Neuroradiology最新文献

{"title":"Regional T2 value differences assess lumbar disc degeneration: a 3.0-T MRI retrospective study.","authors":"Shunmin Wang, Jiangang Shi, Tiefeng Li, Xiaofeng Zhang, Kaiqiang Sun, Yu Chen","doi":"10.1007/s00234-025-03762-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03762-3","url":null,"abstract":"<p><strong>Objectives: </strong>To quantify region-specific T2 relaxation dynamics in lumbar disc degeneration and evaluate their correlations with Pfirrmann grades and herniation morphology, focusing on early microstructural detection.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 130 lumbar discs (L1-S1) from 26 patients with single-segment disc herniation using 3.0-T MRI. T2 relaxation mapping was systematically performed with anatomical compartment segmentation defining four regions of interest: anterior annulus fibrosus, nucleus pulposus, posterior annulus fibrosus, and herniated tissue. Standardized circular ROIs (2.5-mm diameter) were applied to non-herniated regions, while herniations underwent area-matched elliptical contouring. Pfirrmann grading (I-V) was independently validated by two board-certified musculoskeletal radiologists. Statistical analyses employed nonparametric Kruskal-Wallis tests for inter-grade T2 comparisons and Spearman's rank correlation (ρ) to quantify degeneration associations.</p><p><strong>Results: </strong>Statistically significant differences in T2 values were observed across the three anatomical compartments (*p*<0.05). T2 relaxation times demonstrated an inverse correlation with Pfirrmann degeneration grades, exhibiting the strongest association in the nucleus pulposus (middle compartment; r=-0.542). This correlation intensified with advancing degeneration. Sagittal T2 comparisons revealed significant differences between Pfirrmann grade I/II and IV/V groups in all compartments, while the nucleus pulposus showed significant differences between grades I/II and III. Within identical degeneration grades, nucleus pulposus T2 values exceeded those of the anterior annulus fibrosus. Specifically, in Pfirrmann I/II discs, posterior annulus values surpassed anterior annulus values, whereas in grade IV/V discs, nucleus pulposus values exceeded posterior annulus values, with no significant anterior-posterior difference. Cross-sectionally, the nucleus pulposus exhibited the highest T2 values, while herniated tissue demonstrated the lowest.</p><p><strong>Conclusions: </strong>Region-specific T2 mapping demonstrates potential for detecting early microstructural degeneration within lumbar intervertebral discs.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Society of Neuroradiology (ESNR).","authors":"","doi":"10.1007/s00234-025-03765-0","DOIUrl":"10.1007/s00234-025-03765-0","url":null,"abstract":"","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptake patterns of Adult-type Non-Enhanced diffuse gliomas on [¹¹C] methionine positron emission tomography : Previous presentations: none.","authors":"Shoji Yasuda, Naoya Imai, Hirohito Yano, Yuka Ikegame, Soko Ikuta, Takashi Maruyama, Noriyuki Nakayama, Morio Kumagai, Yoshihiro Muragaki, Jun Shinoda, Tsuyoshi Izumo","doi":"10.1007/s00234-025-03746-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03746-3","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the uptake patterns of adult-type non-enhanced gliomas in the pre-angiogenic phase on [¹¹C] methionine (MET) PET.</p><p><strong>Methods: </strong>We included 52 astrocytoma (Group A), 34 oligodendroglioma (Group O), and 21 glioblastoma (Group G) cases. Regions of interest (ROIs) were defined based on T2-weighted images of high-intensity lesions encompassing tumor volume. The maximum tumor-to-brain ratios (TBR_max) were calculated from PET data. ROIs were internally layered at 5-mm intervals from the tumor surface to assess MET uptake distribution. Moderate (TBR_max ≥1.3) and high (TBR_max ≥2.0) uptakes were classified into three patterns based on the extent and distribution.