Neuroradiology最新文献

{"title":"An enlarged nonfistulous artery mimicking an additional feeder in a pediatric pial arteriovenous fistula: an angiographic pitfall.","authors":"Sena Aksoy, Songül Şenadım, Arsida Bajrami, Serdar Geyik","doi":"10.1007/s00234-026-04224-0","DOIUrl":"https://doi.org/10.1007/s00234-026-04224-0","url":null,"abstract":"<p><p>Pial arteriovenous fistulas (PAVFs) are rare high-flow vascular lesions requiring precise characterization of the fistulous angioarchitecture before treatment. We report a pediatric PAVF in which an enlarged artery adjacent to the fistula initially appeared suspicious for additional fistulous supply. Superselective angiography demonstrated normal cortical arterial arborization and parenchymal perfusion without early venous drainage, confirming that the enlarged vessel did not participate directly in the arteriovenous shunt. Selective coil embolization achieved complete immediate occlusion of the fistulous communication while preserving the adjacent normal cortical arterial supply. This case illustrates that arterial enlargement alone does not establish participation in a PAVF and highlights an angiographic pitfall relevant to treatment planning.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of 3D pCASL perfusion in glioma grading according to the WHO 2021 classification: a retrospective study of 530 cases.","authors":"Artem I Batalov, Natalia E Zakharova, Nadezhda E Elagina, Eduard L Pogosbekyan, Ivan V Chekhonin, Ramin M Afandiev, Dmitry Yu Usachev, Igor N Pronin","doi":"10.1007/s00234-026-04225-z","DOIUrl":"https://doi.org/10.1007/s00234-026-04225-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the diagnostic performance of three-dimensional pseudo-continuous arterial spin labeling (3D pCASL) for preoperative grading of gliomas within the 2021 WHO classification framework and to assess protocol-specific tumor blood flow thresholds for differentiating CNS WHO grade 2 from grade 3-4 tumors.</p><p><strong>Methods: </strong>This retrospective single-center study included 530 patients with newly diagnosed supratentorial glial tumors examined between 2011 and 2024. Nineteen non-diffuse CNS WHO grade 1 tumors were retained for descriptive purposes only and excluded from all grading analyses; the primary analytical cohort therefore comprised 511 gliomas (grade 2, n = 75; grade 3, n = 152; grade 4, n = 284). Diagnoses were reassigned within the WHO 2021 framework using the histological and molecular information available for each patient; tumors lacking molecular information required for an integrated WHO diagnosis were designated NOS. All patients underwent 3.0 T MRI with 3D pCASL. Maximum tumor blood flow (maxTBF) and normalized TBF relative to white matter (nTBF WM) and gray matter (nTBF GM) were measured using approximately 30-mm² hotspot ROIs.</p><p><strong>Results: </strong>In gliomas, maxTBF, nTBF WM, and nTBF GM differentiated grade 2 from grade 3-4 tumors, with AUCs of 0.848, 0.833, and 0.84, respectively. The maxTBF threshold was 63.3 mL/100 g/min; AUCs were 0.743-0.768 for grade 2 versus grade 3 and 0.668-0.715 for grade 3 versus grade 4. After exclusion of NOS cases, glioblastomas and grade 4 astrocytomas did not differ significantly in maxTBF or nTBF (pfdr > 0.05). 3D pCASL also differentiated non-enhancing glioblastomas from grade 2 astrocytomas (maxTBF, pfdr = 0.0018; nTBF, pfdr = 0.0036-0.006), with AUCs of 0.78-0.86, a maxTBF cutoff of 64.1 mL/100 g/min, and specificity up to 96%. maxTBF and nTBF moderately correlated with Ki-67 (r = 0.44-0.50; pfdr < 0.001).</p><p><strong>Conclusions: </strong>3D pCASL provides high diagnostic accuracy for differentiating grade 2 gliomas from high-grade gliomas and grade 2 from grade 3 tumors within the WHO 2021 framework, while remaining fully non-invasive and requiring no contrast agent.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-stage multimodal learning model for functional outcomes prediction in acute ischemic stroke.","authors":"Bin Hu, Zhongping Ai, Hui Xu, Liang Jiang, Hulin Kuang","doi":"10.1007/s00234-026-04219-x","DOIUrl":"https://doi.org/10.1007/s00234-026-04219-x","url":null,"abstract":"<p><p>Predicting functional outcomes in acute ischemic stroke (AIS) patients after endovascular thrombectomy (EVT) remains challenging due to the complex and dynamic nature of disease progression. Existing methods typically rely on single-stage imaging or limited multimodal fusion, failing to fully capture disease progression and cross-modal complementarity. To address this issue, we propose a