Exploring astaxanthin: a comprehensive review on its pharmacokinetics properties and neuroprotective potential.

IF 3.6 4区医学 Q2 NEUROSCIENCES

Nutritional Neuroscience Pub Date : 2025-10-01 Epub Date: 2025-05-13 DOI:10.1080/1028415X.2025.2499559

A S Mohd Shafie, S N Kamarudin, M M R Meor Mohd Affandi, R Siran

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引用次数: 0

Abstract

Background: Carotenoids are naturally occurring bio-pigments found in microalgae, plants, fungi, bacteria, and various aquatic animals. They are generally classified into carotenes and xanthophylls based on their structural features. Among them, astaxanthin-a xanthophyll carotenoid-has attracted increasing attention due to its potent antioxidant, anti-inflammatory, and anti-apoptotic properties, which contribute to a range of health benefits.

Method: This review highlights the structural features, physicochemical properties, pharmacokinetics, and therapeutic potential of astaxanthin, particularly focusing on its neuroprotective effects in neurological disorders. To provide a comprehensive overview, we systematically searched published articles across Scopus, Google Scholar, PubMed, and Medline databases from inception to January 1, 2025.

Results: Recent advancements in drug formulation and delivery technologies have enhanced astaxanthin's ability to cross the blood-brain barrier (BBB), significantly increasing its potential as a therapeutic agent for neurological diseases.

Conclusion: With its multifaceted biological effects and growing evidence of neuroprotection, astaxanthin shows great promise in the treatment of neurological disorders, particularly stroke. These findings support its future development and application in pharmaceutical strategies aimed at brain health.

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探索虾青素：其药代动力学特性和神经保护潜力的综合综述。

背景：类胡萝卜素是天然存在的生物色素，存在于微藻、植物、真菌、细菌和各种水生动物中。根据它们的结构特征，它们通常分为胡萝卜素和叶黄素。其中，虾青素（一种黄叶素类胡萝卜素）因其有效的抗氧化、抗炎和抗细胞凋亡特性而受到越来越多的关注，这些特性有助于一系列健康益处。方法：本文综述了虾青素的结构特征、理化性质、药代动力学和治疗潜力，重点介绍了虾青素在神经系统疾病中的神经保护作用。为了提供一个全面的概述，我们系统地检索了Scopus，谷歌Scholar， PubMed和Medline数据库中从成立到2025年1月1日的已发表文章。结果：近年来药物配方和给药技术的进步增强了虾青素穿过血脑屏障（BBB）的能力，显著增加了虾青素作为神经系统疾病治疗剂的潜力。结论：虾青素具有多方面的生物学效应和越来越多的神经保护证据，在治疗神经系统疾病，特别是中风方面显示出巨大的希望。这些发现支持其未来的发展和应用在针对大脑健康的药物策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.