Nutritional Neuroscience最新文献_第9页

The association between plant and animal protein intake with depression, anxiety, and stress. 植物蛋白和动物蛋白摄入量与抑郁、焦虑和压力之间的关系。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-09 DOI: 10.1080/1028415X.2024.2372194

Bita Forootani, Bahareh Sasanfar, Amin Salehi-Abargouei, Masoud Mirzaei

{"title":"The association between plant and animal protein intake with depression, anxiety, and stress.","authors":"Bita Forootani, Bahareh Sasanfar, Amin Salehi-Abargouei, Masoud Mirzaei","doi":"10.1080/1028415X.2024.2372194","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2372194","url":null,"abstract":"Background: Recent evidence suggests that diet composition is a key biological factor related to the development of depressive disorders. The present study was conducted to investigate the animal and plant protein intake and their replacement in association with depression, anxiety, and stress in Iranian adults.Method: In this cross-sectional study, the dietary intake of 7169 subjects were assessed using a validated food frequency questionnaire. The depression, anxiety, and stress Scale - 21 (DASS-21) questionnaire was used to psychological disorders. Logistic regression was used to obtain odds ratios for depression, anxiety, and stress across quintiles of animal and plant protein.Results: The participants' age range was 20-69 years. Individuals with the highest animal protein consumption had a lower chance for developing depression compared to those with the lowest intakes (OR = 0.73, 95%CI: 0.59-0.90; Ptrend < 0.01). Results also showed a significant association between animal protein intake and anxiety, such that subjects in the highest quintile of animal protein intake had 24% lower odds for anxiety compared to those in the lowest quintile (p < 0.05). We found a significant association between highest quintiles of animal protein intake and a 40% lower risk for stress among female individuals (Ptrend = 0.05). The multivariable-adjusted non-linear analyses also revealed that the replacement of plant protein with animal protein was significantly associated with the likelihood of depression and anxiety (P < 0.05).Conclusion: Animal protein intake might lower the odds of depression and anxiety particularly. Future prospective investigations are proposed to confirm these findings.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-14"},"PeriodicalIF":3.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the acute impact of rosemary consumption on brain activity in healthy volunteers. 研究食用迷迭香对健康志愿者大脑活动的急性影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-06 DOI: 10.1080/1028415X.2024.2370729

Aynur Muduroglu-Kirmizibekmez, Ceren Cati, Alparslan Onder, Sevcan Aydin, Ihsan Kara

{"title":"Investigation of the acute impact of rosemary consumption on brain activity in healthy volunteers.","authors":"Aynur Muduroglu-Kirmizibekmez, Ceren Cati, Alparslan Onder, Sevcan Aydin, Ihsan Kara","doi":"10.1080/1028415X.2024.2370729","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2370729","url":null,"abstract":"Objectives: Rosmarinus officinalis L. (rosemary) is a fragrant plant of the mint family, broadly known as a nourishment flavoring agent; it is additionally utilized in conventional people cures for its anti-inflammatory, diuretic, and antibacterial properties. Intense cognitive impacts from devouring plant-based flavonoids can be measured with electroencephalography (EEG), which records unconstrained brain movement. Brain activity can be evaluated amid independent states or whereas performing attentional assignments. This study aimed to determine the impact of rosemary consumption on cognitive consequences.Methods: Twenty volunteers took part in the study. EEG was taken for each volunteer twice, before drinking rosemary extract and around one hour after drinking it. EEG information was recorded with a Micromed recording framework inspecting rate of 512 Hz. EEG signals were prepared to be utilized in EEGLAB, an open-source toolbox within the MATLAB environment. The information obtained after the EEG recording was compared with the preliminary EEG information.Results: The signal's power spectral density in theta, delta, and beta frequency bands modestly increased in males and females. Even though there was a significant increase in power at the alpha frequency band in both sexes, this increment was not specific channel-wise.Discussion: The obtained data are consistent with the expected results and similar studies conducted, suggesting that the consumption of rosemary is beneficial for cognitive function in the short term. It is anticipated that forthcoming long-term studies will support the existing data.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":3.6,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy as a window of opportunity for dementia prevention: a narrative review. 怀孕是预防痴呆症的机会之窗：叙述性综述。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-06 DOI: 10.1080/1028415X.2024.2371727

Lauren K Hand, Matthew K Taylor, Debra K Sullivan, Catherine F Siengsukon, Jill K Morris, Laura E Martin, Holly R Hull

