Moderate cryptoxanthin intake correlates with maintenance of a proper PINT index in a general Japanese population.

IF 3.6 4区医学 Q2 NEUROSCIENCES

Nutritional Neuroscience Pub Date : 2024-07-25 DOI:10.1080/1028415X.2024.2383082

Masaki Ryuzaki, Hiroki Mizukami, Yuki Takeuchi, Sho Osonoi, Takanori Sasaki, Zhenchao Wang, Hanae Kushibiki, Takahiro Yamada, Keisuke Yamazaki, Saori Ogasawara, Takefusa Tarusawa, Tatsuya Mikami, Kenichi Hakamada, Shigeyuki Nakaji

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引用次数: 0

Abstract

Introduction: Small fibre neuropathy (SFN) is an early manifestation of diabetic polyneuropathy. Although oxidative stress, inflammation and change of intestinal bacterial population are assumed to be their pathogenesis, the effects of dietary nutrition have not been evaluated. The relationship between dietary nutrition intake and pain sensation was evaluated in the Japanese population.

Methods: We conducted the Iwaki project, a population-based study recruiting 1,028 individuals, in 2018. The relationships between the pain threshold from intraepidermal electrical stimulation (PINT) and the amount of dietary nutrition evaluated by a brief-type self-administered diet history questionnaire were examined. The odds ratio was further explored after categorizing subjects based on low (< 63.7 μg/day), intermediate (63.7-159.2 μg/day), and high cryptoxanthin levels (> 159.2 μg/day).

Results: Univariate linear regression analyses showed significant correlations between PINT and cryptoxanthin intake even after adjustments for other nutritional intakes (ß = 0.107, p < 0.01). Multivariate logistic regression analysis revealed low and high cryptoxanthin intake as significant risk factors for abnormal PINT (≥ 0.20 mA). Multivariate linear regression analyses showed significant correlations between PINT and cryptoxanthin intake levels after adjustment for other clinically PINT-related factors (ß = 0.09, p < 0.01).

Conclusions: Adequate intake of cryptoxanthin is recommended to maintain the pain threshold in the Japanese population.

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在日本普通人群中，适量摄入隐黄素与维持适当的 PINT 指数有关。

简介小纤维神经病变（SFN）是糖尿病多发性神经病变的早期表现。虽然氧化应激、炎症和肠道细菌群变化被认为是其发病机制，但膳食营养的影响尚未得到评估。我们在日本人群中评估了膳食营养摄入与痛觉之间的关系：我们于 2018 年开展了岩城项目，这是一项基于人群的研究，共招募了 1028 人。研究考察了表皮内电刺激疼痛阈值（PINT）与通过简短型自填饮食史问卷评估的膳食营养摄入量之间的关系。根据低（< 63.7 μg/天）、中（63.7-159.2 μg/天）和高（> 159.2 μg/天）隐黄质水平对受试者进行分类后，进一步探讨了几率比：结果：单变量线性回归分析表明，即使在调整了其他营养摄入量后，PINT 与隐黄质摄入量之间仍存在显著相关性（ß = 0.107，p p 结论：隐黄质摄入量充足与否与营养素摄入量有关：建议摄入充足的隐黄素以保持日本人的痛阈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.