Effects of Acacia catechu and Scutellaria baicalensis extract on cognitive function in a healthy adult population: a double-blind, randomized, placebo-controlled trial.

Flavonoids, known for their neuroprotective properties, are abundant in Acacia catechu and Scutellaria baicalensis. Yet, human studies on their combined effects are limited.

Objective: This study evaluated the cognitive effects of combined Acacia catechu and Scutellaria baicalensis supplementation in healthy adults.

Methods: In a randomized, double-blind, placebo-controlled trial, 26 males and 59 females (N = 85; 43 ± 8 yrs) consumed the test product (TP) containing 240 mg stem extract of Scutellaria baicalensis and 51 mg heartwood extract of Acacia catechu (UP326, Unigen, Tacoma, WA USA) or placebo (PLA) for four weeks. Cognitive function and biomarkers were assessed throughout the study.

Results: Significant time effects (p < 0.001) were observed across cognitive function assessments, with no differences between groups. Energy and fatigue reports showed a significant time effect (p = 0.023), while no significant differences emerged in general health and well-being scores. Cortisol levels increased significantly over time across conditions (p = 0.005), but no significant changes were observed in change scores or individual visits. Interim (p = 0.023) and final (p = 0.004) absolute basophil levels differed significantly between groups, with no intergroup changes. No significant differences in BDNF, CRP, or health and safety biomarkers were detected between supplemental conditions or over time.

Discussion: Four-week daily TP supplementation significantly enhanced cognitive function without difference from placebo. However, no adverse events or significant blood marker changes were noted, suggesting TP supplementation is generally well-tolerated. Further research is warranted to explore the preventive and attenuating cognitive effects of this supplementation.Trial registration: ISRCTN.org identifier: ISRCTN16548309.