Nutritional Neuroscience最新文献

{"title":"The possible antioxidative effects of ketogenic diet by modifying brain klotho expression: a rat model study.","authors":"Nasrin Ranjbar, Bahador Ebrahimi Behnam, Mehran Mesgari Abbasi, Mahsa Esmaeili, Fatemeh Jolfaei, Jamal Mohammadian, Nadereh Rashtchizadeh, Amir Ghorbanihaghjo, Sina Raeisi","doi":"10.1080/1028415X.2024.2436817","DOIUrl":"10.1080/1028415X.2024.2436817","url":null,"abstract":"<p><p><b>Objectives:</b> The ketogenic diet (KD) has long been used as an alternative nonpharmacological therapy to manage pharmacoresistant epilepsy. The anticonvulsant mechanisms of KD have yet to be fully elucidated. The present study explored whether a KD could exert antioxidative effects by altering brain Klotho (Kl) gene expression.<b>Methods:</b> Thirty male rats were divided into three groups: the normal diet (ND) group received standard rat chow; the calorie-restricted diet (CRD) group was maintained at 90% of the calculated energy need; and the KD group received a diet composed of 8% protein, 2% carbohydrates, and 90% fat (per calorie macronutrient). The levels of β-hydroxybutyrate (BHB) in the serum, <i>Kl</i> gene expression in the brain, and Kl protein, malondialdehyde (MDA), and protein carbonyl (PC) levels in the serum and brain were evaluated by standard methods.<b>Results:</b> The serum BHB levels in the KD group were significantly greater than those in the ND and CRD groups (<i>p</i> < 0.001). The Kl expression in the brain was significantly greater in the KD group than in the ND group (<i>p</i> = 0.028). The brain MDA levels in the KD group were significantly lower than those in the ND group (<i>p</i> = 0.006). Elevated BHB was positively correlated with brain <i>Kl</i> expression (r = 0.668, <i>p</i> < 0.001). The brain MDA levels were negatively correlated with brain <i>Kl</i> expression (r = -0.531, <i>p</i> = 0.003) and serum BHB levels (r = 0.472, <i>p</i> = 0.020).<b>Discussion:</b> KD might exert antioxidative effects by increasing BHB and upregulating <i>Kl</i> in the brain. This could be considered a possible anticonvulsant mechanism of KD.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"968-974"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of <i>Acacia catechu</i> and <i>Scutellaria baicalensis</i> extract on cognitive function in a healthy adult population: a double-blind, randomized, placebo-controlled trial.","authors":"Joesi M Krieger, Anthony M Hagele, Petey W Mumford, Diego De Gregorio, Connor J Gaige, Ethan R Hoffman, Kristen N Gross, Kevin F Holley, Leah E Allen, Chad M Kerksick","doi":"10.1080/1028415X.2024.2442425","DOIUrl":"10.1080/1028415X.2024.2442425","url":null,"abstract":"<p><p>Flavonoids, known for their neuroprotective properties, are abundant in <i>Acacia catechu</i> and <i>Scutellaria baicalensis.</i> Yet, human studies on their combined effects are limited.</p><p><strong>Objective: </strong>This study evaluated the cognitive effects of combined <i>Acacia catechu</i> and <i>Scutellaria baicalensis</i> supplementation in healthy adults.</p><p><strong>Methods: </strong>In a randomized, double-blind, placebo-controlled trial, 26 males and 59 females (<i>N</i> = 85; 43 ± 8 yrs) consumed the test product (TP) containing 240 mg stem extract of <i>Scutellaria baicalensis</i> and 51 mg heartwood extract of <i>Acacia catechu</i> (UP326, Unigen, Tacoma, WA USA) or placebo (PLA) for four weeks. Cognitive function and biomarkers were assessed throughout the study.</p><p><strong>Results: </strong>Significant time effects (<i>p</i> < 0.001) were observed across cognitive function assessments, with no differences between groups. Energy and fatigue reports showed a significant time effect (<i>p</i> = 0.023), while no significant differences emerged in general health and well-being scores. Cortisol levels increased significantly over time across conditions (<i>p</i> = 0.005), but no significant changes were observed in change scores or individual visits. Interim (<i>p</i> = 0.023) and final (<i>p</i> = 0.004) absolute basophil levels differed significantly between groups, with no intergroup changes. No significant differences in BDNF, CRP, or health and safety biomarkers were detected between supplemental conditions or over time.