multimodal deep learning framework that integrates multi-stage imaging and clinical notes for 90-day modified Rankin Scale (mRS) prediction. The proposed model leverages a shared foundation model with Low-Rank Adaptation to encode pre- and post-treatment images. It further introduces a shared feature extraction module and a stage-specific feature extraction module to disentangle shared and stage-specific representations, enabling effective modeling of disease progression across stages. In addition, a bidirectional cross-attention module is employed to enhance semantic alignment between imaging features and clinical notes. Experiments on multi-stage NCCT and MRI datasets demonstrate that the proposed method consistently outperforms single-modality baselines, achieving AUCs of 0.9147 and 0.9479, respectively. Ablation studies further validate the effectiveness of both the multi-stage interaction design and the multimodal fusion strategy. These results suggest that integrating pre- and post-treatment imaging with clinical notes can improve prognostic performance, providing a practical solution for individualized outcome prediction in AIS patients following EVT.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MR elastography and perfusion MRI characterize distinct biomechanical and vascular features of meningiomas.","authors":"Zeynep Fırat, Gazanfer Ekinci, Uğur Türe","doi":"10.1007/s00234-026-04217-z","DOIUrl":"https://doi.org/10.1007/s00234-026-04217-z","url":null,"abstract":"<p><strong>Purpose: </strong>To determine whether MR elastography (MRE) and dynamic susceptibility contrast (DSC) perfusion MRI provide overlapping or complementary information in meningiomas using anatomically matched regions of interest (ROIs).</p><p><strong>Methods: </strong>Fifty-five patients with histopathologically confirmed meningiomas who underwent preoperative 3-T MRE and DSC perfusion MRI were retrospectively analyzed. MRE-derived stiffness and relative cerebral blood volume (rCBV) were evaluated in whole-tumor, MRE-defined high-stiffness (local), and non-focal ROIs. Regional differences, histological subtype associations, stiffness-perfusion correlations, and the influence of calcification were assessed.</p><p><strong>Results: </strong>MRE-derived stiffness was higher in the local than non-focal ROI (p < 0.001), whereas rCBV did not differ significantly (p = 0.274). MRE-derived stiffness and rCBV were not significantly correlated in the local, whole-tumor, or non-focal ROIs (ρ = 0.085-0.182; all p ≥ 0.183). Fibroblastic meningiomas showed lower local rCBV than meningothelial meningiomas (median, 4.01 vs. 9.87; p = 0.004), whereas MRE-derived stiffness did not differ significantly among histological subtypes (local p = 0.748). In the fibroblastic-meningothelial comparison, the stiffness effect size was small with a confidence interval spanning zero (r = - 0.126; 95% bootstrap CI, - 0.51 to 0.29). SWI-detected calcification was associated with lower rCBV but not MRE-derived stiffness.</p><p><strong>Conclusion: </strong>Perfusion did not differ significantly between MRE-defined high-stiffness and non-focal regions, and no significant stiffness-rCBV association was detected across ROI types. Perfusion MRI nevertheless demonstrated histological subtype-related differences not observed with MRE-derived stiffness, suggesting that the two modalities provide different, potentially complementary information about meningioma biomechanical and vascular features.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging findings in hyperammonemic encephalopathy associated with sepsis-induced liver injury: a pilot case series.","authors":"Rustam Talybov, Tatyana Trofimova, Tatyana Kleshchevnikova, Yauhen Statsenko","doi":"10.1007/s00234-026-04230-2","DOIUrl":"https://doi.org/10.1007/s00234-026-04230-2","url":null,"abstract":"<p><strong>Background: </strong>Hyperammonemic encephalopathy (HE) is a severe complication of sepsis-induced liver injury (SILI), often associated with sepsis. However, its neuroimaging manifestations remain poorly understood. The aim of this pilot case series is to describe the brain MRI findings in patients with sepsis and HE.</p><p><strong>Methods: </strong>We analysed brain MRI data from 15 consecutive patients with sepsis and clinically confirmed HE. Assessment of cerebral changes was performed using a standard MRI protocol. The following parameters were evaluated during the analysis: localization and signal intensity characteristics of the lesions on MRI, presence or absence of diffusion restriction, presence magnetic susceptibility artifacts, and reversibility on follow‑up were evaluated descriptively. No control group was included.