Neuroradiology最新文献_第4页

Advanced targeted microsphere embolization for arteriovenous malformations: state-of-the-art and future directions.

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-15 DOI: 10.1007/s00234-025-03584-3

Ali Mortezaei, Khaled M Taghlabi, Nadir Al-Saidi, Saketh Amasa, Rachael E Whitehead, Alex Hoang, Kurt Yaeger, Amir H Faraji, Ramanathan Kadirvel, Sherief Ghozy

{"title":"Advanced targeted microsphere embolization for arteriovenous malformations: state-of-the-art and future directions.","authors":"Ali Mortezaei, Khaled M Taghlabi, Nadir Al-Saidi, Saketh Amasa, Rachael E Whitehead, Alex Hoang, Kurt Yaeger, Amir H Faraji, Ramanathan Kadirvel, Sherief Ghozy","doi":"10.1007/s00234-025-03584-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03584-3","url":null,"abstract":"Background: Arteriovenous malformations (AVMs) present a significant therapeutic challenge, as current treatment modalities frequently fail to achieve complete and rapid obliteration and are associated with substantial morbidity in both the short and long term. This underscores the critical need for innovative therapeutic strategies that enable efficient AVM obliteration while minimizing patient risk. The current review aims to comprehensively assess the role of ATME in AVM management, examining its clinical efficacy, associated risks and benefits, and the economic and ethical implications to provide valuable foundation for future studies and guiding development in treatment strategies for AVMs.Results: Advanced targeted microsphere embolization (ATME) has emerged as a promising therapeutic option, initially developed for the localized treatment of AVMs and unresectable tumors, including liver cancer. By providing targeted delivery, ATME offers potential advantages over conventional approaches in achieving effective local control.Conclusions: ATME are safe and effective for vascular disease and cancer. Although evidence for microspheres in AVMs is scarce, results are promising. Future research could refine eligibility criteria, evaluate treatment techniques, and optimize ATME.","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gray matter alterations and neurotransmitter system associations in hepatitis B virus-related cirrhosis: insights into neuropathogenesis and therapeutic targets.

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-14 DOI: 10.1007/s00234-025-03579-0

Lubin Gou, Junqiang Lei, Huling Ren, Yanli Zhang, Xiaoli Chen, Shuaiwen Wang, Yu Dou

{"title":"Gray matter alterations and neurotransmitter system associations in hepatitis B virus-related cirrhosis: insights into neuropathogenesis and therapeutic targets.","authors":"Lubin Gou, Junqiang Lei, Huling Ren, Yanli Zhang, Xiaoli Chen, Shuaiwen Wang, Yu Dou","doi":"10.1007/s00234-025-03579-0","DOIUrl":"https://doi.org/10.1007/s00234-025-03579-0","url":null,"abstract":"Introduction: The associations between gray matter (GM) change and neurotransmitter systems in hepatitis B virus-related cirrhosis (HBV-RC) are still poorly understood.Methods: We recruited 60 HBV-RC patients and 60 healthy controls (HCs). Difference of GM volume between HBV-RC and HC groups was evaluated at global and voxel levels. The potential relationship between GM morphology and prognostic models of liver function was evaluated at voxel level in HBV-RC patients. The spatial correspondence between regional GM alteration and the distribution of multiple neurotransmitter systems in HBV-RC compared to healthy controls was assessed by the JuSpace toolbox covering various neurotransmitter maps.Results: Total GM volume in HBV-RC group was smaller than in HC group (p < 0.05), and the pattern of GM volume alterations showed significantly increased volume in bilateral thalamus and ventral diencephalon and decreased volume in bilateral basal ganglia and cerebellum (p < 0.05, FWE corrected). In HBV-RC group, the volume of left superior frontal gyrus medial segment and right middle frontal gyrus was positively correlated with serum albumin level and negatively correlated with ALBI score, and serum bilirubin level was negatively correlated with right hippocampus and caudate (p < 0.05, FWE corrected). GM alterations in HBV-RC patients relative to HCs were significantly associated with the intrinsic distribution of various neurotransmitter pathways, including GABAergic, cholinergic, serotonergic, and dopaminergic (p < 0.05).Conclusion: The pattern of GM alteration correlated with liver function and specific neurotransmitter deficits in HBV-RC patients. These findings provide new insight into the complex neuropathogenesis of HBV-RC and the possible therapeutic targets based on neurotransmitter modulation.","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

European Society of Neuroradiology (ESNR).

