Nutritional Neuroscience最新文献

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Hypothalamic regulated physiological function and gene expression changes suggest high fructose corn syrup intake affects neurodevelopment in adolescent female rats. 下丘脑调节的生理功能和基因表达变化表明高果糖玉米糖浆摄入影响青春期雌性大鼠的神经发育。
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-28 DOI: 10.1080/1028415X.2025.2509751
Sundus S Lateef, Vanessa L Mueller, Eloisa Vendematti, Vagner A Benedito, Joseph C Gigliotti, R Chris Skinner, Janet C Tou
{"title":"Hypothalamic regulated physiological function and gene expression changes suggest high fructose corn syrup intake affects neurodevelopment in adolescent female rats.","authors":"Sundus S Lateef, Vanessa L Mueller, Eloisa Vendematti, Vagner A Benedito, Joseph C Gigliotti, R Chris Skinner, Janet C Tou","doi":"10.1080/1028415X.2025.2509751","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2509751","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of drinking different caloric sweeteners from immaturity to young adulthood on hypothalamic controlled physiological functions and hypothalamic global gene expression using a rat model.</p><p><strong>Methods: </strong>Young female Sprague-Dawley rats (age 28 days) were randomly assigned (<i>n</i> = 7 rats/group) to drink water sweetened with 13% (w/w) sugar as either high fructose corn syrup (HFCS), sucrose, fructose, or water (control) for 8 weeks. Hypothalamic controlled physiological function measurements included: energy intake, stress, and estrous cycles. RNA-sequencing (RNA-Seq) was used to investigate global differentially expressed genes (DEGs) in the hypothalamus.</p><p><strong>Results: </strong>Rats drinking HFCS and sucrose solution increased liquid intake, but reduced food intake<i>.</i> Rats drinking HFCS had the highest (<i>p</i> < 0.05) absolute adrenal weight, which is indicative of chronic stress, and had lengthened estrous cycles. The DEGs with the highest fold changes in the hypothalamus of rats drinking HFCS compared to sucrose and fructose were involved in circadian sleep cycles, neuronal processes, and <i>Engrailed-2 (En2)</i> identified in autism spectrum disorder (ASD).</p><p><strong>Conclusion: </strong>Among the different caloric-sweetened solutions, young female rats drinking HFCS solution showed food selectivity, elevated basal stress, and reproductive irregularity, which are characteristics associated with ASD. RNA-Seq revealed DEGs in rats drinking HFCS solution, included disrupted circadian sleep cycles, neurotoxicity, and ASD. The results of this preclinical study suggest that HFCS intake should be limited due to its potential for increasing the risk of neurodevelopmental disorders.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individual and combined walnut oil and blueberry attenuate lipopolysaccharide-induced neuroinflammation in rat microglia. 单独和联合核桃油和蓝莓减轻脂多糖诱导的大鼠小胶质细胞神经炎症。
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-26 DOI: 10.1080/1028415X.2025.2509753
Amanda N Carey, Derek R Fisher, Danielle S Cahoon, Barbara Shukitt-Hale
{"title":"Individual and combined walnut oil and blueberry attenuate lipopolysaccharide-induced neuroinflammation in rat microglia.","authors":"Amanda N Carey, Derek R Fisher, Danielle S Cahoon, Barbara Shukitt-Hale","doi":"10.1080/1028415X.2025.2509753","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2509753","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic microglial activation drives neuroinflammation, contributing to neurodegenerative diseases and cognitive decline. Walnuts and blueberries (BB) have been demonstrated to reduce neuroinflammation, but it is unknown whether they act synergistically to enhance the effects seen with individual treatment. This study examined the individual and synergistic effects of walnut oil (WO) and BB on lipopolysaccharide (LPS)-induced neuroinflammation in rat microglial cells. The effects of pretreatment duration and concentration were also explored.</p><p><strong>Methods: </strong>Rat microglial cells were pretreated for 48 hours, one, two, or four weeks with 0.05, 0.1, 0.2, 0.5 and 1.0 mg/mL BB extract, WO or WOBB, followed by exposure to LPS (100 ng/mL). Cell viability was assessed and standard immunochemical techniques were used to measure levels of the inflammatory biomarkers: nitrite, inducible nitrous oxide synthase (iNOS), and cyclooxygenase-2 (COX-2).