</p><p><strong>Discussion: </strong>Four-week daily TP supplementation significantly enhanced cognitive function without difference from placebo. However, no adverse events or significant blood marker changes were noted, suggesting TP supplementation is generally well-tolerated. Further research is warranted to explore the preventive and attenuating cognitive effects of this supplementation.<b>Trial registration:</b> ISRCTN.org identifier: ISRCTN16548309.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"975-986"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition/exercise interaction in the rat mother-pup dyad: a behavioral and electrophysiological analysis.","authors":"Maria Luísa Figueira de Oliveira, Anna Carolina Lopes de Lira, José Anderson da Silva Gomes, Amanda Ferraz Braz, Fernando Wesley Cavalcanti de Araújo, Arthur Gabriel Aves Furtado de Carvalho Noya, Carol Virgínia Góis Leandro, Rubem Carlos Araujo Guedes","doi":"10.1080/1028415X.2024.2448137","DOIUrl":"10.1080/1028415X.2024.2448137","url":null,"abstract":"<p><strong>Objectives: </strong>Maternal protein malnutrition alters brain functioning, impairing fetal development. Physical exercise during gestation benefits the fetal organism from maternal adaptive changes that may be neuroprotective. This study evaluated the effect of a low-protein diet associated with maternal voluntary physical activity (VPA) on rats' behavioral and brain electrophysiological parameters in the mother-pup dyad.</p><p><strong>Methods: </strong>Female Wistar rats (n = 40) performed VPA on running wheels during a 30-day pre-mating period. Daily running distance, activity duration, and caloric expenditure enabled us to classify the dams as sedentary or exercised. During pregnancy, half of the mothers were fed a low-protein diet (8% protein from casein), and the other half was fed a standard diet with 17% protein from casein. After lactation, when the mothers reached 150-160 days and the pups aged 30-35, animals were tested to evaluate anxiety-like behaviors in the open field and the elevated plus maze, and assess object recognition memory in the open field apparatus. At 160-170 days of life (mothers) and 35-45 days (pups), the animals were subjected to a recording session of the excitability-related phenomenon known as cortical spreading depression (CSD).</p><p><strong>Results: </strong>In the mother-pup dyad, malnutrition accelerated CSD, increased anxiety-like behavior, and impaired memory, whereas VPA produced the opposite effects. The greater impact of exercise was observed among the malnourished animals.</p><p><strong>Discussion: </strong>Our results provide important evidence about the beneficial modulating role of perinatal VPA (before, during and up to 14 days after pregnancy) in reprograming the effects of protein malnutrition on the central nervous system.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"998-1012"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food additives for the central nervous system, useful or harmful? An evidence-based review.","authors":"Mohammadmahdi Fadaei, Amirhossein Sangi Nasab Lahijan, Davood Jahanmehr, Alireza Ahmadi, Reza Asadi-Golshan","doi":"10.1080/1028415X.2024.2433257","DOIUrl":"10.1080/1028415X.2024.2433257","url":null,"abstract":"<p><strong>Objectives: </strong>This review examines how food additives impact the central nervous system (CNS) focusing on the effects of sugars, artificial sweeteners, colorings, and preservatives.</p><p><strong>Methods: </strong>A literature search of PubMed, Scopus, and Web of Science was conducted for studies published since 2010. Key search terms included, food additives, neurotoxicity, cognition, and behavior.</p><p><strong>Results: </strong>It summarizes research findings on additives such as aspartame, stevia, methylene blue, azo dyes, sodium benzoate, and monosodium glutamate. It also covers mechanisms such as oxidative stress, neuroinflammation, and disruptions in neurotransmitter systems. Furthermore, it emphasizes the properties of natural compounds such as garlic (<i>Allium sativum</i>), tetramethylpyrazine, curcumin, licorice root extract (glycyrrhizin), and polyphenols in mitigating CNS damage caused by food additives.</p><p><strong>Discussion: </strong>Although ongoing studies are expanding our knowledge on the effects of these additives, future CNS research should focus on long-term investigations involving subjects to provide a more comprehensive understanding of the cumulative impacts of different additives and update regulatory standards based on new scientific findings.