Neuroradiology最新文献

{"title":"Patterns of abnormal magnetic susceptibility in the brain: an image-based review.","authors":"Kendal Weger, Carrie Carr, V Michelle Silvera, Michael Oien, Heidi Edmonson, Bobby Do, Jason Little","doi":"10.1007/s00234-025-03588-z","DOIUrl":"https://doi.org/10.1007/s00234-025-03588-z","url":null,"abstract":"<p><strong>Purpose: </strong>This article is designed to facilitate a systematic approach to formulating a radiologic differential diagnosis based on the pattern of abnormal magnetic susceptibility on MRI. Susceptibility-weighted imaging (SWI) is a three-dimensional sequence with excellent spatial resolution and superior contrast resolution. It originated from and has largely replaced two-dimensional T2^* weighted sequences. Currently, SWI refers to any high-spatial resolution susceptibility-enhanced sequence from different MR vendors.</p><p><strong>Methods: </strong>There are many entities that have specific patterns unique on SWI. We chose both entities that are commonly encountered in the clinical practice and unusual entities that may present as challenges in making the diagnosis. Each entity is discussed in detail, focusing on salient imaging features seen with SWI and key differences highlighted from other entities.</p><p><strong>Results: </strong>In the first category, lesions with randomly distributed susceptibility abnormalities are described. Further classification is made based on the presence of foci of susceptibility located diffusely through the brain (e.g. diffuse axonal injury) noting the subtleties of the shape, size, and preferential distribution of these foci. Special attention is also directed toward entities that, while random in location, are associated with a specific lesion (e.g. abscess). Finally, clues to correctly diagnose the various pathologies are provided. In the second category, the focus is on lesions that can be classified based upon anatomic locations whether peripheral (e.g. sulcal hemosiderin) versus central distribution.</p><p><strong>Conclusion: </strong>Knowledge of the patterns of susceptibility on SWI and the physics behind this technique are essential for facilitating MR interpretation.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning radiomics for H3K27M mutation prediction in gliomas: A systematic review and meta-analysis.","authors":"Bardia Hajikarimloo, Salem M Tos, Alireza Kooshki, Mohammadamin Sabbagh Alvani, Mohammad Shahir Eftekhar, Arman Hasanzade, Roozbeh Tavanaei, Mohammadhosein Akhlaghpasand, Rana Hashemi, Mohammadreza Ghaffarzadeh-Esfahani, Ibrahim Mohammadzadeh, Mohammad Amin Habibi","doi":"10.1007/s00234-025-03597-y","DOIUrl":"https://doi.org/10.1007/s00234-025-03597-y","url":null,"abstract":"<p><strong>Purpose: </strong>Noninvasive prediction and identification of the H3K27M mutation play an important role in optimizing therapeutic strategies and improving outcomes in gliomas. In this systematic review and meta-analysis, we aimed to evaluate the performance of machine learning (ML)-based models in predicting H3K27M mutation in gliomas.</p><p><strong>Methods: </strong>Literature records were retrieved on September 16th, 2024, in PubMed, Embase, Scopus, and Web of Science. Records were screened according to the eligibility criteria, and the data from the included studies were extracted. The meta-analysis, sensitivity analysis, and meta-regression were conducted using R software.</p><p><strong>Results: </strong>A total of 15 studies were included in our study. Our meta-analysis demonstrated a pooled AUC, sensitivity, and specificity of 0.87 (95% CI: 0.77-0.97), 92% (95% CI: 83%-96%), and 89% (95% CI: 86%-91%)), respectively. The subgroup meta-analysis revealed that despite the higher sensitivity of the deep learning (DL) models, the sensitivity is not superior to ML (P = 0.6). In contrast, the ML-based pooled specificity was significantly higher (P < 0.01). The meta-analysis revealed a 78.1 (95% CI: 33.3 - 183.5). The SROC curve indicated an AUC of 0.921, and the estimated sensitivity is 0.898 concurrent with the false positive rate of 0.126, which indicates high sensitivity with a low false positive rate.</p><p><strong>Conclusion: </strong>Our systematic review and meta-analysis demonstrated that ML-based magnetic resonance imaging (MRI) radiomics models are associated with promising diagnostic performance in predicting H3K27M mutation in gliomas.