Nutritional Neuroscience最新文献

Dietary factors and the incidence of intracranial aneurysms: a Mendelian randomization research. 饮食因素与颅内动脉瘤发病率：孟德尔随机研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-02 DOI: 10.1080/1028415X.2024.2403894

Gu Linazi, Aierpati Maimaiti, Zulihuma Abulaiti, Niyaziaili Adili, Jiaoqiong Guan, Aimitaji Abulaiti

{"title":"Dietary factors and the incidence of intracranial aneurysms: a Mendelian randomization research.","authors":"Gu Linazi, Aierpati Maimaiti, Zulihuma Abulaiti, Niyaziaili Adili, Jiaoqiong Guan, Aimitaji Abulaiti","doi":"10.1080/1028415X.2024.2403894","DOIUrl":"10.1080/1028415X.2024.2403894","url":null,"abstract":"Background: Intracranial aneurysms (IAs) pose a significant threat to morbidity and mortality, yet their etiology remains inadequately comprehended. The present study employs Mendelian randomization (MR) to investigate the relationship among dietary elements with IAs, encompassing unruptured intracranial aneurysms (uIA) as well as aneurysmal subarachnoid hemorrhage (aSAH).Methods: The current study employed a double-sample MR test utilizing genome-wide association study (GWAS) summary data from the IEU and IAs' meta-analysis to investigate the genetically predicted consumption levels of various dietary factors using GWAS data. Causation was assessed by techniques of MR-Egger, weighted mode, and median, as well as IVW. To guarantee the accuracy of the results, pleiotropy and heterogeneity evaluations were also carried out.Results: The findings of the study indicate a positive correlation between the intake of alcohol, lamb/mutton, and pork with the risk of IAs (IVW all p < 0.05). Conversely, a negative correlation was observed regarding dried fruit consumption and the risk of aSAH (IVW p < 0.05). There was only scant evidence supporting the association between alcohol intake frequency and an elevated risk of uIA (IVW method p < 0.05). The MR analysis outcomes were authenticated by the MR-PRESSO method and were deemed reliable. Furthermore, sensitivity calculations, such as pleiotropy and homogeneity test, leave-one-out evaluation, and funnel charts, validated the robustness of the results.Conclusions: The findings suggest that reducing alcohol, lamb/mutton, and pork intake, and increasing dried fruit intake may be potential strategies for the prevention of IAs and aSAH. Additional research is necessary to validate these outcomes and elucidate the underlying mechanisms.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrient intake and food selectivity in children with Tourette syndrome. 妥瑞症儿童的营养摄入和食物选择性。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-02 DOI: 10.1080/1028415X.2024.2408978

Bobbie L Smith, Katerina Vafeiadou, Amanda K Ludlow

{"title":"Nutrient intake and food selectivity in children with Tourette syndrome.","authors":"Bobbie L Smith, Katerina Vafeiadou, Amanda K Ludlow","doi":"10.1080/1028415X.2024.2408978","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2408978","url":null,"abstract":"Objectives: Children with Tourette syndrome (TS) have been shown to exhibit high levels of food selectivity; however, its association with nutritional status has yet to be explored. The current study explored macro and micronutrient intake and food selectivity among children with and without TS, using 24-hour dietary recall and the Child Eating Behaviour Questionnaire.Method: Parents of 43 children diagnosed with TS and 38 age-matched children without a clinical diagnosis completed an online 24-hour food diary.Results: Fifty-eight per cent of children with TS were identified as falling outside of the healthy BMI range (underweight = 24.2%; overweight = 27.3%; obese = 6.1%). Children with TS also consumed fewer portions of fruit and vegetables along with meeting the daily reference nutrient intake guidelines significantly less often for vitamins B3, B6 and C, selenium and phosphorus compared to children without TS.Conclusions: Understanding the nutritional risk of children with TS relative to other children is important to clinicians and health care professionals who oversee nutritional inspection in primary care, and caregivers who are worried about the impact of limited or restricted diets.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-carbohydrate diet as a nutritional intervention in a major depression disorder: focus on relapse prevention. 将低碳水化合物饮食作为重度抑郁症的营养干预措施：关注预防复发。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-01 Epub Date: 2024-01-21 DOI: 10.1080/1028415X.2024.2303218

