NeuroradiologyPub Date : 2025-09-30DOI: 10.1007/s00234-025-03788-7
Mehmet Tarık Tatoğlu, Başak Atalay
{"title":"Incidental detection of anterior clinoid meningioma on [⁶⁸Ga]Ga-DOTATATE PET/CT in a patient with suspected neuroendocrine tumor.","authors":"Mehmet Tarık Tatoğlu, Başak Atalay","doi":"10.1007/s00234-025-03788-7","DOIUrl":"https://doi.org/10.1007/s00234-025-03788-7","url":null,"abstract":"<p><p>Meningiomas are the most common extra-axial tumors of the central nervous system. They are slow-growing, benign lesions usually originating from the dura. They are usually detected incidentally. Anterior clinoid meningiomas are important because of their proximity to critical structures such as the optic canal and internal carotid artery. Due to their somatostatin receptor expression, especially SSTR2, <sup>68</sup>Ga-DOTA0-Tyr3-octreotate ([⁶⁸Ga]Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT) imaging has been used in both the diagnosis and follow-up of meningiomas. We report a rare case of anterior clinoid meningioma detected incidentally on [⁶⁸Ga]Ga-DOTATATE PET/CT.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroradiologyPub Date : 2025-09-26DOI: 10.1007/s00234-025-03779-8
Rosa Schubert, Maharani Budi Santoso, Yan Li, Cornelius Deuschl, Ramazan Jabbarli, Ulrich Sure, Michael Forsting, Hanna Styczen
{"title":"Perimesencephalic non-aneurysmal subarachnoid hemorrhage: is there a need for repeat digital subtraction angiography?","authors":"Rosa Schubert, Maharani Budi Santoso, Yan Li, Cornelius Deuschl, Ramazan Jabbarli, Ulrich Sure, Michael Forsting, Hanna Styczen","doi":"10.1007/s00234-025-03779-8","DOIUrl":"https://doi.org/10.1007/s00234-025-03779-8","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the diagnostic yield and clinical relevance of repeated digital subtraction angiography (DSA) in patients with spontaneous perimesencephalic non-aneurysmal subarachnoid hemorrhage (PMSAH) and to evaluate DSA-related complication rates.</p><p><strong>Methods: </strong>Retrospective analysis of 82 patients with PMSAH confirmed by non-contrast CT between March 2002 and February 2025. All patients underwent initial computed tomography angiography (CTA) and first DSA on average within 24 h. If no bleeding source was identified, a second DSA was performed after 10-14 days. Clinical data, radiological findings, and complications were evaluated.</p><p><strong>Results: </strong>The initial DSA showed no vascular abnormality in 76/82 patients (92.7%). A second DSA was performed in 60/76 cases (78.9%) and identified two small basilar artery aneurysms (3.3%) that were not visible on the initial CTA or DSA but were detectable on repeat 3D rotational angiography (3DRA). Procedure-related complications occurred in three DSAs (2%), including a cerebellar infarct, supratentorial embolism, and local puncture site complication. Most patients had a benign clinical course, and only one in-hospital death was documented.</p><p><strong>Conclusion: </strong>The diagnostic benefit of repeat DSA in typical PMSAH is low, with no clear therapeutic impact and a relevant risk of complications. Given the benign course of PMSAH and the availability of high-resolution non-invasive imaging such as dual-source, photon-counting CTA, or vessel wall MRI, repeat DSA should be reserved for selected cases with atypical features or clinical deterioration.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroradiologyPub Date : 2025-09-26DOI: 10.1007/s00234-025-03780-1
Sheng-Qi Hu, Chun Zeng, Jinbiao Yao, Mirzat Turhon, Ting Liu, Wenqiang Li, Xinjian Yang
{"title":"Quantitative digital subtraction angiography analysis and predictive factors for incomplete occlusion in posterior communicating artery aneurysms after endovascular treatment.","authors":"Sheng-Qi Hu, Chun Zeng, Jinbiao Yao, Mirzat Turhon, Ting Liu, Wenqiang Li, Xinjian Yang","doi":"10.1007/s00234-025-03780-1","DOIUrl":"https://doi.org/10.1007/s00234-025-03780-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to identify predictive factors for incomplete occlusion in posterior communicating artery (PCoA) aneurysms after endovascular treatment (EVT) and investigate the role of fetal-type posterior cerebral artery (fPCA) in occlusion outcomes using quantitative digital subtraction angiography (QDSA).