Structured assessment of brain MRI in Covid-19-related neurological disease: an international multicentre study.

IF 2.6 3区 医学 Q2 CLINICAL NEUROLOGY
Stéphane Kremer, Tarek A Yousry, Rafael Rehwald, François Lersy, Nicolas Meyer, Simonetta Gerevini, Angela Napolitano, Àlex Rovira, Ng Karelys, Leandro Tavares Lucato, Maria da Graça Morais Martin, Ana Lícia da Rocha Alves Pinto, Luke Dixon, Brynmor Jones, Ana Ramos, Elena Salvador, Núria Bargalló, Laura Oleaga, Nicoletta Anzalone, Andrea Falini, Francesco Carletti, Chandrasekhar Hoskote, Agathe Chammas, Benoit Lhermitte, Béatrice Lannes, Thibaut de Misouard, François Cotton, Hans Rolf Jäger
{"title":"Structured assessment of brain MRI in Covid-19-related neurological disease: an international multicentre study.","authors":"Stéphane Kremer, Tarek A Yousry, Rafael Rehwald, François Lersy, Nicolas Meyer, Simonetta Gerevini, Angela Napolitano, Àlex Rovira, Ng Karelys, Leandro Tavares Lucato, Maria da Graça Morais Martin, Ana Lícia da Rocha Alves Pinto, Luke Dixon, Brynmor Jones, Ana Ramos, Elena Salvador, Núria Bargalló, Laura Oleaga, Nicoletta Anzalone, Andrea Falini, Francesco Carletti, Chandrasekhar Hoskote, Agathe Chammas, Benoit Lhermitte, Béatrice Lannes, Thibaut de Misouard, François Cotton, Hans Rolf Jäger","doi":"10.1007/s00234-025-03787-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Neuroradiological findings associated with neurological presentations in acute SARS-CoV-2 infection are very heterogeneous. We aimed to develop a standardized framework for describing MR neuroimaging patterns in Covid-19, to test this in an international multicentre study and to determine the prevalence of observed MRI patterns and their association with clinical presentation and outcome.</p><p><strong>Methods: </strong>An international expert consortium developed a framework for assessment of brain MRI patterns in Covid-19 based on published literature and professional experience. We performed a retrospective analysis of the proposed framework, involving brain MRI scans from 458 Covid-19 patients with neurological symptoms, including data from 1 February to 31 May 2020. Two readers at 25 centres across five countries assessed the local MRI studies regarding the presence of one or more predefined MRI patterns. Imaging and clinical data were analysed using Bayesian statistics.</p><p><strong>Results: </strong>Of 458 patients, 58.5% had an abnormal MRI. Overall, 94% of all imaging pathologies seen were captured by our proposed classification. Ischemic strokes were the most frequent pattern overall (25.6%), followed by microhaemorrhages (15.9%). Ischemic infarct patterns were more frequent in non-ICU patients, while the haemorrhagic patterns were more frequent in ICU patients. White matter lesions (10.9%) were more frequent than grey matter lesions (8.1%), and leptomeningeal contrast enhancement was present in 8.3% of patients. Patient outcome was not associated with any MRI patterns.</p><p><strong>Conclusion: </strong>Our proposed classification of specific MRI patterns in Covid-19, covered 94% of observed abnormalities, while patient outcome, death or home discharge, was not associated with any MRI patterns.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00234-025-03787-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: Neuroradiological findings associated with neurological presentations in acute SARS-CoV-2 infection are very heterogeneous. We aimed to develop a standardized framework for describing MR neuroimaging patterns in Covid-19, to test this in an international multicentre study and to determine the prevalence of observed MRI patterns and their association with clinical presentation and outcome.

Methods: An international expert consortium developed a framework for assessment of brain MRI patterns in Covid-19 based on published literature and professional experience. We performed a retrospective analysis of the proposed framework, involving brain MRI scans from 458 Covid-19 patients with neurological symptoms, including data from 1 February to 31 May 2020. Two readers at 25 centres across five countries assessed the local MRI studies regarding the presence of one or more predefined MRI patterns. Imaging and clinical data were analysed using Bayesian statistics.

Results: Of 458 patients, 58.5% had an abnormal MRI. Overall, 94% of all imaging pathologies seen were captured by our proposed classification. Ischemic strokes were the most frequent pattern overall (25.6%), followed by microhaemorrhages (15.9%). Ischemic infarct patterns were more frequent in non-ICU patients, while the haemorrhagic patterns were more frequent in ICU patients. White matter lesions (10.9%) were more frequent than grey matter lesions (8.1%), and leptomeningeal contrast enhancement was present in 8.3% of patients. Patient outcome was not associated with any MRI patterns.

Conclusion: Our proposed classification of specific MRI patterns in Covid-19, covered 94% of observed abnormalities, while patient outcome, death or home discharge, was not associated with any MRI patterns.

脑MRI对covid -19相关神经系统疾病的结构化评估:一项国际多中心研究
目的:急性SARS-CoV-2感染中与神经学表现相关的神经放射学表现非常不均匀。我们的目标是建立一个描述Covid-19中MR神经成像模式的标准化框架,在一项国际多中心研究中对此进行测试,并确定观察到的MRI模式的患病率及其与临床表现和结果的关联。方法:国际专家联盟根据已发表的文献和专业经验,制定了Covid-19脑MRI模式评估框架。我们对提出的框架进行了回顾性分析,涉及458名有神经系统症状的Covid-19患者的脑MRI扫描,包括2020年2月1日至5月31日的数据。来自五个国家25个中心的两位读者评估了当地MRI研究中一个或多个预定义MRI模式的存在。影像学和临床资料采用贝叶斯统计分析。结果:458例患者中,58.5%有MRI异常。总的来说,94%的影像学病理被我们提出的分类所捕获。缺血性中风是最常见的类型(25.6%),其次是微出血(15.9%)。缺血性梗死模式在非ICU患者中更常见,而出血模式在ICU患者中更常见。白质病变(10.9%)比灰质病变(8.1%)更常见,8.3%的患者出现薄脑膜对比增强。患者预后与任何MRI模式无关。结论:我们提出的Covid-19特定MRI模式分类涵盖了94%的观察到的异常,而患者结局、死亡或出院与任何MRI模式无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Neuroradiology
Neuroradiology 医学-核医学
CiteScore
5.30
自引率
3.60%
发文量
214
审稿时长
4-8 weeks
期刊介绍: Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信