Nutritional Neuroscience最新文献_第5页

Insect-derived extracts and peptides in neuroprotection. 昆虫提取物和肽在神经保护中的作用。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-08-19 DOI: 10.1080/1028415X.2024.2392410

Shivam Bhola, Eun-Jung Park, Hae-Jeung Lee

引用次数: 0

The effect of the modified Atkins diet and anti-seizure medications on lipid marker levels in adults with epilepsy. 改良阿特金斯饮食和抗癫痫药物对成人癫痫患者血脂标志物水平的影响。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-04 DOI: 10.1080/1028415X.2024.2397624

Ashley L Muller, Luisa Diaz-Arias, Mackenzie C Cervenka, Tanya J W McDonald

{"title":"The effect of the modified Atkins diet and anti-seizure medications on lipid marker levels in adults with epilepsy.","authors":"Ashley L Muller, Luisa Diaz-Arias, Mackenzie C Cervenka, Tanya J W McDonald","doi":"10.1080/1028415X.2024.2397624","DOIUrl":"10.1080/1028415X.2024.2397624","url":null,"abstract":"Objectives: Some anti-seizure medications (ASMs) are known to induce liver enzymes and impact lipid values that include total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglyceride (TG). In addition, use of ketogenic diet therapies, including the modified Atkins diet (MAD), has also influenced lipids. Here, we explored the combined impact of enzyme inducing ASMs (EIASMs) and MAD on lipid values in adults with epilepsy.Methods: Diet-naïve adults with epilepsy who began MAD were divided into three groups based on ASM use: EIASMs, non-EIASMs, and those on no ASMs. Demographic information, epilepsy-specific clinical history, anthropometrics and lipid values were obtained through retrospective chart review at baseline and after a minimum of 12 months of MAD use.Results: Forty-two adults on MAD had baseline and follow up 12-month lipid outcomes. There was a significant increase in median levels of TC, LDL, non-HDL, and HDL after 12 months of MAD use. There was no change in median levels of TG. When separated according to ASM category, adults on non-EIASMs showed significant elevations in TC, HDL, and LDL after 12 months of MAD use. In contrast, adults on EIASMs only showed a significant increase in HDL after 12 months of MAD use.Discussion: The increase in atherogenic cholesterol levels observed after 12 months of MAD use was most pronounced in adults with epilepsy on non-EIASMs and not observed in adults with epilepsy on EIASMs despite a higher proportion of abnormal cholesterol levels at baseline in those on EIASMs.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"563-572"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basic approach on the protective effects of hesperidin and naringin in Alzheimer's disease. 研究橙皮甙和柚皮甙对阿尔茨海默病的保护作用的基本方法。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-03 DOI: 10.1080/1028415X.2024.2397136

Müjgan Kuşi, Eda Becer, Hafize Seda Vatansever

{"title":"Basic approach on the protective effects of hesperidin and naringin in Alzheimer's disease.","authors":"Müjgan Kuşi, Eda Becer, Hafize Seda Vatansever","doi":"10.1080/1028415X.2024.2397136","DOIUrl":"10.1080/1028415X.2024.2397136","url":null,"abstract":"Objectives: Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment. This situation imposes a great burden on individuals, both economically and socially. Today, an effective method for treating the disease and protective approach to tau accumulation has not been developed yet. Studies have been conducted on the effects of hesperidin and naringin flavonoids found in citrus fruits on many diseases.Methods: In this review, the pathophysiology of AD is defined, and the effects of hesperidin and naringin on these factors are summarized.Results: Studies have shown that both components may potentially affect AD due to their antioxidative and anti-inflammatory properties. Based on these effects of the components, it has been shown that they may have ameliorative effects on Aβ, α-synuclein aggregation, tau pathology, and cognitive functions in the pathophysiology of AD.Discussion: There are studies suggesting that hesperidin and naringin may be effective in the prevention/treatment of AD. When these studies are examined, it is seen that more studies should be conducted on the subject.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"550-562"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-hydroxybutyrate and mitochondria mediate the association between medium-chain fatty acids, DHA and mild cognitive impairment: a nested case-control study. β-羟丁酸和线粒体介导中链脂肪酸、DHA与轻度认知障碍之间的关系：一项巢式病例对照研究。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-03 DOI: 10.1080/1028415X.2024.2398364

