Nutritional Neuroscience最新文献_第9页

Malnutrition risk and associated factors in hospitalized older adult patients with neurological diseases: a retrospective cohort study. 住院老年神经系统疾病患者的营养不良风险及相关因素：一项回顾性队列研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-06-07 DOI: 10.1080/1028415X.2024.2363571

Gabriel Alvarado-Luis, Claudia Mimiaga-Hernández

{"title":"Malnutrition risk and associated factors in hospitalized older adult patients with neurological diseases: a retrospective cohort study.","authors":"Gabriel Alvarado-Luis, Claudia Mimiaga-Hernández","doi":"10.1080/1028415X.2024.2363571","DOIUrl":"10.1080/1028415X.2024.2363571","url":null,"abstract":"Introduction: Malnutrition risk (MR) in older adults with neurological disorders is high, but there is little evidence for validated screening tools in this group, as well as for the clinical and socioeconomic factors associated with a high MR.Objectives: To determine the association of MR using the Malnutrition Universal Screening Tool (MUST) with mortality and length of stay (LOS) in older adults with neurological diseases. Secondarily, the association of clinical, and socioeconomic factors with MR and clinical outcomes was sought.Methods: A retrospective cohort study was carried out at a third-level neurological disease referral center in Mexico. All patients older than 60 years admitted from January 2017 to December 2018 were considered. MUST, clinical and socioeconomic factors were assessed at hospital admission. Outcomes were followed up to hospital discharge or a maximum of 6 months.Results: A total of 765 patients were included, of whom 24.7% (n = 189) were at high risk. A high MR was independently associated with mortality (OR 3.09; 95% CI 1.60-5.98, p = .001) and LOS >14 days (OR 4.38; 95% CI 2.79-6.89, p = <.001). The only factors independently associated with high MR was economic dependence and unemployment. Patients with high MR and economic dependence (OR 4.0; 95% CI 1.34-11.99, p = .013) or unemployment (OR 3.43; 95% CI 1.17-10.06, p = .025) had the highest mortality.Conclusions: In hospitalized older adults with neurological diseases, high MR is independently associated with increased mortality and LOS. Economic dependence or unemployment are associated with worse clinical outcomes in patients with high MR.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"209-218"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating chronic stress and chronic pain by manipulating gut microbiota with diet: can we kill two birds with one stone? 通过饮食控制肠道微生物群来治疗慢性压力和慢性疼痛：我们能一石二鸟吗？

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-06-18 DOI: 10.1080/1028415X.2024.2365021

Alessia Costa, Elena Lucarini

{"title":"Treating chronic stress and chronic pain by manipulating gut microbiota with diet: can we kill two birds with one stone?","authors":"Alessia Costa, Elena Lucarini","doi":"10.1080/1028415X.2024.2365021","DOIUrl":"10.1080/1028415X.2024.2365021","url":null,"abstract":"Background: Chronic stress and chronic pain are closely linked by the capacity to exacerbate each other, sharing common roots in the brain and in the gut. The strict intersection between these two neurological diseases makes important to have a therapeutic strategy aimed at preventing both to maintain mental health in patients. Diet is an modifiable lifestyle factor associated with gut-brain axis diseases and there is growing interest in its use as adjuvant to main therapies. Several evidence attest the impact of specific diets or nutrients on chronic stress-related disorders and pain with a good degree of certainty. A daily adequate intake of foods containing micronutrients such as amino acids, minerals and vitamins, as well as the reduction in the consumption of processed food products can have a positive impact on microbiota and gut health. Many nutrients are endowed of prebiotic, anti-inflammatory, immunomodulatory and neuroprotective potential which make them useful tools helping the management of chronic stress and pain in patients. Dietary regimes, as intermittent fasting or caloric restriction, are promising, although further studies are needed to optimize protocols according to patient's medical history, age and sex. Moreover, by supporting gut microbiota health with diet is possible to attenuate comorbidities such as obesity, gastrointestinal dysfunction and mood disorders, thus reducing healthcare costs related to chronic stress or pain.Objective: This review summarize the most recent evidence on the microbiota-mediated beneficial effects of macro- and micronutrients, dietary-related factors, specific nutritional regimens and dietary intervention on these pathological conditions.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"221-244"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life malnutrition role in memory, emotional behavior and motor impairments in early brain lesions with potential for neurodevelopmental disorders: a systematic review with meta-analysis. 早期营养不良对可能导致神经发育障碍的早期脑损伤患者的记忆力、情绪行为和运动障碍的影响：系统综述与荟萃分析。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI: 10.1080/1028415X.2024.2361572

Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Vanessa da Silva Souza, Henrique José Cavalcanti Bezerra Gouveia, Sabrina da Conceição Pereira, Márcia Maria da Silva, Glayciele Leandro de Albuquerque, Bruno Monteiro Paiva Lima, Augusto Vagner Soares Martins de Lira, Ana Elisa Toscano

{"title":"Early-life malnutrition role in memory, emotional behavior and motor impairments in early brain lesions with potential for neurodevelopmental disorders: a systematic review with meta-analysis.","authors":"Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Vanessa da Silva Souza, Henrique José Cavalcanti Bezerra Gouveia, Sabrina da Conceição Pereira, Márcia Maria da Silva, Glayciele Leandro de Albuquerque, Bruno Monteiro Paiva Lima, Augusto Vagner Soares Martins de Lira, Ana Elisa Toscano","doi":"10.1080/1028415X.2024.2361572","DOIUrl":"10.1080/1028415X.2024.2361572","url":null,"abstract":"Objectives: The present study aims to evaluate the impact of early exposure to brain injury and malnutrition on episodic memory and behavior.Methods: For this, a systematic review was carried out in the Medline/Pubmed, Web of Science, Scopus, and LILACS databases with no year or language restrictions.Results: Initially, 1759 studies were detected. After screening, 53 studies remained to be read in full. The meta-analysis demonstrated that exposure to double insults worsens episodic recognition memory but does not affect spatial memory. Early exposure to low-protein diets has been demonstrated to aggravate locomotor and masticatory sequelae. Furthermore, it reduces the weight of the soleus muscle and the muscle fibers of the masseter and digastric muscles. Early exposure to high-fat diets promotes an increase in oxidative stress and inflammation in the brain, increasing anxiety- and depression-like behavior and reducing locomotion.Discussion: Epigenetic modifications were noted in the hippocampus, hypothalamus, and prefrontal cortex depending on the type of dietetic exposure in early life. These findings demonstrate the impact of the double insult on regions involved in cognitive and behavioral processes. Additional studies are essential to understand the real impact of the double insults in the critical period.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"171-193"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of time-restricted eating/feeding on Alzheimer's biomarkers and gut microbiota. 限时进食/喂食对阿尔茨海默氏症生物标志物和肠道微生物群的影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-07-02 DOI: 10.1080/1028415X.2024.2359868

Maha Gasmi, Novi Silvia Hardiany, Marie van der Merwe, Ian J Martins, Aastha Sharma, Ruth Williams-Hooker

