水稻的神经保护潜力:促进大脑健康的营养和治疗策略。

IF 3.6 4区 医学 Q2 NEUROSCIENCES
Sachin Kothawade, Vijaya Padwal, Shreya Bhosale, Priti Mhaske, Rutuja Jedhe, Supriya Makhare, Dwarkadas Baheti
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引用次数: 0

摘要

目的:本文综述了水稻生物活性化合物的神经保护潜力,重点介绍了抗氧化、抗炎和神经再生特性,这些特性可能有助于预防神经退行性疾病。分析的主要化合物包括生育三烯醇、γ -米豆醇和酚酸。方法:我们对现有的研究进行了全面的回顾,详细介绍了水稻生物活性物质支持大脑健康的机制。研究了这些化合物对氧化应激减少、神经炎症调节、神经递质调节和神经发生促进的作用。结果:发现γ -米甲醇和阿魏酸等生物活性物质可降低神经炎症标志物,支持神经递质功能。研究表明,水稻化合物可以增强神经弹性和认知功能,这表明它们在治疗帕金森病和阿尔茨海默病等疾病方面具有潜在作用。结论:虽然临床前证据强调了水稻生物活性物质的治疗前景,但需要进一步的临床研究来证实其疗效,确定最佳剂量,并提高生物利用度。本综述提倡利用水稻开发先进的营养保健品,以连接临床前研究结果和临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuroprotective potential of paddy rice: advancing nutritional and therapeutic strategies for brain health.

Objectives: This review examines the neuroprotective potential of paddy rice bioactive compounds, with a focus on antioxidant, anti-inflammatory, and neuroregenerative properties that may aid in preventing neurodegenerative diseases. Key compounds analyzed include tocotrienols, gamma-oryzanol, and phenolic acids.

Method: We conducted a comprehensive review of existing studies detailing the mechanisms by which paddy rice bioactives support brain health. These compounds were examined for their effects on oxidative stress reduction, neuroinflammation modulation, neurotransmitter regulation, and neurogenesis promotion.

Results: Bioactives such as gamma-oryzanol and ferulic acid were found to decrease neuroinflammatory markers and support neurotransmitter function. Research shows paddy rice compounds enhance neural resilience and cognitive function, suggesting their potential role in managing disorders like Parkinson's and Alzheimer's disease.

Conclusion: While preclinical evidence underscores the therapeutic promise of paddy rice bioactives, further clinical studies are needed to confirm efficacy, establish optimal dosages, and improve bioavailability. This review advocates for advanced nutraceutical development using paddy rice to bridge preclinical findings and clinical applications.

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来源期刊
Nutritional Neuroscience
Nutritional Neuroscience 医学-神经科学
CiteScore
8.50
自引率
2.80%
发文量
236
审稿时长
>12 weeks
期刊介绍: Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.
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