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Australian Diagnostic Criteria for Contrast-Induced Encephalopathy.","authors":"Frederick P Mariajoseph, Leon T Lai, Adrian Praeger, Ronil V Chandra, Justin Moore, Hamed Asadi, Laetitia de Villiers, Tony Goldschlager, Calvin Gan, Kevin Zhou, Albert Ho Yuen Chiu, Ferdinand Miteff, Ramon Martin Banez, Thanh Phan, Davor Pavlin-Premrl, Winston Chong, Sophie Dunkerton, Anoop Madan, Lee-Anne Slater","doi":"10.1007/s00234-025-03601-5","DOIUrl":"https://doi.org/10.1007/s00234-025-03601-5","url":null,"abstract":"<p><strong>Introduction: </strong>Contrast-induced encephalopathy (CIE) is a recognised complication of contrast administration, however diagnosis remains challenging due to its symptom overlap with other neurological conditions and the absence of formal diagnostic criteria.</p><p><strong>Methods: </strong>A modified Delphi study was performed. Consultant physicians with active clinical experience with CIE patients were invited from neurovascular centres in Australia. Initial diagnostic items were derived from an extensive literature review and analysis of local institutional cases across Australia. Three Delphi rounds were conducted. Consensus was defined as ≥ 75% agreement.</p><p><strong>Results: </strong>Seventeen neurovascular specialists from nine neurovascular centres participated (81.0% response rate) between May 2024 and July 2024. In round 1, 15 diagnostic items were presented to participants, which were revised and one additional criteria suggested. In round 2, 14/16 diagnostic items achieved consensus. In round three 14/14 items achieved consensus. Ultimately, a 14-item diagnostic criteria was developed based on participant consensus. The absolute criteria exclude CIE if symptom onset is more than 24 h after contrast administration, or if symptoms can be explained by vessel occlusion/territory ischaemia, intracranial haemorrhage, epilepsy, metabolic derangement, intracranial malignancy or head trauma. The supporting criteria indicate that CIE is more probable if symptoms are reversible, correspond with the distribution of contrast administration, or are associated with reversible contrast staining, cerebral oedema or cortical/subcortical MRI signal change.</p><p><strong>Conclusion: </strong>This study proposes a 14-item diagnostic criteria for CIE based on expert consensus in Australia. Further research is needed to refine CIE as a clinical entity.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transradial versus transfemoral access in diagnostic cerebral angiography: a comprehensive systematic review and meta-analysis of clinical outcomes and complications.","authors":"Abdelrahman M Hamouda, Tasnim El Gazar, Mohamed Ahmed Ali, Saroj Kumar Jha, Mark Cwajna, Nicholas Kendall, Mohamed Derhab, Sherief Ghozy, Zach Pennington, Rahul Kumar, Kogulavadanan Arumaithurai, Waleed Brinjikji, David F Kallmes","doi":"10.1007/s00234-025-03581-6","DOIUrl":"https://doi.org/10.1007/s00234-025-03581-6","url":null,"abstract":"<p><strong>Background: </strong>Diagnostic Cerebral Angiography (CA) is a relatively common procedure that provides detailed evaluation of the brain's blood vessels. With the growing preference for Transradial artery (TRA) access over Transfemoral artery (TFA) access, our review aims to compare clinical outcomes and complications between these two approaches.</p><p><strong>Methods: </strong>We carried out a systematic review using PubMed, Embase, Web of Science, Scopus databases, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Inclusion was limited to studies that exclusively compared TRA versus TFA approaches for cerebral diagnostic purposes.</p><p><strong>Results: </strong>Our study included 27 studies encompassing a total of 12,806 patients. The TRA arm comprised 6,284 patients with a median age of 57.9 years, and 46.4% were male. The TFA arm included 6,522 patients with a median age of 59.0 years, and 44.8% were male. Our analysis revealed that the TFA group had a higher successful Cerebral Angiography (CA) rate (OR = 0.62, p = 0.03), and lower crossover rate (OR: 2.85, p < 0.01) compared to the TRA group. However, the TRA group demonstrated a significantly lower rate of total complications (OR: 0.52, p < 0.01) and shorter hospital length of stay (LOS) in hours ([MD]: -33.25, p < 0.001) compared to the TFA group. There were no significant differences between groups in terms of procedural metrics.</p><p><strong>Conclusion: </strong>Our review highlighted the superiority of the transfemoral artery approach in terms of success rates and lower crossover rates. However, transradial artery access may be preferred due to its association with lower complication rates and shorter hospital stays, aligning with patient-centered outcomes.