</p><p><strong>Results: </strong>TBR_max was significantly lower in Group A than in Groups O and G. TBR_max was more frequently observed in the outermost 0-5 mm layer in all groups. Seventy-three cases with TBR_max ≥1.3 exhibited the whole pattern in 13 (17.8%) and partial or spot patterns in 60 (82.2%) cases; partial or spot pattern cases were most frequently identified as surface/outside patterns (60.3%). Twenty-seven cases with TBR_max ≥2.0 exhibited the whole pattern in 5 (18.5%) and partial or spot patterns in 22 (81.5%) cases; partial or spot pattern cases were identified as central or surface/outside patterns, and none of the cases showed surface/inside patterns, indicating a high-uptake area in the deeper part of the brain.</p><p><strong>Conclusion: </strong>In non-enhanced gliomas, MET accumulation was concentrated at the periphery of the tumor. Although some cases showed MET uptake throughout the tumor, none showed focal high uptake deep in the brain.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged venous transit - where venous outflow meets financial outflow: a cost analysis.","authors":"Manisha Koneru, Janet Mei, Hamza Salim, Dhairya Lakhani, Adam Dmytriw, Adrien Guenego, Dylan Wolman, Shyam Majmundar, Achala Vagal, Aakanksha Sriwastwa, Yasmin Aziz, Meisam Hoseinyazdi, Caline Azzi, Risheng Xu, Hanzhang Lu, Elisabeth Marsh, Richard Leigh, Mona Bahouth, Rafael Llinas, Kambiz Nael, Argye Hillis, Gregory Albers, Jeremy Heit, Tobias Faizy, Vivek Yedavalli","doi":"10.1007/s00234-025-03774-z","DOIUrl":"https://doi.org/10.1007/s00234-025-03774-z","url":null,"abstract":"<p><strong>Purpose: </strong>Healthcare costs in large vessel occlusion acute ischemic stroke (AIS-LVO) patients vary widely despite achieving successful reperfusion. Prolonged venous transit (PVT+) is a new marker of poor venous outflow on pretreatment perfusion imaging associated with various patient outcomes. We aim to explore the relationship between PVT + and acute care cost estimates for AIS-LVO.</p><p><strong>Methods: </strong>Adult AIS-LVO patients achieving successful reperfusion with thrombectomy at three centers in the United States were retrospectively reviewed. Cost estimates were derived from national averages for services in the Centers for Medicare and Medicaid Services data (2025). The primary outcome was total cost estimates for acute intervention, imaging, and post-treatment inpatient care until discharge. Estimates were compared between PVT + and PVT- cohorts.</p><p><strong>Results: </strong>In 109 included patients, the median age was 71 years (IQR 62-80). The cost estimates for total acute stroke care were significantly greater by $11787 in PVT + patients (median $36601 [IQR $24814-$72944] than PVT- patients (median $24814 [IQR $16956-$48388], p = 0.03). Cost of post-treatment care was significantly greater in PVT + patients than PVT- patients (p = 0.03).</p><p><strong>Conclusion: </strong>PVT + demonstrates potential as a useful, versatile pretreatment biomarker, in conjunction with other clinical data, to anticipate in-hospital resources and costs associated with acute stroke care.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of Dual-Energy CT in detecting traumatic vertebral bone marrow edema: a prospective comparative study with MRI in the context of a level I trauma center.","authors":"Thomas Beyer, Erik Volmer, Patrick Gahr, Marc-André Weber","doi":"10.1007/s00234-025-03763-2","DOIUrl":"https://doi.org/10.1007/s00234-025-03763-2","url":null,"abstract":"<p><strong>Background: </strong>Traumatic vertebral fractures present a significant diagnostic challenge in emergency settings. Magnetic resonance imaging (MRI) excels in detecting bone marrow edema but faces practical limitations in acute trauma care. This prospective study evaluates the diagnostic accuracy of Dual-Energy Computed Tomography (DECT) in detecting traumatic vertebral bone marrow edema within a Level I trauma center environment.