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"910-927"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common salt (NaCl) causes developmental, behavioral, and physiological defects in <i>Drosophila melanogaster</i>.","authors":"Swetapadma Sahu, Kalpanarani Dash, Monalisa Mishra","doi":"10.1080/1028415X.2024.2441677","DOIUrl":"10.1080/1028415X.2024.2441677","url":null,"abstract":"<p><strong>Purpose: </strong>The incidence of obesity has surged to pandemic levels in recent decades. Approximately 1.89 million obesity are linked to excessive salt consumption. This study aims to check the toxicity of salt at different concentrations using an invertebrate model organism <i>Drosophila melanogaster.</i></p><p><strong>Methods: </strong>Drosophila food was mixed with different salt concentrations (50, 200, 400, 800 µM). The toxicity of salt in third instar larvae was checked via different experiments such as trypan blue assay, crawling assay, and other histological staining was done to check the deposition of lipid droplets and amount of reactive oxygen species. Food intake analysis was performed to check the feeding rate, and body weight was also calculated to check the obesity index. Several behavioral assays are also performed in adult flies.</p><p><strong>Results: </strong>Most significant abnormalities were seen at 50 and 200 µM concentrations. Feeding rate increased up to 60%, body weight was increased up to 12% in larvae, and 27% in adult at 200 µM concentration. Approximately 60% larvae and 58% adult flies had defective response to extreme heat. 28% larvae and 38% adult flies were not responding to cold temperature. 55% flies had a defective phototaxis behavior and 40% of them showed positive geotaxis at those range. Salt stress leads to the buildup of free radicals, resulting in DNA damage in both the gut and hemolymph.</p><p><strong>Findings: </strong>Most toxic consequences are observed at the lower concentration range as the feeding rate was higher. Flies show aversive response to feed on the higher concentration of salt.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"891-909"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a causal link between folate status and schizophrenia? Evidence from genetic association studies.","authors":"Samantha Yoo, Azita Montazeri, Helene McNulty, Monique Potvin Kent, Julian Little","doi":"10.1080/1028415X.2024.2436822","DOIUrl":"10.1080/1028415X.2024.2436822","url":null,"abstract":"<p><p>Folate and vitamin B₁₂ status, through their critical involvement in DNA synthesis and methylation, may be causally related to the risk of schizophrenia. However, associations with blood status measures may reflect reverse causation or inadequate control for confounders. We aimed to synthesize evidence on the possible causal link between folate/vitamin B₁₂ status and schizophrenia using genetic variants as instrumental variables. MEDLINE, Embase, PsycINFO, and the Cochrane Database of Systematic Reviews were searched for Mendelian Randomization studies that investigated a causal relationship between genetic instruments for folate/vitamin B₁₂ status and schizophrenia onset or progression. We assessed the risk of bias using the Newcastle Ottawa Scale. Odds ratios and 95% confidence intervals were estimated using random effects models. We found 34 case-control studies. None used a formal instrumental variable analysis. Most of the studies had high methodological quality for assessing genetic association. The methylenetetrahydrofolate reductase (<i>MTHFR</i>) polymorphisms (C677T, A1298C) were most studied and homozygosity for the variants showed significant positive associations with the risk of schizophrenia (OR_{677TT vs 677CC}= 1.26 (1.03, 1.55) and OR_{1298CC vs 1298AA}= 1.58 (1.17, 2.13)). Heterozygosity for the variants showed attenuated associations in the same direction as homozygosity. Subgroups of age, sex, ethnicity, and folic acid fortification implementation were mostly underpowered to detect effects with precision. Evidence on the association of <i>MTHFR</i> polymorphisms with schizophrenia symptoms or the relationship between other gene polymorphisms and the risk of schizophrenia was severely limited. We identified significant associations between the <i>MTHFR</i> C677T and A1298C polymorphisms and the risk of schizophrenia at an aggregate level.