Nutritional Neuroscience最新文献

Adherence to unhealthy diets is associated with altered frontal gamma-aminobutyric acid and glutamate concentrations and grey matter volume: preliminary findings. 坚持不健康饮食与额叶γ-氨基丁酸和谷氨酸浓度及灰质体积的改变有关：初步研究结果。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-05-24 DOI: 10.1080/1028415X.2024.2355603

Piril Hepsomali, Adele Costabile, Marieke Schoemaker, Florencia Imakulata, Paul Allen

{"title":"Adherence to unhealthy diets is associated with altered frontal gamma-aminobutyric acid and glutamate concentrations and grey matter volume: preliminary findings.","authors":"Piril Hepsomali, Adele Costabile, Marieke Schoemaker, Florencia Imakulata, Paul Allen","doi":"10.1080/1028415X.2024.2355603","DOIUrl":"10.1080/1028415X.2024.2355603","url":null,"abstract":"Objectives: Common mental disorders (CMD) are associated with impaired frontal excitatory/inhibitory (E/I) balance and reduced grey matter volume (GMV). Larger GMV (in the areas that are implicated in CMD-pathology) and improved CMD-symptomatology have been observed in individuals who adhere to high quality diets. Moreover, preclinical studies have shown altered neurometabolites (primarily gamma-aminobutyric acid: GABA and glutamate: GLU) in relation to diet quality. However, neurochemical correlates of diet quality and how these neurobiological changes are associated with CMD and with its transdiagnostic factor, rumination, is unknown in humans. Therefore, in this study, we examined the associations between diet quality and frontal cortex neuro-chemistry and structure, as well as CMD and rumination in humans.Methods: Thirty adults were classified into high and low diet quality groups and underwent 1H-MRS to measure medial prefrontal cortex (mPFC) metabolite concentrations and volumetric imaging to measure GMV.Results: Low (vs High) diet quality group had reduced mPFC-GABA and elevated mPFC-GLU concentrations, as well as reduced right precentral gyrus (rPCG) GMV. However, CMD and rumination were not associated with diet quality. Notably, we observed a significant negative correlation between rumination and rPCG-GMV and a marginally significant association between rumination and mPFC-GLU concentrations. There was also a marginally significant association between mPFC-GLU concentrations and rPCG-GMV.Discussion: Adhering to unhealthy dietary patterns may be associated with compromised E/I balance, and this could affect GMV, and subsequently, rumination.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"125-137"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediterranean diet and its effects on a growing problem, for a younger population: diet, inflammation and multiple sclerosis. 地中海饮食及其对一个日益严重的问题的影响，针对年轻人群：饮食、炎症和多发性硬化症。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-06-12 DOI: 10.1080/1028415X.2024.2364429

Muhammad Shuraim Gang, Zayan Alidina, Adeena Musheer

引用次数: 0

Synergistic effect of chrysin and kaempferol in ameliorating Cerebral Ischemic Reperfusion injury in rat by controlling expression of proinflammatory mediators NF-κB and STAT3. 通过控制促炎介质 NF-κB 和 STAT3 的表达，菊黄素和山奈酚在改善大鼠脑缺血再灌注损伤方面的协同效应

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-05-29 DOI: 10.1080/1028415X.2024.2358686

Nasima Khanam, Ashutosh Ghosh, Debjani Nath

{"title":"Synergistic effect of chrysin and kaempferol in ameliorating Cerebral Ischemic Reperfusion injury in rat by controlling expression of proinflammatory mediators NF-κB and STAT3.","authors":"Nasima Khanam, Ashutosh Ghosh, Debjani Nath","doi":"10.1080/1028415X.2024.2358686","DOIUrl":"10.1080/1028415X.2024.2358686","url":null,"abstract":"Objectives: The two flavonoids kaempferol and chrysin are known to possess anti-inflammatory and antioxidant activities. In addition, these two flavonoids were reported to display synergistic effects against inflammation. The present study aims to provide an analysis of the combined effects of kaempferol and chrysin on ischemic rat brain induced by endothelin-1.Methods: The neurological deficit score and infarct area of the brain were determined post drug treatment. Histopathological sections displayed the morphological changes in the brain tissue. The brain tissues were processed for assessing the antioxidant and anti-inflammatory activity by measuring superoxide dismutase activity, catalase activity, level of reduced glutathione, brain malondialdehyde, and amount of calcium. The expression level of inflammatory molecules was analyzed by western blotting and immunohistochemistry.Results: The infarct area, neurological score and NF-κB and STAT3 expression levels were significantly reduced.Discussion: The analysis of neuroprotective synergistic activity of kaempferol and chrysin indicated the therapeutic potential of the combination in alleviating cerebral ischemia by controlling expression of proinflammatory mediators.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"138-148"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between dietary intake of fats and transient global amnesia (TGA). 膳食中脂肪摄入量与短暂性全球失忆症（TGA）之间的关系。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-07-16 DOI: 10.1080/1028415X.2024.2359866