Tong Yang, Huilian Duan, Yuan Li, Ning Xu, Zehao Wang, Zhenshu Li, Yongjie Chen, Yue Du, Meilin Zhang, Jing Yan, Changqing Sun, Guangshun Wang, Wen Li, Xin Li, Fei Ma, Guowei Huang

{"title":"β-hydroxybutyrate and mitochondria mediate the association between medium-chain fatty acids, DHA and mild cognitive impairment: a nested case-control study.","authors":"Tong Yang, Huilian Duan, Yuan Li, Ning Xu, Zehao Wang, Zhenshu Li, Yongjie Chen, Yue Du, Meilin Zhang, Jing Yan, Changqing Sun, Guangshun Wang, Wen Li, Xin Li, Fei Ma, Guowei Huang","doi":"10.1080/1028415X.2024.2398364","DOIUrl":"10.1080/1028415X.2024.2398364","url":null,"abstract":"Background: Medium-chain fatty acids (MCFAs) and docosahexaenoic acid (DHA) could affect the occurrence of mild cognitive impairment (MCI). β-hydroxybutyrate (BHB), mitochondrial DNA copy number (mtDNAcn) and mitochondrial DNA (mtDNA) deletions might be their potential mechanisms. This study aimed to explore the relationship between MCFAs, DHA and MCI, and potential mechanisms.Methods: This study used data from Tianjin Elderly Nutrition and Cognition (TENC) cohort study, 120 individuals were identified with new onset MCI during follow-up, 120 individuals without MCI were selected by 1:1 matching sex, age, and education levels as the control group from TENC. Conditional logistic regression analysis and mediation effect analysis were used to explore their relationship.Results: Higher serum octanoic acid levels (OR: 0.633, 95% CI: 0.520, 0.769), higher serum DHA levels (OR: 0.962, 95% CI: 0.942, 0.981), and more mtDNAcn (OR: 0.436, 95% CI: 0.240, 0.794) were associated with lower MCI risk, while more mtDNA deletions was associated with higher MCI risk (OR: 8.833, 95% CI: 3.909, 19.960). Mediation analysis suggested that BHB and mtDNAcn, in series, have mediation roles in the association between octanoic acid and MCI risk, and mtDNA deletions have mediation roles in the association between DHA and MCI risk.Conclusion: Higher serum octanoic acid and DHA levels were associated with lower MCI risk. Octanoic acid could affect the incidence of MCI through BHB, then mitochondria function, or through mitochondria function, or directly. Serum DHA level could affect the incidence of MCI through mitochondria function, or directly.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"573-582"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary inflammatory potential and severe headache or migraine: a systematic review of observational studies. 饮食炎症潜能与严重头痛或偏头痛：观察性研究的系统回顾。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-09 DOI: 10.1080/1028415X.2024.2391814

Nasser S Alqahtani, Mohammed Suleiman Zaroog, Baker Mohammad Abdallah Albow

{"title":"Dietary inflammatory potential and severe headache or migraine: a systematic review of observational studies.","authors":"Nasser S Alqahtani, Mohammed Suleiman Zaroog, Baker Mohammad Abdallah Albow","doi":"10.1080/1028415X.2024.2391814","DOIUrl":"10.1080/1028415X.2024.2391814","url":null,"abstract":"Objectives: We conducted the current systematic review to investigate the association between dietary inflammatory index (DII) and severe headaches or migraine among adults via synthesizing observational evidence.Method: We conducted a systematic literature search of observational studies through PubMed, Scopus, and Web of Science databases from inception until July 2024. The PECO framework was implemented to select eligible studies as follows: Population (adults with severe headache or migraine), Exposure (individuals with the highest adherence to a pro-inflammatory diet), Comparison (individuals with the lowest adherence to a pro-inflammatory diet), Outcome (risk of developing severe headache or migraine, headaches frequency, duration, severity, and migraine-related disability).Results: After reviewing six studies involving 31,958 individuals, we found that following an anti-inflammatory diet is associated with a lower frequency and severity of migraine headaches. Additionally, our research revealed that individuals with migraines tend to have lower adherence to an anti-inflammatory diet when compared to people without migraines. Surprisingly, adherence to a pro-inflammatory diet was linked to a reduced risk of chronic daily headaches.Conclusion: Present findings imply a negative link between an inflammatory diet and severe headaches or migraine. However, further well-designed longitudinal studies are needed to interpret the causality and shed light on the underlying mechanisms.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"532-540"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of brown rice consumption in an iron-induced parkinsonism in Drosophila. 食用糙米对铁诱导的果蝇帕金森症的神经保护作用

