Nutritional Neuroscience最新文献_第8页

Iron and n-3 fatty acid depletion, alone and in combination, during early development provoke neurochemical changes, anhedonia, anxiety and social dysfunction in rats. 在大鼠的早期发育过程中，铁和 n-3 脂肪酸的单独或联合消耗会引起神经化学变化、失神、焦虑和社交功能障碍。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-01 Epub Date: 2023-08-10 DOI: 10.1080/1028415X.2023.2245615

Erna T Kemp, Lizelle Zandberg, Brian H Harvey, Cornelius M Smuts, Jeannine Baumgartner

{"title":"Iron and n-3 fatty acid depletion, alone and in combination, during early development provoke neurochemical changes, anhedonia, anxiety and social dysfunction in rats.","authors":"Erna T Kemp, Lizelle Zandberg, Brian H Harvey, Cornelius M Smuts, Jeannine Baumgartner","doi":"10.1080/1028415X.2023.2245615","DOIUrl":"10.1080/1028415X.2023.2245615","url":null,"abstract":"Objectives: Both iron and omega-3 (n-3) fatty acids (FA) play important roles in the development and functioning of the brain. We investigated the effects of n-3 FA and iron deficiencies, alone and in combination, during early development on behaviour and brain monoamines in rats. Methods: Using a 2-factorial design, female Wistar rats were randomly allocated to one of four diet groups: Control, n-3 FA deficient (n-3 FAD), iron deficient (ID), or n-3 FAD + ID. Females received these diets throughout mating, pregnancy and lactation. Offspring (n = 24/group; male:female = 1:1) continued on the same diet until post-natal day 42-45, and underwent a sucrose preference test (SPT), novel object recognition test, elevated plus maze (EPM) and social interaction test (SIT). Results: ID offspring consumed less sucrose in the SPT and spent more time in closed arms and less time in open arms of the EPM than non-ID offspring. In female offspring only, ID and n-3 FAD reduced time approaching and together in the SIT, with an additive effect of ID and n-3 FAD for even less time approaching and spent together in the n-3 FAD + ID group compared to controls. ID offspring had higher striatal dopamine and norepinephrine and lower frontal cortex dopamine concentrations. N-3 FAD and ID affected frontal cortex serotonin concentrations in a sex-specific manner. Conclusions: Our results suggest that ID and n-3 FAD during early development provoke anhedonia, anxiety and social dysfunction in rats, with potential additive and attenuating effects when combined. These effects may in part be attributed to disturbances in brain neurochemistry and may be sex-specific.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10014032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary quality and the gut microbiome in early-stage Parkinson's disease patients. 帕金森病早期患者的饮食质量和肠道微生物组。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-07-01 Epub Date: 2023-09-14 DOI: 10.1080/1028415X.2023.2253025

Hyun Jeong Yoon, Woorim Kang, Sungyang Jo, Yun Su Hwang, Je Hee Lee, Sun Ju Chung, Yoo Kyoung Park

{"title":"Dietary quality and the gut microbiome in early-stage Parkinson's disease patients.","authors":"Hyun Jeong Yoon, Woorim Kang, Sungyang Jo, Yun Su Hwang, Je Hee Lee, Sun Ju Chung, Yoo Kyoung Park","doi":"10.1080/1028415X.2023.2253025","DOIUrl":"10.1080/1028415X.2023.2253025","url":null,"abstract":"Background: The prevalence of Parkinson's disease (PD) has increased steadily with the increase of the elderly population. PD may influence dietary intake and quality, and the gut microbiome composition. The present study examined differences in dietary intake and quality between PD patients and controls according to sex. In addition, we assessed the gut microbiome composition.Methods: This cross-sectional study was conducted at A Medical Center, Seoul, South Korea. PD severity, swallowing function, olfactory function, and constipation status were examined by a skilled nurse. Dietary data were collected through a semi-quantitative food frequency questionnaire. Stool samples were subjected to microbiome analysis. To examine dietary quality, the Dietary Quality Index-International (DQI-I), Healthy Eating Index (HEI), Index of Nutritional Quality (INQ), Dietary Diversity Score (DDS), and Mediterranean Diet Score (MDS) were used. An independent t-test was used to determine differences between patients and controls. A chi-square test was used to examine frequency differences.Results: Dietary intake did not differ between the PD patient and control groups. Regarding dietary quality, the patients consumed more saturated fat compared to controls. Overall, the dietary differences between the groups were minor. The composition of the gut microbiome differed between PD patients and controls. Lactobacillus and Bifidobacterium genus were most abundant in PD patients. Prevotella VZCB and other Faecalibacterium were most abundant in controls.Conclusions: Our results indicated that PD patients may experience gut microbiome change even in the early stage, while nutritional needs can be met when a balanced diet including various food groups are consumed.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10243267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal vitamin D levels and infant cognitive, motor, language and social-emotional development at 6 and 9 months of age. 产前维生素 D 水平与婴儿 6 个月和 9 个月大时的认知、运动、语言和社会情感发育。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-06-19 DOI: 10.1080/1028415X.2024.2366649