Michał Walaszek, Zofia Kachlik, Wiesław Jerzy Cubała

{"title":"Low-carbohydrate diet as a nutritional intervention in a major depression disorder: focus on relapse prevention.","authors":"Michał Walaszek, Zofia Kachlik, Wiesław Jerzy Cubała","doi":"10.1080/1028415X.2024.2303218","DOIUrl":"10.1080/1028415X.2024.2303218","url":null,"abstract":"Objectives: Mood disorders are trending to be among the leading causes of years lived with disability. Despite multiple treatment options, around 30% patients with major depressive disorder (MDD) develop treatment resistant depression (TRD) and fail to respond to current pharmacological therapies. This study aimed to explore the potential benefits of nutritional treatment strategies, along with their molecular mechanisms of action, focusing especially on low-carbohydrate diet (LCHD), ketogenic diet (KD) and other strategies based on carbohydrates intake reduction.Methods: A comprehensive literature review was conducted to determine the impact of LCHD on alleviating depressive symptoms in patients with MDD, along with an explanation of its mode of action.Results: The study revealed significant impact of nutritional interventions based on restriction in carbohydrate intake such as LCHD, KD or sugar-sweetened beverages (SSB) exclusion on anxiety or depression symptoms reduction, mood improvement and lower risk of cognitive impairment or depression. The efficacy of these approaches is further substantiated by their underlying molecular mechanisms, mainly brain-derived neurotrophic factor (BDNF) which is a potential key target of sugar restriction diets in terms of neuroplasticity.Discussion: Healthcare professionals may consider implementing LCHD strategies for MDD and TRD patients to modify the disease process, maintain euthymia, and prevent depressive episode relapses. Ranging from the exclusion of SSB to the adherence to rigorous LCHD regimens, these nutritional approaches are safe, straightforward to implement, and may confer benefits for well-being and relapse prevention in this specific patient population.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An extract of Hibiscus sabdariffa improves short-term memory in rats with experimental diabetic hyperglycemia. 木槿提取物可改善实验性糖尿病高血糖大鼠的短期记忆。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-01 Epub Date: 2024-01-09 DOI: 10.1080/1028415X.2023.2301166

Silvia J López-Pérez, Mónica E Ureña-Guerrero, Jacinto Bañuelos-Pineda

{"title":"An extract of Hibiscus sabdariffa improves short-term memory in rats with experimental diabetic hyperglycemia.","authors":"Silvia J López-Pérez, Mónica E Ureña-Guerrero, Jacinto Bañuelos-Pineda","doi":"10.1080/1028415X.2023.2301166","DOIUrl":"10.1080/1028415X.2023.2301166","url":null,"abstract":"Background: Calyxes of Hibiscus sabdariffa (Hs) contain anthocyanins, that normalize blood glucose levels (BGL) in diabetic patients. Diabetes also causes memory alterations, which could hypothetically decrease with the consumption of Hs.Objectives: To investigate the effect of dietary supplementation with a Hs extract on working memory and BGL in rats.Methods: Diabetic hyperglycemia (DHG) was induced with streptozotocin (STZ, 55 mg/kg i.p.) in Wistar rats. After 72 h DHG was confirmed, and the consumption of Hs extract began (50 mg/Kg/day). BGL and body weight (BW) were measured at 10, 20 and 30 days after DHG induction in controls and treated animals. Learning and short-term memory were evaluated after 30 days with Novel Object Recognition Test (NOR) and Barnes Maze (BM). The gross hippocampal structure was histologically analyzed.Results: STZ-treated animals presented low BW and persistent DHG (BGL <300 mg/dL). Diabetic animals consuming the Hs extract had a dual response: some showed BGL comparable to controls, while others had levels comparable to diabetic animals not consuming extract. Diabetic animals that consumed the Hs extract had a better performance in NOR and BM than the diabetic animals not consuming the extract. At the histological level, hippocampal morphological differences were observed between diabetic animals that consumed the extract and those that did not.Discussion: The Hs extract used here could be a good co-adjuvant in the treatment of DHG, aimed at mitigating memory deficits and high BGL. These beneficial effects could be attributed to the anthocyanin content in the extract.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain energetics and glucose transport in metabolic diseases: role in neurodegeneration. 代谢性疾病中的脑能量和葡萄糖转运：在神经变性中的作用。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-01 Epub Date: 2024-01-31 DOI: 10.1080/1028415X.2024.2306427

Orquídea G Méndez-Flores, Luisa C Hernández-Kelly, Tatiana N Olivares-Bañuelos, Gabriel López-Ramírez, Arturo Ortega