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cangrelor, a newer P2Y12 inhibitor, in neuro-interventional procedures: a systematic review and updated meta-analysis.","authors":"Ocílio Ribeiro Gonçalves, Ana B Santos, Anthony Hong, Leonardo Januário Campos Cardoso, Márcio Yuri Ferreira, Christian Ken Fukunaga, Victor Arthur Ohannesian, Kelson James Almeida, Filipe Virgilio Ribeiro","doi":"10.1007/s00234-025-03573-6","DOIUrl":"https://doi.org/10.1007/s00234-025-03573-6","url":null,"abstract":"<p><strong>Background: </strong>Cangrelor, a reversible P2Y12 receptor inhibitor commonly utilized in cardiovascular interventions, is increasingly being investigated for its potential in cerebrovascular applications. This study presents a comprehensive evaluation of its safety and efficacy in neuro-interventional procedures, based on a systematic review and meta-analysis of recent evidence.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Cochrane, Web of Science, and Scopus for studies on endovascular therapy with cangrelor-based intravenous antiplatelet therapy for cerebrovascular pathologies. Endpoints included 90-day functional outcomes, successful reperfusion (mTICI 2b-3), mortality, symptomatic intracranial hemorrhage (sICH), hemorrhagic transformation, gastrointestinal bleeding, intraprocedural complications (in-stent thrombosis, thromboembolic events), and retroperitoneal hematoma. Single-proportion analysis with 95% CIs under a random-effects model was conducted.</p><p><strong>Results: </strong>Seventeen studies with 646 patients were included. Favorable 90-day functional outcomes occurred in 57.06% (44.37-69.76%), and successful recanalization in 98.74% (96.63-100.00%). Rates of hemorrhagic transformation, sICH, gastrointestinal bleeding, and retroperitoneal hematoma were 24.06%, 4.64%, 0.02%, and 0.07%, respectively. Intraprocedural in-stent thrombosis occurred in 0.28%, thromboembolic events in 0.48%, and 90-day all-cause mortality was 7.94%.</p><p><strong>Conclusion: </strong>The findings suggest that intravenous cangrelor, used as antiplatelet therapy following neuro-interventional procedures, is both safe and effective. This is reflected in high rates of favorable clinical outcomes, successful recanalization, and low complication rates.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous occurrence of epidural, subdural, and subarachnoid hemorrhages in the spinal canal: a rare case report.","authors":"Arda Çolakoğlu, Kerim Aslan, Barış Genç, Lütfi İncesu","doi":"10.1007/s00234-025-03576-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03576-3","url":null,"abstract":"<p><p>Simultaneous spinal epidural, subdural, and subarachnoid hemorrhages are exceedingly rare, with no prior documented case of all three occurring simultaneously in the literature. We present the case of a 59-year-old woman who developed acute lower back pain and progressive weakness in her lower extremities. MRI revealed three distinct types of hemorrhages: an epidural hematoma extending from T12 to the lumbar spine, a subdural hematoma between T11 and S1, and a subarachnoid hemorrhage involving the cauda equina. Surgical decompression was performed, leading to significant clinical improvement. This case underscores the critical role of MRI in the diagnosis of complex spinal hematomas and highlights the importance of prompt surgical intervention to prevent further neurological deterioration. Our report contributes valuable insights into the management of multifaceted spinal hemorrhages, emphasizing the need for early recognition and treatment in such rare presentations.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated flat panel computed tomography for pre-operative temporal bone imaging: Image quality and dosimetry comparison to conventional high resolution multislice computed tomography.","authors":"Elie Diamandis, Sebastian Johannes Müller, Eya Khadhraoui, Stefan Klebingat, Eric Einspänner, Martin Durisin, Anne Albrecht, Daniel Behme","doi":"10.1007/s00234-025-03592-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03592-3","url":null,"abstract":"<p><strong>Purpose: </strong>High-resolution multislice CT (HR-MSCT) and cone beam CT (CBCT) are commonly used for preoperative temporal bone imaging, with HR-MSCT often preferred due to its shorter scan duration and lower susceptibility to motion artifacts. However, recent advancements in accelerated flat panel CT (Acc-FPCT) available with the latest generation angiography systems have addressed traditional limitations of CBCT by significantly decreasing scan time. This cadaver-based study evaluates the diagnostic performance and radiation dose of Acc-FPCT compared to HR-MSCT in preoperative temporal bone imaging.