Dolat Singh Shekhawat, Kuldeep Singh, Pratibha Singh, Varuna Vyas, Shoban Babu Varthya, Praveen Sharma

{"title":"Prenatal vitamin D levels and infant cognitive, motor, language and social-emotional development at 6 and 9 months of age.","authors":"Dolat Singh Shekhawat, Kuldeep Singh, Pratibha Singh, Varuna Vyas, Shoban Babu Varthya, Praveen Sharma","doi":"10.1080/1028415X.2024.2366649","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2366649","url":null,"abstract":"Aim: Vitamin D is involved in several processes related to the development of neuronal and non-neuronal cells. There is a possible link between maternal vitamin D status in pregnancy and delayed neurocognitive development in the offspring. The aim of the study was to explore the association of maternal and cord blood vitamin D levels with infants' neurodevelopment at 6 and 9 months of age.Methodology: A cohort study was conducted in western Rajasthan, India. Maternal and cord blood samples were collected at the time of delivery. Serum 25(OH)-vitamin D levels were measured in both. Infant neurodevelopment was assessed at 6 and 9 months of age in six domains namely cognitive, receptive language, expressive language, fine motor, gross motor and social-emotional using the Bayley Scale of Infant Development- III (BSID-III).Results: A total of 175 mother-child pairs were enrolled. Among the mothers taking part in this study, 7.3% had deficient and 59.09% had insufficient levels of serum 25(OH) vitamin D during the third trimester of their pregnancy. Maternal and cord blood serum 25-OH vitamin D levels were 18.86 ± 8.53 ng/mL and 17.39 ± 8.87 ng/mL, respectively, and there was a significant correlation (r = 0.9778, p = 0.000) between levels of vitamin D. Based on the repeated measures ANOVA, post hoc Tukey's HSD test, maternal vitamin D levels had a significant relationship (p = 0.047) to the cognitive development of infants at 6 months of age. Furthermore, cord serum vitamin D levels showed a significant association (p = 0.023 and p = 0.010) with the social-emotional development of the infant at the age of 6 and 9 months.Conclusion: Maternal and cord serum 25-OH vitamin D deficiency was significantly associated with the cognitive and social-emotional development of infants.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating chronic stress and chronic pain by manipulating gut microbiota with diet: can we kill two birds with one stone? 通过饮食控制肠道微生物群来治疗慢性压力和慢性疼痛：我们能一石二鸟吗？

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-06-18 DOI: 10.1080/1028415X.2024.2365021