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-05 DOI: 10.1080/1028415X.2024.2399988

Yaaqub Abiodun Uthman, Kasimu Ghandi Ibrahim, Murtala Bello Abubakar, Ismail Sulaiman, Mustapha Umar Imam

{"title":"Neuroprotective effects of brown rice consumption in an iron-induced parkinsonism in Drosophila.","authors":"Yaaqub Abiodun Uthman, Kasimu Ghandi Ibrahim, Murtala Bello Abubakar, Ismail Sulaiman, Mustapha Umar Imam","doi":"10.1080/1028415X.2024.2399988","DOIUrl":"10.1080/1028415X.2024.2399988","url":null,"abstract":"Objectives: Iron (Fe) accumulation and resultant oxidative stress play a significant role in the neuronal death observed in Parkinson's disease (PD). Brown rice (BR) possesses antioxidant properties able to reduce cellular oxidative damage. Thus, we hypothesized that BR may ameliorate Fe-induced parkinsonism due to oxidative stress.Methods: Two - to three-day-old male flies were concurrently exposed to Fe (ferrous sulphate, 1 mM) and interventions, divided into eight groups: control; Fe; BR; white rice (WR); L-dopa (1 mM); Fe (1 mM) + BR; Fe (1 mM) + WR; and Fe (1 mM) + L-dopa (1 mM). The flies were exposed for 15 days to their respective diets, and their behavior, relevant biomarkers, and the expression of related genes were evaluated.Results: Chronic exposure to Fe caused cognitive and locomotor deficits by increasing Fe levels (p = 0.027) in flies' heads, as well as heightened aggression and grooming episodes (p < 0.001). The elevated iron levels induced changes consistent with oxidative stress, evidenced by increased MDA levels (p < 0.001), and reduced activity of catalase (p < 0.001) and glutathione peroxidase (GPx) (p < 0.001), along with decreased dopamine levels (p < 0.001). Additionally, there was dysregulation in the mRNA expression of malvolio, ferritin, Nrf2, DJ-1, GPx, and catalase (p < 0.05). BR prevented the Fe-induced effects (Fe + BR group) even more effectively than L-Dopa (p < 0.001).Conclusion: The findings indicate that BR has the potential to mitigate Fe-induced ROS-mediated damage in a Drosophila model of PD-like disease by modulating key players in the Nrf2 signaling pathway.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"591-601"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal dietary deficiencies in folic acid or choline reduce primary neuron viability after exposure to hypoxia through increased levels of apoptosis. 母体膳食中叶酸或胆碱的缺乏会增加细胞凋亡水平，从而降低原发性神经元在缺氧情况下的存活率。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-05-01 Epub Date: 2024-09-04 DOI: 10.1080/1028415X.2024.2398365

