Neuroradiology最新文献

{"title":"Recanalization of a chronic long segment ICA near-occlusion using a newly designed carotid artery stent.","authors":"Johannes Hensler, J Cordt, F Wodarg, O Jansen","doi":"10.1007/s00234-025-03772-1","DOIUrl":"https://doi.org/10.1007/s00234-025-03772-1","url":null,"abstract":"<p><p>A 67-year-old female presented with subacute transient visual disturbances in her left eye and subacute watershed infarctions in the left MCA territory due to a long segment chronic internal carotid artery (ICA) near-occlusion following ICA stenting (CAS). Angioplasty was performed using two newly designed stents (CARESTO^® heal, Acandis, Pforzheim, Germany) from the ICA origin into the cavernous segment without complications, with a favorable clinical outcome.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FRED X flow diversion stent for intracranial aneurysms: a systematic review and meta-analysis.","authors":"Ali Mortezaei, Muhammed Amir Essibayi, Leila Ghorbi, Jamal Behnood, Khaled M Taghlabi, Ibrahim Mohammadzadeh, Bardia Hajikarimloo, Mohammad Amin Habibi, Ahmed Abdelsalam, Jayro Toledo, Luis Guada, Redi Rahmani, David J Altschul, Alex N Hoang, Adib A Abla, Robert M Starke, Amir H Faraji","doi":"10.1007/s00234-025-03755-2","DOIUrl":"https://doi.org/10.1007/s00234-025-03755-2","url":null,"abstract":"<p><strong>Background: </strong>The Flow Re-Direction Endoluminal Device X (FRED^TM-X, MicroVention, Inc., Terumo Corporation, USA), introduces a dual-layer structure and antithrombotic surface technology, designed to address the limitations of earlier devices in reducing material thrombogenicity and promoting better vessel endothelialization for brain aneurysm. Herein, we present the first systematic review and meta-analysis summarizing available literature to reach a consensus regarding the safety and effectiveness of FRED^TM-X.</p><p><strong>Methods: </strong>A literature search was performed in four electronic databases, PubMed/MEDLINE, Embase, Google Scholar, and Web of Science, for studies that evaluated FRED-X in managing intracranial aneurysms. Proportions were pooled employing the inverse variance method, and binary outcomes were analyzed using odds ratio (OR) and 95% confidence interval (CI). The primary outcome was an aneurysm occlusion at the final follow-up.</p><p><strong>Results: </strong>Eight studies involving 480 patients and 531 aneurysms were included. Most patients were female (81.5%), with a mean age of 56.2 years. Most aneurysms were unruptured (84.1%, 95%CI = 66% - 96.5%) and located in the anterior circulation (86.7%, 95%CI = 75.9% - 94.8%), primarily in the internal carotid artery (64.2%). Procedural data showed a mean procedure time of 68.2 (SD = 38.1) minutes and a fluoroscopy time of 23.5 (SD = 11.7) minutes. The mean aneurysm size was 6.4 mm (SD = 5.1). In-stent stenosis occurred in 1.2% of cases. Adequate occlusion was achieved in 85.9% (95%CI = 79% - 91.8%) of patients at the last follow-up. Symptomatic complications occurred in 4% (95%CI = 0.7% - 9%) of patients, and the overall mortality rate was 0.34% (95%CI = 0.0% - 1.7%).</p><p><strong>Conclusion: </strong>The FRED-X flow diverter is safe and effective in treating intracranial aneurysms. It has low complication rates, minimal in-stent stenosis, and efficient procedural metrics. Long-term studies must confirm its durability and potential for broader applications.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does initiating aspiration with microcatheter navigation improve the efficacy of thrombectomy in acute ischemic stroke patients with vascular angulation at the level of occlusion?","authors":"Mehmet Beyazal, Hasan Dinç, Esat Kaba, Ahmet Tüfekçi","doi":"10.1007/s00234-025-03771-2","DOIUrl":"https://doi.org/10.1007/s00234-025-03771-2","url":null,"abstract":"<p><strong>Background: </strong>Vascular angulation at the level of occlusion negatively affects the success of aspiration thrombectomy in patients with acute ischemic stroke (AIS). This study aims to evaluate the efficacy of the aspiration thrombectomy with microcatheter navigation (ATMN) technique in AIS patients where the direct aspiration first pass technique (DAPT) failed due to vascular angulation at the occlusion level.