Jenneffer Rayane Braga Tibaes, Gabriela Barbosa Fagundes, Lais Bhering Martins, Ana Maria Dos Santos Rodrigues, Alexandre Camargo Campos, Leticia Maria de Souza Cordeiro, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
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引用次数: 0
摘要
目的:比较急性日间禁食对有(OB)和无(N-OB)肥胖女性的情绪、饱腹感和神经营养因子的影响。方法:非随机单组可行性试验。数据收集于门诊诊所和现实世界。参与者在夜间禁食10小时(T1)和食用标准化早餐后10小时的日间禁食期(T2)后进行评估。评估情绪、主观饱腹感、食物渴望和神经营养因子脑源性神经营养因子(BDNF)、神经生长因子(NGF)和胶质细胞系源性神经营养因子(GDNF)。结果:54名受试者入组[平均年龄31岁(SD 9)]。1名OB组参与者在T2前退出,剩下53名参与者(n -OB: n = 29, OB: n = 24)。两组在T2后都经历了饥饿感的增加和饱腹感的减少。肥胖女性的饥饿感增加更大(p = 0.02)。T2后OB组抑郁和愤怒症状加重,而N-OB组疲劳症状加重。T2后N-OB组NGF略有增加,而BDNF和GDNF保持不变。结论:在日常活动中白天禁食会影响情绪和饮食行为,尤其是肥胖女性。考虑到这些不同的影响,禁食干预措施应根据个人需要量身定制。试验注册:ClinicalTrials.gov标识符:NCT03532672。
Effects of a single 10-hour daytime fasting intervention on mood and appetite in female adults with and without obesity: a real-world feasibility trial.
Objective: Comparison of the effect of acute daytime fasting on mood, satiety, and neurotrophic factors in females with (OB) and without obesity (N-OB).Methods: Non-randomized single-arm feasibility trial. Data were collected at an outpatient clinic and from real-world settings. Participants were evaluated after 10 h of nocturnal fasting (T1) and following a 10-hour diurnal fasting period (T2) after consuming a standardized breakfast. Mood, subjective feelings of satiety, food cravings, and neurotrophic factors brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell line-derived neurotrophic factor (GDNF) were assessed.Results: Fifty-four participants were enrolled in the study [mean age 31 (SD 9)]. One participant from the OB group dropped out before T2, leaving 53 participants (N-OB: n = 29, OB: n = 24). Both groups experienced increased hunger and decreased satiety and fullness after T2. Females with obesity had a greater increase in hunger (p = 0.02). Depression and anger symptoms increased in the OB group, whereas fatigue increased in the N-OB group after T2. NGF increased slightly in the N-OB group after T2, while BDNF and GDNF remained unchanged.Conclusion: Daytime fasting during daily activities affects mood and eating behavior, especially in females with obesity. Fasting interventions should be tailored to individual needs, considering these differential effects.Trial registration: ClinicalTrials.gov identifier: NCT03532672.
期刊介绍:
Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.