Alice Yaldiko, Sarah Coonrod, Purvaja Marella, Lauren Hurley, Nafisa M Jadavji

{"title":"Maternal dietary deficiencies in folic acid or choline reduce primary neuron viability after exposure to hypoxia through increased levels of apoptosis.","authors":"Alice Yaldiko, Sarah Coonrod, Purvaja Marella, Lauren Hurley, Nafisa M Jadavji","doi":"10.1080/1028415X.2024.2398365","DOIUrl":"10.1080/1028415X.2024.2398365","url":null,"abstract":"Objective: Ischemic stroke is the leading cause of death and disability globally. By addressing modifiable risk factors, particularly nutrition, the prevalence of stroke and its dire consequences can be mitigated. One-carbon (1C) metabolism is a critical biosynthetic process that is involved in neural tube closure, DNA synthesis, plasticity, and cellular proliferation. Folates and choline are two active components of 1C metabolism. We have previously demonstrated that maternal dietary deficiencies during pregnancy and lactation in folic acid or choline result in worse stroke outcomes in offspring. However, there is insufficient data to understand the neuronal mechanisms involved.Methods: Using C57Bl/6J female mice maintained on control, folic acid (0.3 mg/kg) or choline (choline bitrate 300 mg/kg) deficient diets we collected embryonic primary neurons from offspring and exposed them to hypoxic conditions for 6 hours. To determine whether increased levels of either folic acid or choline can rescue reduced neuronal viability, we supplemented cell media with folic acid and choline prior to and after exposure to hypoxia.Results: Our results suggest that maternal dietary deficiencies in either folic acid or choline during pregnancy negatively impacts offspring neuronal viability after hypoxia. Furthermore, increasing levels of folic acid (250 mg/ml) or choline chloride (250 mg/ml) prior to and after hypoxia have a beneficial impact on neuronal viability.Conclusion: The findings contribute to our understanding of the intricate interplay between maternal dietary factors, 1C metabolism, and the outcome of offspring to hypoxic events, emphasizing the potential for nutritional interventions in mitigating adverse outcomes.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"583-590"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective potential of paddy rice: advancing nutritional and therapeutic strategies for brain health. 水稻的神经保护潜力：促进大脑健康的营养和治疗策略。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-04-28 DOI: 10.1080/1028415X.2025.2497036

Sachin Kothawade, Vijaya Padwal, Shreya Bhosale, Priti Mhaske, Rutuja Jedhe, Supriya Makhare, Dwarkadas Baheti

{"title":"Neuroprotective potential of paddy rice: advancing nutritional and therapeutic strategies for brain health.","authors":"Sachin Kothawade, Vijaya Padwal, Shreya Bhosale, Priti Mhaske, Rutuja Jedhe, Supriya Makhare, Dwarkadas Baheti","doi":"10.1080/1028415X.2025.2497036","DOIUrl":"https://doi.org/10.1080/1028415X.2025.2497036","url":null,"abstract":"Objectives: This review examines the neuroprotective potential of paddy rice bioactive compounds, with a focus on antioxidant, anti-inflammatory, and neuroregenerative properties that may aid in preventing neurodegenerative diseases. Key compounds analyzed include tocotrienols, gamma-oryzanol, and phenolic acids.Method: We conducted a comprehensive review of existing studies detailing the mechanisms by which paddy rice bioactives support brain health. These compounds were examined for their effects on oxidative stress reduction, neuroinflammation modulation, neurotransmitter regulation, and neurogenesis promotion.Results: Bioactives such as gamma-oryzanol and ferulic acid were found to decrease neuroinflammatory markers and support neurotransmitter function. Research shows paddy rice compounds enhance neural resilience and cognitive function, suggesting their potential role in managing disorders like Parkinson's and Alzheimer's disease.Conclusion: While preclinical evidence underscores the therapeutic promise of paddy rice bioactives, further clinical studies are needed to confirm efficacy, establish optimal dosages, and improve bioavailability. This review advocates for advanced nutraceutical development using paddy rice to bridge preclinical findings and clinical applications.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderate cryptoxanthin intake correlates with maintenance of a proper PINT index in a general Japanese population. 在日本普通人群中，适量摄入隐黄素与维持适当的 PINT 指数有关。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-04-01 Epub Date: 2024-07-25 DOI: 10.1080/1028415X.2024.2383082

Masaki Ryuzaki, Hiroki Mizukami, Yuki Takeuchi, Sho Osonoi, Takanori Sasaki, Zhenchao Wang, Hanae Kushibiki, Takahiro Yamada, Keisuke Yamazaki, Saori Ogasawara, Takefusa Tarusawa, Tatsuya Mikami, Kenichi Hakamada, Shigeyuki Nakaji