Zahra Mahmoudi, Ali Tajik, Mahsa Vahdat, Khadijeh Abbasi Mobarakeh, Zahra Saeedirad, Fatemeh Azaryan, Arezoo Amjadi, Farkhondeh Alami, Neda Valisoltani, Masoomeh Alsadat Mirshafaei, Sara Khoshdooz, Maryam Gholamalizadeh, Saeid Doaei, Akram Kooshki

{"title":"The association between dietary intake of fats and transient global amnesia (TGA).","authors":"Zahra Mahmoudi, Ali Tajik, Mahsa Vahdat, Khadijeh Abbasi Mobarakeh, Zahra Saeedirad, Fatemeh Azaryan, Arezoo Amjadi, Farkhondeh Alami, Neda Valisoltani, Masoomeh Alsadat Mirshafaei, Sara Khoshdooz, Maryam Gholamalizadeh, Saeid Doaei, Akram Kooshki","doi":"10.1080/1028415X.2024.2359866","DOIUrl":"10.1080/1028415X.2024.2359866","url":null,"abstract":"Background: Different types of dietary fat may influence memory and cognitive functions. This study aimed to investigate the association between dietary fat intake and transient global amnesia (TGA).Methods: This case-control study was conducted using Persian Sabzevar cohort data on 258 individuals with TGA and 520 individuals without amnesia in Sabzevar Iran. The food frequency questionnaire (FFQ) was used to assess the intake of dietary fats of the participants. All study participants were screened for TGA by a neurologist and their status was determined based on the diagnostic symptoms defined by the Kaplan and Hodges criteria.Results: There was an inverse association between the risk of TGA and dietary intake of alpha-linolenic acid (ALA) (OR = 0.94, CI95%:0.88-0.99, P = 0.01). Also, a positive association was observed between TGA and dietary intake of n-6 fatty acids (OR = 1.18, CI 95%: 1.04-1.33, P = 0.01). The results remained significant after adjustment for age, sex, education, job, marital status, physical activity, BMI, and calorie intake.Conclusion: Omega-3 fatty acids may have beneficial effects; however, omega-6 fatty acids may have adverse effects on the risk of amnesia. Further longitudinal studies are warranted.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"149-155"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blackberry extract prevents lipopolysaccharide-induced depressive-like behavior in female mice: implications for redox status, inflammation, and brain enzymes. 黑莓提取物可预防脂多糖诱发的雌性小鼠抑郁样行为：对氧化还原状态、炎症和脑酶的影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-06-11 DOI: 10.1080/1028415X.2024.2363570

Solange Vega Custódio, Raphaela Cassol Piccoli, Kelen Cristiane Machado Goularte, William Sanabria Simões, Julia Eisenhardt de Mello, Anita Avila de Souza, Isabella Pompeu de Mattos Almeida, Alethéa Gatto Barschak, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Mayara Sandrielly Soares de Aguiar, Roselia Maria Spanevello