</p><p><strong>Methods: </strong>The patients admitted to our institution with AIS due to large vessel occlusion and treated with DAPT as a first-line technique between August 2020 and December 2022 were retrospectively evaluated. The feasibility and success of the ATMN technique in patients with DAPT failure were evaluated. Vascular angulation at the occlusion level was measured and compared.</p><p><strong>Results: </strong>43 patients were included in the study. Successful revascularization was achieved with DAPT in 29 of 43 patients (67.5%). ATMN technique was performed on 14 of 43 patients (32.5%) after DAPT failure. The ATMN technique achieved a high success rate, with 78.5% (11 out of 14) of patients experiencing successful recanalization. The mean vascular angulation at the occlusion level was significantly increased in patients with sufficient recanalization by DAPT as first-line therapy compared to the patients with insufficient recanalization by DAPT who underwent successful thrombectomy with the ATMN technique (143.5 ± 23.3 vs. 107.6 ± 15.6, p ˂ 0.001).</p><p><strong>Conclusion: </strong>This study's results showed that the ATMN technique was a useful alternative with a high level of success in stroke patients with vascular angulation in which DAPT failed to achieve sufficient recanalization.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based acceleration and denoising of 0.55T MRI for enhanced conspicuity of vestibular Schwannoma post contrast administration.","authors":"Maximilian Hinsen, Armin Nagel, Rafael Heiss, Matthias May, Marco Wiesmueller, Claudius Mathy, Martin Zeilinger, Joachim Hornung, Sarina Mueller, Michael Uder, Markus Kopp","doi":"10.1007/s00234-025-03758-z","DOIUrl":"https://doi.org/10.1007/s00234-025-03758-z","url":null,"abstract":"<p><strong>Background and purpose: </strong>Deep-learning (DL) based MRI denoising techniques promise improved image quality and shorter examination times. This advancement is particularly beneficial for 0.55T MRI, where the inherently lower signal-to-noise (SNR) ratio can compromise image quality. Sufficient SNR is crucial for the reliable detection of vestibular schwannoma (VS). The objective of this study is to evaluate the VS conspicuity and acquisition time (TA) of 0.55T MRI examinations with contrast agents using a DL-denoising algorithm.</p><p><strong>Materials and methods: </strong>From January 2024 to October 2024, we retrospectively included 30 patients with VS (9 women). We acquired a clinical reference protocol of the cerebellopontine angle containing a T1w fat-saturated (fs) axial (number of signal averages [NSA] 4) and a T1w Spectral Attenuated Inversion Recovery (SPAIR) coronal (NSA 2) sequence after contrast agent (CA) application without advanced DL-based denoising (w/o DL). We reconstructed the T1w fs CA sequence axial and the T1w SPAIR CA coronal with full DL-denoising mode without change of NSA, and secondly with 1 NSA for T1w fs CA axial and T1w SPAIR coronal (DL&1NSA). Each sequence was rated on a 5-point Likert scale (1: insufficient, 3: moderate, clinically sufficient; 5: perfect) for: overall image quality; VS conspicuity, and artifacts. Secondly, we analyzed the reliability of the size measurements. Two radiologists specializing in head and neck imaging performed the reading and measurements. The Wilcoxon Signed-Rank Test was used for non-parametric statistical comparison.</p><p><strong>Results: </strong>The DL&4NSA axial/coronal study sequence achieved the highest overall IQ (median 4.9). The image quality (IQ) for DL&1NSA was higher (M: 4.0) than for the reference sequence (w/o DL; median 4.0 versus 3.5, each p < 0.01). Similarly, the VS conspicuity was best for DL&4NSA (M: 4.9), decreased for DL&1NSA (M: 4.1), and was lower but still sufficient for w/o DL (M: 3.7, each p < 0.01). The TA for the axial and coronal post-contrast sequences was 8:59 minutes for DL&4NSA and w/o DL and decreased to 3:24 minutes with DL&1NSA.