{"title":"The influence of time-restricted eating/feeding on Alzheimer's biomarkers and gut microbiota.","authors":"Maha Gasmi, Novi Silvia Hardiany, Marie van der Merwe, Ian J Martins, Aastha Sharma, Ruth Williams-Hooker","doi":"10.1080/1028415X.2024.2359868","DOIUrl":"10.1080/1028415X.2024.2359868","url":null,"abstract":"Objectives: Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million individuals globally. Diagnosis typically occurs in advanced stages, and there are limited options for reversing symptoms. Preventive strategies are, therefore, crucial. Time Restricted Eating (TRE) or Time Restricted Feeding (TRF) is one such strategy. Here we review recent research on AD and TRE/TRF in addition to AD biomarkers and gut microbiota.Methods: A comprehensive review of recent studies was conducted to assess the impact of TRE/TRF on AD-related outcomes. This includes the analysis of how TRE/TRF influences circadian rhythms, beta-amyloid 42 (Aß42), pro-inflammatory cytokines levels, and gut microbiota composition.Results: TRE/TRF impacts circadian rhythms and can influence cognitive performance as observed in AD. It lowers beta-amyloid 42 deposition in the brain, a key AD biomarker, and reduces pro-ininflammatory cytokines. The gut microbiome has emerged as a modifiable factor in AD treatment. TRE/TRF changes the structure and composition of the gut microbiota, leading to increased diversity and a decrease in harmful bacteria.Discussion: These findings underscore the potential of TRE/TRF as a preventive strategy for AD. By reducing Aß42 plaques, modulating pro-inflammatory cytokines, and altering gut microbiota composition, TRE/TRF may slow the progression of AD. Further research is needed to confirm these effects and to understand the mechanisms involved. This review highlights TRE/TRF as a promising non-pharmacological intervention in the fight against AD.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"156-170"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigation and mechanism of low dose linoleic acid on depression caused by disorder of gut microbiome. 低剂量亚油酸对肠道微生物群紊乱所致抑郁症的缓解作用及其机制

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI: 10.1080/1028415X.2024.2366648

Haining Yu, Yinan Song, Maoshan Lou, Shengrong Shen

{"title":"Mitigation and mechanism of low dose linoleic acid on depression caused by disorder of gut microbiome.","authors":"Haining Yu, Yinan Song, Maoshan Lou, Shengrong Shen","doi":"10.1080/1028415X.2024.2366648","DOIUrl":"10.1080/1028415X.2024.2366648","url":null,"abstract":"Objectives: Depression is a widely prevalent mental disorder, and nutritional interventions play an increasingly important role in its treatment. In this paper, effects of linoleic acid (LA) on depressive behavior in mice induced by gut microbiome disorders were investigated.Methods: Fifty C57BL/6J male mice were randomly separated into five groups, control group (CK), ceftriaxone sodium group (CRO), low-dose linoleic acid group (LLA, 1 g/kg), medium-dose linoleic acid group (MLA, 2 g/kg), and high-dose linoleic acid group (HLA, 5 g/kg). In the LLA, MLA, and HLA groups, mice were treated with ceftriaxone sodium (CRO) to induce depressive behaviors, followed by LA administration. Behavioral tests were used to evaluate depressive behavior. High-throughput sequencing and Hematoxylin-eosin (H&E) staining in gut microenvironment were carried out. ELISA kits were used to measure brain inflammatory factors, and 5-hydroxy-tryptamine (5-HT). Gas chromatography and western blot were used to determine fatty acids compositions and the enzymes expression involved in lipid metabolism in brain respectively.Results: The results showed that 10 weeks CRO treatment contribute to depressive behavior, gut microbiome disturbance, and serotonin system disturbance. LLA and MLA improved the depressive-like behavior, and significantly increased the levels of 5-HT1A, 5-HTT and 5-HT in the hippocampus. LLA was found to improve the diversity of gut microbiome and alleviate colon tissue damage. Meantime, LLA increased the content of linoleic acid, improved the expression of FADS2 and COX-2, increased IL-10 levels, and decreased IL-6 levels in the brain.Discussion: LA alleviated depressive behavior in mice by improving the gut microenvironment, regulate fatty acid metabolism, and modulate inflammation.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"245-262"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prospective therapeutic benefits of sesamol: neuroprotection in neurological diseases. 芝麻酚的前瞻性治疗益处：神经系统疾病的神经保护作用。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-01-29 DOI: 10.1080/1028415X.2025.2457051

Yuchao Guo, Yaqing Wang, Boyang Xu, Yue Li

引用次数: 0

Plant-based eating pattern and psychological symptoms: a cross-sectional survey among patients with migraine. 植物性饮食模式和心理症状：偏头痛患者的横断面调查

