Nutritional Neuroscience最新文献_第6页

Supplementation with Manihot esculenta Crantz (Cassava) leaves' extract prevents recognition memory deficits and hippocampal antioxidant dysfunction induced by Amyloid-β. 补充木薯叶提取物可防止淀粉样蛋白-β诱导的识别记忆缺陷和海马抗氧化功能障碍。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-09-01 Epub Date: 2023-11-10 DOI: 10.1080/1028415X.2023.2280815

Guilherme Salgado Carrazoni, Nathália Billig Garces, Caroline Ramires Cadore, Priscila Marques Sosa, Roberta Cattaneo, Pâmela Billig Mello-Carpes

{"title":"Supplementation with Manihot esculenta Crantz (Cassava) leaves' extract prevents recognition memory deficits and hippocampal antioxidant dysfunction induced by Amyloid-β.","authors":"Guilherme Salgado Carrazoni, Nathália Billig Garces, Caroline Ramires Cadore, Priscila Marques Sosa, Roberta Cattaneo, Pâmela Billig Mello-Carpes","doi":"10.1080/1028415X.2023.2280815","DOIUrl":"10.1080/1028415X.2023.2280815","url":null,"abstract":"Objective: The Manihot esculenta Crantz (Cassava) is a typical South American plant rich in nutrients and energetic compounds. Lately, our group has shown that non-pharmacological interventions with natural antioxidants present different neuroprotective effects on oxidative balance and memory deficits in AD-like animal models. Here, our objective was to evaluate the neuroprotective effects of Cassava leaves' extract (CAS) in an AD-like model induced by amyloid-beta (Aβ) 25-35 peptide.Methods: Male Wistar rats (n = 40; 60 days old) were subjected to 10 days of CAS supplementation; then, we injected 2 μL Aβ 25-35 in the hippocampus by stereotaxic surgery. Ten days later, we evaluated object recognition (OR) memory. Cassavas' total polyphenols, flavonoids, and condensed tannins content were measured, as well as hippocampal lipid peroxidation and total antioxidant capacity.Results: CAS protected against Aβ-induced OR memory deficits. In addition, Aβ promoted antioxidant capacity decrease, while CAS was able to prevent it, in addition to diminishing lipoperoxidation compared to Aβ.Discussion: We show that treatment with Cassava leaves' extract before AD induction prevents recognition memory deficits related to Aβ hippocampal injection. At least part of these effects can be related to the Cassava leaves' extract supplementation effects on diminishing lipid peroxidation and preventing a decrease in the hippocampal total antioxidant capacity in the hippocampus of AD-like animals without adverse effects. Once cassavais a plant of warm and dry ground that can adapt to growon various soil types and seems to resist several insects, our results enable Cassava to be considered asa potential preventive intervention to avoid or minimizeAD-induced memory deficits worldwide.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"942-950"},"PeriodicalIF":3.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72210262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between vitamin D, depression, and sleep health in the National Health and Nutrition Examination Surveys: a mediation analysis. 国家健康和营养检查调查中维生素D、抑郁和睡眠健康之间的关系:中介分析

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-09-01 Epub Date: 2023-11-14 DOI: 10.1080/1028415X.2023.2279363

Jingliang Shuai, Mengqi Gao, Qi Zou, Youming He

{"title":"Association between vitamin D, depression, and sleep health in the National Health and Nutrition Examination Surveys: a mediation analysis.","authors":"Jingliang Shuai, Mengqi Gao, Qi Zou, Youming He","doi":"10.1080/1028415X.2023.2279363","DOIUrl":"10.1080/1028415X.2023.2279363","url":null,"abstract":"Objective: This study aimed to assess the association between vitamin D and sleep health and to investigate whether depression could mediate this relationship.Methods: A cross-sectional analysis was performed using the 2005-2014 US National Health and Nutrition Examination Survey (NHANES) data. The logistic regression models were conducted to evaluate association of serum vitamin D concentrations with sleep health and depression. Mediation analyses were conducted to investigate the mediated effects of depression on the association of vitamin D with sleep health.Results: In multivariate logistic models, vitamin D was found to be negatively associated with an increased risk of poor sleep health, with an odds ratio (OR) of vitamin D deficiency versus sufficiency was 1.256 (95% CI = 1.084-1.455). Additionally, univariate logistic models showed that vitamin D was also negatively associated with depression risk (vitamin D deficiency vs. sufficiency: OR = 1.699, 95% CI = (1.373-2.103). Further mediation analyses showed that the association of vitamin D with sleep health was mediated by depression, with the mediating effects of depression accounted for 44.56% of the total effects.Conclusion: Vitamin D affects sleep health directly and indirectly through depression. The results suggest that interventions increasing intake of vitamin D should be prioritized to promote sleep health of persons with or at risk of depression.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"934-941"},"PeriodicalIF":3.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92155681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediterranean diet-based intervention to improve depressive symptoms: analysis of the PREDIDEP randomized trial. 地中海饮食干预改善抑郁症状:PREDIDEP随机试验分析

