Nutritional Neuroscience最新文献

{"title":"Effects of phycocyanin-derived oligopeptides, zinc, and selenium on whole-brain NAD-related metabolites and redox-inflammatory markers after low-dose LPS challenge in mice.","authors":"Turkkan O Kaygusuz, Besir Er, Ramazan Ozmen, James R Komorowski, Kazim Sahin","doi":"10.1080/1028415X.2026.2723172","DOIUrl":"https://doi.org/10.1080/1028415X.2026.2723172","url":null,"abstract":"<p><strong>Background: </strong>Systemic lipopolysaccharide (LPS)-induced inflammation can disrupt cerebral redox homeostasis and nicotinamide adenine dinucleotide (NAD)-related metabolism, but the extent to which a multimodal nutritional intervention can attenuate these changes remains unclear.</p><p><strong>Objective: </strong>This study compared the effects of phycocyanin-derived oligopeptides (PC-O), zinc (Zn), selenium (Se), and their combined administration on whole-brain NAD-related metabolites, oxidative status, antioxidant enzyme activities, selected mRNA markers, and the protein abundance of representative neurotrophic, synaptic, astroglial, and inflammatory markers after low-dose LPS exposure.</p><p><strong>Methods: </strong>Forty-two male BALB/c mice were allocated to six groups (n = 7/group). PC-O, Zn, Se, or PC-O + Zn + Se was administered orally for 14 days before intraperitoneal LPS challenge (0.04 mg/kg).</p><p><strong>Results: </strong>LPS was associated with lower concentrations of the four NAD-related analytes and lower antioxidant enzyme activities, higher MDA, reduced BDNF, NGF, Synapsin-1, PGC-1α, and TFAM transcripts, and increased GFAP, IL-1β, and IL-6 transcripts (<i>p</i> < 0.05). Western blot analysis further showed lower BDNF and Synapsin I protein abundance and higher GFAP, IL-1β, and IL-6 protein abundance following LPS exposure (<i>p</i> < 0.05). The single-supplements produced endpoint-dependent changes, whereas the PC-O + Zn + Se group showed the most consistent attenuation across the biochemical, transcript, and selected protein outcomes.</p><p><strong>Conclusion: </strong>Low-dose LPS was associated with coordinated disturbances in brain NAD-related metabolism, redox balance, and inflammatory signaling. The combined intervention produced a broader biochemical and molecular response than the single interventions; however, mechanistic, histological, behavioral, and translational studies are required before clinical relevance can be inferred.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-17"},"PeriodicalIF":3.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/1028415X.2026.2634538","DOIUrl":"10.1080/1028415X.2026.2634538","url":null,"abstract":"","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1213"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of dysphagia risk on body composition and dietary habits in adults with multiple sclerosis.","authors":"N V Franchina Vergel, J Molina-Lopez, E Planells Del Pozo","doi":"10.1080/1028415X.2026.2634120","DOIUrl":"10.1080/1028415X.2026.2634120","url":null,"abstract":"<p><strong>Introduction: </strong>Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system with a high prevalence of dysphagia (43.3%), increasing the risk of aspiration pneumonia, malnutrition and dehydration.</p><p><strong>Objectives: </strong>This study aimed to (i) describe the sociodemographic and anthropometric characteristics of adults with MS; (ii) estimate the risk of dysphagia and evaluate speech and oropharyngeal impairments in relation to this risk and (iii) examine dietary patterns and nutritional status indicators according to the presence or absence of dysphagia risk.</p><p><strong>Methodology: </strong>An observational, cross-sectional and analytical study was conducted in 52 patients with MS from Granada. Body composition was assessed by multifrequency bioelectrical impedance analysis (NUTRILAB). Dietary intake was recorded using three 24-hour recalls and a food frequency questionnaire (FFQ). Data were processed using Dietowin software. The speech and language-therapy assessment included the Yale Swallow Protocol, TOMASS and a taste perception protocol.</p><p><strong>Results: </strong>57.7% of participants were at risk of dysphagia. 'Double texture alert' and 'salivation alteration' were significantly more frequent in the at-risk group. No significant differences were found between participants with and without dysphagia risk in anthropometric measures - excepting FFM and BMR - or nutrient intake. However, 61.5% of the sample showed excess body weight and altered intake of macro- and micronutrients. Moreover, more than 50% of participants exhibited inadequacies in consumption habits across most food groups.</p><p><strong>Conclusions: </strong>A high prevalence of dysphagia risk was observed. Patients at risk tended to show higher BMI, inadequate intake and taste alterations. These findings highlight the need for early screening and interdisciplinary, individualised nutritional and speech therapy interventions.