</p><p><strong>Methods: </strong>We analyzed 287 patients with 292 PCoA aneurysms treated with EVT between 2016 and 2022. Aneurysms were categorized into incomplete (n = 49) and complete (n = 243) occlusion groups based on follow-up DSA. Clinical, morphological, and hemodynamic parameters from QDSA were compared, and independent risk factors were identified via multivariate logistic regression. Predictive performance was evaluated using area under the curve (AUC) and subgroup analysis with Benjamini-Hochberg correction for fPCA effects.</p><p><strong>Results: </strong>Independent risk factors for incomplete occlusion included size (p < 0.001, OR = 1.127), neck cerebral blood flow (CBF) (p = 0.001, OR = 4.024), simple coiling (p < 0.001, OR = 4.635), ruptured status (p = 0.002, OR = 3.281), and fPCA (p = 0.030, OR = 2.218). AUCs for the combined model, size, neck CBF, simple coiling, ruptured status, and fPCA were 0.822, 0.721, 0.708, 0.656, and 0.603, respectively. In the fPCA subgroup, ruptured status, neck CBF, neck cerebral blood volume (CBV), PCoA CBF, and PCoA CBV showed significance, while in the non-fPCA subgroup, only simple coiling and size remained significant.</p><p><strong>Conclusion: </strong>Size, neck CBF, simple coiling, ruptured status, and fPCA are independent risk factors for incomplete occlusion in PCoA aneurysms treated with EVT. fPCA likely influences incomplete occlusion through hemodynamic changes.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroradiologyPub Date : 2025-09-26DOI: 10.1007/s00234-025-03787-8
Stéphane Kremer, Tarek A Yousry, Rafael Rehwald, François Lersy, Nicolas Meyer, Simonetta Gerevini, Angela Napolitano, Àlex Rovira, Ng Karelys, Leandro Tavares Lucato, Maria da Graça Morais Martin, Ana Lícia da Rocha Alves Pinto, Luke Dixon, Brynmor Jones, Ana Ramos, Elena Salvador, Núria Bargalló, Laura Oleaga, Nicoletta Anzalone, Andrea Falini, Francesco Carletti, Chandrasekhar Hoskote, Agathe Chammas, Benoit Lhermitte, Béatrice Lannes, Thibaut de Misouard, François Cotton, Hans Rolf Jäger
{"title":"Structured assessment of brain MRI in Covid-19-related neurological disease: an international multicentre study.","authors":"Stéphane Kremer, Tarek A Yousry, Rafael Rehwald, François Lersy, Nicolas Meyer, Simonetta Gerevini, Angela Napolitano, Àlex Rovira, Ng Karelys, Leandro Tavares Lucato, Maria da Graça Morais Martin, Ana Lícia da Rocha Alves Pinto, Luke Dixon, Brynmor Jones, Ana Ramos, Elena Salvador, Núria Bargalló, Laura Oleaga, Nicoletta Anzalone, Andrea Falini, Francesco Carletti, Chandrasekhar Hoskote, Agathe Chammas, Benoit Lhermitte, Béatrice Lannes, Thibaut de Misouard, François Cotton, Hans Rolf Jäger","doi":"10.1007/s00234-025-03787-8","DOIUrl":"https://doi.org/10.1007/s00234-025-03787-8","url":null,"abstract":"<p><strong>Purpose: </strong>Neuroradiological findings associated with neurological presentations in acute SARS-CoV-2 infection are very heterogeneous. We aimed to develop a standardized framework for describing MR neuroimaging patterns in Covid-19, to test this in an international multicentre study and to determine the prevalence of observed MRI patterns and their association with clinical presentation and outcome.</p><p><strong>Methods: </strong>An international expert consortium developed a framework for assessment of brain MRI patterns in Covid-19 based on published literature and professional experience. We performed a retrospective analysis of the proposed framework, involving brain MRI scans from 458 Covid-19 patients with neurological symptoms, including data from 1 February to 31 May 2020. Two readers at 25 centres across five countries assessed the local MRI studies regarding the presence of one or more predefined MRI patterns. Imaging and clinical data were analysed using Bayesian statistics.</p><p><strong>Results: </strong>Of 458 patients, 58.5% had an abnormal MRI. Overall, 94% of all imaging pathologies seen were captured by our proposed classification. Ischemic strokes were the most frequent pattern overall (25.6%), followed by microhaemorrhages (15.9%). Ischemic infarct patterns were more frequent in non-ICU patients, while the haemorrhagic patterns were more frequent in ICU patients. White matter lesions (10.9%) were more frequent than grey matter lesions (8.1%), and leptomeningeal contrast enhancement was present in 8.3% of patients. Patient outcome was not associated with any MRI patterns.</p><p><strong>Conclusion: </strong>Our proposed classification of specific MRI patterns in Covid-19, covered 94% of observed abnormalities, while patient outcome, death or home discharge, was not associated with any MRI patterns.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroradiologyPub Date : 2025-09-26DOI: 10.1007/s00234-025-03786-9