</p><p><strong>Conclusions: </strong>This study underlines that advanced DL-based denoising techniques can reduce the examination time by more than half while simultaneously improving image quality.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesial temporal lobe epilepsy with hippocampal sclerosis: comparative clinical and arterial spin labeling findings according to neocortical MRI changes.","authors":"Sri Venkata Ganesh Viswanadh Kalaparti, Ashalatha Radhakrishnan, Deepti A Narasimhaiah, Rajalakshmi Poyuran, George C Vilanilam, Bejoy Thomas","doi":"10.1007/s00234-025-03735-6","DOIUrl":"https://doi.org/10.1007/s00234-025-03735-6","url":null,"abstract":"<p><strong>Purpose: </strong>High-field strength MRI reveals that Mesial Temporal Sclerosis (MTS) can be divided into two entities-(1) MTLE-HS (Mesial Temporal lobe epilepsy with hippocampal involvement), (2) MTLE-HS[N] (Mesial temporal lobe epilepsy with hippocampal sclerosis, and neocortical changes). The purpose of the study was to identify clinical, electrophysiological, histopathological, post-operative outcome differences between these entities and evaluate the role of Arterial spin labeling (ASL) in this regard.</p><p><strong>Methods: </strong>Prospective observational study in MTS-patients undergoing epilepsy protocol-MRI (including 3D-ASL with pseudo-continuous tagging), followed by anterior-temporal lobectomy + amygdalohippocampectomy (ATL + AH). Based on T2WI/3D-FLAIR MRI findings, patients were classified into MTLE-HS and MTLE-HS[N]. The ASL, clinical, VEEG, histopathological characteristics, postoperative outcomes were compared.</p><p><strong>Results: </strong>The MTLE-HS[N] and MTLE-HS groups had 63 and 37 patients respectively. MTLE-HS[N] group showed earlier age of epilepsy onset (7.82 ± 6.19y vs. 11.12 ± 8.1y, P-value = 0.04) and higher incidence of neocortical epileptogenesis (66.67% vs. 13.51%, P-value < 0.001). Histopathology revealed diffuse temporal neocortical astrogliosis in all patients, myelin loss in some patients from both groups and neocortical dysplasia in 6 patients with no significant differences in individual histopathological characteristics or postoperative outcomes. Within the MTLE-HS[N] group, more patients with neocortical epileptogenesis had ASL abnormality (P < 0.05). Qualitative ASL abnormality was also seen in most (83.33%) patients with neocortical dysplasia.</p><p><strong>Conclusion: </strong>Although MTLE-HS and MTLE-HS[N] show differences in certain clinical, electrophysiological features, the postoperative outcomes were not different. MRI cannot predict the histopathological substrate responsible for temporal neocortical changes. ASL may be useful in predicting neocortical epileptogenesis. It could also help to postulate the presence of dysplasia, although this needs further evaluation for confirmation.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A propensity score matching analysis of the efficacy and safety of middle meningeal artery embolization versus burr hole drainage in the treatment of chronic subdural hematomas.","authors":"Junhui Li, Zhengwen Chen, Junjie Shao, Qi Jia, Zhixiang Fan, Qingfeng Huang, Xiaojian Lu","doi":"10.1007/s00234-025-03740-9","DOIUrl":"https://doi.org/10.1007/s00234-025-03740-9","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy and safety of middle meningeal artery embolization (MMAE) and burr hole drainage in the treatment of chronic subdural hematoma (CSDH).</p><p><strong>Methods: </strong>Patients diagnosed with CSDH who underwent MMAE or surgical treatment were retrospectively recruited to this single-center study. Propensity score matching (PSM) analysis was carried out to compare the efficacy and safety of MMAE and burr hole drainage. Efficacy outcomes included hematoma clearance, cure, recurrence, and re-intervention rates within a 90-day postoperative follow-up period. Safety outcomes included the modified Rankin Scale (mRS) of 0-2 at the 90-day postoperative follow-up, procedure-related complications during hospitalization, and hospital stay length.