</p><p><strong>Methods: </strong>Between May 2020 and July 2023, 291 DECT examinations were performed on adult patients presenting with suspected or confirmed spinal injury. From these, 233 (80.1%) met quality criteria for analysis. A subgroup of 47 patients underwent additional MRI as reference standard, with 44 (93.6%) providing diagnostically evaluable images. Two board-certified radiologists independently assessed vertebral bone marrow edema presence in blinded, randomized evaluations using both modalities. Diagnostic parameters, examination times, radiation exposure, and cost-efficiency were analyzed.</p><p><strong>Results: </strong>DECT demonstrated an overall sensitivity of 82.9% and specificity of 96.6% for detecting vertebral bone marrow edema compared to MRI. The thoracolumbar junction showed highest sensitivity (91.7% for L3). DECT examination time was 7.2 minutes (including post-processing) versus 12 minutes for MRI, meaning MRI required 66.7% more time than DECT. DECT radiation exposure showed a mean dose-length product increase of only 3% compared to conventional CT. Body mass index showed no significant influence on DECT interpretability (p=0.196) or diagnostic accuracy except in isolated segments (L3, T11). Cost-benefit analysis revealed potential savings of 49.1% (€104.40) per spinal segment with DECT-based diagnostic pathways.</p><p><strong>Conclusion: </strong>DECT offers high diagnostic accuracy for detecting traumatic vertebral bone marrow edema with substantial time and cost advantages compared to MRI. The technique demonstrates particular value in acute trauma settings, while acknowledging limitations from artifacts (19.9% of cases) primarily caused by medical devices. These findings support implementing DECT as an efficient alternative to MRI in spinal trauma diagnostics.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recanalization of a chronic long segment ICA near-occlusion using a newly designed carotid artery stent.","authors":"Johannes Hensler, J Cordt, F Wodarg, O Jansen","doi":"10.1007/s00234-025-03772-1","DOIUrl":"https://doi.org/10.1007/s00234-025-03772-1","url":null,"abstract":"<p><p>A 67-year-old female presented with subacute transient visual disturbances in her left eye and subacute watershed infarctions in the left MCA territory due to a long segment chronic internal carotid artery (ICA) near-occlusion following ICA stenting (CAS). Angioplasty was performed using two newly designed stents (CARESTO^® heal, Acandis, Pforzheim, Germany) from the ICA origin into the cavernous segment without complications, with a favorable clinical outcome.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast 3D wheel acquisition versus conventional parallel imaging in cerebral magnetic resonance angiography for the evaluation of intracranial aneurysms : Original Article.","authors":"Satomu Hanamatsu, Kazuhiro Murayama, Yoshiharu Ohno, Aoi Tahara, Reina Fujisawa, Yunosuke Kumazawa, Tomoki Takahashi, Kaori Yamamoto, Masato Ikedo, Masanori Inoue","doi":"10.1007/s00234-025-03776-x","DOIUrl":"https://doi.org/10.1007/s00234-025-03776-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the effectiveness of the Fast 3D wheel (Fast 3Dw) technique in cerebral magnetic resonance angiography (MRA) and compare it with the conventional parallel imaging (PI) technique. The primary objective was to determine whether Fast 3Dw could reduce the examination time while maintaining image quality and diagnostic accuracy in patients with cerebral aneurysms.</p><p><strong>Methods: </strong>This retrospective study included 50 patients with unruptured cerebral aneurysms who underwent 3D time-of-flight MRA using either PI or Fast 3Dw techniques on a 3T magnetic resonance imaging scanner. The image quality was quantitatively assessed using the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), aneurysm diameter, and vessel diameter. Qualitative image assessments included vascular clarity, artifacts, and diagnostic confidence level and were evaluated using a 5-point scale. Statistical comparisons were performed using t-tests, Wilcoxon signed-rank tests, and weighted kappa statistics.