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1174-1186"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential effects of genistein in preventing progressive loss of cognitive functions in wild-type mice.","authors":"Karolina Pierzynowska, Lidia Gaffke, Zuzanna Cyske, Grażyna Jerzemowska, Grzegorz Węgrzyn, Magdalena Podlacha","doi":"10.1080/1028415X.2026.2634117","DOIUrl":"10.1080/1028415X.2026.2634117","url":null,"abstract":"<p><p>Mild cognitive impairment occurring with age is an intermediate stage between normal cognitive functioning and dementia. Precisely, because of the lack of unequivocal symptoms, the deterioration of cognitive functions that occurs with age is a growing concern for the aging population. Therefore, the aim of this study was to verify the prophylactic potential of genistein (5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) in preventing memory loss of healthy individuals. The experiments were conducted using wild-type mice of both sexes that were not genetically modified. Analysis of cognitive processes in genistein-supplemented and untreated animals was carried out using behavioral tests (elevated plus maze, novel object recognition, and Morris water maze tests). In addition, microscopic assessment of the number of amyloid beta deposits in key brain structures for memory processes was performed. Our results suggest that genistein has a potential in preventing the impairment of memory processes resulting from aging. This proposal is supported not only by the results of behavioral tests, but also by microscopic analyses showing a reduction in the number of beta-amyloid aggregates in the brain after genistein supplementation.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1153-1173"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of prebiotic intervention foods on caregiver-reported infant sleep and caregiver sleep quality during complementary feeding- secondary analysis of a randomized control trial.","authors":"Xiaoxi Fu, Amy L Lovell, Clare R Wall, Teresa Gontijo De Castro, Yannan Jiang, Robyn L Lawrence, Nisha Mahawar, Barbara C Galland","doi":"10.1080/1028415X.2026.2635535","DOIUrl":"10.1080/1028415X.2026.2635535","url":null,"abstract":"<p><strong>Background: </strong>Sleep is essential for infant health and cognitive development. Poor sleep increases the risk of childhood obesity and weakens immune health. Infant sleep is a major concern for parents, as disruptions can impact parental sleep and overall well-being, leading to various negative consequences. Prebiotic foods introduced during the complementary feeding period may potentially improve infant sleep and, consequently, parental sleep. However, to our knowledge, no studies have yet explored this relationship.</p><p><strong>Methods: </strong>As a secondary outcome analysis of a three-arm parallel randomized control trial (ACTRN12620000026921), this paper compared the effects of kūmara (K group, n = 93) or kūmara with added resistant starch (K⁺ group, n = 93) to a control group (n = 95) on infant sleep and caregiver sleep quality during the first four months of complementary feeding. Infant and caregiver sleep were subjectively assessed at baseline (prior to solids), and at two (Complementary Feeding 2, CF2) and four (Complementary Feeding 4, CF4) months post-introduction to solids, using the caregiver-reported Brief Infant Sleep Questionnaire (BISQ) and Patient-Reported Outcomes Measurement Information System (PROMIS®) scales for Sleep Disturbance and Sleep-Related Impairment, respectively.</p><p><strong>Results: </strong>Compared to the control group, infants in the K group had significantly less nocturnal wakefulness (8.4 min, <i>p</i> = 0.023) at CF4. The K⁺ group showed a near-significant increase in daytime sleep (11.4 min, <i>p</i> = 0.053) but also trends toward more reports of problematic nighttime sleep at CF2. Caregiver sleep outcomes did not differ significantly.</p><p><strong>Discussion: </strong>Kūmara consumption may reduce nocturnal wakefulness in infants, but further research incorporating objective sleep measures and exploring underlying mechanisms is needed.</p><p><strong>Trial registration: </strong>Australian New Zealand Clinical Trials Registry identifier: ACTRN12620000026921.