Nutritional Neuroscience最新文献

{"title":"Association between healthy dietary pattern and common mental disorders in women: a cross-sectional population-based study.","authors":"Jéssica Casagrande Oliveira, Anderson Garcez, Juvenal Soares Dias-da-Costa, Maria Teresa Anselmo Olinto","doi":"10.1080/1028415X.2024.2448923","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2448923","url":null,"abstract":"<p><strong>Objectives: </strong>Scientific evidence suggests an association between diet quality and the prevalence of common mental disorders (CMD) in women. Thus, this study aimed to investigate the association between a healthy dietary pattern and CMD among women.</p><p><strong>Methods: </strong>A cross-sectional population-based study was conducted on a representative sample of 1128 women, aged 20-69 years, residing in the urban area of São Leopoldo, RS, Brazil. A validated food frequency questionnaire was used to assess dietary intake. A healthy dietary pattern, primarily consisting of fruits and vegetables, was identified using principal component analysis. CMD were evaluated using the Self-Reporting Questionnaire (SRQ-20: score ≥ 8). Prevalence ratios (PR) with 95% confidence intervals (CI) were estimated using multivariate Poisson regression with robust variance.</p><p><strong>Results: </strong>The overall prevalence of CMD was 33.2% (95% CI: 30.6-36.1). After adjusting for potential confounding factors, a statistically significant inverse relationship between a healthy dietary pattern and CMD was observed. High adherence to a healthy dietary pattern was associated with a lower prevalence of CMD (PR = 0.74; 95% CI: 0.59-0.95; <i>p</i> = 0.017). Women with a higher score on the healthy dietary pattern were 26% less likely to have CMD.</p><p><strong>Conclusions: </strong>This study highlights a significant inverse association between a healthy dietary pattern and CMD in women. A high prevalence of CMD was also observed in this population group. These findings underscore the importance of promoting healthy dietary intake to prevent psychiatric disorders.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-9"},"PeriodicalIF":3.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common salt (NaCl) causes developmental, behavioral, and physiological defects in <i>Drosophila melanogaster</i>.","authors":"Swetapadma Sahu, Kalpanarani Dash, Monalisa Mishra","doi":"10.1080/1028415X.2024.2441677","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2441677","url":null,"abstract":"<p><strong>Purpose: </strong>The incidence of obesity has surged to pandemic levels in recent decades. Approximately 1.89 million obesity are linked to excessive salt consumption. This study aims to check the toxicity of salt at different concentrations using an invertebrate model organism <i>Drosophila melanogaster.</i></p><p><strong>Methods: </strong>Drosophila food was mixed with different salt concentrations (50, 200, 400, 800 µM). The toxicity of salt in third instar larvae was checked via different experiments such as trypan blue assay, crawling assay, and other histological staining was done to check the deposition of lipid droplets and amount of reactive oxygen species. Food intake analysis was performed to check the feeding rate, and body weight was also calculated to check the obesity index. Several behavioral assays are also performed in adult flies.</p><p><strong>Results: </strong>Most significant abnormalities were seen at 50 and 200 µM concentrations. Feeding rate increased up to 60%, body weight was increased up to 12% in larvae, and 27% in adult at 200 µM concentration. Approximately 60% larvae and 58% adult flies had defective response to extreme heat. 28% larvae and 38% adult flies were not responding to cold temperature. 55% flies had a defective phototaxis behavior and 40% of them showed positive geotaxis at those range. Salt stress leads to the buildup of free radicals, resulting in DNA damage in both the gut and hemolymph.</p><p><strong>Findings: </strong>Most toxic consequences are observed at the lower concentration range as the feeding rate was higher. Flies show aversive response to feed on the higher concentration of salt.