</p><p><strong>Results: </strong>Pathological changes were observed in all 15 patients. Symmetrical involvement of the insular cortex and cingulate gyrus was the most frequent pattern (13/15, 86.7%), followed by basal ganglia lesions (1/15) and cortico‑subcortical hemispheric lesions (1/15). All lesions were hyperintense on T2‑WI and FLAIR, with diffusion restriction on DWI suggestive of cytotoxic oedema. Follow-up MRI was performed in all patients after treatment adjustment and renal replacement therapy, demonstrating marked regression of all noted changes, concurrent with normalization of serum ammonia, transaminases, lactate and sepsis markers.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection frequency of cystic rhomboid lip in a nonoperative clinical population: an MR imaging morphologic study.","authors":"Benqi Zhao, Jian Ding, Xiaowei Song, Chen Zhang, Jing Li, Jie Li, Zhuozhao Zheng, Weitao Man","doi":"10.1007/s00234-026-04213-3","DOIUrl":"https://doi.org/10.1007/s00234-026-04213-3","url":null,"abstract":"<p><strong>Purpose: </strong>The cystic rhomboid lip (CRL), a diverticular expansion of the fourth ventricular lateral recess at the foramen of Luschka, is familiar to posterior fossa surgeons but remains incompletely characterized on Magnetic Resonance (MR) imaging. We aimed to determine its MR imaging detection frequency and morphologic features in a nonoperative referral population and to evaluate a practical recognition framework against surgically confirmed cystic cerebellopontine angle (CPA) mimics.</p><p><strong>Methods: </strong>In this retrospective 2-center study, 662 consecutive patients who underwent thin-section skull base MR imaging for suspected posterior fossa cranial nerve disorders (2022-2024) were independently reviewed by 2 neuroradiologists. Based on anatomic and surgical literature, CRL was defined a priori by two required features at the foramen of Luschka: anterior displacement of CN IX-X and posterior displacement of the choroid plexus (the CN-choroid plexus separation sign), with a CSF-equivalent signal in the intervening space. Ipsilateral lateral recess dilatation was considered a supportive but nonmandatory feature. Extension pattern was classified with a radiologic adaptation of the Akiyama framework. The same features were then assessed in 54 surgically and histopathologically confirmed cystic or solid-cystic lesions at the level of the lower cranial nerves.</p><p><strong>Results: </strong>CRL was detected in 42/662 patients (6.3%; 95% CI, 4.7-8.5%), comprising 48 lesions (6 bilateral). Mean age was 55.8 ± 15.8 years; 61.9% were women. Mean maximum diameter was 15.7 ± 2.8 mm. A jugular foramen extension pattern (JFT) was present in 43/48 lesions (89.6%) and a lateral extension pattern (LET) in 5/48 (10.4%); JFT lesions were larger than LET lesions. Lateral recess dilatation was present in 32/48 lesions (66.7%). The CN-choroid plexus separation sign was present in 48/48 CRLs and in 0/54 comparison lesions. CSF-equivalent signal was present in 14/54 comparison lesions (25.9%), all arachnoid cysts accompanying a solid tumor, none of which showed the separation sign. Interobserver agreement was perfect for CRL detection (κ = 1.00) and extension pattern (κ = 1.00) and excellent for diameter measurements (ICC, 0.91-0.93).</p><p><strong>Conclusion: </strong>CRL is a relatively common finding on thin-section skull base MR imaging (6.3%). The CN-choroid plexus separation sign with CSF-equivalent signal reliably distinguishes it from cystic CPA mimics.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contralateral DTI-ALPS index as a prognostic biomarker in IDH-wildtype glioblastoma: integrating extent of resection and sex-stratified analyses.","authors":"Tayfun Aygün, Arif Keski̇n, Özgür Palancı, Mustafa Namık Öztanır, Nurullah Yücel, Gulam Heki̇moğlu","doi":"10.1007/s00234-026-04220-4","DOIUrl":"https://doi.org/10.1007/s00234-026-04220-4","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate the independent prognostic value of the contralateral DTI-ALPS index in IDH-wildtype glioblastoma, incorporating tumor morphometry, extent of resection, and sex-stratified analyses within a multivariable framework.