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-09-01 Epub Date: 2023-11-22 DOI: 10.1080/1028415X.2023.2283290

Beatriz M Cabrera-Suárez, Jose L Hernández-Fleta, Patricio Molero, Ana González-Pinto, Francisca Lahortiga, Claudio Cabrera, Carlos Chiclana-Actis, Almudena Sánchez-Villegas

{"title":"Mediterranean diet-based intervention to improve depressive symptoms: analysis of the PREDIDEP randomized trial.","authors":"Beatriz M Cabrera-Suárez, Jose L Hernández-Fleta, Patricio Molero, Ana González-Pinto, Francisca Lahortiga, Claudio Cabrera, Carlos Chiclana-Actis, Almudena Sánchez-Villegas","doi":"10.1080/1028415X.2023.2283290","DOIUrl":"10.1080/1028415X.2023.2283290","url":null,"abstract":"Background: The effect of an intervention based on Mediterranean diet on reducing recurrence risk or subsyndromal depressive symptoms in recovered depressed patients has not been explored.Methods: The PREDIDEP study was a two-year randomized trial designed to assess the effect of the Mediterranean Diet enriched with extra virgin olive oil on depression recurrence. At baseline and at four, eight, 16, 20, and 24 months of follow-up, depressive symptoms were evaluated through the Beck Depression inventory. Cox regression analysis was fitted to assess the role of dietary intervention on the risk of depression recurrence. Mixed effects linear models were used to assess changes in depressive subsyndromal symptoms according to the intervention.Results: After two years of intervention, the dietary intervention group (n = 103) compared to the control group (n = 93) showed no differences regarding depression recurrence risk as main outcome. As secondary outcomes, an improvement of depressive symptoms was yielded at four (-2.15; 95% CI = -4.00 to -0.29) and eight months (-2.42; 95% CI = -4.17 to -0.67) in the intervention group, with no changes in control group. Moreover, at 20 months, significant differences were found between groups (-3.35; 95% CI = -6.08 to -0.61).Conclusions: An intervention with Mediterranean diet in patients with previous depressive episodes might contribute to the reduction of depressive subsyndromal symptoms.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"951-961"},"PeriodicalIF":3.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does hazelnut consumption affect brain health and function against neurodegenerative diseases? 食用榛子会影响大脑健康和功能，预防神经退行性疾病吗？

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-09-01 Epub Date: 2023-12-27 DOI: 10.1080/1028415X.2023.2296164

Shadi Talebi, Fariba Khodagholi, Zahra Bahaeddin, Mitra Ansari Dezfouli, Arman Zeinaddini-Meymand, Samuel Berchi Kankam, Forough Foolad, Fatemeh Alijaniha, Fatemeh Fayazi Piranghar

{"title":"Does hazelnut consumption affect brain health and function against neurodegenerative diseases?","authors":"Shadi Talebi, Fariba Khodagholi, Zahra Bahaeddin, Mitra Ansari Dezfouli, Arman Zeinaddini-Meymand, Samuel Berchi Kankam, Forough Foolad, Fatemeh Alijaniha, Fatemeh Fayazi Piranghar","doi":"10.1080/1028415X.2023.2296164","DOIUrl":"10.1080/1028415X.2023.2296164","url":null,"abstract":"Introduction: A healthy daily diet and consuming certain nutrients, such as polyphenols, vitamins, and unsaturated fatty acids, may help neuronal health maintenance. Polyphenolic chemicals, which have antioxidant and anti-inflammatory properties, are involved in the neuroprotective pathway. Because of their nutritional value, nuts have been shown in recent research to be helpful in neuroprotection.Objective: Hazelnut is often consumed worldwide in various items, including processed foods, particularly in bakery, chocolate, and confectionery products. This nut is an excellent source of vitamins, amino acids, tocopherols, phytosterols, polyphenols, minerals, and unsaturated fatty acids. Consuming hazelnut may attenuate the risk of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington's disease due to its anti-inflammatory and anti-oxidant qualities.Results: Many documents introduce hazelnut as an excellent choice to provide neuroprotection against neurodegenerative disorders and there is some direct proof of its neuroprotective effects.Discussion: So hazelnut consumption in daily diet may reduce neurodegenerative disease risk and be advantageous in reducing the imposed costs of dealing with neurodegenerative diseases.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1008-1024"},"PeriodicalIF":3.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dietary fat intake and history of stroke in US adults: findings from National Health and Nutrition Examination Survey 2007-2018. 美国成年人膳食脂肪摄入量与中风病史之间的关系：2007-2018 年全国健康与营养调查的结果。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-08-22 DOI: 10.1080/1028415X.2024.2391652