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-13 DOI: 10.1007/s00234-025-03587-0

引用次数: 0

Significance of the corpus callosum and inferior fronto-occipital fasciculus in recovery after traumatic brain injury.

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-11 DOI: 10.1007/s00234-025-03577-2

E L Pogosbekian, E V Sharova, L M Fadeeva, E V Alexandrova, I V Chekhonin, N E Zakharova, I N Pronin

{"title":"Significance of the corpus callosum and inferior fronto-occipital fasciculus in recovery after traumatic brain injury.","authors":"E L Pogosbekian, E V Sharova, L M Fadeeva, E V Alexandrova, I V Chekhonin, N E Zakharova, I N Pronin","doi":"10.1007/s00234-025-03577-2","DOIUrl":"https://doi.org/10.1007/s00234-025-03577-2","url":null,"abstract":"Objective: To analyze the correlations between the consciousness state scores and the fractional anisotropy (FA) values in various segments of the Corpus Callosum (CC) and Inferior Fronto-Occipital Fasciculus (IFOF) at different stages of recovery after traumatic brain injury (TBI).Methods: Diffusion tensor imaging (DTI) was performed in 43 TBI patients and 22 healthy volunteers. The consciousness levels were estimated with the CRS-R scale. The tracts were divided into segments using a template based on tractograms of healthy volunteers, and the correlations between the CRS-R scores and the FA values were calculated for each tract segment.Results: In the acute period after TBI, 15 segments of the CC and IFOF demonstrated significant correlations (p < 0.05). In the long-term period, the highest number (24) of correlations were found in the studied tracts segments. In the subacute period, only 3 segments with correlations were detected.Conclusions: We propose a new pipeline, which yields spatial localization of correlations between the fractional anisotropy values and the CRS-R scores in patients after TBI. It allows us to make assumptions about the functioning of neural networks.Significance: This work provides new information concerning the organization of fiber tracts and neural networks in TBI patients and may improve neurorehabilitation approaches.","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normalization of the percentage of signal recovery derived from dynamic susceptibility contrast perfusion MRI in brain tumors.

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-11 DOI: 10.1007/s00234-025-03580-7

Francesco Sanvito, Jingwen Yao, Nicholas S Cho, Donatello Telesca, Noriko Salamon, Timothy F Cloughesy, Benjamin M Ellingson

{"title":"Normalization of the percentage of signal recovery derived from dynamic susceptibility contrast perfusion MRI in brain tumors.","authors":"Francesco Sanvito, Jingwen Yao, Nicholas S Cho, Donatello Telesca, Noriko Salamon, Timothy F Cloughesy, Benjamin M Ellingson","doi":"10.1007/s00234-025-03580-7","DOIUrl":"https://doi.org/10.1007/s00234-025-03580-7","url":null,"abstract":"The universalizability of the metric percentage of signal recovery (PSR) derived from dynamic susceptibility contrast (DSC) perfusion MRI is limited by its dependency of acquisition parameters. In this technical assessment, we tested different reference tissues for PSR normalization and found the normal-appearing white matter (NAWM) to have the least inter-patient variability when using a fixed PSR-optimized protocol. A logarithmic normalization using NAWM improved the consistency of PSR values when a cohort of brain tumor patients was analyzed by synthetically changing acquisition parameters (while keeping the protocol uniform within the cohort). Additionally, the NAWM logarithmic normalization was better than no normalization and linear normalization at maintaining the consistency of both values and ranks within the cohort while a synthetic random variation of the acquisition parameter was applied (i.e., with a heterogeneous protocol within the cohort). Future PSR studies may consider reporting logarithmic normalized PSR (nPSRln) values to potentially improve the comparability across studies.","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging the artery of Percheron: a pictorial review of associated pathology with important mimics of bithalamic abnormalities.

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-10 DOI: 10.1007/s00234-025-03585-2