{"title":"Brain energetics and glucose transport in metabolic diseases: role in neurodegeneration.","authors":"Orquídea G Méndez-Flores, Luisa C Hernández-Kelly, Tatiana N Olivares-Bañuelos, Gabriel López-Ramírez, Arturo Ortega","doi":"10.1080/1028415X.2024.2306427","DOIUrl":"10.1080/1028415X.2024.2306427","url":null,"abstract":"Objectives: Neurons and glial cells are the main functional and structural elements of the brain, and the former depends on the latter for their nutritional, functional and structural organization, as well as for their energy maintenance.Methods: Glucose is the main metabolic source that fulfills energetic demands, either by direct anaplerosis or through its conversion to metabolic intermediates. Development of some neurodegenerative diseases have been related with modifications in the expression and/or function of glial glucose transporters, which might cause physiological and/or pathological disturbances of brain metabolism. In the present contribution, we summarized the experimental findings that describe the exquisite adjustment in expression and function of glial glucose transporters from physiologic to pathologic metabolism, and its relevance to neurodegenerative diseases.Results: A exhaustive literature review was done in order to gain insight into the role of brain energetics in neurodegenerative disease. This study made evident a critical involvement of glucose transporters and thus brain energetics in the development of neurodegenerative diseases.Discussion: An exquisite adjustment in the expression and function of glial glucose transporters from physiologic to pathologic metabolism is a biochemical signature of neurodegenerative diseases.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose intolerance induces anxiety-like behaviors independent of obesity and insulin resistance in a novel model of nutritional metabolic stress. 在一种新型营养代谢压力模型中，葡萄糖不耐受会诱发焦虑样行为，而与肥胖和胰岛素抵抗无关。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-01 Epub Date: 2024-02-06 DOI: 10.1080/1028415X.2024.2310419

Mohammed Al-Onaizi, Kawthar Braysh, Selma S Alkafeef, Dana Altarrah, Shorouk Dannoon, Dalal Alasousi, Hawraa Adel, Mariam Al-Ajmi, Anwar Kandari, Rawan Najem, Rasheeba Nizam, Michayla R Williams, Sumi John, Thangavel Alphonse Thanaraj, Rasheed Ahmad, Heba Al-Hussaini, Fahd Al-Mulla, Fawaz Alzaid

{"title":"Glucose intolerance induces anxiety-like behaviors independent of obesity and insulin resistance in a novel model of nutritional metabolic stress.","authors":"Mohammed Al-Onaizi, Kawthar Braysh, Selma S Alkafeef, Dana Altarrah, Shorouk Dannoon, Dalal Alasousi, Hawraa Adel, Mariam Al-Ajmi, Anwar Kandari, Rawan Najem, Rasheeba Nizam, Michayla R Williams, Sumi John, Thangavel Alphonse Thanaraj, Rasheed Ahmad, Heba Al-Hussaini, Fahd Al-Mulla, Fawaz Alzaid","doi":"10.1080/1028415X.2024.2310419","DOIUrl":"10.1080/1028415X.2024.2310419","url":null,"abstract":"Objectives: Type 2 diabetes (T2D) is a metabolic disease of major public health concern. It impacts peripheral tissues and the central nervous system, leading to systemic dysmetabolism and neurocognitive impairments, including memory deficits, anxiety, and depression. The metabolic determinants of these neurocognitive impairments remain unidentified. Here, we sought to address this question by developing a proprietary (P-) high-fat diet (HFD), in which glucose intolerance precedes weight gain and insulin resistance.Methods: The P-HFD model was nutritionally characterized, and tested in vivo in mice that underwent behavioral and metabolic testing. The diet was benchmarked against reference models. .Results: P-HFD has 42% kcal from fat, high monounsaturated/polyunsaturated fatty acid ratio, and 10% (w/v) sucrose in drinking water. When administered, from the early stages of glucose intolerance alone, animals exhibit anxiety-like behavior, without depression nor recognition memory deficits. Long-term P-HFD feeding leads to weight gain, brain glucose hypometabolism as well as impaired recognition memory. Using an established genetic model of T2D (db/db) and of diet-induced obesity (60% kcal from fat) we show that additional insulin resistance and obesity are associated with depressive-like behaviors and recognition memory deficits.Discussion: Our findings demonstrate that glucose intolerance alone can elicit anxiety-like behavior. Through this study, we also provide a novel nutritional model (P-HFD) to characterize the discrete effects of glucose intolerance on cognition, behavior, and the physiology of metabolic disease.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease. 辅助性水飞蓟素补充剂及其对阿尔茨海默病患者疾病严重程度、氧化应激和炎症的影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-01 Epub Date: 2024-02-14 DOI: 10.1080/1028415X.2023.2301163

