Nutritional Neuroscience最新文献

{"title":"Prenatal vitamin D levels and infant cognitive, motor, language and social-emotional development at 6 and 9 months of age.","authors":"Dolat Singh Shekhawat, Kuldeep Singh, Pratibha Singh, Varuna Vyas, Shoban Babu Varthya, Praveen Sharma","doi":"10.1080/1028415X.2024.2366649","DOIUrl":"10.1080/1028415X.2024.2366649","url":null,"abstract":"<p><strong>Aim: </strong>Vitamin D is involved in several processes related to the development of neuronal and non-neuronal cells. There is a possible link between maternal vitamin D status in pregnancy and delayed neurocognitive development in the offspring. The aim of the study was to explore the association of maternal and cord blood vitamin D levels with infants' neurodevelopment at 6 and 9 months of age.</p><p><strong>Methodology: </strong>A cohort study was conducted in western Rajasthan, India. Maternal and cord blood samples were collected at the time of delivery. Serum 25(OH)-vitamin D levels were measured in both. Infant neurodevelopment was assessed at 6 and 9 months of age in six domains namely cognitive, receptive language, expressive language, fine motor, gross motor and social-emotional using the Bayley Scale of Infant Development- III (BSID-III).</p><p><strong>Results: </strong>A total of 175 mother-child pairs were enrolled. Among the mothers taking part in this study, 7.3% had deficient and 59.09% had insufficient levels of serum 25(OH) vitamin D during the third trimester of their pregnancy. Maternal and cord blood serum 25-OH vitamin D levels were 18.86 ± 8.53 ng/mL and 17.39 ± 8.87 ng/mL, respectively, and there was a significant correlation (r = 0.9778, <i>p</i> = 0.000) between levels of vitamin D. Based on the repeated measures ANOVA, post hoc Tukey's HSD test, maternal vitamin D levels had a significant relationship (<i>p</i> = 0.047) to the cognitive development of infants at 6 months of age. Furthermore, cord serum vitamin D levels showed a significant association (<i>p</i> = 0.023 and <i>p</i> = 0.010) with the social-emotional development of the infant at the age of 6 and 9 months.</p><p><strong>Conclusion: </strong>Maternal and cord serum 25-OH vitamin D deficiency was significantly associated with the cognitive and social-emotional development of infants.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"263-272"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin and macular carotenoids and relations to academic achievement among school-aged children.","authors":"Laura M Rosok, Corinne N Cannavale, Shelby A Keye, Hannah D Holscher, Lisa Renzi-Hammond, Naiman A Khan","doi":"10.1080/1028415X.2024.2370175","DOIUrl":"10.1080/1028415X.2024.2370175","url":null,"abstract":"<p><strong>Objectives: </strong>Carotenoids are plant pigments that accumulate in human tissue (e.g. macula and skin) and can serve as biomarkers for diet quality; however, knowledge on skin and macular carotenoids in relation to cognition in children is limited. This study aimed to address this gap by assessing links between skin and macular carotenoids and academic achievement in school-aged children.</p><p><strong>Methods: </strong>Children 7-12 years old (<i>n</i> = 81) participated in a crosssectional study. Skin and macular carotenoids were measured with reflection spectroscopy and heterochromatic flicker photometry, respectively. Academic achievement was measured using Woodcock-Johnson IV (WJ-IV). Body Mass Index was calculated using height and weight measurements, demographic information was collected using a family demographics and pediatric health history questionnaire, and carotenoid intake was assessed using 7-day diet records.</p><p><strong>Results: </strong>Skin carotenoids were not related to macular pigment (<i>r</i> = 0.08, <i>p</i> = 0.22). Adjusting for age, sex, BMI percentile, household income, and total carotenoid consumption (mg/1000kcal), skin carotenoids were predictive of math (β = 0.27, <i>p</i> = 0.02), broad math (β = 0.36, <i>p</i> < 0.01) and math calculation (β = 0.38, <i>p</i> < 0.01). Skin carotenoids displayed trending relationships with broad reading (β = 0.23, <i>p</i> = 0.05) and reading fluency (β = 0.22, <i>p</i> = 0.07). There were no significant associations between macular pigment and academic achievement (all β's ≤ 0.07, all <i>p</i>'s ≥ 0.56).