Mansi Jantre, David C Howlett

{"title":"Imaging the artery of Percheron: a pictorial review of associated pathology with important mimics of bithalamic abnormalities.","authors":"Mansi Jantre, David C Howlett","doi":"10.1007/s00234-025-03585-2","DOIUrl":"https://doi.org/10.1007/s00234-025-03585-2","url":null,"abstract":"Background and purpose: The Artery of Percheron (AoP) supplying bilateral paramedian thalami and rostral midbrain is a rare anatomical variant. In the event of occlusion of AoP, a characteristic pattern of ischaemia is seen, presenting as bithalamic signal abnormality on magnetic resonance imaging (MRI). However, this particular imaging finding has significant radiological and clinical overlap with other conditions, necessitating a comprehensive understanding of the imaging characteristics and potential differential diagnosis. The aim of this pictorial essay is to provide a visual documentation of varying appearances of AoP infarction on imaging and highlighting other important pathologies that may cause similar appearance.Methods: Retrospective collection and review of imaging from patients with confirmed AoP infarction and other pathologies causing bithalamic signal abnormalities and identify crucial imaging caveats for differentiation.Results: We present a comprehensive visual spectrum of AoP infarction patterns, including bithalamic involvement (paramedian thalamic lesions) with or without midbrain involvement. Additionally, the \"V\" sign, observed on FLAIR and DWI sequences, is fairly characteristic of AoP infarction. Other important vascular causes seen include top of basilar artery syndrome, internal cerebral vein thrombosis as well as neoplastic lesions including diffuse midline glioma (DMG) H3 K27-altered. Additionally various inflammatory, metabolic and infective etiologies including viral encephalitis like Japanese encephalitis can cause a similar appearance.Conclusions: This pictorial essay demonstrates the diverse patterns of AoP infarction and emphasizes the significance of recognizing important mimics of this condition, highlighting the need for a meticulous evaluation. Improved awareness and understanding of these imaging characteristics will contribute to more effective management of patients with thalamic strokes.","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of 7T MRI imaging of pituitary microadenomas: are we there yet?

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-08 DOI: 10.1007/s00234-025-03554-9

Benoit Testud, Aurélien Destruel, Thomas Troalen, Jean-Philippe Ranjeva, Maxime Guye

{"title":"Review of 7T MRI imaging of pituitary microadenomas: are we there yet?","authors":"Benoit Testud, Aurélien Destruel, Thomas Troalen, Jean-Philippe Ranjeva, Maxime Guye","doi":"10.1007/s00234-025-03554-9","DOIUrl":"10.1007/s00234-025-03554-9","url":null,"abstract":"Purpose: 7T MRI imaging of the pituitary gland is an emerging technique. The purpose of this article is to review the current status of the 7T MRI of the pituitary gland, particularly in the context of pituitary microadenoma pathology. We will discuss technical challenges and parallel transmission opportunities.Methods: Follow-up study selection and data extraction were performed following PRISMA guidelines. We focused on diagnostic performance and acquisition protocols. Inclusion criteria were: MRI imaging studies of pituitary adenoma at 7T. Exclusion criteria were: Case reports and reviews; studies which did not report MRI protocols; surgical planning studies; studies focusing exclusively on macroadenomas for which ultra-high magnetic field imaging is less decisive than microadenomas in clinical practice.Results: Six studies were included. 7T MRI outperformed 1.5 or 3T MRI for the detection of microadenomas. Acquisition protocols employed were heterogeneous, with two-dimensional T2-w and T1-w turbo spin-echo sequences, three-dimensional T1-w isotropic spin-echo and gradient-echo sequences (resolution: 0.6 and 0.8 mm), and dynamic contrast-enhanced T1-w sequences.Conclusion: 7T MRI is a promising tool for overcoming the difficulties encountered by conventional MRI, particularly in the case of Cushing disease. However, there is insufficient data to precisely define an optimal protocol yet.","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ex vivo ultra-high field magnetic resonance imaging of human epileptogenic specimens from primarily the temporal lobe: A systematic review. 主要来自颞叶的人类致痫标本的体外超高场磁共振成像：系统综述。

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-08 DOI: 10.1007/s00234-024-03474-0

Marie-Julie D K Lemmens, R H G J van Lanen, D Uher, A J Colon, M C Hoeberigs, G Hoogland, A Roebroeck, D Ivanov, B A Poser, R P W Rouhl, P A M Hofman, I Gijselhart, G S Drenthen, J F A Jansen, W H Backes, K Rijkers, O E M G Schijns