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1187-1199"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amino acid disruptions in autism spectrum disorder: from etiology to therapeutic avenues.","authors":"Uday Kiran Gandam, Alanka Ketan Kumar, Sandhya Annamaneni","doi":"10.1080/1028415X.2026.2631555","DOIUrl":"10.1080/1028415X.2026.2631555","url":null,"abstract":"<p><p>Autism Spectrum Disorder (ASD) is a significant health concern in children globally due to its increasing prevalence, complex phenotype manifesting in a range of neuro-developmental disabilities which persist lifelong. As early intervention is linked to improved outcomes and better quality of life in ASD patients, the lack of specific screening and diagnostic criteria is an important concern. Since the discovery of autism in 1943, extensive molecular profiling studies at genomic, transcriptomic, proteomic and metabolomic levels have been conducted but failed to establish or define an ASD signature. Emerging studies emphasizes the implication of metabolic disruption in autism. Hence, the current review focuses on the meta-analysis of metabolome studies to explore and highlight the biochemical intricacies linked to autism specific phenotype. In particular, the review deals with dysregulations in amino acid pathways involved in the complex physiology of ASD. Systemic exploitation of the metabolic profiles in ASD could not only reveal markers with diagnostic significance but also indicate target-oriented treatment avenues.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1123-1135"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic action of human milk oligosaccharides and lactoferrin enhances neurodevelopment in piglets: evidence from MRS based metabolic profiling.","authors":"Md Mahmudul Amin, Tanjina Amin, Adikari Arachchige Dilki Indrachapa Adikari, Xiaoming Zheng, Zhaolin Chen, Bing Wang","doi":"10.1080/1028415X.2026.2637610","DOIUrl":"10.1080/1028415X.2026.2637610","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the synergistic effects of combined human milk oligosaccharides (HMOs) and lactoferrin (Lf) supplementation on brain metabolites and neurotransmitters in neonatal piglets using proton magnetic resonance spectroscopy (¹H-MRS).</p><p><strong>Methods: </strong>Three-day-old male domestic piglets were randomly assigned to three groups and fed for 35 days with a standard pig milk replacer supplemented as follows: control (methylcellulose, 1.8 g/L; n = 14), combined HMOs (cHMOs, 70% 2'-FL and 30% 3'-SL:6'-SL in a 1:2.5 ratio, 1.8 g/L; n = 16), or cHMOs + Lf (cHMOs, 1.8 g/L + Lf, 0.5 g/L; n = 14). <i>In vivo</i> ¹H-MRS was performed on postnatal day 38-39 using a 3 T scanner (TE = 30 ms) to assess regional brain metabolite profiles.</p><p><strong>Results: </strong>The combined cHMOs and Lf group exhibited significantly higher absolute levels of total lipids and macromolecules (tLM), along with increased relative concentrations of glutathione (GSH), total creatine (tCr), total choline (tCho), and tLM (<i>p</i> < 0.05). The cHMOs alone group showed a similar upward trend in tCr, tCho, and tLM, but exhibited significantly higher absolute levels of total N-acetylaspartate (tNAA) (<i>p</i> < 0.05) compared with the other two groups. Collectively, these findings indicate distinct metabolic profiles among the treatment groups.</p><p><strong>Conclusions: </strong>The combined cHMOs and Lf supplementation may synergistically support neurodevelopment by enhancing lipid mobilization, energy metabolism, and antioxidant capacity, while cHMOs alone promotes brain development by improving neuronal integrity and synaptic activity in piglets - a translational model for human infants. To our knowledge, these findings have not been previously reported.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1200-1212"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between dietary habits and gut metabolome profile in Parkinson's disease: a case-control study.","authors":"Hakan Ekmekci, F Hümeyra Yerlikaya Aydemir, Abdullah Sivrikaya, Cihat Özgüncü, Ömer Faruk Ildız, Mustafa Topkafa","doi":"10.1080/1028415X.2026.2628828","DOIUrl":"10.1080/1028415X.2026.2628828","url":null,"abstract":"<p><p><b>Introduction and Aim:</b> The role of gastrointestinal alterations and changes in microbiota in the pathogenesis of Parkinson's disease (PD) is gaining increasing recognition. This study aimed to investigate the impact of dietary habits and nutritional content on gut metabolomes (calprotectin, short-chain fatty acids, zonulin, and lipopolysaccharides) in individuals diagnosed with PD.<b>Materials:</b> In this cross-sectional case-control study, 89 patients with PD and 58 healthy controls were enrolled. Dietary habits over the past month were evaluated using a Food Frequency Questionnaire (FFQ). Metabolome levels from stool and blood samples were analyzed using Enzyme-Linked ImmunoSorbent Assay (ELISA) and gas chromatography. Data analysis was performed using both parametric and non-parametric tests, as well as Spearman correlation analysis.<b>Results:</b> Calprotectin and lipopolysaccharide (LPS) levels were significantly higher in the stool samples of patients with PD compared to controls, whereas butyric acid and isobutyric acid levels were significantly lower. No significant differences were observed between the groups in terms of zonulin, total short-chain fatty acids (SCFA), or acetic acid levels. Nutritional analysis revealed a negative correlation between the consumption of walnuts, olive oil, and fruit and inflammatory markers (calprotectin, LPS) in the PD group.