</p><p><strong>Discussion: </strong>Skin carotenoids were positively associated with academic abilities in children, while macular carotenoids did not display this relationship. Future interventions examining prospective effects of changes in carotenoids in different tissues on childhood academic achievement are warranted.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"308-320"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the acute impact of rosemary consumption on brain activity in healthy volunteers.","authors":"Aynur Muduroglu-Kirmizibekmez, Ceren Cati, Alparslan Onder, Sevcan Aydin, Ihsan Kara","doi":"10.1080/1028415X.2024.2370729","DOIUrl":"10.1080/1028415X.2024.2370729","url":null,"abstract":"<p><strong>Objectives: </strong><i>Rosmarinus officinalis L.</i> (rosemary) is a fragrant plant of the mint family, broadly known as a nourishment flavoring agent; it is additionally utilized in conventional people cures for its anti-inflammatory, diuretic, and antibacterial properties. Intense cognitive impacts from devouring plant-based flavonoids can be measured with electroencephalography (EEG), which records unconstrained brain movement. Brain activity can be evaluated amid independent states or whereas performing attentional assignments. This study aimed to determine the impact of rosemary consumption on cognitive consequences.</p><p><strong>Methods: </strong>Twenty volunteers took part in the study. EEG was taken for each volunteer twice, before drinking rosemary extract and around one hour after drinking it. EEG information was recorded with a Micromed recording framework inspecting rate of 512 Hz. EEG signals were prepared to be utilized in EEGLAB, an open-source toolbox within the MATLAB environment. The information obtained after the EEG recording was compared with the preliminary EEG information.</p><p><strong>Results: </strong>The signal's power spectral density in theta, delta, and beta frequency bands modestly increased in males and females. Even though there was a significant increase in power at the alpha frequency band in both sexes, this increment was not specific channel-wise.</p><p><strong>Discussion: </strong>The obtained data are consistent with the expected results and similar studies conducted, suggesting that the consumption of rosemary is beneficial for cognitive function in the short term. It is anticipated that forthcoming long-term studies will support the existing data.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"321-332"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of the Prime Diet Quality Score (PDQS) with depression and anxiety symptoms: the Isfahan functional disorders (ISFUN) cohort study.","authors":"Fahimeh Haghighatdoost, Awat Feizi, Parisa Hajihashemi, Hassan Shahoon, Alireza Ani, Hamidreza Roohafza, Peyman Adibi","doi":"10.1080/1028415X.2024.2372190","DOIUrl":"10.1080/1028415X.2024.2372190","url":null,"abstract":"<p><strong>Background: </strong>Due to scarce epidemiologic data regarding the Prime Diet Quality Score (PDQS) and mental health disorders, this study aimed to investigate the association of PDQS with depression and anxiety symptoms in Iranian adults.</p><p><strong>Methods: </strong>This cross-sectional analysis was performed using the baseline data collected for the Isfahan functional disorders (ISFUN) cohort study. ISFUN was established in 2017 and enrolled apparently healthy adults, aged 18-65 years in Isfahan, Iran. Information on usual dietary intakes was collected using a validated Dish-based, 106-item food frequency questionnaire. The severity of depression and anxiety was assessed using a validated Iranian version of the Hospital Anxiety and Depression Scale.</p><p><strong>Results: </strong>A total number of1892 participants were enrolled in the present study. In total, 54.50% of subjects were female. In the fully adjusted model, participants with PDQS lower than median compared with those with PDQS higher than median had higher risk of depression (OR =   1.62; 95% CI: 1.11, 2.37) and anxiety (OR: 1.57; 95% CI: 1.08, 2.27). In stratified analysis by sex, males with PDQS lower than median compared with those with PDQS higher than median had greater risk for depressive (OR: 1.57) and anxiety symptoms (OR =   1.52). However, in females, no significant association was found between PDQS and odds of depression, and anxiety in the fully adjusted model.</p><p><strong>Conclusion: </strong>We found evidence indicating a significant inverse association between PDQS and depression and anxiety symptoms among Iranian adults. Further studies, in particular with prospective design, are required to confirm these findings.