Ji Su Ko, Yangsean Choi, Eunseon Jeong, Ji Eun Park, Ho Sung Kim
{"title":"Association between cerebrovascular imaging markers and glymphatic function in a large-scale cognitively normal population.","authors":"Ji Su Ko, Yangsean Choi, Eunseon Jeong, Ji Eun Park, Ho Sung Kim","doi":"10.1007/s00234-025-03786-9","DOIUrl":"10.1007/s00234-025-03786-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association between cerebrovascular imaging markers and glymphatic function in cognitively normal individuals.</p><p><strong>Methods: </strong>This retrospective study included 574 cognitively normal participants who underwent brain magnetic resonance imaging from January to October 2023. Glymphatic function was assessed using diffusion tensor image analysis along the perivascular space index (ALPS-index). Cerebrovascular imaging markers, including white matter hyperintensity (WMH) burden, cerebral microbleeds (CMBs), and choroid plexus volume (CPV), were quantified using automated segmentation methods. The presence of lacunes in the basal ganglia or old infarcts in other areas was visually determined. Associations between cerebrovascular markers and ALPS-index were analyzed using multivariable regression and partial correlation analyses.</p><p><strong>Results: </strong>The mean age of the included participants was 68.9 ± 10.4 years (male, 40.9%; hypertension, 43.7%; diabetes, 20.4%; Mini-Mental State Examination [MMSE] score, 27.6 ± 1.6). A lower ALPS-index, reflecting impaired glymphatic clearance, was significantly associated with higher WMH burden (β=-0.231, p < 0.001), increased CPV fraction (β=-0.234, p < 0.001), and a greater number of deep CMBs (β=-0.087, p = 0.038). The participants with basal ganglia lacunes (ALPS-index: 1.32 ± 0.19), old infarcts other than basal ganglia (ALPS-index: 1.34 ± 0.19), or both (ALPS-index: 1.27 ± 0.19) had significantly lower ALPS-indices than those without these conditions (ALPS-index: 1.43 ± 0.21; all, p < 0.001).</p><p><strong>Conclusion: </strong>Cerebrovascular imaging findings are significantly associated with glymphatic dysfunction in cognitively normal individuals, highlighting the need for further studies on glymphatic-targeted interventions in cerebrovascular disease prevention.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regional T2 value differences assess lumbar disc degeneration: a 3.0-T MRI retrospective study.","authors":"Shunmin Wang, Jiangang Shi, Tiefeng Li, Xiaofeng Zhang, Kaiqiang Sun, Yu Chen","doi":"10.1007/s00234-025-03762-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03762-3","url":null,"abstract":"<p><strong>Objectives: </strong>To quantify region-specific T2 relaxation dynamics in lumbar disc degeneration and evaluate their correlations with Pfirrmann grades and herniation morphology, focusing on early microstructural detection.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 130 lumbar discs (L1-S1) from 26 patients with single-segment disc herniation using 3.0-T MRI. T2 relaxation mapping was systematically performed with anatomical compartment segmentation defining four regions of interest: anterior annulus fibrosus, nucleus pulposus, posterior annulus fibrosus, and herniated tissue. Standardized circular ROIs (2.5-mm diameter) were applied to non-herniated regions, while herniations underwent area-matched elliptical contouring. Pfirrmann grading (I-V) was independently validated by two board-certified musculoskeletal radiologists. Statistical analyses employed nonparametric Kruskal-Wallis tests for inter-grade T2 comparisons and Spearman's rank correlation (ρ) to quantify degeneration associations.