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition/exercise interaction in the rat mother-pup dyad: a behavioral and electrophysiological analysis.","authors":"Maria Luísa Figueira de Oliveira, Anna Carolina Lopes de Lira, José Anderson da Silva Gomes, Amanda Ferraz Braz, Fernando Wesley Cavalcanti de Araújo, Arthur Gabriel Aves Furtado de Carvalho Noya, Carol Virgínia Góis Leandro, Rubem Carlos Araujo Guedes","doi":"10.1080/1028415X.2024.2448137","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2448137","url":null,"abstract":"<p><strong>Objectives: </strong>Maternal protein malnutrition alters brain functioning, impairing fetal development. Physical exercise during gestation benefits the fetal organism from maternal adaptive changes that may be neuroprotective. This study evaluated the effect of a low-protein diet associated with maternal voluntary physical activity (VPA) on rats' behavioral and brain electrophysiological parameters in the mother-pup dyad.</p><p><strong>Methods: </strong>Female Wistar rats (n = 40) performed VPA on running wheels during a 30-day pre-mating period. Daily running distance, activity duration, and caloric expenditure enabled us to classify the dams as sedentary or exercised. During pregnancy, half of the mothers were fed a low-protein diet (8% protein from casein), and the other half was fed a standard diet with 17% protein from casein. After lactation, when the mothers reached 150-160 days and the pups aged 30-35, animals were tested to evaluate anxiety-like behaviors in the open field and the elevated plus maze, and assess object recognition memory in the open field apparatus. At 160-170 days of life (mothers) and 35-45 days (pups), the animals were subjected to a recording session of the excitability-related phenomenon known as cortical spreading depression (CSD).</p><p><strong>Results: </strong>In the mother-pup dyad, malnutrition accelerated CSD, increased anxiety-like behavior, and impaired memory, whereas VPA produced the opposite effects. The greater impact of exercise was observed among the malnourished animals.</p><p><strong>Discussion: </strong>Our results provide important evidence about the beneficial modulating role of perinatal VPA (before, during and up to 14 days after pregnancy) in reprograming the effects of protein malnutrition on the central nervous system.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-15"},"PeriodicalIF":3.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic evaluation and meta-analysis of the effects of major dietary patterns on cognitive function in healthy adults.","authors":"HanQing Guo, Qi Tian, XueMei Qin, Qing Luo, XiuMei Gong, Qinghan Gao","doi":"10.1080/1028415X.2024.2342164","DOIUrl":"10.1080/1028415X.2024.2342164","url":null,"abstract":"<p><strong>Purpose: </strong>Evidence shows diet promotes brain health. Combining foods and nutrients may have beneficial synergistic effects, but the effects on cognitive function interventions are inconsistent. So, a meta-analysis of RCTs was conducted to examine the specific effects on cognitive function.</p><p><strong>Methods: </strong>We searched four databases from creation to April 2023. Eligible randomized controlled trials were identified. A random-effects meta-analysis was used to combine standardized mean differences (SMD) (95% confidence intervals [CI]), and homogeneity tests for a variance were calculated.</p><p><strong>Results: </strong>A total of 19 studies involving 12,119 participants were included in this systematic review. The dietary intervention group had a positive effect on overall cognitive functioning compared to the control group (SMD = 0.14, 95% CI [0.08, 0.20], <i>P</i> < 0.00001). The dietary intervention improved executive function, processing speed and language skills (SMD = -0.10, 95% CI [-0.17,-0.04], <i>P</i> = 0.002, <i>I</i>² = 0%), (SMD = -0.16, 95% CI [-0.23,-0.09], <i>P</i> < 0.00001, <i>I</i>² = 0%), (SMD = 0.10, 95% CI [0.01, 0.20], <i>P</i> = 0.03, <i>I</i>² = 0%). The dietary intervention had no effect on delayed memory and spatial ability (SMD = 0.04, 95% CI [-0.02, 0.09], <i>P</i> = 0.20, <i>I</i>² = 0%), (SMD = 0.08, 95% CI [-0.01, 0.16], <i>P</i> = 0.08, <i>I</i>² = 0%).</p><p><strong>Conclusion: </strong>The Mediterranean diet, a diet with restricted caloric intake, a diet incorporating aerobic exercise, a low-carbohydrate diet, and a healthy lifestyle diet (increased intake of fruits and vegetables, and weight and blood pressure management) appear to have positive effects on cognitively healthy adults, as reflected in their overall cognitive, processing speed, executive, and language functions.</p><p><strong>Prospero registration number: </strong>CRD42023414704.