Juanying Zhen, Bernard Man Yung Cheung, Chao Li

{"title":"Association between dietary fat intake and history of stroke in US adults: findings from National Health and Nutrition Examination Survey 2007-2018.","authors":"Juanying Zhen, Bernard Man Yung Cheung, Chao Li","doi":"10.1080/1028415X.2024.2391652","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2391652","url":null,"abstract":"Objectives: Diet is an important target for primary prevention of stroke. There are mixed findings on the relationship between dietary fat intake and stroke. We aimed to investigate the relationship of stroke with fats, including total fat, saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA).Methods: We analysed data on 27,673 participants who had valid data on dietary fat intake and history of stroke from the National Health and Nutrition Examination Survey 2007-2018. History of stroke was defined according to previous diagnosis by doctors or other health professional. Data on 24-h dietary recalls was collected using Automated Multiple-Pass Method. Age, sex, race/ethnicity, total calories, body mass index, diabetes, hypertension, hypercholesterolaemia, smoking, alcohol consumption and physical activity were adjusted in multivariable models.Results: 3.8% (n = 1,054) of participants had a diagnosis of stroke. History of stroke was inversely associated with total fat (OR = 0.89, 95% CI = 0.79-0.99, P = 0.037), SFA (OR = 0.46, 95% CI = 0.23-0.91) and MUFA (OR = 0.08, 95% CI = 0.02-0.38, P = 0.002) from supplements. There was an inverse association between history of stroke and PUFA intake (from diet: quartile 4 vs quartile 1, OR = 0.58, 95% CI = 0.43-0.78, P for trend = 0.003; from supplements: OR = 0.44, 95% CI = 0.27-0.72, P = 0.001).Conclusions: In this large-scale nationally representative study, stroke is inversely associated with fat intake from supplements and PUFA intake from diet. While lifestyle choices may not be the most vital health factor for stroke patients, increasing fat intake from specific supplements does provide additional motivation for undertaking the difficult challenge of stroke prevention.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-9"},"PeriodicalIF":3.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of probiotics as an adjunctive therapy with Ritalin among ADHD children and adolescents: a triple-blind randomized controlled trial. 益生菌作为利他林的辅助疗法对多动症儿童和青少年的影响：三重盲法随机对照试验。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-08-20 DOI: 10.1080/1028415X.2024.2391655

Zahra Sadat Sangsefidi, Zohreh Sadat Sangsefidi, Fatemeh Moharreri, Aazam Sadat Heydari Yazdi, Saeid Eslami, Bahareh Emadzadeh, Behrouz Ghorani, Mahboobe Sarabi-Jamab, Atefeh Farahmand, Atena Modiri Dovom, Ali Ghanaei, Maryam Emadzadeh

