Nutritional Neuroscience最新文献

{"title":"Acute effects of <i>Hibiscus sabdariffa</i> on blood pressure and cognitive function.","authors":"Lucy Ellis, Stephania Aragón-Rojas, Louise Dye, Christine Boesch","doi":"10.1080/1028415X.2025.2462944","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2462944","url":null,"abstract":"<p><strong>Introduction: </strong><i>Hibiscus sabdariffa</i> is well known for its blood pressure lowering properties, particularly in hypertensive individuals. To date, effects of hibiscus on cognitive performance have not been assessed, hence the current pilot study explored the acute effects of hibiscus consumption on cognitive performance and metabolic outcomes in overweight individuals.</p><p><strong>Methods: </strong>Twenty participants aged 35 ± 2.8 years with a BMI of 30 ± 1.2 (kg/m²) were recruited to a randomised, placebo-controlled crossover study. Participants received either a hibiscus-containing beverage or an inert placebo alongside a high carbohydrate breakfast. Metabolic and cognitive measures were assessed across a 2-hour postprandial period.</p><p><strong>Results: </strong>Consumption of the hibiscus drink significantly reduced postprandial glucose response compared to placebo after 30 and 45 min, with no change in blood pressure. Hibiscus consumption significantly attenuated the decline in delayed word recall on the visual verbal learning test. Additionally, there was a decrease in retroactive interference after hibiscus, suggesting that newly learned information interfered less with recall of previously learned information in comparison to placebo. Furthermore, non-significant improvements (<i>p</i> = 0.063) in executive function and pattern separation were observed following hibiscus consumption.</p><p><strong>Conclusion: </strong>To summarise, this pilot study demonstrates that acute hibiscus consumption moderately affects aspects of memory and executive function, coupled with beneficial effects on postprandial glucose response. Further research is warranted to confirm these findings in larger sample sizes and to determine the effect of longer-term consumption of hibiscus on these outcomes.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-11"},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection.","authors":"Rarchita Sharma, Lokesh Bhate, Yogeeta Agrawal, Ashok Aspatwar","doi":"10.1080/1028415X.2025.2469170","DOIUrl":"10.1080/1028415X.2025.2469170","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative disorder marked by progressive motor symptoms, including tremors, bradykinesia, and postural instability. The disease is characterized by dopaminergic neuron degeneration in the substantia nigra, leading to cognitive decline and motor dysfunction. Dietary supplements, known as nutraceuticals, have numerous health and medical benefits for treating and preventing the disease. Nutraceuticals offer neuroprotection through several mechanisms, including iron chelation, modulation of the cell-signaling pathway, scavenging of superoxide radicals and ROS, and suppression of inflammation. This review highlights the therapeutic potential of nutraceuticals as a complementary approach to traditional pharmaceutical treatments. Nutritional supplements such as Coenzyme Q10, Lycopene, Resveratrol, and Omega-3 fatty acids offer neuroprotection by targeting alpha-synuclein misfolding, oxidative stress, mitochondrial dysfunction, and neuroinflammation, potentially reducing the disease progression and improving patients' quality of life.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive function in response to a pecan-enriched meal: a randomized, double-blind, cross-over study in healthy adults.","authors":"Alyssa J Guadagni, M Catherine Prater, Chad M Paton, Jamie A Cooper","doi":"10.1080/1028415X.2025.2461018","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2461018","url":null,"abstract":"<p><strong>Objective: </strong>To examine cognitive responses to a pecan-enriched (68 g) meal or an isocaloric control meal in healthy adults.</p><p><strong>Methods: </strong>Thirty-one adults completed a double-blind, randomized crossover trial with two testing visits: a pecan-enriched shake (PEC) (68 g pecans) or a high saturated fat shake as control (CON). A cognitive battery, visual analog scale for motivation, and the Stanford Sleepiness Scale were administered at fasting and 1, 2, 3, and 4 h postprandially.