{"title":"Ex vivo ultra-high field magnetic resonance imaging of human epileptogenic specimens from primarily the temporal lobe: A systematic review.","authors":"Marie-Julie D K Lemmens, R H G J van Lanen, D Uher, A J Colon, M C Hoeberigs, G Hoogland, A Roebroeck, D Ivanov, B A Poser, R P W Rouhl, P A M Hofman, I Gijselhart, G S Drenthen, J F A Jansen, W H Backes, K Rijkers, O E M G Schijns","doi":"10.1007/s00234-024-03474-0","DOIUrl":"10.1007/s00234-024-03474-0","url":null,"abstract":"Purpose: Magnetic resonance imaging (MRI) is the preferred diagnostic tool for the detection of structural cerebral lesions in patients with epilepsy. Ultra-high field (UHF) MRI with field strengths ≥7 Tesla has been reported to improve the visualization and delineation of epileptogenic lesions. The use of ex vivo UHF MRI may expand our knowledge on the detection and detailed micromorphology of subtle epileptogenic lesions by bridging the gap between in vivo MRI and histopathology.Methods: A systematic review of available literature was conducted following PRISMA guidelines. A descriptive analysis of included articles was performed, focusing on (I) the ability of ex vivo UHF MRI to detect subtle abnormalities related to epilepsy, (II) different post-processing methods, and (III) concordance between UHF MRI and histopathology.Results: Eleven studies with focus on the depiction of focal cortical dysplasia (n = 4) or hippocampal sclerosis (n = 7) as causative lesion of drug-resistant epilepsy were included. Ex vivo UHF MRI proved its ability to visualize the anatomy of cortical and hippocampal structures in greater detail when compared to ex vivo conventional field strengths. Different MRI post-processing methods enabled differentiation between lesional subtypes and provided novel insights into (peri)lesional characteristics. Concordance between ex vivo UHF MRI findings and histopathology was high.Conclusion: Acquisition of ex vivo UHF MRI and its image processing has the potential to depict epileptogenic abnormalities in greater detail with a spatial resolution approximating histological images. The translation of ex vivo UHF MRI features to in vivo clinical settings remains challenging and urges further exploration.","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thalamic microstructural alterations in cerebral small vessel disease with mild cognitive impairment: insights from diffusion kurtosis imaging.

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-06 DOI: 10.1007/s00234-025-03578-1

Binglan Li, Bang Zeng, Peng Zeng, Dan Luo, Yuling Peng, Qiyuan Zhu, Zichun Yan, Ying Chai, Lisha Nie, Dan Wang, Yanyun Xiang, Yongmei Li

{"title":"Thalamic microstructural alterations in cerebral small vessel disease with mild cognitive impairment: insights from diffusion kurtosis imaging.","authors":"Binglan Li, Bang Zeng, Peng Zeng, Dan Luo, Yuling Peng, Qiyuan Zhu, Zichun Yan, Ying Chai, Lisha Nie, Dan Wang, Yanyun Xiang, Yongmei Li","doi":"10.1007/s00234-025-03578-1","DOIUrl":"https://doi.org/10.1007/s00234-025-03578-1","url":null,"abstract":"Purpose: This study aimed to investigate thalamic microstructural alterations in cerebral small vessel disease (CSVD) patients with mild cognitive impairment (MCI) using diffusion kurtosis imaging (DKI), and to examine the associations between DKI parameters and cognitive performance.Methods: The study included 80 CSVD patients and 40 healthy controls (HC). Based on Montreal Cognitive Assessment (MoCA) scores, CSVD patients were divided into MCI (n = 40) and non-MCI (n = 40) groups. DKI parameters of the thalamus and its subregions were compared among the three groups and correlated with cognitive performance.Results: CSVD-MCI patients exhibited significant alterations in DKI parameters, predominantly in the left thalamus. Compared to HC, CSVD-MCI patients showed reduced FA and decreased kurtosis parameters (KFA, MK, AK), along with increased diffusivity metrics (MD, AD, RD). Subregional analysis revealed the most pronounced changes in the left posterior, medial, and ventral groups. The lateral geniculate nucleus showed particularly significant reductions in FA and KFA. Cognitive assessments revealed significant correlations between DKI parameters and cognitive performance, with BNT and VFT scores showing strong correlations with DKI parameters in the left thalamus, particularly in the posterior nucleus and pulvinar.Conclusion: Thalamic microstructural alterations may play a crucial role in cognitive decline among CSVD patients. Diffusion kurtosis imaging parameters may provide novel perspectives for investigating the mechanisms of cognitive deterioration in CSVD patients.","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective analysis into the haemorrhage rate during follow-up of asymptomatic high-grade intracranial dural arterio-venous fistulas (dAVF) - results from a single centre study.

IF 2.4 3区医学

Neuroradiology Pub Date : 2025-03-06 DOI: 10.1007/s00234-025-03572-7

Kaustubha Ghate, Matthew Page, Shane Lee, James Caldwell, Ben McGuinness

引用次数: 0