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The symptomatology of Attention-Deficit/Hyperactivity Disorder and the genetic control of vitamin D levels.","authors":"Cibele Edom Bandeira, Fernando Godoy Pereira das Neves, Diego Luiz Rovaris, Eugenio Horacio Grevet, Monique Dias-Soares, Caroline da Silva, Fabiane Dresch, Bruna Santos da Silva, Claiton Henrique Dotto Bau, Flávio Milman Shansis, Júlia Pasqualini Genro, Verônica Contini","doi":"10.1080/1028415X.2024.2351322","DOIUrl":"10.1080/1028415X.2024.2351322","url":null,"abstract":"<p><strong>Objectives: </strong>Vitamin D deficiency has been associated with psychiatric disorders and behavioral phenotypes such as Attention-Deficit/Hyperactivity Disorder (ADHD). Considering that vitamin D levels are polygenic, we aim to evaluate the overall effects of its genetic architecture on symptoms of inattention, hyperactivity, and impulsivity and on the serum levels of vitamin D in two independent samples of adults, as well as the specific effects of five relevant polymorphisms in vitamin D-related genes.</p><p><strong>Methods: </strong>We evaluated 870 subjects from an ADHD sample (407 cases and 463 controls) and 319 subjects from an academic community (nutrigenetic sample). Vitamin D serum levels were obtained through Elisa test and genetic data by TaqMan™ allelic discrimination and Infinium PsychArray-24 BeadChip genotyping. Polygenic Scores (PGS) were calculated on PRSice2 based on the latest GWAS for Vitamin D and statistical analyses were conducted at Plink and SPSS software.</p><p><strong>Results: </strong>Vitamin D PGSs were associated with inattention in the ADHD sample and with hyperactivity when inattention symptoms were included as covariates. In the nutrigenetic sample, <i>CYP2R1</i> rs10741657 and <i>DHCR7</i> rs12785878 were nominally associated with impulsivity and hyperactivity, respectively, and both with vitamin D levels. In the clinical sample, <i>RXRG</i> rs2134095 was associated with impulsivity.</p><p><strong>Discussion: </strong>Our findings suggest a shared genetic architecture between vitamin D levels and ADHD symptoms, as evidenced by the associations observed with PGS and specific genes related to vitamin D levels. Interestingly, differential effects for vitamin D PGS were found in inattention and hyperactivity, which should be considered in further studies involving ADHD.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"87-97"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization study supports relative carbohydrate intake as an independent risk factor for amyotrophic lateral sclerosis.","authors":"Youjie Zeng, Ren Guo, Si Cao, Sarel Chavarria Gonzalez, Ke Pang, Chunxia Liu, Heng Yang","doi":"10.1080/1028415X.2024.2352196","DOIUrl":"10.1080/1028415X.2024.2352196","url":null,"abstract":"<p><strong>Objectives: </strong>Observational studies suggested a potential correlation between dietary intake and amyotrophic lateral sclerosis (ALS), but conflicting findings exist and causality remains unclear. Here, we performed a Mendelian randomization (MR) analysis to evaluate the causal impact of relative intake of (i) carbohydrate, (ii) fat, and (iii) protein on ALS risk.</p><p><strong>Methods: </strong>The genome-wide association summary statistics of three dietary macronutrient intake traits and ALS were obtained. Initially, forward and reverse univariable MR (UVMR) analysis were conducted using the inverse variance weighted (IVW) method as the primary approach, supplemented by MR-Egger, weighted median, and maximum likelihood. Subsequently, multivariable MR (MVMR) analysis was performed to assess the independent causal effects of each dietary. Additionally, diverse sensitivity tests were conducted to evaluate the reliability of the MR analyses.</p><p><strong>Results: </strong>The forward UVMR analysis conducted by IVW indicated that relative carbohydrate intake significantly increased ALS risk. Furthermore, results from three other MR methods paralleled those from IVW. However, the other two dietary intake traits did not have a causative impact on ALS risk. The reverse UVMR analysis indicated that ALS did not causatively influence the three dietary intake traits. The MVMR analysis showed that after adjusting for the effects of the other two dietary intake traits, relative carbohydrate intake independently and significantly increased ALS risk. Sensitivity tests indicated no significant heterogeneity or horizontal pleiotropy.