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"940-951"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrient-heavy metal interaction and mixed heavy metal exposure in relation to cognition across lifespan: review evidence, potential mechanisms, and implications.","authors":"Yuanfei Liu, Zumin Shi, Jianghong Liu","doi":"10.1080/1028415X.2024.2436818","DOIUrl":"10.1080/1028415X.2024.2436818","url":null,"abstract":"<p><p><b>Objectives:</b> Increasing research has shown that heavy metal as a neurotoxicant affects cognitive function across the lifespan. Nutritional status may modify susceptibility to heavy metal exposures, which further impacts cognition.<b>Methods:</b> We conducted a comprehensive search for cross-sectional studies, longitudinal studies, case-control studies and clinical trials on the interaction between nutrient and heavy metal, as well as mixed heavy metal exposure, in relation to cognition across the lifespan.<b>Results:</b> Six cross-sectional studies, 20 longitudinal studies, two case-control studies and two clinical trials were identified. Studies confirmed the interactions between heavy metals (e.g. iron, lead, mercury, cadmium, copper and manganese) and various nutrients (e.g. protein, minerals, vitamins and polyunsaturated fatty acids) in relation to cognition. Sufficient essential nutrients may attenuate the adverse effect of heavy metals on cognitive performance while nutritional deficiency could increase metal toxicity. These interactions can be found in infants, children, adolescents and adults. However, current studies are limited and generate mixed results across different age groups. Potential mechanisms include nutrients reducing the bioaccumulation of metal in the same food source and lowering the toxicity of metal by moderating neurochemistry.<b>Discussion:</b> Further longitudinal study is necessary to explore different types of interactions, elucidate further physiological mechanisms and adjust more confounding variables to increase confidence in causal effect. A comprehensive understanding of metal-nutrient interaction in human cognition could help facilitate earlier detection and prevention.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"928-939"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-ferroptotic effects of natural polyphenols in nervous system injury: a narrative literature review.","authors":"Davood Nasiry, Ali Reza Khalatbary","doi":"10.1080/1028415X.2024.2448924","DOIUrl":"10.1080/1028415X.2024.2448924","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have shown that ferroptosis, a newly identified regulated cell death characterized by increased lipid peroxidation and accumulation of toxic lipid peroxides, is closely related to the pathophysiological processes of nervous system diseases which can be inhibited with iron chelators, lipophilic antioxidants, and lipid peroxidation inhibitors.</p><p><strong>Objective: </strong>To review the current evidence on the efficacy of various natural polyphenols in nervous system injury.</p><p><strong>Methods: </strong>The data selected for this review were collected by searching the MEDLINE/PubMed, Web of Science, Scopus, and Google Scholar database for articles published in English between 2000 and 2024 using the following terms: cell death, regulated cell death, ferroptosis, lipid peroxides, iron, and glutathione peroxidase.</p><p><strong>Results: </strong>Natural polyphenols have been found to have some protective effects against nervous system disorders, which are attributed to a variety of biological properties, particularly antioxidant, immunomodulatory, and anti-inflammatory effects. The preclinical studies conducted on the use of the most common dietary polyphenols, including resveratrol, EGCG, curcumin, quercetin, gastrodin, baicalein & baicalin, carthamin, galangin, puerarin, morachalcone, and carnosic acid with the molecular mechanisms have been discussed. On the other hand, the results of a few clinical studies emphasize the primary role of iron in neuronal degeneration following some of nervous system injury.