{"title":"Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection.","authors":"Rarchita Sharma, Lokesh Bhate, Yogeeta Agrawal, Ashok Aspatwar","doi":"10.1080/1028415X.2025.2469170","DOIUrl":null,"url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative disorder marked by progressive motor symptoms, including tremors, bradykinesia, and postural instability. The disease is characterized by dopaminergic neuron degeneration in the substantia nigra, leading to cognitive decline and motor dysfunction. Dietary supplements, known as nutraceuticals, have numerous health and medical benefits for treating and preventing the disease. Nutraceuticals offer neuroprotection through several mechanisms, including iron chelation, modulation of the cell-signaling pathway, scavenging of superoxide radicals and ROS, and suppression of inflammation. This review highlights the therapeutic potential of nutraceuticals as a complementary approach to traditional pharmaceutical treatments. Nutritional supplements such as Coenzyme Q10, Lycopene, Resveratrol, and Omega-3 fatty acids offer neuroprotection by targeting alpha-synuclein misfolding, oxidative stress, mitochondrial dysfunction, and neuroinflammation, potentially reducing the disease progression and improving patients' quality of life.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-17"},"PeriodicalIF":3.6000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutritional Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1028415X.2025.2469170","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder marked by progressive motor symptoms, including tremors, bradykinesia, and postural instability. The disease is characterized by dopaminergic neuron degeneration in the substantia nigra, leading to cognitive decline and motor dysfunction. Dietary supplements, known as nutraceuticals, have numerous health and medical benefits for treating and preventing the disease. Nutraceuticals offer neuroprotection through several mechanisms, including iron chelation, modulation of the cell-signaling pathway, scavenging of superoxide radicals and ROS, and suppression of inflammation. This review highlights the therapeutic potential of nutraceuticals as a complementary approach to traditional pharmaceutical treatments. Nutritional supplements such as Coenzyme Q10, Lycopene, Resveratrol, and Omega-3 fatty acids offer neuroprotection by targeting alpha-synuclein misfolding, oxidative stress, mitochondrial dysfunction, and neuroinflammation, potentially reducing the disease progression and improving patients' quality of life.
期刊介绍：
Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
