Ji Su Ko, Yangsean Choi, Eunseon Jeong, Ji Eun Park, Ho Sung Kim
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引用次数: 0
Abstract
Purpose: This study aimed to investigate the association between cerebrovascular imaging markers and glymphatic function in cognitively normal individuals.
Methods: This retrospective study included 574 cognitively normal participants who underwent brain magnetic resonance imaging from January to October 2023. Glymphatic function was assessed using diffusion tensor image analysis along the perivascular space index (ALPS-index). Cerebrovascular imaging markers, including white matter hyperintensity (WMH) burden, cerebral microbleeds (CMBs), and choroid plexus volume (CPV), were quantified using automated segmentation methods. The presence of lacunes in the basal ganglia or old infarcts in other areas was visually determined. Associations between cerebrovascular markers and ALPS-index were analyzed using multivariable regression and partial correlation analyses.
Results: The mean age of the included participants was 68.9 ± 10.4 years (male, 40.9%; hypertension, 43.7%; diabetes, 20.4%; Mini-Mental State Examination [MMSE] score, 27.6 ± 1.6). A lower ALPS-index, reflecting impaired glymphatic clearance, was significantly associated with higher WMH burden (β=-0.231, p < 0.001), increased CPV fraction (β=-0.234, p < 0.001), and a greater number of deep CMBs (β=-0.087, p = 0.038). The participants with basal ganglia lacunes (ALPS-index: 1.32 ± 0.19), old infarcts other than basal ganglia (ALPS-index: 1.34 ± 0.19), or both (ALPS-index: 1.27 ± 0.19) had significantly lower ALPS-indices than those without these conditions (ALPS-index: 1.43 ± 0.21; all, p < 0.001).
Conclusion: Cerebrovascular imaging findings are significantly associated with glymphatic dysfunction in cognitively normal individuals, highlighting the need for further studies on glymphatic-targeted interventions in cerebrovascular disease prevention.
期刊介绍:
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.