{"title":"Effect of probiotics as an adjunctive therapy with Ritalin among ADHD children and adolescents: a triple-blind randomized controlled trial.","authors":"Zahra Sadat Sangsefidi, Zohreh Sadat Sangsefidi, Fatemeh Moharreri, Aazam Sadat Heydari Yazdi, Saeid Eslami, Bahareh Emadzadeh, Behrouz Ghorani, Mahboobe Sarabi-Jamab, Atefeh Farahmand, Atena Modiri Dovom, Ali Ghanaei, Maryam Emadzadeh","doi":"10.1080/1028415X.2024.2391655","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2391655","url":null,"abstract":"Objective: Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common mental disorders in children. Evidence regarding the impact of probiotics supplementation in ADHD children is limited and controversial. Thus, this study aimed to assess the effect of probiotics as an adjunctive therapy with Ritalin among ADHD children and adolescents.Methods: This study was a triple-blind, randomized controlled trial of 60 Iranian ADHD patients aged four to sixteen. The participants were randomly assigned to receive probiotics supplements containing both Lactobacillus plantarum PTCC 1896™ (A7) and Bifidobacterium animalis subsp. Lactis (BB-12®) (n = 30) or placebo (n = 30) for 8 weeks. ADHD symptoms were assessed using Conners' Parent Rating Scale (CPRS) and Integrated Visual and Auditory Continuous Performance Test (IVA/CPT) at baseline and during the study.Results: This study showed a significant decrease in the CPRS total score after 4 weeks of intervention in the probiotic group (baseline: 43.96 ± 21.52; fourth week: 37.22 ± 23.01; p = 0.01). However, no significant finding was found for the total score of the CPRS after 8 weeks. Moreover, at the end of the study, a significant increase was observed in score of auditory response control in the probiotic versus the placebo group (probiotic: 91.55 ± 16.69; placebo: 80.55 ± 17.43; p = 0.02).Conclusions: Probiotics supplementation with Ritalin may have some beneficial effects among ADHD children and adolescents, such as improving auditory response control and total score of CPRS. However, further clinical trials are required to clarify the impact of probiotics on ADHD.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-10"},"PeriodicalIF":3.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insect-derived extracts and peptides in neuroprotection. 昆虫提取物和肽在神经保护中的作用。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-08-19 DOI: 10.1080/1028415X.2024.2392410

Shivam Bhola, Eun-Jung Park, Hae-Jeung Lee

引用次数: 0

Gut microbiota, vitamin A deficiency and autism spectrum disorder: an interconnected trio - a systematic review. 肠道微生物群、维生素 A 缺乏症和自闭症谱系障碍：相互关联的三重奏--系统综述。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-08-13 DOI: 10.1080/1028415X.2024.2389498

Fatima Ezzahra Kacimi, Latifa Didou, Soumia Ed Day, Fatima Zahra Azzaoui, Mhamed Ramchoun, Hicham Berrougui, Hanane Khalki, Samira Boulbaroud

{"title":"Gut microbiota, vitamin A deficiency and autism spectrum disorder: an interconnected trio - a systematic review.","authors":"Fatima Ezzahra Kacimi, Latifa Didou, Soumia Ed Day, Fatima Zahra Azzaoui, Mhamed Ramchoun, Hicham Berrougui, Hanane Khalki, Samira Boulbaroud","doi":"10.1080/1028415X.2024.2389498","DOIUrl":"https://doi.org/10.1080/1028415X.2024.2389498","url":null,"abstract":"Accumulating evidence proves that children with autism have gastrointestinal problems. However, a significant difference in gut microbiota (GM) exists between autistic and non-autistic children. These changes in the GM may stem from several factors. Recently, researchers focused on nutritional factors, especially vitamin deficiency. Thus, our systematic review investigates the connections among autism, GM alterations, and vitamin A deficiency (VAD), by analyzing studies sourced from PubMed and Embase databases spanning from 2010 to 2022. Adhering to PRISMA guidelines, we meticulously selected 19 pertinent studies that established links between autism and GM changes or between autism and VAD. Our findings uniformly point to significant alterations in the GM of individuals with autism, indicating these changes as promising biomarkers for the disorder. Despite the consistent association of GM alterations with autism, our analysis revealed no notable differences in GM composition between individuals with autism and those experiencing VAD. This suggests that VAD, especially when encountered early in life, might play a role in the onset of autism. Furthermore, our review underscores a distinct correlation between reduced levels of retinoic acid in children with autism, a disparity that could relate to the severity of autism symptoms. The implications of our findings are twofold: they not only reinforce the significance of GM alterations as potential diagnostic markers but also spotlight the critical need for further research into nutritional interventions. Specifically, vitamin A supplementation emerges as a promising avenue for alleviating autism symptoms, warranting deeper investigation into its therapeutic potential.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-11"},"PeriodicalIF":3.6,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fruits and vegetables intake may be associated with a reduced odds of multiple sclerosis: a systematic review and dose-response meta-analysis of observational studies. 水果和蔬菜摄入可能与多发性硬化症几率降低有关：观察性研究的系统综述和剂量反应荟萃分析。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-08-01 Epub Date: 2023-10-18 DOI: 10.1080/1028415X.2023.2268390