{"title":"Blackberry extract prevents lipopolysaccharide-induced depressive-like behavior in female mice: implications for redox status, inflammation, and brain enzymes.","authors":"Solange Vega Custódio, Raphaela Cassol Piccoli, Kelen Cristiane Machado Goularte, William Sanabria Simões, Julia Eisenhardt de Mello, Anita Avila de Souza, Isabella Pompeu de Mattos Almeida, Alethéa Gatto Barschak, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Mayara Sandrielly Soares de Aguiar, Roselia Maria Spanevello","doi":"10.1080/1028415X.2024.2363570","DOIUrl":"10.1080/1028415X.2024.2363570","url":null,"abstract":"This study evaluated the effects of Rubus sp. extract on behavioral and neurochemical parameters in female mice submitted to experimental model of depression induced by lipopolysaccharide (LPS). The results indicated that Rubus sp. extract protected against depressive-like behavior induced by LPS. Moreover, the administration of Rubus sp. extract was effective in preventing the increase in reactive species and nitrites levels, as well as the decrease in catalase activity induced by LPS in the cerebral cortex. In the serum, the Rubus sp. extract was effective in preventing the decrease in catalase activity induced by LPS. Treatment with Rubus sp. extract attenuated the increase in acetylcholinesterase activity induced by LPS in the cerebral cortex. Finally, blackberry extract also downregulated IL-1β levels in cerebral cortex. In conclusion, our findings demonstrated that treatment with Rubus sp. exerted antidepressant, antioxidant, anticholinesterase and anti-inflammatory effects in a model of depressive - like behavior induced by LPS in female mice. This highlights Rubus sp. as a potential therapeutic agent for individuals with major depressive disorder.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"194-208"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malnutrition risk and associated factors in hospitalized older adult patients with neurological diseases: a retrospective cohort study. 住院老年神经系统疾病患者的营养不良风险及相关因素：一项回顾性队列研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-06-07 DOI: 10.1080/1028415X.2024.2363571

Gabriel Alvarado-Luis, Claudia Mimiaga-Hernández

{"title":"Malnutrition risk and associated factors in hospitalized older adult patients with neurological diseases: a retrospective cohort study.","authors":"Gabriel Alvarado-Luis, Claudia Mimiaga-Hernández","doi":"10.1080/1028415X.2024.2363571","DOIUrl":"10.1080/1028415X.2024.2363571","url":null,"abstract":"Introduction: Malnutrition risk (MR) in older adults with neurological disorders is high, but there is little evidence for validated screening tools in this group, as well as for the clinical and socioeconomic factors associated with a high MR.Objectives: To determine the association of MR using the Malnutrition Universal Screening Tool (MUST) with mortality and length of stay (LOS) in older adults with neurological diseases. Secondarily, the association of clinical, and socioeconomic factors with MR and clinical outcomes was sought.Methods: A retrospective cohort study was carried out at a third-level neurological disease referral center in Mexico. All patients older than 60 years admitted from January 2017 to December 2018 were considered. MUST, clinical and socioeconomic factors were assessed at hospital admission. Outcomes were followed up to hospital discharge or a maximum of 6 months.Results: A total of 765 patients were included, of whom 24.7% (n = 189) were at high risk. A high MR was independently associated with mortality (OR 3.09; 95% CI 1.60-5.98, p = .001) and LOS >14 days (OR 4.38; 95% CI 2.79-6.89, p = <.001). The only factors independently associated with high MR was economic dependence and unemployment. Patients with high MR and economic dependence (OR 4.0; 95% CI 1.34-11.99, p = .013) or unemployment (OR 3.43; 95% CI 1.17-10.06, p = .025) had the highest mortality.Conclusions: In hospitalized older adults with neurological diseases, high MR is independently associated with increased mortality and LOS. Economic dependence or unemployment are associated with worse clinical outcomes in patients with high MR.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"209-218"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating chronic stress and chronic pain by manipulating gut microbiota with diet: can we kill two birds with one stone? 通过饮食控制肠道微生物群来治疗慢性压力和慢性疼痛：我们能一石二鸟吗？

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-06-18 DOI: 10.1080/1028415X.2024.2365021