Seyed Mohammad Navabi, Daniel Elieh-Ali-Komi, Daryoush Afshari, Farjam Goudarzi, Ehsan Mohammadi-Noori, Kiana Heydari, Fatemeh Heydarpour, Amir Kiani

{"title":"Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease.","authors":"Seyed Mohammad Navabi, Daniel Elieh-Ali-Komi, Daryoush Afshari, Farjam Goudarzi, Ehsan Mohammadi-Noori, Kiana Heydari, Fatemeh Heydarpour, Amir Kiani","doi":"10.1080/1028415X.2023.2301163","DOIUrl":"10.1080/1028415X.2023.2301163","url":null,"abstract":"Background: Brain tissue in Alzheimer's patients is exposed to oxidative stress. Silymarin is an adjunct drug that has anti-inflammatory and antioxidant properties.Objective: This study aimed to evaluate the effect of silymarin on biomarkers of oxidative stress, inflammation, and disease severity in Alzheimer's patients.Methods: This randomized, single-blind clinical trial study was performed on 33 patients with Alzheimer's disease (AD) whose disease was confirmed by DSM-5 criteria and by brain imaging. Patients in the case group received three 250 mg silymarin capsules daily (each containing 150 mg silymarin), as an adjunctive medication in addition to the routine medication regimen. In the placebo group (control), patients received the same amount of placebo. All patients underwent Mini Mental State Exam (MMSE) and a panel of blood tests including malondialdehyde, neopterin, catalase, paraoxonase-1, total oxidative status, and total antioxidant capacity to reevaluate the changes pre/postintervention at the end of the trimester.Results: The catalase and MDA serum levels after the adjunctive silymarin treatment decreased significantly (Catalasebefore silymarin = 9.29 ± 7.02 vs Catalaseafter silymarin = 5.32 ± 2.97, p = 0.007 and MDAbefore silymarin = 4.29 ± 1.90 vs MDAafter silymarin = 1.66 ± 0.84, p < 0.001) while MMSE increased notably (MMSEbefore silymarin = 10.39 ± 6.42 vs MMSEafter silymarin = 13.37 ± 6.81, p < 0.001).Conclusion: Silymarin can be effective as an adjunct drug and a powerful antioxidant in reducing oxidative stress and improving the course of AD.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of level of adherence to Mediterranean diet with cognitive and dementia status in subjects with chronic diseases: a cross-sectional study. 慢性病患者坚持地中海饮食的程度与认知和痴呆状况的关系：一项横断面研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-01 Epub Date: 2024-03-14 DOI: 10.1080/1028415X.2024.2304941

Abeer Al Hatab, Kishore Ganana Sam, Semira Abdi Beshir, Asim Ahmed Elnour, Nadia Al Mazrouei, Khalid Awad Al-Kubaisi, Maisoun Alkaabi, Abdulla Al Amoodi, Vineetha Menon, Abuelnor Mohammed, Sami Fatehi Abdalla

{"title":"Association of level of adherence to Mediterranean diet with cognitive and dementia status in subjects with chronic diseases: a cross-sectional study.","authors":"Abeer Al Hatab, Kishore Ganana Sam, Semira Abdi Beshir, Asim Ahmed Elnour, Nadia Al Mazrouei, Khalid Awad Al-Kubaisi, Maisoun Alkaabi, Abdulla Al Amoodi, Vineetha Menon, Abuelnor Mohammed, Sami Fatehi Abdalla","doi":"10.1080/1028415X.2024.2304941","DOIUrl":"10.1080/1028415X.2024.2304941","url":null,"abstract":"Background: The Mediterranean diet has been linked to brain neuroprotection. Evidence from meta-analyses showed reduced risk of dementia with greater intake of vegetables and fruits, fish, and the Mediterranean diet. The current study raises important questions about the association between low risk dementia and Mediterranean diet.Objective: The objective was to evaluate the association between levels of adherence to the Mediterranean diet and dementia and cognitive status in subjects 50 years of age and older.Method: The Mediterranean Diet Adherence Screener (MEDAS), the modified 30-item 'Diagnostic and Statistical Manual of Mental Disorders Third Edition (DSM-III) risk of dementia, and the Standard Mini-Mental Status Examination (SMMSE) cognitive status scores were used to assess the levels of adherence to the Mediterranean diet'.Results: A total of 150 subjects were enrolled in the study. Forty-one (27.3%) had 'suspected or confirmed dementia, while 48 individuals (32%) were categorized as having moderate to severe cognitive decline. Subjects who reported moderate to high adherence to the Mediterranean diet (55, 36.7%) had significantly lower dementia scores (7.0 3.8 versus 17.6 5.1) and higher cognitive (25.4 3.8 versus 8.6 7.2) scores compared to those (38, 25.3%) who reported low adherence to the Mediterranean diet.Conclusion: Subjects who were highly or moderately adherent to the Mediterranean diet had significantly lower dementia scores and better cognitive status than those with low adherence.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the pattern electroretinogram as a proxy measure for dopamine in the context of iron deficiency. 评估视网膜模式图作为缺铁情况下多巴胺的替代测量指标。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-01 Epub Date: 2024-01-25 DOI: 10.1080/1028415X.2024.2304943