</p><p><strong>Results: </strong>Statistically significant differences in T2 values were observed across the three anatomical compartments (*p*<0.05). T2 relaxation times demonstrated an inverse correlation with Pfirrmann degeneration grades, exhibiting the strongest association in the nucleus pulposus (middle compartment; r=-0.542). This correlation intensified with advancing degeneration. Sagittal T2 comparisons revealed significant differences between Pfirrmann grade I/II and IV/V groups in all compartments, while the nucleus pulposus showed significant differences between grades I/II and III. Within identical degeneration grades, nucleus pulposus T2 values exceeded those of the anterior annulus fibrosus. Specifically, in Pfirrmann I/II discs, posterior annulus values surpassed anterior annulus values, whereas in grade IV/V discs, nucleus pulposus values exceeded posterior annulus values, with no significant anterior-posterior difference. Cross-sectionally, the nucleus pulposus exhibited the highest T2 values, while herniated tissue demonstrated the lowest.</p><p><strong>Conclusions: </strong>Region-specific T2 mapping demonstrates potential for detecting early microstructural degeneration within lumbar intervertebral discs.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroradiologyPub Date : 2025-09-24DOI: 10.1007/s00234-025-03765-0
{"title":"European Society of Neuroradiology (ESNR).","authors":"","doi":"10.1007/s00234-025-03765-0","DOIUrl":"10.1007/s00234-025-03765-0","url":null,"abstract":"","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uptake patterns of Adult-type Non-Enhanced diffuse gliomas on [<sup>11</sup>C] methionine positron emission tomography : Previous presentations: none.","authors":"Shoji Yasuda, Naoya Imai, Hirohito Yano, Yuka Ikegame, Soko Ikuta, Takashi Maruyama, Noriyuki Nakayama, Morio Kumagai, Yoshihiro Muragaki, Jun Shinoda, Tsuyoshi Izumo","doi":"10.1007/s00234-025-03746-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03746-3","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the uptake patterns of adult-type non-enhanced gliomas in the pre-angiogenic phase on [<sup>11</sup>C] methionine (MET) PET.</p><p><strong>Methods: </strong>We included 52 astrocytoma (Group A), 34 oligodendroglioma (Group O), and 21 glioblastoma (Group G) cases. Regions of interest (ROIs) were defined based on T2-weighted images of high-intensity lesions encompassing tumor volume. The maximum tumor-to-brain ratios (TBR<sub>max</sub>) were calculated from PET data. ROIs were internally layered at 5-mm intervals from the tumor surface to assess MET uptake distribution. Moderate (TBR<sub>max</sub> ≥1.3) and high (TBR<sub>max</sub> ≥2.0) uptakes were classified into three patterns based on the extent and distribution.</p><p><strong>Results: </strong>TBR<sub>max</sub> was significantly lower in Group A than in Groups O and G. TBR<sub>max</sub> was more frequently observed in the outermost 0-5 mm layer in all groups. Seventy-three cases with TBR<sub>max</sub> ≥1.3 exhibited the whole pattern in 13 (17.8%) and partial or spot patterns in 60 (82.2%) cases; partial or spot pattern cases were most frequently identified as surface/outside patterns (60.3%). Twenty-seven cases with TBR<sub>max</sub> ≥2.0 exhibited the whole pattern in 5 (18.5%) and partial or spot patterns in 22 (81.5%) cases; partial or spot pattern cases were identified as central or surface/outside patterns, and none of the cases showed surface/inside patterns, indicating a high-uptake area in the deeper part of the brain.</p><p><strong>Conclusion: </strong>In non-enhanced gliomas, MET accumulation was concentrated at the periphery of the tumor. Although some cases showed MET uptake throughout the tumor, none showed focal high uptake deep in the brain.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroradiologyPub Date : 2025-09-22DOI: 10.1007/s00234-025-03774-z
Manisha Koneru, Janet Mei, Hamza Salim, Dhairya Lakhani, Adam Dmytriw, Adrien Guenego, Dylan Wolman, Shyam Majmundar, Achala Vagal, Aakanksha Sriwastwa, Yasmin Aziz, Meisam Hoseinyazdi, Caline Azzi, Risheng Xu, Hanzhang Lu, Elisabeth Marsh, Richard Leigh, Mona Bahouth, Rafael Llinas, Kambiz Nael, Argye Hillis, Gregory Albers, Jeremy Heit, Tobias Faizy, Vivek Yedavalli
