大规模认知正常人群中脑血管成像标志物与淋巴功能的关系。

IF 2.6 3区 医学 Q2 CLINICAL NEUROLOGY
Ji Su Ko, Yangsean Choi, Eunseon Jeong, Ji Eun Park, Ho Sung Kim
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引用次数: 0

摘要

目的:探讨认知正常人群脑血管影像学指标与淋巴功能的关系。方法:这项回顾性研究包括574名认知正常的参与者,他们于2023年1月至10月接受了脑磁共振成像。采用沿血管周围空间指数(ALPS-index)的弥散张量图像分析评估淋巴功能。脑血管成像标志物,包括白质高强度(WMH)负担、脑微出血(CMBs)和脉络膜丛体积(CPV),采用自动分割方法进行量化。在基底节区存在凹窝或在其他区域的陈旧性梗死被目测。采用多变量回归和偏相关分析分析脑血管标志物与alps指数的相关性。结果:纳入受试者的平均年龄为68.9±10.4岁(男性40.9%,高血压43.7%,糖尿病20.4%,MMSE评分27.6±1.6)。较低的alps指数反映了淋巴清除受损,与较高的WMH负担显著相关(β=-0.231, p)。结论:脑血管成像结果与认知正常个体的淋巴功能障碍显著相关,提示有必要进一步研究针对淋巴系统的干预措施在脑血管疾病预防中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between cerebrovascular imaging markers and glymphatic function in a large-scale cognitively normal population.

Purpose: This study aimed to investigate the association between cerebrovascular imaging markers and glymphatic function in cognitively normal individuals.

Methods: This retrospective study included 574 cognitively normal participants who underwent brain magnetic resonance imaging from January to October 2023. Glymphatic function was assessed using diffusion tensor image analysis along the perivascular space index (ALPS-index). Cerebrovascular imaging markers, including white matter hyperintensity (WMH) burden, cerebral microbleeds (CMBs), and choroid plexus volume (CPV), were quantified using automated segmentation methods. The presence of lacunes in the basal ganglia or old infarcts in other areas was visually determined. Associations between cerebrovascular markers and ALPS-index were analyzed using multivariable regression and partial correlation analyses.

Results: The mean age of the included participants was 68.9 ± 10.4 years (male, 40.9%; hypertension, 43.7%; diabetes, 20.4%; Mini-Mental State Examination [MMSE] score, 27.6 ± 1.6). A lower ALPS-index, reflecting impaired glymphatic clearance, was significantly associated with higher WMH burden (β=-0.231, p < 0.001), increased CPV fraction (β=-0.234, p < 0.001), and a greater number of deep CMBs (β=-0.087, p = 0.038). The participants with basal ganglia lacunes (ALPS-index: 1.32 ± 0.19), old infarcts other than basal ganglia (ALPS-index: 1.34 ± 0.19), or both (ALPS-index: 1.27 ± 0.19) had significantly lower ALPS-indices than those without these conditions (ALPS-index: 1.43 ± 0.21; all, p < 0.001).

Conclusion: Cerebrovascular imaging findings are significantly associated with glymphatic dysfunction in cognitively normal individuals, highlighting the need for further studies on glymphatic-targeted interventions in cerebrovascular disease prevention.

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来源期刊
Neuroradiology
Neuroradiology 医学-核医学
CiteScore
5.30
自引率
3.60%
发文量
214
审稿时长
4-8 weeks
期刊介绍: Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
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