{"title":"Pregnancy as a window of opportunity for dementia prevention: a narrative review.","authors":"Lauren K Hand, Matthew K Taylor, Debra K Sullivan, Catherine F Siengsukon, Jill K Morris, Laura E Martin, Holly R Hull","doi":"10.1080/1028415X.2024.2371727","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2371727","url":null,"abstract":"Dementia is a debilitating condition with a disproportionate impact on women. While sex differences in longevity contribute to the disparity, the role of the female sex as a biological variable in disease progression is not yet fully elucidated. Metabolic dysfunctions are drivers of dementia etiology, and cardiometabolic diseases are among the most influential modifiable risk factors. Pregnancy is a time of enhanced vulnerability for metabolic disorders. Many dementia risk factors, such as hypertension or blood glucose dysregulation, often emerge for the first time in pregnancy. While such cardiometabolic complications in pregnancy pose a risk to the health trajectory of a woman, increasing her odds of developing type 2 diabetes or chronic hypertension, it is not fully understood how this relates to her risk for dementia. Furthermore, structural and functional changes in the maternal brain have been reported during pregnancy suggesting it is a time of neuroplasticity for the mother. Therefore, pregnancy may be a window of opportunity to optimize metabolic health and support the maternal brain. Healthy dietary patterns are known to reduce the risk of cardiometabolic diseases and have been linked to dementia prevention, yet interventions targeting cognitive function in late life have largely been unsuccessful. Earlier interventions are needed to address the underlying metabolic dysfunctions and potentially reduce the risk of dementia, and pregnancy offers an ideal opportunity to intervene. This review discusses current evidence regarding maternal brain health and the potential window of opportunity in pregnancy to use diet to address neurological health disparities for women.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-13"},"PeriodicalIF":3.6,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folic acid and autism: updated evidences. 叶酸与自闭症：最新证据。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-05 DOI: 10.1080/1028415X.2024.2367855

Cristiane Vasconcelos, Ingrid Schweigert Perry, Carmem Gottfried, Rudimar Riesgo, Kamila Castro

{"title":"Folic acid and autism: updated evidences.","authors":"Cristiane Vasconcelos, Ingrid Schweigert Perry, Carmem Gottfried, Rudimar Riesgo, Kamila Castro","doi":"10.1080/1028415X.2024.2367855","DOIUrl":"10.1080/1028415X.2024.2367855","url":null,"abstract":"Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that impairs communication, socialization, and behavior. The association of ASD with folic acid has been investigated due to the importance of this vitamin for neurological health. This study is an update of the publication 'Folic acid and autism: What do we know?' and aims to systematically review studies examining the relationship between folic acid and ASD. The search resulted in 2,389 studies on folic acid and ASD, which were selected by two reviewers based on their titles and abstracts. Studies meeting the inclusion criteria were fully read. The 52 included studies involved 10,429 individuals diagnosed with ASD and assessed the intake of vitamin B6, folic acid, and vitamin B12; serum levels of these vitamins, homocysteine, and methionine; therapeutic interventions using folic acid; and the association between maternal exposure to this vitamin and the risk of ASD. The evidence of insufficient folic acid intake in most individuals with ASD remains consistent in this update. No association was found between maternal exposure to folic acid and the risk of ASD in their children. Despite observed improvements in communication, socialization, and behavior in individuals with ASD following folic acid interventions, it is crucial to consider the individuality and complexity of ASD. Given the relevance of the topic, there remains a need for more high-quality research and clinical trials characterized by rigorous methodological designs.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-35"},"PeriodicalIF":3.6,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life malnutrition role in memory, emotional behavior and motor impairments in early brain lesions with potential for neurodevelopmental disorders: a systematic review with meta-analysis. 早期营养不良对可能导致神经发育障碍的早期脑损伤患者的记忆力、情绪行为和运动障碍的影响：系统综述与荟萃分析。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-04 DOI: 10.1080/1028415X.2024.2361572

Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Vanessa da Silva Souza, Henrique José Cavalcanti Bezerra Gouveia, Sabrina da Conceição Pereira, Márcia Maria da Silva, Glayciele Leandro de Albuquerque, Bruno Monteiro Paiva Lima, Augusto Vagner Soares Martins de Lira, Ana Elisa Toscano