</p><p><strong>Results: </strong>Among the 183 CSDH patients, 34.4% (63 patients) received MMAE and 65.6% (120 patients) underwent burr hole drainage surgery. The MMAE group showed a higher hematoma clearance rate (90.62±8.98% vs. 81.12±18.62%, P=0.005), higher cure rate (63.4% vs. 41.5%, P=0.047), and lower recurrence rate (2.4% vs. 14.6%, P=0.048) after PSM compared to the burr hole group. The re-intervention rates in the MMAE and burr hole groups showed no significant differences (2.4% vs. 7.3%, P=0.305). Safety outcomes favored the MMAE group, with a lower 90-day mRS score (0.34±0.53 vs. 0.73±0.55, P=0.02) and shorter hospital stay (6.41±2.53 days vs. 9.29±3.71 days, P<0.001). Surgery-related adverse events occurred in 4.9% of the MMAE group and 9.7% of the burr hole group patients (P=0.392).</p><p><strong>Conclusions: </strong>MMAE was a safe and efficacious alternative procedure for CSDH treatment that showed a reduced recurrence rate.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional MRI activity and connectivity in inflammatory bowel disease: a systematic review.","authors":"Maria Veatriki Christodoulou, George A Alexiou, Marios Lampros, Loukas Astrakas, Konstantinos H Katsanos, Maria I Argyropoulou","doi":"10.1007/s00234-025-03756-1","DOIUrl":"https://doi.org/10.1007/s00234-025-03756-1","url":null,"abstract":"<p><strong>Purpose: </strong>Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), primarily affects the gastrointestinal tract but can also present with systemic manifestations, including those affecting the central nervous system (CNS). Resting-state functional MRI (rs-fMRI) provides insights into alterations in brain activity and connectivity. This review aims to evaluate rs-fMRI findings in IBD patients compared to healthy controls and to explore potential differences between CD and UC.</p><p><strong>Methods: </strong>A systematic search of PubMed/MEDLINE and SCOPUS identified rs-fMRI studies in neurologically asymptomatic IBD patients. Observational rs-fMRI studies assessing local neural activity and/or functional connectivity, were included.</p><p><strong>Results: </strong>Twenty-seven studies met eligibility criteria and findings were summarized descriptively based on rs-fMRI analysis technique, given the methodological variability. UC patients showed reduced neural activity in the hippocampus and altered functional connectivity in the visual and cerebellar networks, highlighting memory and motor control disruptions. CD patients exhibited increased neural activity in the anterior cingulate cortex and frontal regions, alongside altered connectivity in multiple sensory and higher-order cognitive networks. Both IBD types displayed disruptions in key networks, including the default mode, salience, and cerebellar networks, associated with emotional processing, pain perception and stress response regulation.</p><p><strong>Conclusion: </strong>Despite shared rs-fMRI disruptions, UC is primarily associated with decreased neural activity in areas linked to memory and motor coordination, whereas CD exhibits increased activity in regions regulating emotion and cognition. Connectivity disruptions underscore the broader impact of IBD on brain function, emphasizing the role of the brain-gut axis in emotional and sensory impairments.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting molecular subtypes of pediatric medulloblastoma using MRI-based artificial intelligence: A systematic review and meta-analysis.","authors":"Jiaying Liu, Zhenzhuang Zou, Yunfei He, Zhenfeng Guo, Changwei Yi, Bo Huang","doi":"10.1007/s00234-025-03759-y","DOIUrl":"https://doi.org/10.1007/s00234-025-03759-y","url":null,"abstract":"<p><strong>Background: </strong>This meta-analysis aims to assess the diagnostic performance of artificial intelligence (AI) based on magnetic resonance imaging (MRI) in detecting molecular subtypes of pediatric medulloblastoma (MB) in children.