</p><p><strong>Methods: </strong>Six different Acc-FPCT protocols were acquired on five whole-head cadaveric specimens (ten temporal bones). Three neuroradiologists experienced in temporal bone imaging assessed the image quality of Acc-FPCT protocols in comparison to that of HR-MSCT for the visualization of 31 landmarks of middle and inner ear using a 5-point Likert scale. We also compared radiation dose parameters (CT dose index and dose length product) among the protocols.</p><p><strong>Results: </strong>Two high-Resolution Acc-FPCT protocols were found to be superior to HR-MSCT by all raters (p < 0.001). There were no significant differences between the two HR-FPCT protocols (p = 0.25). The remaining Acc-FPCT protocols were rated significantly inferior to HR-MSCT. The inter-rater reliability was excellent (ICC (2,k) = 0.925; CI [0.92-0.93]). The dose length product was significantly lower in all Acc-FPCT protocols compared to HR-MSCT.</p><p><strong>Conclusion: </strong>The results of our cadaver-based study highlight the utility of certain Acc-FPCT protocols as a viable alternative to HR-MSCT in preoperative temporal bone imaging, improving the visualization of critical anatomical landmarks without increasing radiation exposure.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving differentiation of hemorrhagic brain metastases from non-neoplastic hematomas using radiomics and clinical feature fusion.","authors":"Linyang Cui, Luyue Yu, Sai Shao, Liping Zuo, Hongjun Hou, Jie Liu, Wenjun Zhang, Ju Liu, Qiang Wu, Dexin Yu","doi":"10.1007/s00234-025-03590-5","DOIUrl":"https://doi.org/10.1007/s00234-025-03590-5","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to develop and validate a fusion model combining multi-sequence MRI radiomics and clinico-radiological features to distinguish hemorrhagic brain metastasis covered by hematoma (HBM.cbh) from non-neoplastic intracranial hematomas (nn-ICH).</p><p><strong>Methods: </strong>The data of 146 patients with pathologically or clinically proven HBM.cbh (n = 55) and nn-ICH (n = 91) were collected from two clinical institutions. Radiomics features were extracted from various regions (hemorrhage and/or edema) based on T2-weighted, T1-weighted, fluid-attenuated inversion-recovery, and T1 contrast-enhanced imaging. Synthetic minority over-sampling technique (SMOTE) was performed to balance the minority group (HBM.cbh). Logistic regression (LR) and k-nearest neighbors (KNN) were utilized to construct the models based on clinico-radiological factors (clinical model), radiomic features from various modalities of MRI (radiomics model), and their combination (fusion model). The area under the curve (AUC) values of different models on the external dataset were compared using DeLong's test.</p><p><strong>Results: </strong>The 4-sequence radiomics model based on the entire region performed the best in all radiomics models, with or without SMOTE, where the AUCs were 0.83 and 0.84, respectively. The AUC of clinical mode was 0.71 with SMOTE, and 0.62 without SMOTE. The fusion model demonstrated excellent predictive value with or without SMOTE (AUC: 0.93 and 0.90, respectively), outperforming both the radiomics and clinical model (0.93 vs. 0.83, 0.71, p < 0.05 and 0.90 vs. 0.84, 0.62, p < 0.05, respectively).</p><p><strong>Conclusions: </strong>The multi-sequence radiomics model is an effective method for differentiating HBM.cbh from nn-ICH. It can yield the best diagnostic performance prediction model when combined with clinico-radiological features.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pretreatment and early treatment with statins on safety and efficacy outcomes in patients after acute ischemic stroke undergoing endovascular thrombectomy: a systematic review and meta-analysis.","authors":"Ocílio Ribeiro Gonçalves, Gabriel de Almeida Monteiro, Ana B Santos, Anthony Hong, Maria Antonia Oliveira Machado Pereira, Christian Ken Fukunaga, Hilária Saugo Faria, Luis Otávio Nogueira, Filipe Virgilio Ribeiro, Márcio Yuri Ferreira, João Victor Araújo de Oliveira, Kelson James Almeida","doi":"10.1007/s00234-025-03583-4","DOIUrl":"https://doi.org/10.1007/s00234-025-03583-4","url":null,"abstract":"<p><strong>Introduction: </strong>It remains unclear whether early statin treatment and statin pre-treatment could change prognosis in patients after ischemic stroke undergoing endovascular thrombectomy (EVT).</p><p><strong>Objectives: </strong>This study aims to assess whether both statins pretreatment and early statins in-hospital treatment impact the outcomes of patients with acute ischemic stroke (AIS) undergoing EVT.