Alessia Costa, Elena Lucarini

{"title":"Treating chronic stress and chronic pain by manipulating gut microbiota with diet: can we kill two birds with one stone?","authors":"Alessia Costa, Elena Lucarini","doi":"10.1080/1028415X.2024.2365021","DOIUrl":"10.1080/1028415X.2024.2365021","url":null,"abstract":"Background: Chronic stress and chronic pain are closely linked by the capacity to exacerbate each other, sharing common roots in the brain and in the gut. The strict intersection between these two neurological diseases makes important to have a therapeutic strategy aimed at preventing both to maintain mental health in patients. Diet is an modifiable lifestyle factor associated with gut-brain axis diseases and there is growing interest in its use as adjuvant to main therapies. Several evidence attest the impact of specific diets or nutrients on chronic stress-related disorders and pain with a good degree of certainty. A daily adequate intake of foods containing micronutrients such as amino acids, minerals and vitamins, as well as the reduction in the consumption of processed food products can have a positive impact on microbiota and gut health. Many nutrients are endowed of prebiotic, anti-inflammatory, immunomodulatory and neuroprotective potential which make them useful tools helping the management of chronic stress and pain in patients. Dietary regimes, as intermittent fasting or caloric restriction, are promising, although further studies are needed to optimize protocols according to patient's medical history, age and sex. Moreover, by supporting gut microbiota health with diet is possible to attenuate comorbidities such as obesity, gastrointestinal dysfunction and mood disorders, thus reducing healthcare costs related to chronic stress or pain.Objective: This review summarize the most recent evidence on the microbiota-mediated beneficial effects of macro- and micronutrients, dietary-related factors, specific nutritional regimens and dietary intervention on these pathological conditions.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"221-244"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life malnutrition role in memory, emotional behavior and motor impairments in early brain lesions with potential for neurodevelopmental disorders: a systematic review with meta-analysis. 早期营养不良对可能导致神经发育障碍的早期脑损伤患者的记忆力、情绪行为和运动障碍的影响：系统综述与荟萃分析。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI: 10.1080/1028415X.2024.2361572

Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Vanessa da Silva Souza, Henrique José Cavalcanti Bezerra Gouveia, Sabrina da Conceição Pereira, Márcia Maria da Silva, Glayciele Leandro de Albuquerque, Bruno Monteiro Paiva Lima, Augusto Vagner Soares Martins de Lira, Ana Elisa Toscano

{"title":"Early-life malnutrition role in memory, emotional behavior and motor impairments in early brain lesions with potential for neurodevelopmental disorders: a systematic review with meta-analysis.","authors":"Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Vanessa da Silva Souza, Henrique José Cavalcanti Bezerra Gouveia, Sabrina da Conceição Pereira, Márcia Maria da Silva, Glayciele Leandro de Albuquerque, Bruno Monteiro Paiva Lima, Augusto Vagner Soares Martins de Lira, Ana Elisa Toscano","doi":"10.1080/1028415X.2024.2361572","DOIUrl":"10.1080/1028415X.2024.2361572","url":null,"abstract":"Objectives: The present study aims to evaluate the impact of early exposure to brain injury and malnutrition on episodic memory and behavior.Methods: For this, a systematic review was carried out in the Medline/Pubmed, Web of Science, Scopus, and LILACS databases with no year or language restrictions.Results: Initially, 1759 studies were detected. After screening, 53 studies remained to be read in full. The meta-analysis demonstrated that exposure to double insults worsens episodic recognition memory but does not affect spatial memory. Early exposure to low-protein diets has been demonstrated to aggravate locomotor and masticatory sequelae. Furthermore, it reduces the weight of the soleus muscle and the muscle fibers of the masseter and digastric muscles. Early exposure to high-fat diets promotes an increase in oxidative stress and inflammation in the brain, increasing anxiety- and depression-like behavior and reducing locomotion.Discussion: Epigenetic modifications were noted in the hippocampus, hypothalamus, and prefrontal cortex depending on the type of dietetic exposure in early life. These findings demonstrate the impact of the double insult on regions involved in cognitive and behavioral processes. Additional studies are essential to understand the real impact of the double insults in the critical period.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"171-193"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of time-restricted eating/feeding on Alzheimer's biomarkers and gut microbiota. 限时进食/喂食对阿尔茨海默氏症生物标志物和肠道微生物群的影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-07-02 DOI: 10.1080/1028415X.2024.2359868

Maha Gasmi, Novi Silvia Hardiany, Marie van der Merwe, Ian J Martins, Aastha Sharma, Ruth Williams-Hooker