</p><p><strong>Results: </strong>BB, WO, and WOBB reduced LPS-induced nitrite, COX-2 and iNOS relative to control, with higher concentrations and longer treatment durations typically being most beneficial. All treatments showed similar ability to reduce iNOS expression, while BB had a stronger effect on reducing nitrite production than WO and WOBB. There were no significant differences between treatment effects on COX-2 expression.</p><p><strong>Conclusion: </strong>BB and WO each reduced LPS-induced inflammation in microglia, but their combination was not more effective, suggesting no synergistic effect. This result suggests that they may work through similar mechanisms to attenuate inflammation in microglia. Overall, the reduction in neuroinflammation shows that the addition of BBs or walnuts to the diet may attenuate neuroinflammation linked to neurodegeneration.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":3.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary factors and the incidence of intracranial aneurysms: a Mendelian randomization research. 饮食因素与颅内动脉瘤发病率:孟德尔随机研究。
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-10-02 DOI: 10.1080/1028415X.2024.2403894
Gu Linazi, Aierpati Maimaiti, Zulihuma Abulaiti, Niyaziaili Adili, Jiaoqiong Guan, Aimitaji Abulaiti
{"title":"Dietary factors and the incidence of intracranial aneurysms: a Mendelian randomization research.","authors":"Gu Linazi, Aierpati Maimaiti, Zulihuma Abulaiti, Niyaziaili Adili, Jiaoqiong Guan, Aimitaji Abulaiti","doi":"10.1080/1028415X.2024.2403894","DOIUrl":"10.1080/1028415X.2024.2403894","url":null,"abstract":"<p><strong>Background: </strong>Intracranial aneurysms (IAs) pose a significant threat to morbidity and mortality, yet their etiology remains inadequately comprehended. The present study employs Mendelian randomization (MR) to investigate the relationship among dietary elements with IAs, encompassing unruptured intracranial aneurysms (uIA) as well as aneurysmal subarachnoid hemorrhage (aSAH).</p><p><strong>Methods: </strong>The current study employed a double-sample MR test utilizing genome-wide association study (GWAS) summary data from the IEU and IAs' meta-analysis to investigate the genetically predicted consumption levels of various dietary factors using GWAS data. Causation was assessed by techniques of MR-Egger, weighted mode, and median, as well as IVW. To guarantee the accuracy of the results, pleiotropy and heterogeneity evaluations were also carried out.</p><p><strong>Results: </strong>The findings of the study indicate a positive correlation between the intake of alcohol, lamb/mutton, and pork with the risk of IAs (IVW all <i>p</i> < 0.05). Conversely, a negative correlation was observed regarding dried fruit consumption and the risk of aSAH (IVW <i>p</i> < 0.05). There was only scant evidence supporting the association between alcohol intake frequency and an elevated risk of uIA (IVW method <i>p</i> < 0.05). The MR analysis outcomes were authenticated by the MR-PRESSO method and were deemed reliable. Furthermore, sensitivity calculations, such as pleiotropy and homogeneity test, leave-one-out evaluation, and funnel charts, validated the robustness of the results.</p><p><strong>Conclusions: </strong>The findings suggest that reducing alcohol, lamb/mutton, and pork intake, and increasing dried fruit intake may be potential strategies for the prevention of IAs and aSAH. Additional research is necessary to validate these outcomes and elucidate the underlying mechanisms.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"613-621"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of serum vitamin C concentrations with Alzheimer's disease mortality among U.S. adults. 血清维生素 C 浓度与美国成年人阿尔茨海默病死亡率的关系。
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-11-12 DOI: 10.1080/1028415X.2024.2403900
Li Zhou, Ting Wang, Dan Chen, Guangwen Cheng, Wenfang Li, Xiaoli Cai, Jingling Liao, Wei Bao, Shuang Rong