</p><p><strong>Results: </strong>Consumption of the PEC shake led to superior cognitive performance in Rapid Visual Information Processing percent correct and false alarms (<i>p </i>= 0.021 and <i>p </i>= 0.001), Choice Reaction Time percent correct (<i>p </i>= 0.005), Digit Vigilance false alarms (<i>p </i>= 0.036), Immediate Word Recall correct and error responses (<i>p </i>= 0.007 and <i>p </i>= 0.008), and Delayed Word Recall correct and error responses (<i>p </i>= 0.002 for both). Conversely, CON led to better performance in Word Recognition percent correct and correct reaction time measures (<i>p </i>= 0.017 and <i>p </i>= 0.005) and Numeric Working Memory percent correct measures (<i>p </i>= 0.034).</p><p><strong>Conclusion: </strong>Consumption of a pecan-enriched meal enhanced cognitive performance compared to control. More than one-third (8/23) of the cognitive measures were favorable for pecan (4 in attention and processing speed, 4 in memory and learning), whereas only 3 were favorable for control (2 in memory and learning, 1 in executive function).<b>Trial registration</b>: ClinicalTrials.gov identifier: NCT05230212.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Cornus mas</i> ameliorates AlCl₃-induced Alzheimer's disease in rats with metabolic syndrome by regulating inflammation and oxidative stress.","authors":"Zatiye Ayça Çevikelli Yakut, Elvan Bakar, Filiz Sanal, Dicle Çevik, Çetin Hakan Karadağ, Etil Güzelmeriç","doi":"10.1080/1028415X.2025.2460384","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2460384","url":null,"abstract":"<p><strong>Objectives: </strong>Alzheimer's disease (AD) results from different risk variables, such as metabolic syndrome (MetS) and environmental factors. The benefits of <i>Cornus mas</i> L. on diabetes are well-known. However, the impacts of <i>C. mas</i> fruits on AD or MetS-related cognitive dysfunction have not yet been studied. We evaluated the impact of <i>C. mas</i> fruit (80% ethanol) extract in an animal model of MetS and AD.</p><p><strong>Methods: </strong>Male Spraque-Dawley rats were administered a high-fat, high-sugar diet for 105 days alone or with an AlCl₃ intraperitoneal injection for the last 60 days. <i>C. mas</i> fruit extract (400, 700, and 1000 mg/kg peroral) was administered for 60 days. After conducting behavioral tests and measuring blood pressure, hippocampal tissues and serum samples were obtained. The phytochemical analyses were conducted on <i>C. mas</i> fruit extract.</p><p><strong>Results: </strong><i>C. mas</i> alleviated MetS by reducing blood glucose, total cholesterol, and systolic blood pressure levels. Behavioral tests demonstrated that <i>C. mas</i> improves AlCl₃-related cognitive decline in rats with MetS, which was supported by the neuroprotective effect of <i>C. mas</i> in histological analysis. <i>C. mas</i> dose-dependently reduced amyloid-β, malondialdehyde levels, acetylcholinesterase activity in the hippocampus, proinflammatory cytokines in serum, and elevated glutathione levels in the hippocampus. Phytochemical analyses revealed that <i>C. mas</i> fruit contains loganic acid, cornuside, and anthocyanins.</p><p><strong>Discussion: </strong><i>C. mas</i> fruit extract in every three doses given could improve cognitive decline due to MetS and AlCl₃ through alleviation of MetS, oxidative stress and inflammation, prevention of amyloid deposition, and increased cholinergic transmission.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-21"},"PeriodicalIF":3.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic potential of chlorogenic acid in alleviating olanzapine-induced metabolic syndrome in rats: a key role of hypothalamic satiety proteins.","authors":"Zeinab Ebrahimian, Bibi Marjan Razavi, Seyed Ali Mousavi Shaegh, Hossein Hosseinzadeh","doi":"10.1080/1028415X.2025.2460385","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2460385","url":null,"abstract":"<p><p><b>Objectives:</b> Olanzapine (Olz) is an effective antipsychotic medication for schizophrenia; however, its use is associated with weight gain and metabolic disorders. Chlorogenic acid (CGA), a dietary polyphenol, has a promising potential for the treatment of obesity, diabetes, and hypertension. This study aimed to determine whether CGA could effectively manage Olz-induced metabolic syndrome (MetS) in a rat model, with metformin (Met) as a positive control.<b>Methods:</b> Female Wistar rats were divided into seven groups: control; Olz (5 mg/kg/day, IP); CGA (20, 40, and 80 mg/kg/day, gavage) plus Olz; Met (100 mg/kg/day, gavage) plus Olz; and CGA (80 mg/kg/day, gavage) for 30 days. Metabolic parameters including body weight, fasting blood glucose, triglycerides, and blood pressure were assessed. This study focused on evaluating serum levels of leptin and adiponectin, as well as hypothalamic protein expression of pro-opiomelanocortin (POMC), neuropeptide Y (NPY), AMP-activated protein kinase (AMPK), and 5-HT2C receptors (5-HT2CR), which are known to influence energy balance and potentially play a role in Olz-induced metabolic abnormalities.