</p><p><strong>Conclusion: </strong>Some of the findings indicated that natural polyphenols as antioxidant supplements have anti-ferroptotic effects in nervous system disorders.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"952-967"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between healthy dietary pattern and common mental disorders in women: a cross-sectional population-based study.","authors":"Jéssica Casagrande Oliveira, Anderson Garcez, Juvenal Soares Dias-da-Costa, Maria Teresa Anselmo Olinto","doi":"10.1080/1028415X.2024.2448923","DOIUrl":"10.1080/1028415X.2024.2448923","url":null,"abstract":"<p><strong>Objectives: </strong>Scientific evidence suggests an association between diet quality and the prevalence of common mental disorders (CMD) in women. Thus, this study aimed to investigate the association between a healthy dietary pattern and CMD among women.</p><p><strong>Methods: </strong>A cross-sectional population-based study was conducted on a representative sample of 1128 women, aged 20-69 years, residing in the urban area of São Leopoldo, RS, Brazil. A validated food frequency questionnaire was used to assess dietary intake. A healthy dietary pattern, primarily consisting of fruits and vegetables, was identified using principal component analysis. CMD were evaluated using the Self-Reporting Questionnaire (SRQ-20: score ≥ 8). Prevalence ratios (PR) with 95% confidence intervals (CI) were estimated using multivariate Poisson regression with robust variance.</p><p><strong>Results: </strong>The overall prevalence of CMD was 33.2% (95% CI: 30.6-36.1). After adjusting for potential confounding factors, a statistically significant inverse relationship between a healthy dietary pattern and CMD was observed. High adherence to a healthy dietary pattern was associated with a lower prevalence of CMD (PR = 0.74; 95% CI: 0.59-0.95; <i>p</i> = 0.017). Women with a higher score on the healthy dietary pattern were 26% less likely to have CMD.</p><p><strong>Conclusions: </strong>This study highlights a significant inverse association between a healthy dietary pattern and CMD in women. A high prevalence of CMD was also observed in this population group. These findings underscore the importance of promoting healthy dietary intake to prevent psychiatric disorders.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1013-1021"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum cryptoxanthin levels and migraine in American adults: results from NHANES.","authors":"Shuai Qing, Jianfeng Wang, Shiming Huang, Min Xiao, Qishan Yi","doi":"10.1080/1028415X.2024.2443092","DOIUrl":"10.1080/1028415X.2024.2443092","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress and neuroinflammation play critical roles in the pathogenesis of migraine, a neurovascular disease. Cryptoxanthin is a carotenoid known for its potent antioxidant and anti-inflammatory properties. However, the specific association between serum cryptoxanthin levels and migraine remains unclear. This study aims to evaluate the correlation between migraine and serum cryptoxanthin levels.</p><p><strong>Methods: </strong>For this cross-sectional analysis, information was gathered from individuals ≥20 years who took part in the National Health and Nutrition Examination Survey from 2001 to 2004. Details information was collected on migraines, serum cryptoxanthin levels and various crucial factors. Multivariable logistic regression and restricted cubic spline regression analyses were performed to investigate the relationship between serum cryptoxanthin and the occurrence of migraines.</p><p><strong>Results: </strong>The study included 8,645 participants, of whom 20.00%(1734/8645) experienced migraine. There was a nonlinear relationship (<i>p</i> < 0.001) between serum cryptoxanthin levels and migraine, which was depicted as an L-shaped curve. The occurrence rate of individuals with serum cryptoxanthin levels below 26.64 nmol/dL experiencing migraine was 0.976 (95% CI: 0.965∼0.987, <i>p</i><0.001).</p><p><strong>Conclusion: </strong>In adults among the United States, increased levels of serum cryptoxanthin were associated with decreased risk of migriane with a turning point at around 26.64 nmol/dL in American adults. Further studys are needed to confirm our findings.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"987-997"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}