</p><p><strong>Results: </strong>The mean examination time for Fast 3Dw (171.5 ± 4.9 s) was significantly shorter than that for PI (383.8 ± 13.2 s; p < 0.05). Fast 3Dw exhibited a significantly higher SNR (50.0 ± 14.2) than PI (46.6 ± 12.9; p < 0.05), while CNR showed no significant difference between the two techniques. No significant differences in aneurysm diameters and vessel diameters were observed between the two methods. Qualitative evaluations demonstrated no significant differences in vascular clarity, artifacts, and diagnostic confidence levels between the two methods.</p><p><strong>Conclusion: </strong>The Fast 3Dw technique significantly reduces examination time while maintaining image quality and diagnostic accuracy in cerebral MRA compared to PI. This method may be a viable alternative for routine cerebral MRA in clinical practice.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal-type posterior communicating artery increases hemodynamic stress in posterior communicating artery bifurcation aneurysms: a CFD-based analysis.","authors":"Roland Schwab, Rebecca Janiszewski, Erelle Fuchs, Maximilian Thormann, Belal Neyazi, Vanessa Magdalena Swiatek, I Erol Sandalcioglu, Philipp Berg, Daniel Behme, Samuel Voß, Janneck Stahl","doi":"10.1007/s00234-025-03785-w","DOIUrl":"https://doi.org/10.1007/s00234-025-03785-w","url":null,"abstract":"<p><strong>Backround: </strong>The cs of bifurcation aneurysms in the posterior communicating arterflow characteristiy (PCOM) have rarely been studied. The likelihood of a complete PCOM aneurysm occlusion after endovascular treatment is reduced with the presence of a fetal posterior communicating artery (fPCOM). As a result, anatomical variations in PCOM aneurysms represent a major challenge for the endovascular treatment. This study addresses hemodynamic variations in PCOM aneurysms of either fetal or adult type.</p><p><strong>Methods: </strong>3D-DSA data of 14 patients with bifurcation aneurysms located in the PCOM junction were collected. Nine patients presented with a fPCOM and five patients an adult PCOM (aPCOM). Patient-specific 3D models containing at least one bifurcation distal the aneurysm in the anterior circulation as well as the PCOM itself were extracted using image-based blood flow simulations. Seven hemodynamic parameters were calculated for all aneurysm models to characterize the intra-aneurysmal blood flow. The PCOM outflow was artificially varied to represent both fPCOM and aPCOM conditions for each model resulting in 28 simulations.</p><p><strong>Results: </strong>Fetal‑type PCOM showed higher intra‑aneurysmal mean velocity (median 0.09 vs. 0.06 m/s), maximum velocity (0.17 vs. 0.14 m/s), averaged wall shear stress (1.67 vs. 1.27 Pa), neck inflow rate (40.9 vs. 22.4 ml/min), and inflow concentration index (0.56 vs. 0.40), with lower pulsatility index (1.73 vs. 1.89). Those differences were significant whereas mean oscillatory shear index did not differ significantly.</p><p><strong>Conclusion: </strong>The presence of anatomical variations affects the hemodynamic parameters of PCOM bifurcation aneurysms. In particular, the presence of an fPCOM has an unfavorable effect on the intra-aneurysmal flow dynamics.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of resolve DWI and DCE MRI in differentiating benign and malignant skull base lesions.","authors":"Pradeep Mohanasundaram, Jyoti Kumar, Gaurav Shanker Pradhan, Daljit Singh, Ishwar Singh","doi":"10.1007/s00234-025-03760-5","DOIUrl":"https://doi.org/10.1007/s00234-025-03760-5","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the utility of RESOLVE Diffusion-Weighted Imaging (DWI) and Dynamic Contrast-Enhanced (DCE) MRI in differentiating benign and malignant skull base lesions using qualitative and quantitative imaging parameters.