{"title":"Prolonged venous transit - where venous outflow meets financial outflow: a cost analysis.","authors":"Manisha Koneru, Janet Mei, Hamza Salim, Dhairya Lakhani, Adam Dmytriw, Adrien Guenego, Dylan Wolman, Shyam Majmundar, Achala Vagal, Aakanksha Sriwastwa, Yasmin Aziz, Meisam Hoseinyazdi, Caline Azzi, Risheng Xu, Hanzhang Lu, Elisabeth Marsh, Richard Leigh, Mona Bahouth, Rafael Llinas, Kambiz Nael, Argye Hillis, Gregory Albers, Jeremy Heit, Tobias Faizy, Vivek Yedavalli","doi":"10.1007/s00234-025-03774-z","DOIUrl":"https://doi.org/10.1007/s00234-025-03774-z","url":null,"abstract":"<p><strong>Purpose: </strong>Healthcare costs in large vessel occlusion acute ischemic stroke (AIS-LVO) patients vary widely despite achieving successful reperfusion. Prolonged venous transit (PVT+) is a new marker of poor venous outflow on pretreatment perfusion imaging associated with various patient outcomes. We aim to explore the relationship between PVT + and acute care cost estimates for AIS-LVO.</p><p><strong>Methods: </strong>Adult AIS-LVO patients achieving successful reperfusion with thrombectomy at three centers in the United States were retrospectively reviewed. Cost estimates were derived from national averages for services in the Centers for Medicare and Medicaid Services data (2025). The primary outcome was total cost estimates for acute intervention, imaging, and post-treatment inpatient care until discharge. Estimates were compared between PVT + and PVT- cohorts.</p><p><strong>Results: </strong>In 109 included patients, the median age was 71 years (IQR 62-80). The cost estimates for total acute stroke care were significantly greater by $11787 in PVT + patients (median $36601 [IQR $24814-$72944] than PVT- patients (median $24814 [IQR $16956-$48388], p = 0.03). Cost of post-treatment care was significantly greater in PVT + patients than PVT- patients (p = 0.03).</p><p><strong>Conclusion: </strong>PVT + demonstrates potential as a useful, versatile pretreatment biomarker, in conjunction with other clinical data, to anticipate in-hospital resources and costs associated with acute stroke care.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroradiologyPub Date : 2025-09-22DOI: 10.1007/s00234-025-03763-2
Thomas Beyer, Erik Volmer, Patrick Gahr, Marc-André Weber
{"title":"Diagnostic accuracy of Dual-Energy CT in detecting traumatic vertebral bone marrow edema: a prospective comparative study with MRI in the context of a level I trauma center.","authors":"Thomas Beyer, Erik Volmer, Patrick Gahr, Marc-André Weber","doi":"10.1007/s00234-025-03763-2","DOIUrl":"https://doi.org/10.1007/s00234-025-03763-2","url":null,"abstract":"<p><strong>Background: </strong>Traumatic vertebral fractures present a significant diagnostic challenge in emergency settings. Magnetic resonance imaging (MRI) excels in detecting bone marrow edema but faces practical limitations in acute trauma care. This prospective study evaluates the diagnostic accuracy of Dual-Energy Computed Tomography (DECT) in detecting traumatic vertebral bone marrow edema within a Level I trauma center environment.</p><p><strong>Methods: </strong>Between May 2020 and July 2023, 291 DECT examinations were performed on adult patients presenting with suspected or confirmed spinal injury. From these, 233 (80.1%) met quality criteria for analysis. A subgroup of 47 patients underwent additional MRI as reference standard, with 44 (93.6%) providing diagnostically evaluable images. Two board-certified radiologists independently assessed vertebral bone marrow edema presence in blinded, randomized evaluations using both modalities. Diagnostic parameters, examination times, radiation exposure, and cost-efficiency were analyzed.</p><p><strong>Results: </strong>DECT demonstrated an overall sensitivity of 82.9% and specificity of 96.6% for detecting vertebral bone marrow edema compared to MRI. The thoracolumbar junction showed highest sensitivity (91.7% for L3). DECT examination time was 7.2 minutes (including post-processing) versus 12 minutes for MRI, meaning MRI required 66.7% more time than DECT. DECT radiation exposure showed a mean dose-length product increase of only 3% compared to conventional CT. Body mass index showed no significant influence on DECT interpretability (p=0.196) or diagnostic accuracy except in isolated segments (L3, T11). Cost-benefit analysis revealed potential savings of 49.1% (€104.40) per spinal segment with DECT-based diagnostic pathways.</p><p><strong>Conclusion: </strong>DECT offers high diagnostic accuracy for detecting traumatic vertebral bone marrow edema with substantial time and cost advantages compared to MRI. The technique demonstrates particular value in acute trauma settings, while acknowledging limitations from artifacts (19.9% of cases) primarily caused by medical devices. These findings support implementing DECT as an efficient alternative to MRI in spinal trauma diagnostics.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}