<b>Results:</b> Olz caused substantial hyperphagia, weight gain, hypertension, and liver damage, along with elevated fasting blood glucose, triglycerides, and leptin levels. CGA and Met mitigated these effects, although Olz-induced elevation of adiponectin levels remained unaffected by either treatment. Mechanistically, Olz reduced 5-HT2CR protein levels, a trend that was observed in the CGA and Met therapy groups. Olz also enhanced NPY protein levels and the pAMPK/AMPK ratio while lowering POMC protein levels. These alterations were reversed in rats administered CGA or Met.<b>Discussion:</b> These findings suggest that CGA effectively attenuated the adverse metabolic consequences of Olz by modulating leptin, NPY, POMC, and AMPK protein levels. CGA's therapeutic potential highlights its potential as a dietary intervention for managing antipsychotic-induced metabolic disturbances.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to unhealthy diets is associated with altered frontal gamma-aminobutyric acid and glutamate concentrations and grey matter volume: preliminary findings.","authors":"Piril Hepsomali, Adele Costabile, Marieke Schoemaker, Florencia Imakulata, Paul Allen","doi":"10.1080/1028415X.2024.2355603","DOIUrl":"10.1080/1028415X.2024.2355603","url":null,"abstract":"<p><strong>Objectives: </strong>Common mental disorders (CMD) are associated with impaired frontal excitatory/inhibitory (E/I) balance and reduced grey matter volume (GMV). Larger GMV (in the areas that are implicated in CMD-pathology) and improved CMD-symptomatology have been observed in individuals who adhere to high quality diets. Moreover, preclinical studies have shown altered neurometabolites (primarily gamma-aminobutyric acid: GABA and glutamate: GLU) in relation to diet quality. However, neurochemical correlates of diet quality and how these neurobiological changes are associated with CMD and with its transdiagnostic factor, rumination, is unknown in humans. Therefore, in this study, we examined the associations between diet quality and frontal cortex neuro-chemistry and structure, as well as CMD and rumination in humans.</p><p><strong>Methods: </strong>Thirty adults were classified into high and low diet quality groups and underwent 1H-MRS to measure medial prefrontal cortex (mPFC) metabolite concentrations and volumetric imaging to measure GMV.</p><p><strong>Results: </strong>Low (vs High) diet quality group had reduced mPFC-GABA and elevated mPFC-GLU concentrations, as well as reduced right precentral gyrus (rPCG) GMV. However, CMD and rumination were not associated with diet quality. Notably, we observed a significant negative correlation between rumination and rPCG-GMV and a marginally significant association between rumination and mPFC-GLU concentrations. There was also a marginally significant association between mPFC-GLU concentrations and rPCG-GMV.</p><p><strong>Discussion: </strong>Adhering to unhealthy dietary patterns may be associated with compromised E/I balance, and this could affect GMV, and subsequently, rumination.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"125-137"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean diet and its effects on a growing problem, for a younger population: diet, inflammation and multiple sclerosis.","authors":"Muhammad Shuraim Gang, Zayan Alidina, Adeena Musheer","doi":"10.1080/1028415X.2024.2364429","DOIUrl":"10.1080/1028415X.2024.2364429","url":null,"abstract":"","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"219-220"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of chrysin and kaempferol in ameliorating Cerebral Ischemic Reperfusion injury in rat by controlling expression of proinflammatory mediators NF-κB and STAT3.","authors":"Nasima Khanam, Ashutosh Ghosh, Debjani Nath","doi":"10.1080/1028415X.2024.2358686","DOIUrl":"10.1080/1028415X.2024.2358686","url":null,"abstract":"<p><strong>Objectives: </strong>The two flavonoids kaempferol and chrysin are known to possess anti-inflammatory and antioxidant activities. In addition, these two flavonoids were reported to display synergistic effects against inflammation. The present study aims to provide an analysis of the combined effects of kaempferol and chrysin on ischemic rat brain induced by endothelin-1.