{"title":"Moderate cryptoxanthin intake correlates with maintenance of a proper PINT index in a general Japanese population.","authors":"Masaki Ryuzaki, Hiroki Mizukami, Yuki Takeuchi, Sho Osonoi, Takanori Sasaki, Zhenchao Wang, Hanae Kushibiki, Takahiro Yamada, Keisuke Yamazaki, Saori Ogasawara, Takefusa Tarusawa, Tatsuya Mikami, Kenichi Hakamada, Shigeyuki Nakaji","doi":"10.1080/1028415X.2024.2383082","DOIUrl":"10.1080/1028415X.2024.2383082","url":null,"abstract":"Introduction: Small fibre neuropathy (SFN) is an early manifestation of diabetic polyneuropathy. Although oxidative stress, inflammation and change of intestinal bacterial population are assumed to be their pathogenesis, the effects of dietary nutrition have not been evaluated. The relationship between dietary nutrition intake and pain sensation was evaluated in the Japanese population.Methods: We conducted the Iwaki project, a population-based study recruiting 1,028 individuals, in 2018. The relationships between the pain threshold from intraepidermal electrical stimulation (PINT) and the amount of dietary nutrition evaluated by a brief-type self-administered diet history questionnaire were examined. The odds ratio was further explored after categorizing subjects based on low (< 63.7 μg/day), intermediate (63.7-159.2 μg/day), and high cryptoxanthin levels (> 159.2 μg/day).Results: Univariate linear regression analyses showed significant correlations between PINT and cryptoxanthin intake even after adjustments for other nutritional intakes (ß = 0.107, p < 0.01). Multivariate logistic regression analysis revealed low and high cryptoxanthin intake as significant risk factors for abnormal PINT (≥ 0.20 mA). Multivariate linear regression analyses showed significant correlations between PINT and cryptoxanthin intake levels after adjustment for other clinically PINT-related factors (ß = 0.09, p < 0.01).Conclusions: Adequate intake of cryptoxanthin is recommended to maintain the pain threshold in the Japanese population.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"481-491"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dietary fat intake and history of stroke in US adults: findings from National Health and Nutrition Examination Survey 2007-2018. 美国成年人膳食脂肪摄入量与中风病史之间的关系：2007-2018 年全国健康与营养调查的结果。

IF 3.6 4区医学

Nutritional Neuroscience Pub Date : 2025-04-01 Epub Date: 2024-08-22 DOI: 10.1080/1028415X.2024.2391652

Juanying Zhen, Bernard Man Yung Cheung, Chao Li

{"title":"Association between dietary fat intake and history of stroke in US adults: findings from National Health and Nutrition Examination Survey 2007-2018.","authors":"Juanying Zhen, Bernard Man Yung Cheung, Chao Li","doi":"10.1080/1028415X.2024.2391652","DOIUrl":"10.1080/1028415X.2024.2391652","url":null,"abstract":"Objectives: Diet is an important target for primary prevention of stroke. There are mixed findings on the relationship between dietary fat intake and stroke. We aimed to investigate the relationship of stroke with fats, including total fat, saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA).Methods: We analysed data on 27,673 participants who had valid data on dietary fat intake and history of stroke from the National Health and Nutrition Examination Survey 2007-2018. History of stroke was defined according to previous diagnosis by doctors or other health professional. Data on 24-h dietary recalls was collected using Automated Multiple-Pass Method. Age, sex, race/ethnicity, total calories, body mass index, diabetes, hypertension, hypercholesterolaemia, smoking, alcohol consumption and physical activity were adjusted in multivariable models.Results: 3.8% (n = 1,054) of participants had a diagnosis of stroke. History of stroke was inversely associated with total fat (OR = 0.89, 95% CI = 0.79-0.99, P = 0.037), SFA (OR = 0.46, 95% CI = 0.23-0.91) and MUFA (OR = 0.08, 95% CI = 0.02-0.38, P = 0.002) from supplements. There was an inverse association between history of stroke and PUFA intake (from diet: quartile 4 vs quartile 1, OR = 0.58, 95% CI = 0.43-0.78, P for trend = 0.003; from supplements: OR = 0.44, 95% CI = 0.27-0.72, P = 0.001).Conclusions: In this large-scale nationally representative study, stroke is inversely associated with fat intake from supplements and PUFA intake from diet. While lifestyle choices may not be the most vital health factor for stroke patients, increasing fat intake from specific supplements does provide additional motivation for undertaking the difficult challenge of stroke prevention.","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"513-521"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0