{"title":"Association of serum vitamin C concentrations with Alzheimer's disease mortality among U.S. adults.","authors":"Li Zhou, Ting Wang, Dan Chen, Guangwen Cheng, Wenfang Li, Xiaoli Cai, Jingling Liao, Wei Bao, Shuang Rong","doi":"10.1080/1028415X.2024.2403900","DOIUrl":"10.1080/1028415X.2024.2403900","url":null,"abstract":"<p><strong>Background: </strong>The association between vitamin C status and Alzheimer's disease (AD) mortality remains unclear.</p><p><strong>Methods: </strong>A total of 4864 adults aged 60 years or above from the National Health and Nutrition Examination Survey III 1988-1994 were included in this study. Serum vitamin C levels were measured by the fully automated electrochemiluminescence immunoassay. Death and underlying causes of death were ascertained by linkage to death records through December 31, 2019. Cox proportional hazards regression models were used to evaluate the association between serum vitamin C and AD mortality.</p><p><strong>Results: </strong>During 65,251 person-years of follow-up (a median follow-up of 12.0 years), 158 deaths occurred from AD. After adjustment for age, sex, race/ethnicity, socioeconomic status, lifestyle and dietary factors, body mass index, baseline diseases and vitamin C supplement use, compared with participants with deficiency serum vitamin C concentrations (< 53 µmol/L), the multivariate-adjusted HR (95% CI) for AD mortality was 0.62 (0.39-0.99) for participants with adequate serum vitamin C concentrations (53-70 µmol/L) and 0.64 (0.34-1.18) for participants with saturate serum vitamin C concentrations <b>(</b>> 70 µmol/L).</p><p><strong>Conclusion: </strong>In this nationally representative sample of US adults, higher serum vitamin C was significantly associated with lower risk of AD mortality. These findings suggest that maintaining adequate vitamin C status may aid in lowering AD mortality risk.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"622-630"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insect-derived extracts and peptides in neuroprotection. 昆虫提取物和肽在神经保护中的作用。
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-08-19 DOI: 10.1080/1028415X.2024.2392410
Shivam Bhola, Eun-Jung Park, Hae-Jeung Lee
{"title":"Insect-derived extracts and peptides in neuroprotection.","authors":"Shivam Bhola, Eun-Jung Park, Hae-Jeung Lee","doi":"10.1080/1028415X.2024.2392410","DOIUrl":"10.1080/1028415X.2024.2392410","url":null,"abstract":"<p><p>Throughout history, various cultures have recognized the significance of insects and have integrated them into traditional medicinal practices. In addition to medicines, insects are garnering attention as a sustainable and nutritious dietary alternative. Although edible insects have long been recognized as food sources in many Asian cultures, recent scientific studies have highlighted their potential therapeutic benefits, particularly in the field of neuroprotection. This review explores insect-derived extracts and peptides, elucidating their neuroprotective potential. This review highlights the potential use of insects as a source of neuroprotective agents. Advancements in neuroprotection may find a key ally in insects as our understanding of the symbiotic relationship between insects and human health becomes more profound.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"541-549"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of the modified Atkins diet and anti-seizure medications on lipid marker levels in adults with epilepsy. 改良阿特金斯饮食和抗癫痫药物对成人癫痫患者血脂标志物水平的影响。
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-04 DOI: 10.1080/1028415X.2024.2397624
Ashley L Muller, Luisa Diaz-Arias, Mackenzie C Cervenka, Tanya J W McDonald
{"title":"The effect of the modified Atkins diet and anti-seizure medications on lipid marker levels in adults with epilepsy.","authors":"Ashley L Muller, Luisa Diaz-Arias, Mackenzie C Cervenka, Tanya J W McDonald","doi":"10.1080/1028415X.2024.2397624","DOIUrl":"10.1080/1028415X.2024.2397624","url":null,"abstract":"<p><strong>Objectives: </strong>Some anti-seizure medications (ASMs) are known to induce liver enzymes and impact lipid values that include total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglyceride (TG). In addition, use of ketogenic diet therapies, including the modified Atkins diet (MAD), has also influenced lipids. Here, we explored the combined impact of enzyme inducing ASMs (EIASMs) and MAD on lipid values in adults with epilepsy.