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"360-369"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between plant and animal protein intake with depression, anxiety, and stress.","authors":"Bita Forootani, Bahareh Sasanfar, Amin Salehi-Abargouei, Masoud Mirzaei","doi":"10.1080/1028415X.2024.2372194","DOIUrl":"10.1080/1028415X.2024.2372194","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence suggests that diet composition is a key biological factor related to the development of depressive disorders. The present study was conducted to investigate the animal and plant protein intake and their replacement in association with depression, anxiety, and stress in Iranian adults.</p><p><strong>Method: </strong>In this cross-sectional study, the dietary intake of 7169 subjects were assessed using a validated food frequency questionnaire. The depression, anxiety, and stress Scale - 21 (DASS-21) questionnaire was used to psychological disorders. Logistic regression was used to obtain odds ratios for depression, anxiety, and stress across quintiles of animal and plant protein.</p><p><strong>Results: </strong>The participants' age range was 20-69 years. Individuals with the highest animal protein consumption had a lower chance for developing depression compared to those with the lowest intakes (OR = 0.73, 95%CI: 0.59-0.90; P_trend< 0.01). Results also showed a significant association between animal protein intake and anxiety, such that subjects in the highest quintile of animal protein intake had 24% lower odds for anxiety compared to those in the lowest quintile (<i>p</i> < 0.05). We found a significant association between highest quintiles of animal protein intake and a 40% lower risk for stress among female individuals (P_trend= 0.05). The multivariable-adjusted non-linear analyses also revealed that the replacement of plant protein with animal protein was significantly associated with the likelihood of depression and anxiety (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Animal protein intake might lower the odds of depression and anxiety particularly. Future prospective investigations are proposed to confirm these findings.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"370-383"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary riboflavin intake and cognitive decline in older adults: a cross-sectional analysis.","authors":"Kai Zhang, Tianyi Cai, Yu Han, Zhaoxuan Gu, Rui Hu, Zhengyan Hou, Xiaoqi Yu, Yafang Gao, Min Gao, Tianzhou Liu, Yixin Zhang","doi":"10.1080/1028415X.2024.2375171","DOIUrl":"10.1080/1028415X.2024.2375171","url":null,"abstract":"<p><strong>Background: </strong>Research exploring the link between dietary riboflavin intake and cognitive decline in this demographic is limited. Our aim was to examine the association between riboflavin intake levels and cognitive decline.</p><p><strong>Methods: </strong>The National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2014 were utilized in this cross-sectional analysis. The Consortium to Establish a Registry for Alzheimer's Disease test Word Learning delayed recall trial (DR), Digit Symbol Substitution Test (DSST), Animal Fluency Test(AFT) and Z test were used to evaluate cognitive performance. Multivariate logistic regression, restricted cubic spline and subgroup analysis were performed to evaluate the associations between riboflavin intake and cognitive decline.</p><p><strong>Results: </strong>The study included a total of 2255 patients, with 47.9% being male. The incidence of cognitive decline was 23.8%. After adjusting for all selected covariates, we found that high riboflavin intake was associated with a lower risk of cognitive impairment in adults in the United States. When riboflavin intake was used as a Categorical variable, compared to those with the lowest intake, the odds ratio (OR) of individuals with the highest riboflavin intake for DR test, AFT test, DSST test and Z test were 0.73 (95% CI: 0.53~1), 0.68(95% CI: 0.49-0.96),0.53(95% CI: 0.37-0.77) and 0.56(95% CI: 0.39-0.8). The study also found an L-shaped association between riboflavin intake and cognitive decline, with an inflection point at approximately 2.984 mg/d.</p><p><strong>Conclusions: </strong>Our cross-sectional study in a nationwide sample of American old adults suggests that dietary riboflavin intake was negative associated with cognitive decline.