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 153 IDH-wildtype glioblastoma patients from the publicly available UPENN-GBM dataset. Contralateral DTI-ALPS was calculated using DSI Studio via manual ROI placement; tumor morphometry was derived from expert-annotated segmentation labels using 3D Slicer. Survival analyses included Kaplan-Meier estimation, multivariable Cox regression, time-dependent ROC, restricted cubic spline, and sequential C-index comparison with likelihood-ratio testing.</p><p><strong>Results: </strong>The contralateral DTI-ALPS index independently predicted overall survival after adjustment for age, sex, tumor volume, and GTR status (HR = 0.405, 95% CI: 0.227-0.725, p = 0.002). Each one standard deviation increase in DTI-ALPS was associated with a 24.2% reduction in mortality risk. GTR ≥ 90% (HR = 0.651, p = 0.017) and age (HR = 1.021, p = 0.007) also retained independent significance. DTI-ALPS significantly improved model discrimination beyond age alone (C-index: 0.625 → 0.653 → 0.668; likelihood-ratio test p = 0.002). Time-dependent AUC reached 0.741 at 6 months. ALPS-based stratification was more pronounced in the subtotal resection subgroup. Sex-stratified analyses showed numerically stronger associations in females, but formal interaction testing did not confirm effect modification. In an exploratory MGMT subset (n = 57), DTI-ALPS did not retain independent significance after MGMT adjustment.</p><p><strong>Conclusion: </strong>The contralateral DTI-ALPS index may provide complementary prognostic information beyond established clinical predictors in IDH-wildtype glioblastoma; however, given the incomplete MGMT methylation data and ongoing methodological debate regarding the biological validity of DTI-ALPS, these findings should be considered exploratory. Prospective validation in cohorts with complete molecular and treatment data is required.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric thalamic tumours: a predictive MR phenotype.","authors":"Pritika Gaur, Francisco Sepulveda, Enrico De Vita, Annemarie Knill, Jessica Cooper, Asthik Biswas, Felice D'Arco, Sniya Sudhakar, Patricia Varga, Ulrike Löbel, Kshitij Mankad","doi":"10.1007/s00234-026-04222-2","DOIUrl":"https://doi.org/10.1007/s00234-026-04222-2","url":null,"abstract":"<p><strong>Purpose: </strong>To utilise MR phenotyping in accurately predicting paediatric thalamic tumour type via qualitative MR analysis and quantitative diffusion histogram analysis, with the aim of optimising pre-surgical planning and patient outcomes.</p><p><strong>Methods: </strong>Patients with tumours epicentred in the thalamus were identified through an electronic patient record search (2000 to 2024). Radiological features evaluated included tumour margins, homogeneity, cystic components, T1 and T2 signal, contrast enhancement, and haemorrhage. Histopathological tumour type, WHO grade, and molecular subtype were recorded. Tumour masks incorporating both solid and cystic components were manually drawn on T2-weighted b0 images and ADC histograms were constructed and analysed.</p><p><strong>Results: </strong>34 patients (12 male, 22 female) were included, with a mean age of 10.4 years (range 2.4 months to 16 years). Diffuse midline gliomas (DMG) accounted for 24% and pilocytic astrocytomas (PA) for 28% of the cohort. Further tumour types included low-grade astrocytomas (9%), DNETs, PXAs, and embryonal tumours (8.8% each), with germinoma, glioblastoma, supratentorial ependymoma, ganglioglioma, lymphoma, and ATRT each comprising 3%. ADC p10 was significantly lower in DMG than PA (877 ± 152 vs. 1053 ± 152 × 10⁻⁶ mm²/s; t = 2.25, df = 13, p = 0.042, Cohen's d = 1.16). ADC mean showed a large but non-significant difference (p = 0.068). PAs were well-defined and microcystic with brush-like enhancement. DMGs were ill-defined with patchy enhancement, lower ADC values, and frequent susceptibility artefact.</p><p><strong>Conclusion: </strong>Distinctive qualitative and quantitative MR features, particularly ADC p10, can guide the neuroradiologist in predicting tumour type and informing the decision between safe maximal resection and biopsy-first surgical pathways.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal hematoma resolution after burr-hole evacuation with adjunctive scepter mini-assisted middle meningeal artery embolization: A multicenter matched cohort study.","authors":"Mohamad Alheer, Peter B Sporns, Gabriel Broocks, Mete Dadak, Tawfik Moher Alsady, Bayan Alhaj Moustafa, Amy A Görtz, Christopher Nimsky, Sabrina Kirchleitner, Asmaa Alhaj Moustafa, Katja Döring, Mike P Wattjes, André Kemmling, Mohammad Almohammad","doi":"10.1007/s00234-026-04203-5","DOIUrl":"https://doi.org/10.1007/s00234-026-04203-5","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the radiographic and clinical outcomes of adjunctive middle meningeal artery embolization (MMAE) performed with the Scepter Mini dual-lumen balloon microcatheter following burr-hole evacuation for chronic subdural hematoma (cSDH), and to explore the feasibility of characterizing distal embolic penetration using the proposed MMA Embolization Penetration Score (MMA-EPS).