Alessia Costa, Elena Lucarini

{"title":"Treating chronic stress and chronic pain by manipulating gut microbiota with diet: can we kill two birds with one stone?","authors":"Alessia Costa, Elena Lucarini","doi":"10.1080/1028415X.2024.2365021","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2365021","url":null,"abstract":"Background: Chronic stress and chronic pain are closely linked by the capacity to exacerbate each other, sharing common roots in the brain and in the gut. The strict intersection between these two neurological diseases makes important to have a therapeutic strategy aimed at preventing both to maintain mental health in patients. Diet is an modifiable lifestyle factor associated with gut-brain axis diseases and there is growing interest in its use as adjuvant to main therapies. Several evidence attest the impact of specific diets or nutrients on chronic stress-related disorders and pain with a good degree of certainty. A daily adequate intake of foods containing micronutrients such as amino acids, minerals and vitamins, as well as the reduction in the consumption of processed food products can have a positive impact on microbiota and gut health. Many nutrients are endowed of prebiotic, anti-inflammatory, immunomodulatory and neuroprotective potential which make them useful tools helping the management of chronic stress and pain in patients. Dietary regimes, as intermittent fasting or caloric restriction, are promising, although further studies are needed to optimize protocols according to patient's medical history, age and sex. Moreover, by supporting gut microbiota health with diet is possible to attenuate comorbidities such as obesity, gastrointestinal dysfunction and mood disorders, thus reducing healthcare costs related to chronic stress or pain.Objective: This review summarize the most recent evidence on the microbiota-mediated beneficial effects of macro- and micronutrients, dietary-related factors, specific nutritional regimens and dietary intervention on these pathological conditions.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between dietary inflammatory index and risk of neuromyelitis optica spectrum disorder: a case-control study. 膳食炎症指数与神经脊髓炎视谱系障碍风险之间的关系：一项病例对照研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-06-13 DOI: 10.1080/1028415X.2024.2342154

Leila Darvishi, Vahid Shaygannejad, Marjan Mansourian, Parvane Saneei, Omid Mirmosayyeb, Sayyed Morteza Safavi

{"title":"The association between dietary inflammatory index and risk of neuromyelitis optica spectrum disorder: a case-control study.","authors":"Leila Darvishi, Vahid Shaygannejad, Marjan Mansourian, Parvane Saneei, Omid Mirmosayyeb, Sayyed Morteza Safavi","doi":"10.1080/1028415X.2024.2342154","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2342154","url":null,"abstract":"Background and aim: Neuromyelitis optica spectrum disorder (NMOSD) is a severe and rare inflammatory disease affecting the central nervous system through optic neuritis and transverse myelitis. Present study aimed to investigate the association between dietary inflammatory index (DII) and risk of NMOSD.Methods: In this case-control study, 30 NMOSD cases and 90 aged matched healthy individuals were recruited. Habitual dietary intakes were assessed by a validated 168-item food frequency questionnaire to calculate the DII score. A multiple adjusted regression was used to determine the odd ratio (OR) of NMOSD across DII tertiles. The Residual method was applied to adjust the energy intake.Results: Participants in the top of DII tertile were more likely to have NMOSD in the crude model compared to those with the lowest one (OR: 4.18; 95%CI: 1.43-12.21). It was the case when multivariable confounders were considered in adjustment model I (OR: 3.98; 95%CI: 1.34-11.82) and II (OR: 4.43; 95%CI: 1.36-14.38), such that, individuals with a greater DII score had 3.98 and 4.43-time higher risk of NMOSD in model I and II, respectively.Conclusion: The Present study suggests that greater adherence to a pro-inflammatory diet may be associated with an increased risk of NMOSD.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediterranean diet and its effects on a growing problem, for a younger population: diet, inflammation and multiple sclerosis. 地中海饮食及其对一个日益严重的问题的影响，针对年轻人群：饮食、炎症和多发性硬化症。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-06-12 DOI: 10.1080/1028415X.2024.2364429

Muhammad Shuraim Gang, Zayan Alidina, Adeena Musheer

引用次数: 0

Blackberry extract prevents lipopolysaccharide-induced depressive-like behavior in female mice: implications for redox status, inflammation, and brain enzymes. 黑莓提取物可预防脂多糖诱发的雌性小鼠抑郁样行为：对氧化还原状态、炎症和脑酶的影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-06-11 DOI: 10.1080/1028415X.2024.2363570

Solange Vega Custódio, Raphaela Cassol Piccoli, Kelen Cristiane Machado Goularte, William Sanabria Simões, Julia Eisenhardt de Mello, Anita Avila de Souza, Isabella Pompeu de Mattos Almeida, Alethéa Gatto Barschak, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Mayara Sandrielly Soares de Aguiar, Roselia Maria Spanevello