{"title":"The influence of time-restricted eating/feeding on Alzheimer's biomarkers and gut microbiota.","authors":"Maha Gasmi, Novi Silvia Hardiany, Marie van der Merwe, Ian J Martins, Aastha Sharma, Ruth Williams-Hooker","doi":"10.1080/1028415X.2024.2359868","DOIUrl":"10.1080/1028415X.2024.2359868","url":null,"abstract":"Objectives: Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million individuals globally. Diagnosis typically occurs in advanced stages, and there are limited options for reversing symptoms. Preventive strategies are, therefore, crucial. Time Restricted Eating (TRE) or Time Restricted Feeding (TRF) is one such strategy. Here we review recent research on AD and TRE/TRF in addition to AD biomarkers and gut microbiota.Methods: A comprehensive review of recent studies was conducted to assess the impact of TRE/TRF on AD-related outcomes. This includes the analysis of how TRE/TRF influences circadian rhythms, beta-amyloid 42 (Aß42), pro-inflammatory cytokines levels, and gut microbiota composition.Results: TRE/TRF impacts circadian rhythms and can influence cognitive performance as observed in AD. It lowers beta-amyloid 42 deposition in the brain, a key AD biomarker, and reduces pro-ininflammatory cytokines. The gut microbiome has emerged as a modifiable factor in AD treatment. TRE/TRF changes the structure and composition of the gut microbiota, leading to increased diversity and a decrease in harmful bacteria.Discussion: These findings underscore the potential of TRE/TRF as a preventive strategy for AD. By reducing Aß42 plaques, modulating pro-inflammatory cytokines, and altering gut microbiota composition, TRE/TRF may slow the progression of AD. Further research is needed to confirm these effects and to understand the mechanisms involved. This review highlights TRE/TRF as a promising non-pharmacological intervention in the fight against AD.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"156-170"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigation and mechanism of low dose linoleic acid on depression caused by disorder of gut microbiome. 低剂量亚油酸对肠道微生物群紊乱所致抑郁症的缓解作用及其机制

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI: 10.1080/1028415X.2024.2366648

Haining Yu, Yinan Song, Maoshan Lou, Shengrong Shen

{"title":"Mitigation and mechanism of low dose linoleic acid on depression caused by disorder of gut microbiome.","authors":"Haining Yu, Yinan Song, Maoshan Lou, Shengrong Shen","doi":"10.1080/1028415X.2024.2366648","DOIUrl":"10.1080/1028415X.2024.2366648","url":null,"abstract":"Objectives: Depression is a widely prevalent mental disorder, and nutritional interventions play an increasingly important role in its treatment. In this paper, effects of linoleic acid (LA) on depressive behavior in mice induced by gut microbiome disorders were investigated.Methods: Fifty C57BL/6J male mice were randomly separated into five groups, control group (CK), ceftriaxone sodium group (CRO), low-dose linoleic acid group (LLA, 1 g/kg), medium-dose linoleic acid group (MLA, 2 g/kg), and high-dose linoleic acid group (HLA, 5 g/kg). In the LLA, MLA, and HLA groups, mice were treated with ceftriaxone sodium (CRO) to induce depressive behaviors, followed by LA administration. Behavioral tests were used to evaluate depressive behavior. High-throughput sequencing and Hematoxylin-eosin (H&E) staining in gut microenvironment were carried out. ELISA kits were used to measure brain inflammatory factors, and 5-hydroxy-tryptamine (5-HT). Gas chromatography and western blot were used to determine fatty acids compositions and the enzymes expression involved in lipid metabolism in brain respectively.Results: The results showed that 10 weeks CRO treatment contribute to depressive behavior, gut microbiome disturbance, and serotonin system disturbance. LLA and MLA improved the depressive-like behavior, and significantly increased the levels of 5-HT1A, 5-HTT and 5-HT in the hippocampus. LLA was found to improve the diversity of gut microbiome and alleviate colon tissue damage. Meantime, LLA increased the content of linoleic acid, improved the expression of FADS2 and COX-2, increased IL-10 levels, and decreased IL-6 levels in the brain.Discussion: LA alleviated depressive behavior in mice by improving the gut microenvironment, regulate fatty acid metabolism, and modulate inflammation.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"245-262"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0