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-01-28 DOI: 10.1080/1028415X.2025.2454168

Elham Karimi, Hajar Heidari, Maryam Kazemi, Amir Hadi, Gholamreza Askari, Fariborz Khorvash, Arman Arab

{"title":"Plant-based eating pattern and psychological symptoms: a cross-sectional survey among patients with migraine.","authors":"Elham Karimi, Hajar Heidari, Maryam Kazemi, Amir Hadi, Gholamreza Askari, Fariborz Khorvash, Arman Arab","doi":"10.1080/1028415X.2025.2454168","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2454168","url":null,"abstract":"Objectives: The present study evaluated the association between plant-based diet index (PDI) and psychological symptoms, including depressive symptoms, stress, and anxiety among Iranian women diagnosed with migraine headaches.Methods: A cross-sectional study was conducted on 262 patients with migraine (aged 20-50 years; body mass index, 18.5-30 kg/m²). Three versions of the PDI were calculated: overall PDI, healthy PDI (hPDI), and unhealthy PDI (uPDI) based on dietary data collected via a 168-item food frequency questionnaire (FFQ). Psychological symptoms, including depressive symptoms, anxiety, and stress, were assessed using the Depression, Anxiety, Stress Scale-21 (DASS-21) questionnaire.Results: After adjustment for potential confounders, patients in the highest tertile of the PDI showed a lower risk of depressive symptoms [odds ratio (OR) = 0.41, 95% confidence interval (CI): 0.22, 0.77]. Furthermore, inverse associations were evident between the PDI score and the risk of stress (OR = 0.46, 95% CI: 0.24, 0.85).Discussion: Higher adherence to a plant-based eating pattern is associated with a reduced risk of psychological symptoms. However, future longitudinal studies and clinical trials should replicate our observations and delineate the underlying mechanisms driving these associations.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":3.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-ferroptotic effects of natural polyphenols in nervous system injury: a narrative literature review. 天然多酚在神经系统损伤中的抗衰作用：叙述性文献综述。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-01-17 DOI: 10.1080/1028415X.2024.2448924

Davood Nasiry, Ali Reza Khalatbary

{"title":"Anti-ferroptotic effects of natural polyphenols in nervous system injury: a narrative literature review.","authors":"Davood Nasiry, Ali Reza Khalatbary","doi":"10.1080/1028415X.2024.2448924","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2448924","url":null,"abstract":"Background: Recent studies have shown that ferroptosis, a newly identified regulated cell death characterized by increased lipid peroxidation and accumulation of toxic lipid peroxides, is closely related to the pathophysiological processes of nervous system diseases which can be inhibited with iron chelators, lipophilic antioxidants, and lipid peroxidation inhibitors.Objective: To review the current evidence on the efficacy of various natural polyphenols in nervous system injury.Methods: The data selected for this review were collected by searching the MEDLINE/PubMed, Web of Science, Scopus, and Google Scholar database for articles published in English between 2000 and 2024 using the following terms: cell death, regulated cell death, ferroptosis, lipid peroxides, iron, and glutathione peroxidase.Results: Natural polyphenols have been found to have some protective effects against nervous system disorders, which are attributed to a variety of biological properties, particularly antioxidant, immunomodulatory, and anti-inflammatory effects. The preclinical studies conducted on the use of the most common dietary polyphenols, including resveratrol, EGCG, curcumin, quercetin, gastrodin, baicalein & baicalin, carthamin, galangin, puerarin, morachalcone, and carnosic acid with the molecular mechanisms have been discussed. On the other hand, the results of a few clinical studies emphasize the primary role of iron in neuronal degeneration following some of nervous system injury.Conclusion: Some of the findings indicated that natural polyphenols as antioxidant supplements have anti-ferroptotic effects in nervous system disorders.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-16"},"PeriodicalIF":3.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrient-heavy metal interaction and mixed heavy metal exposure in relation to cognition across lifespan: review evidence, potential mechanisms, and implications. 营养素-重金属相互作用和混合重金属暴露与认知的关系：回顾证据、潜在机制和影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-01-13 DOI: 10.1080/1028415X.2024.2436818