Danial Fotros, Morvarid Noormohammadi, Soodeh Razeghi Jahromi, Mohammadjavad Abdolkarimi

{"title":"Fruits and vegetables intake may be associated with a reduced odds of multiple sclerosis: a systematic review and dose-response meta-analysis of observational studies.","authors":"Danial Fotros, Morvarid Noormohammadi, Soodeh Razeghi Jahromi, Mohammadjavad Abdolkarimi","doi":"10.1080/1028415X.2023.2268390","DOIUrl":"10.1080/1028415X.2023.2268390","url":null,"abstract":"Introduction: Multiple sclerosis (MS) is an immune-mediated condition of the central nervous system (CNS). Intake of fruits and vegetables high in vitamins, minerals, fiber, and active molecules contributes to the body's overall health, immunity, and physiological function. This study sought to review the literature and investigate the relationship between fruits and vegetables consumption and MS odds.Methods: In the current systematic review and meta-analysis, a systematic search of original databases from inception to 21 Dec 2022 was conducted based on the PRISMA 2020 statement. Human observational studies examining the association between fruits or vegetables consumption and MS prevalence were included if they reported and provided effect size with 95% confidence intervals (CIs).Results: The systematic review and meta-analysis included eight studies. Random effect model showed the protective effect of fruits (I2 = 81.0%, P for heterogeneity < 0.001; pooled OR = 0.52, 95%CI = 0.27, 0.97, P-value = 0.042) and vegetables consumption (I2 = 73.5%, P for heterogeneity = 0.002; pooled OR = 0.61, 95%CI = 0.38, 1.00, P-value = 0.050) on MS odds. According to a linear dose-response meta-analysis of four case-control studies, an increase of 100 grams of fruits per day reduced the odds of MS by 9% (I2 = 0.0%, P for heterogeneity = 0.77; pooled OR = 0.91, 95%CI = 0.83, 0.99, P-value = 0.021).Conclusion: Consumption of fruits and vegetables may be associated with a potential protective effect against MS. However, further confirmation is required through prospective longitudinal studies and randomized clinical trials.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"887-898"},"PeriodicalIF":3.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49680394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between short-chain fatty acid levels and mood disorder symptoms: a systematic review. 短链脂肪酸水平与情绪障碍症状之间的关系:一项系统综述

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2024-08-01 Epub Date: 2023-11-17 DOI: 10.1080/1028415X.2023.2277970

Caroline Fussing Bruun, Tue Haldor Hansen, Maj Vinberg, Lars Vedel Kessing, Klara Coello

{"title":"Associations between short-chain fatty acid levels and mood disorder symptoms: a systematic review.","authors":"Caroline Fussing Bruun, Tue Haldor Hansen, Maj Vinberg, Lars Vedel Kessing, Klara Coello","doi":"10.1080/1028415X.2023.2277970","DOIUrl":"10.1080/1028415X.2023.2277970","url":null,"abstract":"Background: Available evidence points to a possible role of Short Chain Fatty Acids (SCFAs) in mood disorders. This is the first systematic review to map the associations between SCFA levels and mood disorder symptoms.Methods: Following the PRISMA guidelines, the databases PubMed, Embase, and PsycINFO were searched for studies that assessed SCFA levels in human populations with mood disorder symptoms, or animal models of mood disorder. Risk of bias was assessed by the Strengthening of Reporting of Observational Studies in Epidemiology (STROBE) checklist.Results: 19 studies were included and could be divided into animal (n=8) and human studies (n=11), with the animal studies including 166 animals and 100 controls, and the human studies including 662 participants and 330 controls. The studies were characterized by heterogeneity and methodological challenges on multiple parameters, limiting the validity and transferability of findings. Notably, only two of the clinical studies assessed the presence of mood disorder with diagnostic criteria, and no studies of mania or bipolar disorder met the inclusion criteria.Discussion: Despite significant methodological limitations, associations between SCFA levels and depressive symptoms were reported in most of the studies. However, the direction of these associations and the specific SCFAs identified varied. The quantification of SCFA levels in mood disorders is an emerging yet sparsely studied research field. Although there is some evidence suggesting a link between SCFAs and depressive symptoms, the directionality of effects and mechanisms are unclear and the relation to manic symptoms is uninvestigated.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"899-912"},"PeriodicalIF":3.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0