Different intermittent fasting regimens decrease anxious and depressive-like behaviour, but show damage to brain tissues in healthy Wistar rats.

IF 3.6 4区医学 Q2 NEUROSCIENCES

Nutritional Neuroscience Pub Date : 2025-07-20 DOI:10.1080/1028415X.2025.2533967

Naís Lira Soares, Hassler Clementino Cavalcante, Soniellson de Lima Ferreira, Fernanda Beatriz Lima do Nascimento, Isabelle Karoline Carvalho Costa, Thaís Bayma Barbosa Rolim, Marcos Dos Santos Lima, Adriano Francisco Alves, Kamila Sabino Batista, Jailane de Souza Aquino

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引用次数: 0

Abstract

Background: Different intermittent fasting (IF) regimens have been used in healthy individuals to improve body composition; however, other potential benefits or harm, such as modulation of behaviours, are little studied in healthy populations. The present study aimed to evaluate the influence of different IF regimens on parameters related to the behavioural and cerebral aspects in healthy rats and compare them to caloric restriction.

Methods: Adult Wistar rats were randomised into five groups: control (CON); caloric restriction (CR); time-restricted feeding (TRF); alternate-day fasting (ADF); and alternate-day modified fasting (ADMF), and then evaluated during four weeks.

Results: The ADF and ADMF groups had the lowest weight over the weeks and decreased depressive-like behaviour, while TRF decreased anxiety-like behaviour. However, all experimental groups presented some damage in the brain tissues (central cortex and hippocampus), and ADF had the largest area of ⁣⁣NF-κB marking.

Conclusion: Although all groups submitted to IF showed benefits in behaviour, they also presented damage to brain tissues (gemistocystic astrocytes, and ischemic neuronal cell bodies).

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不同的间歇性禁食方案会减少焦虑和抑郁样行为，但会对健康Wistar大鼠的脑组织造成损害。

背景：不同的间歇性禁食（IF）方案已用于健康个体以改善身体成分；然而，其他潜在的益处或危害，如行为调节，在健康人群中很少得到研究。本研究旨在评估不同IF方案对健康大鼠行为和大脑方面相关参数的影响，并将其与热量限制进行比较。方法：将成年Wistar大鼠随机分为5组：对照组（CON）；热量限制；限时进料；隔日禁食；和隔日改良禁食（ADMF），然后在四周内进行评估。结果：ADF和ADMF组在数周内体重最低，抑郁样行为减少，而TRF组减少焦虑样行为。但各实验组脑组织（中央皮层和海马）均出现一定程度的损伤，其中ADF的NF-κB标记面积最大。结论：虽然所有接受IF治疗的组都表现出行为上的益处，但它们也表现出对脑组织（双囊星形胶质细胞和缺血性神经元细胞体）的损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.