Yuanfei Liu, Zumin Shi, Jianghong Liu

{"title":"Nutrient-heavy metal interaction and mixed heavy metal exposure in relation to cognition across lifespan: review evidence, potential mechanisms, and implications.","authors":"Yuanfei Liu, Zumin Shi, Jianghong Liu","doi":"10.1080/1028415X.2024.2436818","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2436818","url":null,"abstract":"Objectives: Increasing research has shown that heavy metal as a neurotoxicant affects cognitive function across the lifespan. Nutritional status may modify susceptibility to heavy metal exposures, which further impacts cognition.Methods: We conducted a comprehensive search for cross-sectional studies, longitudinal studies, case-control studies and clinical trials on the interaction between nutrient and heavy metal, as well as mixed heavy metal exposure, in relation to cognition across the lifespan.Results: Six cross-sectional studies, 20 longitudinal studies, two case-control studies and two clinical trials were identified. Studies confirmed the interactions between heavy metals (e.g. iron, lead, mercury, cadmium, copper and manganese) and various nutrients (e.g. protein, minerals, vitamins and polyunsaturated fatty acids) in relation to cognition. Sufficient essential nutrients may attenuate the adverse effect of heavy metals on cognitive performance while nutritional deficiency could increase metal toxicity. These interactions can be found in infants, children, adolescents and adults. However, current studies are limited and generate mixed results across different age groups. Potential mechanisms include nutrients reducing the bioaccumulation of metal in the same food source and lowering the toxicity of metal by moderating neurochemistry.Discussion: Further longitudinal study is necessary to explore different types of interactions, elucidate further physiological mechanisms and adjust more confounding variables to increase confidence in causal effect. A comprehensive understanding of metal-nutrient interaction in human cognition could help facilitate earlier detection and prevention.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-12"},"PeriodicalIF":3.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food additives for the central nervous system, useful or harmful? An evidence-based review. 食品添加剂对中枢神经系统有益还是有害？基于证据的回顾。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-01-08 DOI: 10.1080/1028415X.2024.2433257

Mohammadmahdi Fadaei, Amirhossein Sangi Nasab Lahijan, Davood Jahanmehr, Alireza Ahmadi, Reza Asadi-Golshan

{"title":"Food additives for the central nervous system, useful or harmful? An evidence-based review.","authors":"Mohammadmahdi Fadaei, Amirhossein Sangi Nasab Lahijan, Davood Jahanmehr, Alireza Ahmadi, Reza Asadi-Golshan","doi":"10.1080/1028415X.2024.2433257","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2433257","url":null,"abstract":"Objectives: This review examines how food additives impact the central nervous system (CNS) focusing on the effects of sugars, artificial sweeteners, colorings, and preservatives.Methods: A literature search of PubMed, Scopus, and Web of Science was conducted for studies published since 2010. Key search terms included, food additives, neurotoxicity, cognition, and behavior.Results: It summarizes research findings on additives such as aspartame, stevia, methylene blue, azo dyes, sodium benzoate, and monosodium glutamate. It also covers mechanisms such as oxidative stress, neuroinflammation, and disruptions in neurotransmitter systems. Furthermore, it emphasizes the properties of natural compounds such as garlic (Allium sativum), tetramethylpyrazine, curcumin, licorice root extract (glycyrrhizin), and polyphenols in mitigating CNS damage caused by food additives.Discussion: Although ongoing studies are expanding our knowledge on the effects of these additives, future CNS research should focus on long-term investigations involving subjects to provide a more comprehensive understanding of the cumulative impacts of different additives and update regulatory standards based on new scientific findings.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0