{"title":"Early-life malnutrition role in memory, emotional behavior and motor impairments in early brain lesions with potential for neurodevelopmental disorders: a systematic review with meta-analysis.","authors":"Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Vanessa da Silva Souza, Henrique José Cavalcanti Bezerra Gouveia, Sabrina da Conceição Pereira, Márcia Maria da Silva, Glayciele Leandro de Albuquerque, Bruno Monteiro Paiva Lima, Augusto Vagner Soares Martins de Lira, Ana Elisa Toscano","doi":"10.1080/1028415X.2024.2361572","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2361572","url":null,"abstract":"Objectives: The present study aims to evaluate the impact of early exposure to brain injury and malnutrition on episodic memory and behavior.Methods: For this, a systematic review was carried out in the Medline/Pubmed, Web of Science, Scopus, and LILACS databases with no year or language restrictions.Results: Initially, 1759 studies were detected. After screening, 53 studies remained to be read in full. The meta-analysis demonstrated that exposure to double insults worsens episodic recognition memory but does not affect spatial memory. Early exposure to low-protein diets has been demonstrated to aggravate locomotor and masticatory sequelae. Furthermore, it reduces the weight of the soleus muscle and the muscle fibers of the masseter and digastric muscles. Early exposure to high-fat diets promotes an increase in oxidative stress and inflammation in the brain, increasing anxiety- and depression-like behavior and reducing locomotion.Discussion: Epigenetic modifications were noted in the hippocampus, hypothalamus, and prefrontal cortex depending on the type of dietetic exposure in early life. These findings demonstrate the impact of the double insult on regions involved in cognitive and behavioral processes. Additional studies are essential to understand the real impact of the double insults in the critical period.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigation and mechanism of low dose linoleic acid on depression caused by disorder of gut microbiome. 低剂量亚油酸对肠道微生物群紊乱所致抑郁症的缓解作用及其机制

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-04 DOI: 10.1080/1028415X.2024.2366648

Haining Yu, Yinan Song, Maoshan Lou, Shengrong Shen

{"title":"Mitigation and mechanism of low dose linoleic acid on depression caused by disorder of gut microbiome.","authors":"Haining Yu, Yinan Song, Maoshan Lou, Shengrong Shen","doi":"10.1080/1028415X.2024.2366648","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2366648","url":null,"abstract":"Objectives: Depression is a widely prevalent mental disorder, and nutritional interventions play an increasingly important role in its treatment. In this paper, effects of linoleic acid (LA) on depressive behavior in mice induced by gut microbiome disorders were investigated.Methods: Fifty C57BL/6J male mice were randomly separated into five groups, control group (CK), ceftriaxone sodium group (CRO), low-dose linoleic acid group (LLA, 1 g/kg), medium-dose linoleic acid group (MLA, 2 g/kg), and high-dose linoleic acid group (HLA, 5 g/kg). In the LLA, MLA, and HLA groups, mice were treated with ceftriaxone sodium (CRO) to induce depressive behaviors, followed by LA administration. Behavioral tests were used to evaluate depressive behavior. High-throughput sequencing and Hematoxylin-eosin (H&E) staining in gut microenvironment were carried out. ELISA kits were used to measure brain inflammatory factors, and 5-hydroxy-tryptamine (5-HT). Gas chromatography and western blot were used to determine fatty acids compositions and the enzymes expression involved in lipid metabolism in brain respectively.Results: The results showed that 10 weeks CRO treatment contribute to depressive behavior, gut microbiome disturbance, and serotonin system disturbance. LLA and MLA improved the depressive-like behavior, and significantly increased the levels of 5-HT1A, 5-HTT and 5-HT in the hippocampus. LLA was found to improve the diversity of gut microbiome and alleviate colon tissue damage. Meantime, LLA increased the content of linoleic acid, improved the expression of FADS2 and COX-2, increased IL-10 levels, and decreased IL-6 levels in the brain.Discussion: LA alleviated depressive behavior in mice by improving the gut microenvironment, regulate fatty acid metabolism, and modulate inflammation.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of time-restricted eating/feeding on Alzheimer's biomarkers and gut microbiota. 限时进食/喂食对阿尔茨海默氏症生物标志物和肠道微生物群的影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-02 DOI: 10.1080/1028415X.2024.2359868

Maha Gasmi, Novi Silvia Hardiany, Marie van der Merwe, Ian J Martins, Aastha Sharma, Ruth Williams-Hooker