{"title":"Blackberry extract prevents lipopolysaccharide-induced depressive-like behavior in female mice: implications for redox status, inflammation, and brain enzymes.","authors":"Solange Vega Custódio, Raphaela Cassol Piccoli, Kelen Cristiane Machado Goularte, William Sanabria Simões, Julia Eisenhardt de Mello, Anita Avila de Souza, Isabella Pompeu de Mattos Almeida, Alethéa Gatto Barschak, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Mayara Sandrielly Soares de Aguiar, Roselia Maria Spanevello","doi":"10.1080/1028415X.2024.2363570","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2363570","url":null,"abstract":"ABSTRACTThis study evaluated the effects of Rubus sp. extract on behavioral and neurochemical parameters in female mice submitted to experimental model of depression induced by lipopolysaccharide (LPS). The results indicated that Rubus sp. extract protected against depressive-like behavior induced by LPS. Moreover, the administration of Rubus sp. extract was effective in preventing the increase in reactive species and nitrites levels, as well as the decrease in catalase activity induced by LPS in the cerebral cortex. In the serum, the Rubus sp. extract was effective in preventing the decrease in catalase activity induced by LPS. Treatment with Rubus sp. extract attenuated the increase in acetylcholinesterase activity induced by LPS in the cerebral cortex. Finally, blackberry extract also downregulated IL-1β levels in cerebral cortex. In conclusion, our findings demonstrated that treatment with Rubus sp. exerted antidepressant, antioxidant, anticholinesterase and anti-inflammatory effects in a model of depressive - like behavior induced by LPS in female mice. This highlights Rubus sp. as a potential therapeutic agent for individuals with major depressive disorder.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malnutrition risk and associated factors in hospitalized older adult patients with neurological diseases: a retrospective cohort study. 住院老年神经系统疾病患者的营养不良风险及相关因素：一项回顾性队列研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-06-07 DOI: 10.1080/1028415X.2024.2363571

Gabriel Alvarado-Luis, Claudia Mimiaga-Hernández

{"title":"Malnutrition risk and associated factors in hospitalized older adult patients with neurological diseases: a retrospective cohort study.","authors":"Gabriel Alvarado-Luis, Claudia Mimiaga-Hernández","doi":"10.1080/1028415X.2024.2363571","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2363571","url":null,"abstract":"Introduction: Malnutrition risk (MR) in older adults with neurological disorders is high, but there is little evidence for validated screening tools in this group, as well as for the clinical and socioeconomic factors associated with a high MR.Objectives: To determine the association of MR using the Malnutrition Universal Screening Tool (MUST) with mortality and length of stay (LOS) in older adults with neurological diseases. Secondarily, the association of clinical, and socioeconomic factors with MR and clinical outcomes was sought.Methods: A retrospective cohort study was carried out at a third-level neurological disease referral center in Mexico. All patients older than 60 years admitted from January 2017 to December 2018 were considered. MUST, clinical and socioeconomic factors were assessed at hospital admission. Outcomes were followed up to hospital discharge or a maximum of 6 months.Results: A total of 765 patients were included, of whom 24.7% (n = 189) were at high risk. A high MR was independently associated with mortality (OR 3.09; 95% CI 1.60-5.98, p = .001) and LOS >14 days (OR 4.38; 95% CI 2.79-6.89, p = <.001). The only factors independently associated with high MR was economic dependence and unemployment. Patients with high MR and economic dependence (OR 4.0; 95% CI 1.34-11.99, p = .013) or unemployment (OR 3.43; 95% CI 1.17-10.06, p = .025) had the highest mortality.Conclusions: In hospitalized older adults with neurological diseases, high MR is independently associated with increased mortality and LOS. Economic dependence or unemployment are associated with worse clinical outcomes in patients with high MR.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naringenin: its chemistry and roles in neuroprotection. 柚皮苷：其化学性质和在神经保护中的作用。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-06-01 Epub Date: 2023-08-10 DOI: 10.1080/1028415X.2023.2243089

Ayomide Victor Atoki, Patrick Maduabuchi Aja, Tijjani Salihu Shinkafi, Erick Nyakundi Ondari, Chinaza Godswill Awuchi