</p><p><strong>Discussion: </strong>MR analysis supported relative carbohydrate independently increasing ALS risk. Nevertheless, further validation of this finding in future large cohorts is required.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"116-124"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The possible association of dietary fiber intake with the incidence of depressive symptoms in the Korean population.","authors":"Sung Keun Park, Chang-Mo Oh, Jae-Hong Ryoo, Ju Young Jung","doi":"10.1080/1028415X.2024.2352194","DOIUrl":"10.1080/1028415X.2024.2352194","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigates the effect of dietary fiber on the prevention of depressive symptoms.</p><p><strong>Methods: </strong>In a cohort of 88,826 Korean adults (57,284 men and 31,542 women), we longitudinally evaluated the risk of depressive symptoms according to quartiles of dietary fiber intake for 5.8 years of follow-up. A food frequency questionnaire was used in evaluating dietary fiber intake. Depressive symptoms were assessed by the Center for Epidemiological Studies-Depression (CES-D) scale, in which CES-D ≥ 16 was defined as depressive symptoms. The Cox proportional hazards model was used to calculate the adjusted hazard ratio (HR) and 95% confidence intervals (CI) for depressive symptoms (adjusted HR [95% CI]). Subgroup analysis was performed for gender and BMI (≥25 or <25).</p><p><strong>Result: </strong>In men, the risk of depressive symptoms significantly decreased with the increase of dietary fiber (quartile 1: reference, quartile 2: 0.93 [0.87-0.99], quartile 3: 0.91 [0.85-0.98] and quartile 4: 0.84 [0.77-0.92]). This association was more prominently observed in men with BMI ≥ 25 (quartile 1: reference, quartile 2: 0.95 [0.86-1.06], quartile 3: 0.88 [0.79-0.99] and quartile 4: 0.84 [0.73-0.97]). Women did not show a significant association between quartile groups of dietary fiber intake and the risk of depressive symptoms across subgroup analysis for BMI.</p><p><strong>Conclusion: </strong>High intake of dietary fiber is potentially effective in reducing depressive symptoms in Korean men. The protective effect of dietary fiber on depressive symptoms may vary by gender and obesity.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"98-106"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurturing development: how a mother's nutrition shapes offspring's brain through the gut.","authors":"Mara Ioana Ionescu, Carmen Denise Mihaela Zahiu, Adelina Vlad, Felicia Galos, Gratiela Gradisteanu Pircalabioru, Ana-Maria Zagrean, Siobhain M O'Mahony","doi":"10.1080/1028415X.2024.2349336","DOIUrl":"10.1080/1028415X.2024.2349336","url":null,"abstract":"<p><p>Pregnancy is a transformative period marked by profound physical and emotional changes, with far-reaching consequences for both mother and child. Emerging research has illustrated the pivotal role of a mother's diet during pregnancy in influencing the prenatal gut microbiome and subsequently shaping the neurodevelopment of her offspring. The intricate interplay between maternal gut health, nutrition, and neurodevelopmental outcomes has emerged as a captivating field of investigation within developmental science. Acting as a dynamic bridge between mother and fetus, the maternal gut microbiome, directly and indirectly, impacts the offspring's neurodevelopment through diverse pathways. This comprehensive review delves into a spectrum of studies, clarifying putative mechanisms through which maternal nutrition, by modulating the gut microbiota, orchestrates the early stages of brain development. Drawing insights from animal models and human cohorts, this work underscores the profound implications of maternal gut health for neurodevelopmental trajectories and offers a glimpse into the formulation of targeted interventions able to optimize the health of both mother and offspring. The prospect of tailored dietary recommendations for expectant mothers emerges as a promising and accessible intervention to foster the growth of beneficial gut bacteria, potentially leading to enhanced cognitive outcomes and reduced risks of neurodevelopmental disorders.