Dietary total antioxidant capacity associated with nutritional status and clinical condition of patients with multiple sclerosis.

IF 3.6 4区医学 Q2 NEUROSCIENCES

Nutritional Neuroscience Pub Date : 2025-06-15 DOI:10.1080/1028415X.2025.2516627

Fernanda Nunes Maia, Bruna Yhang da Costa Silva, Renan Souto Pereira, Larissa da Silva Albuquerque, Vitor Wagner de Sousa Lacerda, José Artur Costa D'Almeida, Maria Luisa Pereira de Melo

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引用次数: 0

Abstract

Objective: To identify dietary total antioxidant capacity (DTAC) in people with MS (PwMS) and evaluate its interrelation with nutritional status and disease progression.

Methods: Cross-sectional, quantitative study with 127 patients with MS recruited from the Interdisciplinary Center for Assistance, Research and Teaching in Neuroimmunology (CIAPEN) (Fortaleza, Ceará, Brazil). The clinical parameters were clinical phenotype, the expanded disability status scale (EDSS), the medical research council (MRC) muscle scale, and Magnetic Resonance Imaging (MRI) evaluation. Weight and height measurements were obtained to calculate the body mass index (BMI), waist circumference (WC) and estimate body fat percentage (BF%). The DTAC was estimated using food intake data from the 24DR and the intake of antioxidant supplements.

Results: As for the nutritional status, it was found that 48 (37.80%) and 64 (50.39%) had excess adiposity according to the BMI and BF%, respectively, and 67 (53.60%) had elevated WC. Higher DTAC was associated with higher WC (r = 0.192, p = 0.032) and BF% (r = 0.246, p = 0.005); and higher intake of energy (r = 0.418, p < 0.001). There was no association between the clinical phenotype of the disease, the EDSS, the presence of visible lesions and the DTAC tertiles. However, in the unadjusted model, it was observed that the second tertile of DTAC reduced by 64% (OR = 0.36; 95% CI: 0.14-0.96) the individual's chance of having lower muscle strength, assessed by the MRC muscle scale.

Conclusion: Healthy nutrition, especially sufficient intake of dietary antioxidants, should be encouraged in PwMS.

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膳食总抗氧化能力与多发性硬化症患者营养状况和临床状况的关系

目的：了解多发性硬化症（PwMS）患者膳食总抗氧化能力（DTAC），并评价其与营养状况和疾病进展的关系。方法：从神经免疫学跨学科援助、研究和教学中心（CIAPEN）（Fortaleza, cear，巴西）招募127例MS患者进行横断面定量研究。临床参数包括临床表型、扩展残疾状态量表（EDSS）、医学研究委员会（MRC）肌肉量表和磁共振成像（MRI）评价。测量体重和身高，计算体重指数（BMI）、腰围（WC）和体脂率（BF%）。DTAC是根据24DR的食物摄入数据和抗氧化剂补充剂的摄入来估计的。结果：营养状况方面，BMI和BF%分别为48例（37.80%）和64例（50.39%），WC升高67例（53.60%）。较高的DTAC与较高的WC （r = 0.192, p = 0.032）和BF% （r = 0.246, p = 0.005）相关；结论：PwMS患者应提倡健康营养，特别是膳食中摄入足够的抗氧化剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.