<b>Discussion:</b> The findings support the presence of intestinal barrier dysfunction and inflammation in PD. A correlation was observed between dietary content and the intestinal metabolome profile. These results suggest that dietary interventions may be a potential strategy for managing PD.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1111-1122"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146207637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prebiotic-based banana snacks (<i>Musa sapientum</i> L.) alleviate cognitive impairment by reducing brain inflammation, apoptosis, microglial activation, and dendritic spine loss in obese rats.","authors":"Piangkwan Sa-Nguanmoo, Nattayaporn Apaijai, Hiranya Pintana, Titikorn Chunchai, Busarin Arunsak, Aphisek Kongkaew, Wasana Pratchayasakul, Sakamon Devahastin, Nipon Chattipakorn, Siriporn C Chattipakorn","doi":"10.1080/1028415X.2026.2632672","DOIUrl":"10.1080/1028415X.2026.2632672","url":null,"abstract":"<p><strong>Objectives: </strong>Prebiotics may reduce adiposity and inflammation, improving cognitive function in obese rats, mediated by modulation of the gut-brain axis. Banana-based snacks are promising prebiotic foods. However, their effects on gut microbiota, inflammation, brain reactive oxygen species (ROS) production, microglial morphology, dendritic spine density, and cognitive function remain underexplored in high-fat diet (HFD)-induced obese rats.</p><p><strong>Methods: </strong>Seventy-two male rats were maintained on either a normal diet (ND) or a HFD for 16-weeks. At week 13, ND-fed rats were subdivided into six groups (<i>n</i> = 6/group) receiving either a vehicle (NDV, 10.5 mL/kg/day twice daily), prebiotic snacks from bananas at ripening stages 2-5 (NDS2-5, 7.47 g in water, 10.5 mL/kg/day twice daily), or inulin (NDI, 2 g/kg/day in water, 10.5 mL/kg/day twice daily). HFD-fed rats were similarly subdivided into six groups (<i>n</i> = 6/group) with either a vehicle (HFV), banana-based prebiotic snacks (HFS2-5), or inulin (HFI), administered for four weeks at the same doses as the ND-fed rats.</p><p><strong>Results: </strong>HFD-fed rats exhibited both obesity and insulin resistance, gut dysbiosis, inflammation, and cognitive impairment. However, rats receiving inulin or banana-based prebiotics from all ripening stages exhibited improved cognitive function by reducing gut dysbiosis, oxidative stress, inflammation, brain ROS, apoptosis, dendritic spine loss, and microglial activation.</p><p><strong>Conclusions: </strong>Prebiotic banana snacks from all ripening stages may protect against HFD-induced cognitive impairment by enhancing gut health and reducing inflammation and oxidative stress, potentially via the gut-brain axis. These findings support their potential use as functional foods to promote both cognitive and metabolic health.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1136-1152"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egg intake and the risk of glioma and head and neck cancers: a systematic review and dose-response meta-analysis of observational studies.","authors":"Mohammad Amin Mohammadi, Ali Kosari, Gholamreza Askari, Omid Sadeghi","doi":"10.1080/1028415X.2026.2628827","DOIUrl":"10.1080/1028415X.2026.2628827","url":null,"abstract":"<p><p>Findings on the relationship between egg consumption and risk of glioma and head and neck cancer (HNC) are conflicting. A 2019 meta-analysis reported no significant association between egg intake and glioma risk. However, several eligible articles have been published since the release of that meta-analysis. In addition, there is no evidence of a dose-response relationship in this regard. Also, we found no meta-analysis investigating the association between egg intake and HNC. Therefore, we aimed to conduct a comprehensive meta-analysis to summarize current evidence on the relationship between egg consumption and the risk of glioma and HNC. We systematically searched PubMed, Scopus, Web of Sciences, and Google Scholar until August 2024, for observational studies that reported the association between egg consumption and the risk of glioma and HNC. In total, eleven studies, including seven studies on glioma and four studies on HNC, were included in the current meta-analysis. These studies included 1,274,437 participants with 4199 cases of glioma and 3164 cases of HNC. The meta-analysis was performed using a random-effects model. We found that egg consumption was associated with a reduced risk of glioma, particularly in Eastern populations (i.e. Asian populations) (RR: 0.51, 95% CI: 0.35-0.73). Additionally, in the non-linear dose-response analysis, egg consumption above 50 grams per day (>1 egg/day) gradually increased the risk of HNC. In conclusion, we found a significant inverse association between egg and glioma risk among Eastern populations and a positive association between egg intake and HNC risk in the dosages of >50 grams per day.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1097-1110"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}