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"50-72"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum cryptoxanthin levels and migraine in American adults: results from NHANES.","authors":"Shuai Qing, Jianfeng Wang, Shiming Huang, Min Xiao, Qishan Yi","doi":"10.1080/1028415X.2024.2443092","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2443092","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress and neuroinflammation play critical roles in the pathogenesis of migraine, a neurovascular disease. Cryptoxanthin is a carotenoid known for its potent antioxidant and anti-inflammatory properties. However, the specific association between serum cryptoxanthin levels and migraine remains unclear. This study aims to evaluate the correlation between migraine and serum cryptoxanthin levels.</p><p><strong>Methods: </strong>For this cross-sectional analysis, information was gathered from individuals ≥20 years who took part in the National Health and Nutrition Examination Survey from 2001 to 2004. Details information was collected on migraines, serum cryptoxanthin levels and various crucial factors. Multivariable logistic regression and restricted cubic spline regression analyses were performed to investigate the relationship between serum cryptoxanthin and the occurrence of migraines.</p><p><strong>Results: </strong>The study included 8,645 participants, of whom 20.00%(1734/8645) experienced migraine. There was a nonlinear relationship (<i>p</i> < 0.001) between serum cryptoxanthin levels and migraine, which was depicted as an L-shaped curve. The occurrence rate of individuals with serum cryptoxanthin levels below 26.64 nmol/dL experiencing migraine was 0.976 (95% CI: 0.965∼0.987, <i>p</i><0.001).</p><p><strong>Conclusion: </strong>In adults among the United States, increased levels of serum cryptoxanthin were associated with decreased risk of migriane with a turning point at around 26.64 nmol/dL in American adults. Further studys are needed to confirm our findings.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-11"},"PeriodicalIF":3.6,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of <i>Acacia catechu</i> and <i>Scutellaria baicalensis</i> extract on cognitive function in a healthy adult population: a double-blind, randomized, placebo-controlled trial.","authors":"Joesi M Krieger, Anthony M Hagele, Petey W Mumford, Diego De Gregorio, Connor J Gaige, Ethan R Hoffman, Kristen N Gross, Kevin F Holley, Leah E Allen, Chad M Kerksick","doi":"10.1080/1028415X.2024.2442425","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2442425","url":null,"abstract":"<p><p>Flavonoids, known for their neuroprotective properties, are abundant in <i>Acacia catechu</i> and <i>Scutellaria baicalensis.</i> Yet, human studies on their combined effects are limited.</p><p><strong>Objective: </strong>This study evaluated the cognitive effects of combined <i>Acacia catechu</i> and <i>Scutellaria baicalensis</i> supplementation in healthy adults.</p><p><strong>Methods: </strong>In a randomized, double-blind, placebo-controlled trial, 26 males and 59 females (<i>N</i> = 85; 43 ± 8 yrs) consumed the test product (TP) containing 240 mg stem extract of <i>Scutellaria baicalensis</i> and 51 mg heartwood extract of <i>Acacia catechu</i> (UP326, Unigen, Tacoma, WA USA) or placebo (PLA) for four weeks. Cognitive function and biomarkers were assessed throughout the study.</p><p><strong>Results: </strong>Significant time effects (<i>p</i> < 0.001) were observed across cognitive function assessments, with no differences between groups. Energy and fatigue reports showed a significant time effect (<i>p</i> = 0.023), while no significant differences emerged in general health and well-being scores. Cortisol levels increased significantly over time across conditions (<i>p</i> = 0.005), but no significant changes were observed in change scores or individual visits. Interim (<i>p</i> = 0.023) and final (<i>p</i> = 0.004) absolute basophil levels differed significantly between groups, with no intergroup changes. No significant differences in BDNF, CRP, or health and safety biomarkers were detected between supplemental conditions or over time.</p><p><strong>Discussion: </strong>Four-week daily TP supplementation significantly enhanced cognitive function without difference from placebo. However, no adverse events or significant blood marker changes were noted, suggesting TP supplementation is generally well-tolerated. Further research is warranted to explore the preventive and attenuating cognitive effects of this supplementation.<b>Trial registration:</b> ISRCTN.org identifier: ISRCTN16548309.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":3.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}