</p><p><strong>Methods: </strong>Diet-naïve adults with epilepsy who began MAD were divided into three groups based on ASM use: EIASMs, non-EIASMs, and those on no ASMs. Demographic information, epilepsy-specific clinical history, anthropometrics and lipid values were obtained through retrospective chart review at baseline and after a minimum of 12 months of MAD use.</p><p><strong>Results: </strong>Forty-two adults on MAD had baseline and follow up 12-month lipid outcomes. There was a significant increase in median levels of TC, LDL, non-HDL, and HDL after 12 months of MAD use. There was no change in median levels of TG. When separated according to ASM category, adults on non-EIASMs showed significant elevations in TC, HDL, and LDL after 12 months of MAD use. In contrast, adults on EIASMs only showed a significant increase in HDL after 12 months of MAD use.</p><p><strong>Discussion: </strong>The increase in atherogenic cholesterol levels observed after 12 months of MAD use was most pronounced in adults with epilepsy on non-EIASMs and not observed in adults with epilepsy on EIASMs despite a higher proportion of abnormal cholesterol levels at baseline in those on EIASMs.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"563-572"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basic approach on the protective effects of hesperidin and naringin in Alzheimer's disease. 研究橙皮甙和柚皮甙对阿尔茨海默病的保护作用的基本方法。
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-03 DOI: 10.1080/1028415X.2024.2397136
Müjgan Kuşi, Eda Becer, Hafize Seda Vatansever
{"title":"Basic approach on the protective effects of hesperidin and naringin in Alzheimer's disease.","authors":"Müjgan Kuşi, Eda Becer, Hafize Seda Vatansever","doi":"10.1080/1028415X.2024.2397136","DOIUrl":"10.1080/1028415X.2024.2397136","url":null,"abstract":"<p><strong>Objectives: </strong>Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment. This situation imposes a great burden on individuals, both economically and socially. Today, an effective method for treating the disease and protective approach to tau accumulation has not been developed yet. Studies have been conducted on the effects of hesperidin and naringin flavonoids found in citrus fruits on many diseases.</p><p><strong>Methods: </strong>In this review, the pathophysiology of AD is defined, and the effects of hesperidin and naringin on these factors are summarized.</p><p><strong>Results: </strong>Studies have shown that both components may potentially affect AD due to their antioxidative and anti-inflammatory properties. Based on these effects of the components, it has been shown that they may have ameliorative effects on Aβ, α-synuclein aggregation, tau pathology, and cognitive functions in the pathophysiology of AD.</p><p><strong>Discussion: </strong>There are studies suggesting that hesperidin and naringin may be effective in the prevention/treatment of AD. When these studies are examined, it is seen that more studies should be conducted on the subject.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"550-562"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
β-hydroxybutyrate and mitochondria mediate the association between medium-chain fatty acids, DHA and mild cognitive impairment: a nested case-control study. β-羟丁酸和线粒体介导中链脂肪酸、DHA与轻度认知障碍之间的关系:一项巢式病例对照研究。
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-03 DOI: 10.1080/1028415X.2024.2398364
Tong Yang, Huilian Duan, Yuan Li, Ning Xu, Zehao Wang, Zhenshu Li, Yongjie Chen, Yue Du, Meilin Zhang, Jing Yan, Changqing Sun, Guangshun Wang, Wen Li, Xin Li, Fei Ma, Guowei Huang
{"title":"β-hydroxybutyrate and mitochondria mediate the association between medium-chain fatty acids, DHA and mild cognitive impairment: a nested case-control study.","authors":"Tong Yang, Huilian Duan, Yuan Li, Ning Xu, Zehao Wang, Zhenshu Li, Yongjie Chen, Yue Du, Meilin Zhang, Jing Yan, Changqing Sun, Guangshun Wang, Wen Li, Xin Li, Fei Ma, Guowei Huang","doi":"10.1080/1028415X.2024.2398364","DOIUrl":"10.1080/1028415X.2024.2398364","url":null,"abstract":"<p><strong>Background: </strong>Medium-chain fatty acids (MCFAs) and docosahexaenoic acid (DHA) could affect the occurrence of mild cognitive impairment (MCI). β-hydroxybutyrate (BHB), mitochondrial DNA copy number (mtDNAcn) and mitochondrial DNA (mtDNA) deletions might be their potential mechanisms. This study aimed to explore the relationship between MCFAs, DHA and MCI, and potential mechanisms.