{"title":"The influence of time-restricted eating/feeding on Alzheimer's biomarkers and gut microbiota.","authors":"Maha Gasmi, Novi Silvia Hardiany, Marie van der Merwe, Ian J Martins, Aastha Sharma, Ruth Williams-Hooker","doi":"10.1080/1028415X.2024.2359868","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2359868","url":null,"abstract":"Objectives: Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million individuals globally. Diagnosis typically occurs in advanced stages, and there are limited options for reversing symptoms. Preventive strategies are, therefore, crucial. Time Restricted Eating (TRE) or Time Restricted Feeding (TRF) is one such strategy. Here we review recent research on AD and TRE/TRF in addition to AD biomarkers and gut microbiota.Methods: A comprehensive review of recent studies was conducted to assess the impact of TRE/TRF on AD-related outcomes. This includes the analysis of how TRE/TRF influences circadian rhythms, beta-amyloid 42 (Aß42), pro-inflammatory cytokines levels, and gut microbiota composition.Results: TRE/TRF impacts circadian rhythms and can influence cognitive performance as observed in AD. It lowers beta-amyloid 42 deposition in the brain, a key AD biomarker, and reduces pro-ininflammatory cytokines. The gut microbiome has emerged as a modifiable factor in AD treatment. TRE/TRF changes the structure and composition of the gut microbiota, leading to increased diversity and a decrease in harmful bacteria.Discussion: These findings underscore the potential of TRE/TRF as a preventive strategy for AD. By reducing Aß42 plaques, modulating pro-inflammatory cytokines, and altering gut microbiota composition, TRE/TRF may slow the progression of AD. Further research is needed to confirm these effects and to understand the mechanisms involved. This review highlights TRE/TRF as a promising non-pharmacological intervention in the fight against AD.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-15"},"PeriodicalIF":3.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal overnutritional programming impairs the hypophagia and neuron activation induced by acute lipopolysaccharide in adult male rats. 新生儿营养过剩会影响成年雄性大鼠在急性脂多糖诱导下的食欲减退和神经元活化。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-01 Epub Date: 2023-08-31 DOI: 10.1080/1028415X.2023.2250967

Ana Luiza Wunderlich, Larissa Stopa, Andressa Busetti Martins, Camila Franciele de Souza, Érica Monteiro, Danielly Aguiar, Rhauany Guergolette, Polyana Shishido, Cassia Thais Zaia, Ernane Uchoa

{"title":"Neonatal overnutritional programming impairs the hypophagia and neuron activation induced by acute lipopolysaccharide in adult male rats.","authors":"Ana Luiza Wunderlich, Larissa Stopa, Andressa Busetti Martins, Camila Franciele de Souza, Érica Monteiro, Danielly Aguiar, Rhauany Guergolette, Polyana Shishido, Cassia Thais Zaia, Ernane Uchoa","doi":"10.1080/1028415X.2023.2250967","DOIUrl":"10.1080/1028415X.2023.2250967","url":null,"abstract":"Nutritional status during critical windows in early development can challenge metabolic functions and physiological responses to immune stress in adulthood, such as the systemic inflammation induced by lipopolysaccharide (LPS). The aim of this study was to investigate the long-term effects of post-natal over- and undernutrition on the anorexigenic effect of LPS and its association with neuronal activation in the brainstem and hypothalamus of male rats. Animals were raised in litters of 3 (small - SL), 10 (normal - NL), or 16 (large - LL) pups per dam. On post-natal day 60, male rats were treated with LPS (500 µg/Kg) or vehicle for the evaluation of food intake and c-Fos expression in the area postrema (AP), nucleus of solitary tract (NTS), and paraventricular (PVN), arcuate (ARC), ventromedial (VMH), and dorsomedial (DMH) nuclei of the hypothalamus. SL, NL, and LL animals showed a decreased food consumption after LPS treatment. In under- and normonourished animals, peripheral LPS induced an increase in neuronal activation in the brainstem, PaV, PaMP, and ARC and a decrease in the number of c-Fos-ir neurons in the DMH. Overnourished rats showed a reduced hypophagic response, lower neuron activation in the NTS and PaMP, and no response in the DMH induced by LPS. These results indicate that early nutritional programming displays different responses to LPS, by means of neonatal overnutrition decreasing LPS-mediated anorexigenic effect and neuronal activation in the NTS and hypothalamic nuclei.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"734-744"},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10121843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between adherence to the Mediterranean dietary pattern during early pregnancy and behavioral, mood and cognitive development in children under 1 year of age: a prospective cohort study. 怀孕早期坚持地中海饮食模式与 1 岁以下儿童行为、情绪和认知发展之间的关系：一项前瞻性队列研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-01 Epub Date: 2023-08-25 DOI: 10.1080/1028415X.2023.2249635

Bahareh Jabbarzadeh Ganjeh, Amin Mirrafiei, Ahmad Jayedi, Majid Mirmohammadkhani, Alireza Emadi, Farzaneh Ehsani, Sakineh Shab-Bidar

