><p><strong>Results: </strong>A total of 9 independent studies were enrolled, including 485 PD patients and 338 controls. In this meta-analysis, we discovered that, in comparison to healthy controls, stool acetic (SMD: -0.80; 95% CI: -1.23, -0.37), butyric (SMD: -0.71; 95% CI: -1.19, -0.24) and propionic acids (SMD: -0.98; 95% CI: -1.57, -0.40) were decreased, while plasma butyric (SMD: 0.25; 95% CI: 0.05, 0.44), isobutyric (SMD: 0.35, 95% CI: 0.11, 0.59) and propionic acids (SMD: 0.37, 95% CI: 0.16, 0.58) were increased in PD patients. Other SCFAs were not significantly different between the two groups.</p><p><strong>Conclusions: </strong>The evidence from this meta-analysis demonstrates that the stool and plasma SCFAs of PD patients are distinct from those of the control group. This study highlights SCFAs' potential importance as novel interventional targets.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary creatine intake and mental health among the Korean population.","authors":"Sergej M Ostojic, Sonja Baltic, Dragana Zanini","doi":"10.1080/1028415X.2025.2558118","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2558118","url":null,"abstract":"<p><p>Several population-based studies suggest that dietary creatine may benefit depression and cognitive function, but no research has examined overall mental health in a non-U.S. population or included adolescents. This cross-sectional study investigated the relationship between daily creatine consumption and mental health indicators using data from the 2022 Korean National Health and Nutrition Examination Survey (KNHANES). Data were analyzed from 5,257 individuals (56% female, mean age 51.1 ± 19.0 years) who provided dietary intake information and completed at least one mental health assessment. The mean daily creatine intake was 10.3 ± 9.5 mg/kg body mass (95% CI, 10.0 -10.5). One-way ANOVA showed significant differences in depression scores across quartiles of creatine intake (F = 4.003, <i>p</i> = 0.007), with higher depression scores in the lowest quartile compared to all others (<i>p</i> ≤ 0.05). The prevalence of depression was greatest among participants in the lowest quartile (6.9%) versus Q2 (3.3%), Q3 (4.3%), and Q4 (3.6%) (p≤0.05). Participants in the lowest quartile also reported higher rates of suicidal thoughts, plans, and attempts compared to those in higher quartiles (<i>p</i> ≤ 0.05). Higher creatine intake was associated with lower odds of generalized anxiety disorder after controlling for biomarkers of creatine turnover and demographic variables (<i>p</i> ≤ 0.05), but this relationship was not significant when lifestyle factors were included (<i>p</i> > 0.05). These findings suggest that higher dietary creatine intake may have modest protective effects against depression, suicidality, and anxiety. However, given the cross-sectional design, causality cannot be inferred, and further longitudinal and interventional studies are needed to confirm these associations and explore underlying mechanisms.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-9"},"PeriodicalIF":3.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}