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, and Cochrane Central Register of Controlled Trials from inception to June 2024. The early statin use was defined as in-hospital administration of statins post-stroke onset. The statin pre-treatment was defined as the regular use of statins because of any previous indication. The efficacy outcomes were favorable functional outcomes at 90 days, reduced neurological deterioration, and NIHSS improvement greater or equal to 4 points from baseline. We defined a favorable functional outcome as a mRS of 0-2 points. The safety outcomes included symptomatic intracranial hemorrhage (sICH), any ICH, and all-cause death. All statistical analyses were performed using R version 4.4.0.</p><p><strong>Results: </strong>Seven observational studies comprising 2,440 patients were included. The incidence of favorable functional outcomes (mRS 0-2) in 90 days(RR 1.74; 95% CI 1.38-2.20; p < 0.001; I² = 52.4%) was significantly increased in the early statins group compared with the non-statins group. In addition, sICH (RR 0.48; 95% CI 0.29-0.80; p = 0.005; I² = 45.2%), any ICH (RR 0.65; 95% CI 0.52-0.81; p < 0.001; I² = 0.0%), neurological deterioration (RR 0.36; 95% CI 0.26-0.49; p < 0.001; I² = 0%), and death in 90 days (RR 0.38; 95% CI 0.28-0.53; p < 0.001; I² = 15%) was significantly lower in the early statins group compared with the non-statins group. No difference between groups in neurological improvement was identified (RR 1.32; 95% CI 0.98-1.78; p = 0.065; I² = 66%). In the statins pre-treatment analysis there was no difference between groups in the incidence of successful recanalization (OR 2.62; 95% CI 0.80-8.53; p = 0.11; I² = 69%), the incidence of favorable functional outcomes (mRS 0-2) in 90 days (OR 1.53; 95% CI 0.82-2.83; p = 0.18; I² = 35%) and neurological improvement (OR 1.35; 95% CI 0.69-2.65; p = 0.38; I² = 0%).</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis identified that early statin treatment is correlated with significant improvement in efficacy and safety outcomes of endovascular thrombectomy. On the other hand, statins pretreatment had no considerable positive impact on outcomes of endovascular thrombectomy.. Large randomized controlled trials are needed to confirm our findings.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodegeneration correlates of iron-related lesions and leptomeningeal inflammation in multiple sclerosis clinical subtypes.","authors":"Aigli G Vakrakou, Ioannis Papadopoulos, Maria-Evgenia Brinia, Dimitrios Karathanasis, Dimitrios Panaretos, Panos Stathopoulos, Anastasia Alexaki, Varvara Pantoleon, Efstratios Karavasilis, Georgios Velonakis, Leonidas Stefanis, Maria-Eleftheria Evangelopoulos, Constantinos Kilidireas","doi":"10.1007/s00234-025-03595-0","DOIUrl":"https://doi.org/10.1007/s00234-025-03595-0","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to investigate the significant implications of different types of lesions as assessed by QSM (quantitative-susceptibility-mapping) as well as leptomeningeal contrast-enhancement in a cohort of Relapsing-Remitting (RR) and Primary Progressive (PP) MS patients and to assess their association with clinical disability and MRI-measures of brain structural damage.</p><p><strong>Methods: </strong>Different types of white-matter lesions were identified and quantified using QSM in 24 RRMS and 15 PPMS (11 patients with follow-up MRI). Leptomeningeal contrast-enhancement (LMCE; foci) was assessed on 3D-FLAIR post-gadolinium.</p><p><strong>Results: </strong>Both RRMS and PPMS presented PRL (paramagnetic-rim lesions) and LMCE, with PPMS showing a trend towards more LMCE (RRMS 37%, PPMS 53%). In QSM RRMS patients showed more hyperintense white-matter lesions with greater lesion volume. In RRMS PRL correlated with disease duration and lesion burden especially the volume of juxtacortical Flair-hyperintense lesions. Besides, the presence of PRL lesions in PPMS was associated with subcortical atrophy mainly thalamus and pallidum volumetry. In all MS-cohort, patients with more than 3-PRLs exhibited reduced regional cortical thickness in specific temporal areas and post/para central gyrus. Forest-analysis selected age, increased NAWM (normal appearing white-matter) QSM intensity, total lesion volume and the presence of LMCE as informative predictors of cortical thickness. After anti-CD20 treatment, no significant change was observed regarding the number of PRL and LMCE, but the percentage of PRL lesions over the total lesion types and the QSM rim intensity increased.</p><p><strong>Conclusion: </strong>Our findings suggest that QSM-lesion types and leptomeningeal inflammation capture different aspects of progressive disease biology in both RRMS and PPMS.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}