{"title":"The relationship between adherence to the Mediterranean dietary pattern during early pregnancy and behavioral, mood and cognitive development in children under 1 year of age: a prospective cohort study.","authors":"Bahareh Jabbarzadeh Ganjeh, Amin Mirrafiei, Ahmad Jayedi, Majid Mirmohammadkhani, Alireza Emadi, Farzaneh Ehsani, Sakineh Shab-Bidar","doi":"10.1080/1028415X.2023.2249635","DOIUrl":"10.1080/1028415X.2023.2249635","url":null,"abstract":"Purpose: To investigate the potential relationship between diet quality, represented by the Mediterranean diet score, during early pregnancy and behavioral, mood, and cognitive development in children under 1 year of age in a prospective cohort study in Iran.Methods: 658 Iranian pregnant women and their infants participated in this prospective birth cohort study. The Mediterranean diet score was calculated by using data from a food frequency questionnaire during the first trimester of pregnancy. We assessed the children's development using the Ages and Stages Questionnaire (ASQ) at 6-month age. We used Cox proportional hazard model to calculate the hazard ratio (HR) and 95% confidence interval (CI) of ASQ domains across categories of the Mediterranean diet score.Results: The mean age of the mothers was 28.8 ± 5.08 years old, and the average follow-up duration was 90 weeks. The mean BMI of the mothers before pregnancy was 25.1 ± 4.43 kg/m2. In the multivariable-adjusted model, those infants whose mothers were in the second (HR: 0.44; 95% CI: 0.19, 1.04; P = 0.06) and third (HR: 0.39; 95% CI: 0.17, 0.89; P = 0.03) tertiles of the Mediterranean diet score had a lower risk of communication impairment compared to those who were at the first tertile. There was no association between maternal adherence to the Mediterranean diet during early pregnancy and other domains of the ASQ.Conclusions: Greater adherence to the Mediterranean dietary pattern during the first trimester of pregnancy may be favorably associated with communication abilities at 6-month aged infants. More large-scale cohort studies are needed to confirm our findings.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"726-733"},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10124108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blueberry extracts antagonize Aβ_25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus. 蓝莓提取物可拮抗 Aβ25-35 的神经毒性，并通过 MEK-ERK-BDNF/UCH-L1 信号通路在大鼠和小鼠海马中发挥神经保护作用。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-01 Epub Date: 2023-08-30 DOI: 10.1080/1028415X.2023.2252640

Long Tan, Han Zhang, Haiqiang Li, Shoudan Sun, Quanjun Lyu, Yugang Jiang

{"title":"Blueberry extracts antagonize Aβ25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus.","authors":"Long Tan, Han Zhang, Haiqiang Li, Shoudan Sun, Quanjun Lyu, Yugang Jiang","doi":"10.1080/1028415X.2023.2252640","DOIUrl":"10.1080/1028415X.2023.2252640","url":null,"abstract":"Background: The neuroprotective potential of blueberry (BB) extracts against Alzheimer's disease (AD) has been previously hinted at, while its exact mechanism has remained largely enigmatic.Objective: Our study endeavored to unravel the impacts and mechanisms by which BB extracts ameliorated the learning and memory prowess of AD-afflicted mice, with a specific focus on the MEK-ERK pathway.Methods: We employed 3-month-old APP/PS1 transgenic mice and stratified them into three distinct groups: AD+BB, AD, and control (CT). The Morris Water Maze Test (MWMT) was then administered to gauge their learning and memory faculties. In vitro experiments were executed on Aβ25-35-afflicted rat hippocampal neurons, which were subsequently treated with varying concentrations of BB extracts. We then assessed the expression levels of genes and proteins integral to the MEK-ERKBDNF/UCH-L1 pathway.Results: The data showed that the AD mice demonstrated compromised learning and memory faculties in MWMT. However, the AD+BB cohort showcased marked improvements in performance. Furthermore, in the AD subset, significant elevations in the expressions of MEK2 and ERK1/2 were observed, both at the mRNA and protein levels. Conversely, UCH-L1 mRNA expressions exhibited a decline, while BDNF expressions surged significantly. However, post BB extract treatment, the expressions of MEK2 and ERK1/2 were subdued, with UCH-L1 and BDNF mRNA expressions reverting to control levels.Conclusions: Our findings propounded that BB extracts could offer therapeutic promise for AD by bolstering learning and memory capacities. The unwarranted activation of the MEK-ERK pathway, coupled with the aberrant expressions of BDNF and UCH-L1, might underpin AD's pathogenesis.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"745-760"},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10118340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0