</p><p><strong>Methods: </strong>This study used data from Tianjin Elderly Nutrition and Cognition (TENC) cohort study, 120 individuals were identified with new onset MCI during follow-up, 120 individuals without MCI were selected by 1:1 matching sex, age, and education levels as the control group from TENC. Conditional logistic regression analysis and mediation effect analysis were used to explore their relationship.</p><p><strong>Results: </strong>Higher serum octanoic acid levels (OR: 0.633, 95% CI: 0.520, 0.769), higher serum DHA levels (OR: 0.962, 95% CI: 0.942, 0.981), and more mtDNAcn (OR: 0.436, 95% CI: 0.240, 0.794) were associated with lower MCI risk, while more mtDNA deletions was associated with higher MCI risk (OR: 8.833, 95% CI: 3.909, 19.960). Mediation analysis suggested that BHB and mtDNAcn, in series, have mediation roles in the association between octanoic acid and MCI risk, and mtDNA deletions have mediation roles in the association between DHA and MCI risk.</p><p><strong>Conclusion: </strong>Higher serum octanoic acid and DHA levels were associated with lower MCI risk. Octanoic acid could affect the incidence of MCI through BHB, then mitochondria function, or through mitochondria function, or directly. Serum DHA level could affect the incidence of MCI through mitochondria function, or directly.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"573-582"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary inflammatory potential and severe headache or migraine: a systematic review of observational studies. 饮食炎症潜能与严重头痛或偏头痛:观察性研究的系统回顾。
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-09 DOI: 10.1080/1028415X.2024.2391814
Nasser S Alqahtani, Mohammed Suleiman Zaroog, Baker Mohammad Abdallah Albow
{"title":"Dietary inflammatory potential and severe headache or migraine: a systematic review of observational studies.","authors":"Nasser S Alqahtani, Mohammed Suleiman Zaroog, Baker Mohammad Abdallah Albow","doi":"10.1080/1028415X.2024.2391814","DOIUrl":"10.1080/1028415X.2024.2391814","url":null,"abstract":"<p><strong>Objectives: </strong>We conducted the current systematic review to investigate the association between dietary inflammatory index (DII) and severe headaches or migraine among adults via synthesizing observational evidence.</p><p><strong>Method: </strong>We conducted a systematic literature search of observational studies through PubMed, Scopus, and Web of Science databases from inception until July 2024. The PECO framework was implemented to select eligible studies as follows: Population (adults with severe headache or migraine), Exposure (individuals with the highest adherence to a pro-inflammatory diet), Comparison (individuals with the lowest adherence to a pro-inflammatory diet), Outcome (risk of developing severe headache or migraine, headaches frequency, duration, severity, and migraine-related disability).</p><p><strong>Results: </strong>After reviewing six studies involving 31,958 individuals, we found that following an anti-inflammatory diet is associated with a lower frequency and severity of migraine headaches. Additionally, our research revealed that individuals with migraines tend to have lower adherence to an anti-inflammatory diet when compared to people without migraines. Surprisingly, adherence to a pro-inflammatory diet was linked to a reduced risk of chronic daily headaches.</p><p><strong>Conclusion: </strong>Present findings imply a negative link between an inflammatory diet and severe headaches or migraine. However, further well-designed longitudinal studies are needed to interpret the causality and shed light on the underlying mechanisms.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"532-540"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective effects of brown rice consumption in an iron-induced parkinsonism in Drosophila. 食用糙米对铁诱导的果蝇帕金森症的神经保护作用
IF 3.6 4区 医学
Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-05 DOI: 10.1080/1028415X.2024.2399988
Yaaqub Abiodun Uthman, Kasimu Ghandi Ibrahim, Murtala Bello Abubakar, Ismail Sulaiman, Mustapha Umar Imam
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