{"title":"水稻的神经保护潜力：促进大脑健康的营养和治疗策略。","authors":"Sachin Kothawade, Vijaya Padwal, Shreya Bhosale, Priti Mhaske, Rutuja Jedhe, Supriya Makhare, Dwarkadas Baheti","doi":"10.1080/1028415X.2025.2497036","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This review examines the neuroprotective potential of paddy rice bioactive compounds, with a focus on antioxidant, anti-inflammatory, and neuroregenerative properties that may aid in preventing neurodegenerative diseases. Key compounds analyzed include tocotrienols, gamma-oryzanol, and phenolic acids.</p><p><strong>Method: </strong>We conducted a comprehensive review of existing studies detailing the mechanisms by which paddy rice bioactives support brain health. These compounds were examined for their effects on oxidative stress reduction, neuroinflammation modulation, neurotransmitter regulation, and neurogenesis promotion.</p><p><strong>Results: </strong>Bioactives such as gamma-oryzanol and ferulic acid were found to decrease neuroinflammatory markers and support neurotransmitter function. Research shows paddy rice compounds enhance neural resilience and cognitive function, suggesting their potential role in managing disorders like Parkinson's and Alzheimer's disease.</p><p><strong>Conclusion: </strong>While preclinical evidence underscores the therapeutic promise of paddy rice bioactives, further clinical studies are needed to confirm efficacy, establish optimal dosages, and improve bioavailability. This review advocates for advanced nutraceutical development using paddy rice to bridge preclinical findings and clinical applications.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-20"},"PeriodicalIF":3.6000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuroprotective potential of paddy rice: advancing nutritional and therapeutic strategies for brain health.\",\"authors\":\"Sachin Kothawade, Vijaya Padwal, Shreya Bhosale, Priti Mhaske, Rutuja Jedhe, Supriya Makhare, Dwarkadas Baheti\",\"doi\":\"10.1080/1028415X.2025.2497036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This review examines the neuroprotective potential of paddy rice bioactive compounds, with a focus on antioxidant, anti-inflammatory, and neuroregenerative properties that may aid in preventing neurodegenerative diseases. Key compounds analyzed include tocotrienols, gamma-oryzanol, and phenolic acids.</p><p><strong>Method: </strong>We conducted a comprehensive review of existing studies detailing the mechanisms by which paddy rice bioactives support brain health. These compounds were examined for their effects on oxidative stress reduction, neuroinflammation modulation, neurotransmitter regulation, and neurogenesis promotion.</p><p><strong>Results: </strong>Bioactives such as gamma-oryzanol and ferulic acid were found to decrease neuroinflammatory markers and support neurotransmitter function. Research shows paddy rice compounds enhance neural resilience and cognitive function, suggesting their potential role in managing disorders like Parkinson's and Alzheimer's disease.</p><p><strong>Conclusion: </strong>While preclinical evidence underscores the therapeutic promise of paddy rice bioactives, further clinical studies are needed to confirm efficacy, establish optimal dosages, and improve bioavailability. This review advocates for advanced nutraceutical development using paddy rice to bridge preclinical findings and clinical applications.</p>\",\"PeriodicalId\":19423,\"journal\":{\"name\":\"Nutritional Neuroscience\",\"volume\":\" \",\"pages\":\"1-20\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutritional Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/1028415X.2025.2497036\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutritional Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1028415X.2025.2497036","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Neuroprotective potential of paddy rice: advancing nutritional and therapeutic strategies for brain health.
Objectives: This review examines the neuroprotective potential of paddy rice bioactive compounds, with a focus on antioxidant, anti-inflammatory, and neuroregenerative properties that may aid in preventing neurodegenerative diseases. Key compounds analyzed include tocotrienols, gamma-oryzanol, and phenolic acids.
Method: We conducted a comprehensive review of existing studies detailing the mechanisms by which paddy rice bioactives support brain health. These compounds were examined for their effects on oxidative stress reduction, neuroinflammation modulation, neurotransmitter regulation, and neurogenesis promotion.
Results: Bioactives such as gamma-oryzanol and ferulic acid were found to decrease neuroinflammatory markers and support neurotransmitter function. Research shows paddy rice compounds enhance neural resilience and cognitive function, suggesting their potential role in managing disorders like Parkinson's and Alzheimer's disease.
Conclusion: While preclinical evidence underscores the therapeutic promise of paddy rice bioactives, further clinical studies are needed to confirm efficacy, establish optimal dosages, and improve bioavailability. This review advocates for advanced nutraceutical development using paddy rice to bridge preclinical findings and clinical applications.
期刊介绍：
Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.
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