</p><p><strong>Methods: </strong>This prospective study included 44 patients with 45 skull base lesions who underwent MRI with RESOLVE DWI and DCE-MRI. Apparent diffusion coefficient (ADC) values and lesion-to-medulla ADC ratios were calculated from DWI. Perfusion parameters (Ktrans, Kep, Ve) and time-intensity curve (TIC) were derived from DCE-MRI. Benign and malignant lesions were statistically compared, and receiver operating characteristic analysis was performed to evaluate diagnostic capability.</p><p><strong>Results: </strong>Malignant lesions had significantly lower mean ADC values (0.88 × 10⁻³ mm²/s) than benign lesions (1.05 × 10⁻³ mm²/s, p = 0.033). The lesion-to-medulla ADC ratio was also significantly lower in malignant lesions (1.03 vs. 1.25, p = 0.029), yielding 89% sensitivity and 44% specificity at a cutoff ≤ 1.167 (AUC = 0.695). Among DCE-MRI parameters, both Kep and the distribution of time-intensity curve (TIC) showed significant differences between benign and malignant lesions (p = 0.037 and p < 0.001, respectively). Kep was higher in malignant lesions (0.98 vs. 0.78), with an AUC of 0.689, 94% sensitivity, and 52% specificity at a cutoff of ≥ 0.581. Ktrans and Ve did not show significant statistical difference.</p><p><strong>Conclusion: </strong>RESOLVE DWI and DCE-MRI are effective non-invasive tools for differentiating benign and malignant skull base lesions. The ADC ratio and Kep are valuable quantitative markers, while TIC pattern analysis offers complementary qualitative insights, enhancing diagnostic confidence.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FRED X flow diversion stent for intracranial aneurysms: a systematic review and meta-analysis.","authors":"Ali Mortezaei, Muhammed Amir Essibayi, Leila Ghorbi, Jamal Behnood, Khaled M Taghlabi, Ibrahim Mohammadzadeh, Bardia Hajikarimloo, Mohammad Amin Habibi, Ahmed Abdelsalam, Jayro Toledo, Luis Guada, Redi Rahmani, David J Altschul, Alex N Hoang, Adib A Abla, Robert M Starke, Amir H Faraji","doi":"10.1007/s00234-025-03755-2","DOIUrl":"https://doi.org/10.1007/s00234-025-03755-2","url":null,"abstract":"<p><strong>Background: </strong>The Flow Re-Direction Endoluminal Device X (FRED^TM-X, MicroVention, Inc., Terumo Corporation, USA), introduces a dual-layer structure and antithrombotic surface technology, designed to address the limitations of earlier devices in reducing material thrombogenicity and promoting better vessel endothelialization for brain aneurysm. Herein, we present the first systematic review and meta-analysis summarizing available literature to reach a consensus regarding the safety and effectiveness of FRED^TM-X.</p><p><strong>Methods: </strong>A literature search was performed in four electronic databases, PubMed/MEDLINE, Embase, Google Scholar, and Web of Science, for studies that evaluated FRED-X in managing intracranial aneurysms. Proportions were pooled employing the inverse variance method, and binary outcomes were analyzed using odds ratio (OR) and 95% confidence interval (CI). The primary outcome was an aneurysm occlusion at the final follow-up.</p><p><strong>Results: </strong>Eight studies involving 480 patients and 531 aneurysms were included. Most patients were female (81.5%), with a mean age of 56.2 years. Most aneurysms were unruptured (84.1%, 95%CI = 66% - 96.5%) and located in the anterior circulation (86.7%, 95%CI = 75.9% - 94.8%), primarily in the internal carotid artery (64.2%). Procedural data showed a mean procedure time of 68.2 (SD = 38.1) minutes and a fluoroscopy time of 23.5 (SD = 11.7) minutes. The mean aneurysm size was 6.4 mm (SD = 5.1). In-stent stenosis occurred in 1.2% of cases. Adequate occlusion was achieved in 85.9% (95%CI = 79% - 91.8%) of patients at the last follow-up. Symptomatic complications occurred in 4% (95%CI = 0.7% - 9%) of patients, and the overall mortality rate was 0.34% (95%CI = 0.0% - 1.7%).</p><p><strong>Conclusion: </strong>The FRED-X flow diverter is safe and effective in treating intracranial aneurysms. It has low complication rates, minimal in-stent stenosis, and efficient procedural metrics. Long-term studies must confirm its durability and potential for broader applications.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}