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"384-393"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy as a window of opportunity for dementia prevention: a narrative review.","authors":"Lauren K Hand, Matthew K Taylor, Debra K Sullivan, Catherine F Siengsukon, Jill K Morris, Laura E Martin, Holly R Hull","doi":"10.1080/1028415X.2024.2371727","DOIUrl":"10.1080/1028415X.2024.2371727","url":null,"abstract":"<p><p>Dementia is a debilitating condition with a disproportionate impact on women. While sex differences in longevity contribute to the disparity, the role of the female sex as a biological variable in disease progression is not yet fully elucidated. Metabolic dysfunctions are drivers of dementia etiology, and cardiometabolic diseases are among the most influential modifiable risk factors. Pregnancy is a time of enhanced vulnerability for metabolic disorders. Many dementia risk factors, such as hypertension or blood glucose dysregulation, often emerge for the first time in pregnancy. While such cardiometabolic complications in pregnancy pose a risk to the health trajectory of a woman, increasing her odds of developing type 2 diabetes or chronic hypertension, it is not fully understood how this relates to her risk for dementia. Furthermore, structural and functional changes in the maternal brain have been reported during pregnancy suggesting it is a time of neuroplasticity for the mother. Therefore, pregnancy may be a window of opportunity to optimize metabolic health and support the maternal brain. Healthy dietary patterns are known to reduce the risk of cardiometabolic diseases and have been linked to dementia prevention, yet interventions targeting cognitive function in late life have largely been unsuccessful. Earlier interventions are needed to address the underlying metabolic dysfunctions and potentially reduce the risk of dementia, and pregnancy offers an ideal opportunity to intervene. This review discusses current evidence regarding maternal brain health and the potential window of opportunity in pregnancy to use diet to address neurological health disparities for women.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"347-359"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal protein malnutrition decreases neuron numbers in the parahippocampal region but not prefrontal cortex in adult rats.","authors":"A C Amaral, J P Lister, J W Rueckemann, M W Wojnarowicz, J A McGaughy, D J Mokler, J R Galler, D L Rosene, R J Rushmore","doi":"10.1080/1028415X.2024.2371256","DOIUrl":"10.1080/1028415X.2024.2371256","url":null,"abstract":"<p><strong>Objective: </strong>Prenatal protein malnutrition produces anatomical and functional changes in the developing brain that persist despite immediate postnatal nutritional rehabilitation. Brain networks of prenatally malnourished animals show diminished activation of prefrontal areas and an increased activation of hippocampal regions during an attentional task [1]. While a reduction in cell number has been documented in hippocampal subfield CA1, nothing is known about changes in neuron numbers in the prefrontal or parahippocampal cortices.</p><p><strong>Methods: </strong>In the present study, we used unbiased stereology to investigate the effect of prenatal protein malnutrition on the neuron numbers in the medial prefrontal cortex and the cortices of the parahippocampal region that comprise the larger functional network.</p><p><strong>Results: </strong>Results show that prenatal protein malnutrition does not cause changes in the neuronal population in the medial prefrontal cortex of adult rats, indicating that the decrease in functional activation during attentional tasks is not due to a reduction in the number of neurons. Results also show that prenatal protein malnutrition is associated with a reduction in neuron numbers in specific parahippocampal subregions: the medial entorhinal cortex and presubiculum.</p><p><strong>Discussion: </strong>The affected regions along with CA1 comprise a tightly interconnected circuit, suggesting that prenatal malnutrition confers a vulnerability to specific hippocampal circuits. These findings are consistent with the idea that prenatal protein malnutrition produces a reorganization of structural and functional networks, which may underlie observed alterations in attentional processes and capabilities.