</p><p><strong>Methods: </strong>The neurological deficit score and infarct area of the brain were determined post drug treatment. Histopathological sections displayed the morphological changes in the brain tissue. The brain tissues were processed for assessing the antioxidant and anti-inflammatory activity by measuring superoxide dismutase activity, catalase activity, level of reduced glutathione, brain malondialdehyde, and amount of calcium. The expression level of inflammatory molecules was analyzed by western blotting and immunohistochemistry.</p><p><strong>Results: </strong>The infarct area, neurological score and NF-κB and STAT3 expression levels were significantly reduced.</p><p><strong>Discussion: </strong>The analysis of neuroprotective synergistic activity of kaempferol and chrysin indicated the therapeutic potential of the combination in alleviating cerebral ischemia by controlling expression of proinflammatory mediators.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"138-148"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary intake of fats and transient global amnesia (TGA).","authors":"Zahra Mahmoudi, Ali Tajik, Mahsa Vahdat, Khadijeh Abbasi Mobarakeh, Zahra Saeedirad, Fatemeh Azaryan, Arezoo Amjadi, Farkhondeh Alami, Neda Valisoltani, Masoomeh Alsadat Mirshafaei, Sara Khoshdooz, Maryam Gholamalizadeh, Saeid Doaei, Akram Kooshki","doi":"10.1080/1028415X.2024.2359866","DOIUrl":"10.1080/1028415X.2024.2359866","url":null,"abstract":"<p><strong>Background: </strong>Different types of dietary fat may influence memory and cognitive functions. This study aimed to investigate the association between dietary fat intake and transient global amnesia (TGA).</p><p><strong>Methods: </strong>This case-control study was conducted using Persian Sabzevar cohort data on 258 individuals with TGA and 520 individuals without amnesia in Sabzevar Iran. The food frequency questionnaire (FFQ) was used to assess the intake of dietary fats of the participants. All study participants were screened for TGA by a neurologist and their status was determined based on the diagnostic symptoms defined by the Kaplan and Hodges criteria.</p><p><strong>Results: </strong>There was an inverse association between the risk of TGA and dietary intake of alpha-linolenic acid (ALA) (OR = 0.94, CI95%:0.88-0.99, <i>P</i> = 0.01). Also, a positive association was observed between TGA and dietary intake of n-6 fatty acids (OR = 1.18, CI 95%: 1.04-1.33, <i>P</i> = 0.01). The results remained significant after adjustment for age, sex, education, job, marital status, physical activity, BMI, and calorie intake.</p><p><strong>Conclusion: </strong>Omega-3 fatty acids may have beneficial effects; however, omega-6 fatty acids may have adverse effects on the risk of amnesia. Further longitudinal studies are warranted.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"149-155"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blackberry extract prevents lipopolysaccharide-induced depressive-like behavior in female mice: implications for redox status, inflammation, and brain enzymes.","authors":"Solange Vega Custódio, Raphaela Cassol Piccoli, Kelen Cristiane Machado Goularte, William Sanabria Simões, Julia Eisenhardt de Mello, Anita Avila de Souza, Isabella Pompeu de Mattos Almeida, Alethéa Gatto Barschak, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Mayara Sandrielly Soares de Aguiar, Roselia Maria Spanevello","doi":"10.1080/1028415X.2024.2363570","DOIUrl":"10.1080/1028415X.2024.2363570","url":null,"abstract":"<p><p>This study evaluated the effects of <i>Rubus sp.</i> extract on behavioral and neurochemical parameters in female mice submitted to experimental model of depression induced by lipopolysaccharide (LPS). The results indicated that <i>Rubus sp.</i> extract protected against depressive-like behavior induced by LPS. Moreover, the administration of <i>Rubus sp.</i> extract was effective in preventing the increase in reactive species and nitrites levels, as well as the decrease in catalase activity induced by LPS in the cerebral cortex. In the serum, the <i>Rubus sp.</i> extract was effective in preventing the decrease in catalase activity induced by LPS. Treatment with <i>Rubus sp.</i> extract attenuated the increase in acetylcholinesterase activity induced by LPS in the cerebral cortex. Finally, blackberry extract also downregulated IL-1β levels in cerebral cortex. In conclusion, our findings demonstrated that treatment with <i>Rubus sp.</i> exerted antidepressant, antioxidant, anticholinesterase and anti-inflammatory effects in a model of depressive - like behavior induced by LPS in female mice. This highlights <i>Rubus sp</i>. as a potential therapeutic agent for individuals with major depressive disorder.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"194-208"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}