</p><p><strong>Methods: </strong>This retrospective multicenter matched cohort study included consecutive patients with cSDH treated with burr-hole evacuation followed by adjunctive MMAE using the Scepter Mini and Onyx™ 18. A matched historical cohort treated with burr-hole evacuation alone served as controls. The primary endpoint was longitudinal hematoma thickness regression on serial computed tomography. Secondary endpoints included functional outcome, recurrence, all-cause mortality, and procedural safety.</p><p><strong>Results: </strong>Twenty-two patients with 38 embolized cSDHs were compared with 22 matched controls comprising 38 cSDHs. All embolized hematomas achieved MMA-EPS Grade 3 or 4 and demonstrated complete radiographic resolution by 6 months, whereas residual hematoma persisted in controls (0.0 ± 0.0 vs. 0.7 ± 0.9 mm). Favorable functional outcome (mRS 0-2) at 6 months was achieved in 86.4% versus 45.5% of patients. Exploratory analyses showed numerically lower recurrence (4.5% vs. 13.6%) and all-cause mortality (0% vs. 13.6%) following MMAE; however, the study was not powered to assess differences in these endpoints. Technical success was achieved in all embolizations without major procedure-related complications.</p><p><strong>Conclusion: </strong>Adjunctive MMAE using the Scepter Mini dual-lumen balloon microcatheter was associated with accelerated hematoma resolution, improved functional recovery, and an excellent procedural safety profile compared with burr-hole evacuation alone.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated hippocampal atrophy in APOE ε4 homozygotes and females: Longitudinal findings from the Tohoku Medical Megabank MRI study.","authors":"Shunji Mugikura, Naoko Mori, Megumi Satake, Ippei Chiba, Makiko Taira, Takuya Koyama, Tomomi Onuma, Tomo Saito, Masato Takase, Ikuko N Motoike, Takanori Hidaka, Akihito Otsuki, Masatsugu Orui, Taku Obara, Fuji Nagami, Naoki Nakaya, Soichi Ogishima, Kazuki Kumada, Fumiki Katsuoka, Seizo Koshiba, Yasuyuki Taki, Ritsuko Shimizu, Shinichi Kuriyama, Kinuko Ohneda, Yoko Izumi, Nobuo Fuse, Atsushi Hozawa, Kengo Kinoshita, Masayuki Yamamoto","doi":"10.1007/s00234-026-04210-6","DOIUrl":"https://doi.org/10.1007/s00234-026-04210-6","url":null,"abstract":"<p><strong>Purpose: </strong>The apolipoprotein E ε4 allele is a major genetic risk factor for Alzheimer's disease, but its longitudinal effect on hippocampal atrophy is unclear. Selective hippocampal atrophy, defined as greater hippocampal volume (HpV) loss relative to total brain volume (TBV), is an early marker of preclinical Alzheimer's disease. We examined age-related effects of APOE ε4 on longitudinal hippocampal atrophy in a large population-based cohort.</p><p><strong>Methods: </strong>We analyzed MRI data from 9,453 adults in the Tohoku Medical Megabank MRI Study, including 5,774 participants with follow-up MRI after a mean interval of 4.7 years. Cross-sectional analyses used linear regression to assess HpV and TBV, adjusting for age, sex, APOE genotype, and intracranial volume. Longitudinal analyses assessed HpV-Ratio and TBV-Ratio, defined as the second MRI volume divided by the first volume, using regression models including age, sex, APOE genotype, MRI interval, and interaction terms between age and APOE genotype and between age and sex. Montreal Cognitive Assessment (MoCA) scores obtained at the second MRI were included to assess effects independent of cognition.</p><p><strong>Results: </strong>No significant APOE genotype effects were observed in cross-sectional analyses. Longitudinally, ε4/ε4 carriers showed greater decline in HpV-Ratio than ε3/ε3 and ε3/ε4 carriers, and females showed lower HpV-Ratio than males. No APOE genotype or sex main effects were observed for TBV-Ratio. Interactions between age and APOE genotype and between age and sex demonstrated age-related acceleration of HpV-Ratio decline in ε4/ε4 carriers and females, and these effects persisted after adjustment for MoCA scores.</p><p><strong>Conclusion: </strong>APOE ε4 homozygosity and female sex accelerate selective hippocampal atrophy in population-based cohorts.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}