{"title":"Naringenin: its chemistry and roles in neuroprotection.","authors":"Ayomide Victor Atoki, Patrick Maduabuchi Aja, Tijjani Salihu Shinkafi, Erick Nyakundi Ondari, Chinaza Godswill Awuchi","doi":"10.1080/1028415X.2023.2243089","DOIUrl":"10.1080/1028415X.2023.2243089","url":null,"abstract":"According to epidemiological research, as the population ages, neurological illnesses are becoming a bigger issue. Despite improvements in the treatment of these diseases, there are still widespread worries about how to find a long-lasting remedy. Several neurological diseases can be successfully treated with natural substances. As a result, current research has been concentrated on finding effective neuroprotective drugs with improved efficacy and fewer side effects. Naringenin is one potential treatment for neurodegenerative diseases. Many citrus fruits, tomatoes, bergamots, and other fruits are rich in naringenin, a flavonoid. This phytochemical is linked to a variety of biological functions. Naringenin has attracted a lot of interest for its ability to exhibit neuroprotection through several mechanisms. In the current article, we present evidence from the literature that naringenin reduces neurotoxicity and oxidative stress in brain tissues. Also, the literatures that are currently accessible shows that naringenin reduces neuroinflammation and other neurological anomalies. Additionally, we found several studies that touted naringenin as a promising anti-amyloidogenic, antidepressant, and neurotrophic treatment option. This review's major goal is to reflect on advancements in knowledge of the molecular processes that underlie naringenin's possible neuroprotective effects. Furthermore, this article also provides highlights of Naringenin with respect to its chemistry and pharmacokinetics.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10014029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anthropometric indices, nutrient intakes and health-related characteristics of patients with multiple sclerosis: a cross-sectional study. 多发性硬化症患者的人体测量指数、营养摄入量和健康相关特征：一项横断面研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-06-01 Epub Date: 2023-07-10 DOI: 10.1080/1028415X.2023.2233175

Mahsa Moazen, Zahra Mousavi-Shirazi-Fard, Zohreh Mazloom, Sadegh Izadi, Maryam Ghaseminasab-Parizi

{"title":"Anthropometric indices, nutrient intakes and health-related characteristics of patients with multiple sclerosis: a cross-sectional study.","authors":"Mahsa Moazen, Zahra Mousavi-Shirazi-Fard, Zohreh Mazloom, Sadegh Izadi, Maryam Ghaseminasab-Parizi","doi":"10.1080/1028415X.2023.2233175","DOIUrl":"10.1080/1028415X.2023.2233175","url":null,"abstract":"Background: Multiple sclerosis (MS) is accompanied by many health-related issues. This study aimed to evaluate the anthropometric indices, nutrient intakes and health-related characteristics of MS patients as well as their possible correlations.Methods: This cross-sectional study was performed on 283 MS patients in Shiraz, Iran, during 2018-2019. Body mass index (BMI) and body composition were measured for each participant. A food frequency questionnaire was used to determine the patients' nutrient intakes. The level of fatigue, disability and quality of life of the individuals were assessed by the modified fatigue impact scale (MFIS), the expanded disability status scale and the multiple sclerosis quality of life-54 questionnaires, respectively.Results: The results revealed that 43.11% of the patients were overweight or obese, and their %body fat (%BF) was 35.65 ± 7.63. Besides, intakes of vitamins A, E, D, folic acid, calcium, zinc and magnesium were significantly lower than recommendations in both genders, and sodium intake was significantly higher than the tolerable upper intake level in females. A significant positive linear correlation was observed between MFIS and BMI (r = 0.12, P = 0.045). Significant positive correlations were also found between psychosocial subscale of MFIS and both of %BF (r = 0.12, P = 0.049) and visceral fat area (r = 0.14, P = 0.02). Unexpectedly, the patients' quality of life showed significant negative correlations with fat free mass and skeletal muscle mass.Conclusion: Being overweight, having a high %BF and poor nutrient intakes are common among MS patients. Improving the patients' lifestyle and dietary intake is recommended to reduce fatigue and increase their life quality.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9820673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0