Sarah F Newbolds, Michael J Wenger

{"title":"Assessing the pattern electroretinogram as a proxy measure for dopamine in the context of iron deficiency.","authors":"Sarah F Newbolds, Michael J Wenger","doi":"10.1080/1028415X.2024.2304943","DOIUrl":"10.1080/1028415X.2024.2304943","url":null,"abstract":"Objectives: Animal studies have suggested that dietary iron deficiency (ID) negatively affects dopamine (DA) synthesis and re-uptake, which in turn negatively affects memory and cognition. This study was intended to assess whether the pattern electroretinogram (pattern ERG) could be used as an indirect measure of DA in college-age women with and without ID by determining the extent to which features of the ERG were sensitive to iron status and were related to other indirect measures of DA.Methods: The pattern ERG was measured in 21 iron deficient non-anemic (IDNA) and 21 iron sufficient (IS) women, who also performed a contrast detection and probabilistic selection task, both with concurrent electroencephalography (EEG). Both spontaneous and task-related blink rates were also measured.Results: The implicit times of the A- and B-waves were significantly longer for the IDNA than for the IS women. Both the amplitudes and implicit times of the A- and B-waves were significantly correlated with levels of serum ferritin (sFt). Only the amplitude of the A-wave was correlated with spontaneous blink rate. It was possible to accurately identify a woman's iron status solely on the basis of the implicit time of the B-wave. Finally, the implicit times of the ERG features mediated the relationship between iron levels and accuracy in the probabilistic selection task.Conclusions: Results suggest the utility of the pattern ERG in testing the hypothesis that iron deficiency affects DA levels in humans and that this may be one of the mechanisms by which iron deficiency negatively affects cognition.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex- and age-dependent associations of EPA and DHA with very short sleep duration in adults: a cross-sectional analysis. 成人 EPA 和 DHA 与极短睡眠时间的关系与性别和年龄有关：横断面分析。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-10-01 Epub Date: 2024-02-09 DOI: 10.1080/1028415X.2024.2303217

Qianning Liu, Qingsong Shan, Zahid Ur Rehman

{"title":"Sex- and age-dependent associations of EPA and DHA with very short sleep duration in adults: a cross-sectional analysis.","authors":"Qianning Liu, Qingsong Shan, Zahid Ur Rehman","doi":"10.1080/1028415X.2024.2303217","DOIUrl":"10.1080/1028415X.2024.2303217","url":null,"abstract":"Objectives: This study aimed to compare the efficacy of dietary intake of eicosapentaenoic acid (EPA; 20:5 ω-3) and docosahexaenoic acid (DHA; 22:6 ω-3) on very short sleep duration (<5 h/night) in adults.Methods: The bootstrap method was used in the multinomial logistic regression to estimate the ORs and corresponding 95% confidence intervals (CIs) of very short sleep duration. We used rolling window method to analyze the effects of EPA and DHA dietary intakes on very short sleep durations in men and women over age. To illustrate the stability of the results for the selected window width, we built a shiny application.Results: Compared to the first quartile, the mean ORs of EPA intake on very short sleep duration and the corresponding 95% CIs for the second, third and fourth quartiles of EPA intake among men under 32 years old were 1.50 (0.56, 3.44) mg, 1.55 (0.59, 3.48) mg, and 3.99 (1.15, 10.01) mg, respectively. Among women over 44 years old, the ORs for DHA intake were 1.12 (0.81, 1.52) mg, 0.94 (0.68, 1.29) mg, and 0.62 (0.38, 0.98) mg for the second, third and fourth quartiles, respectively.Conclusions: The associations of EPA and DHA with very short sleep duration are sex- and age-dependent. In males under the age of 32, a significant positive correlation exists between dietary EPA intake and very short sleep duration. For women above 44 years of age, an increase in DHA intake can notably ameliorate issues of very short sleep duration.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139712745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0