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"333-346"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of dietary depression index in Chinese adults.","authors":"Min Gao, Jiali Zheng, Fangyu Li, Yumeng Yan, Yin Wu, Sha Li, Jun Li, Xiaoguang Li, Hui Wang","doi":"10.1080/1028415X.2024.2376981","DOIUrl":"10.1080/1028415X.2024.2376981","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies have suggested diet was associated with depressive symptoms. We aimed to develop and validate Dietary Depression Index (DDI) based on dietary prediction of depression in a large Chinese cancer screening cohort.</p><p><strong>Methods: </strong>In the training set (<i>n</i> = 2729), we developed DDI by using intake of 20 food groups derived from a food frequency questionnaire to predict depression as assessed by Patient Health Questionnaire-9 based on the reduced rank regression method. Sensitivity, specificity, positive predictive value, and negative predictive value were used to assess the performance of DDI in evaluating depression in the validation dataset (<i>n</i> = 1176).</p><p><strong>Results: </strong>Receiver operating characteristic analysis was constructed to determine the best cut-off value of DDI in predicting depression. In the study population, the DDI ranged from -3.126 to 1.810. The discriminative ability of DDI in predicting depression was good with the AUC of 0.799 overall, 0.794 in males and 0.808 in females. The best cut-off values of DDI for depression prediction were 0.204 overall, 0.330 in males and 0.034 in females. DDI was a validated method to assess the effects of diet on depression.</p><p><strong>Conclusion: </strong>Among individual food components in DDI, fermented vegetables, fresh vegetables, whole grains and onions were inversely associated, whereas legumes, pickled vegetables and rice were positively associated with depressive symptoms.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"394-404"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico and <i>in vivo</i> evaluation of erucic acid against pentylenetetrazole-induced seizures in mice by modulating oxidative stress, neurotransmitters and neuroinflammation markers.","authors":"Sami I Alzarea, Muhammad Afzal, Ehssan Moglad, Hassan H Alhassan, Abdulaziz Ibrahim Alzarea, Omar Awad Alsaidan, Nadeem Sayyed, Imran Kazmi","doi":"10.1080/1028415X.2025.2463677","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2463677","url":null,"abstract":"<p><strong>Background: </strong>Pentylenetetrazole (PTZ) is a commonly used chemical to induce epileptic seizures in experimental animals.</p><p><strong>Aim: </strong>To investigate the neuroprotective effects of erucic acid against PTZ-induced seizures in mice and explore its underlying mechanisms.</p><p><strong>Methodology: </strong>The mice were randomly allocated into four groups: normal control, PTZ-treated (35 mg/kg via intraperitoneal injection), and PTZ + erucic acid (at doses of 10 and 20 mg/kg). Various parameters were assessed, including the percentage of animals experiencing convulsions, latency to death, percentage of deaths, levels of neurotransmitters, pro-inflammatory cytokines such as interleukin-6 (IL-6), interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), nuclear factor kappa B (NF-κB), oxidative stress marker malondialdehyde (MDA), antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and caspase-3. The docking analysis was performed using AutoDock Vina software.</p><p><strong>Results: </strong>Erucic acid markedly reduced the severity and frequency of PTZ-induced seizures, significantly decreased mortality rates, and restored altered neurotransmitter levels in mice. It alleviated oxidative stress by increasing the activity of antioxidant enzymes and reducing malondialdehyde (MDA) levels. Additionally, erucic acid mitigated neuroinflammation by downregulating pro-inflammatory cytokine production and inhibiting NF-κB activation. Molecular docking studies demonstrated that erucic acid exhibited strong binding affinities toward key molecular targets, including GABA (-4.546), NF-κB (-5.982), and caspase-3 (-5.22), suggesting its potential as a neuroprotective agent.</p><p><strong>Conclusion: </strong>Erucic acid may be an effective natural compound in PTZ-induced seizures in mice by restoring neurotransmitters, oxidative stress and neuroinflammatory mediators. It could prove to be a better alternative in the treatment of epilepsy.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-16"},"PeriodicalIF":3.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}