</p><p><strong>Methods: </strong>A thorough review of the literature was performed using PubMed, Embase, and Web of Science to locate pertinent studies released prior to October 2024. Selected studies focused on the diagnostic performance of AI based on MRI in detecting molecular subtypes of pediatric MB. A bivariate random-effects model was used to calculate pooled sensitivity and specificity, both with 95% confidence intervals (CI). Study heterogeneity was assessed using I² statistics.</p><p><strong>Results: </strong>Among the 540 studies determined, eight studies (involving 1195 patients) were included. For the wingless (WNT), the combined sensitivity, specificity, and receiver operating characteristic curve (AUC) based on MRI were 0.73 (95% CI: 0.61-0.83, I² = 19%), 0.94 (95% CI: 0.79-0.99, I² = 93%), and 0.80 (95% CI: 0.77-0.83), respectively. For the sonic hedgehog (SHH), the combined sensitivity, specificity, and AUC were 0.64 (95% CI: 0.51-0.75, I² = 69%), 0.84 (95% CI: 0.80-0.88, I² = 54%), and 0.85 (95% CI: 0.81-0.88), respectively. For Group 3 (G3), the combined sensitivity, specificity, and AUC were 0.89 (95% CI: 0.52-0.98, I² = 82%), 0.70 (95% CI: 0.62-0.77, I² = 44%), and 0.88 (95% CI: 0.84-0.90), respectively. For Group 4 (G4), the combined sensitivity, specificity, and AUC were 0.77 (95% CI: 0.64-0.87, I² = 54%), 0.91 (95% CI: 0.68-0.98, I² = 80%), and 0.86 (95% CI: 0.83-0.89), respectively.</p><p><strong>Conclusions: </strong>MRI-based artificial intelligence shows high diagnostic performance in detecting molecular subtypes of pediatric MB. However, all included studies employed retrospective designs, which may introduce potential biases. More researches using external validation datasets are needed to confirm the results and assess their clinical applicability.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemorheological changes induced by Flow-diverting stents at the aneurysm neck in cerebral circulation.","authors":"Osman Ergin, Ali Bahadir Olcay, Alperen Elek, Ismail Oran","doi":"10.1007/s00234-025-03754-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03754-3","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the hemodynamic effects of flow diverter stent (FDS) implantation on intracranial aneurysms, focusing on shear stress and shear strain rates at the neck region between the stent struts.</p><p><strong>Materials and methods: </strong>Patient-specific geometries were reconstructed from Digital Subtraction Angiography (DSA) cone-beam source images and processed to accurately model arterial anatomy and aneurysm morphology. FDS designs with 48- and 64-wire configurations were modeled while maintaining consistent porosity (65%) across all stents. Blood flow simulations were performed using computational fluid dynamics (CFD) to analyze shear stress and strain rates between the stent struts after FDS implantation.</p><p><strong>Results: </strong>CFD analysis using DSA images from five patients-three with distal internal carotid artery sidewall aneurysms and two with middle cerebral artery bifurcation aneurysms-demonstrated that, prior to stent implantation, shear stress and strain rate values at the aneurysm inlet were generally below established thresholds throughout the cardiac cycle. Following FDS implantation, those values measured between stent struts increased significantly, with some patients exceeding thresholds either throughout the entire cycle or only during systole. Both 48- and 64-wire FDS models exhibited significantly higher shear forces compared to the non-stent models; however, no significant differences were observed between the two stent designs. Aneurysm volume showed a statistically significant positive correlation with the maximum and average shear forces generated through the stent struts.</p><p><strong>Conclusion: </strong>FDS implantation consistently induces supra-physiologic shear stress and shear strain rates across the aneurysm neck between the stent struts. The measured shear forces are significantly correlated with aneurysm volume.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of the CGuard dual-layer stent and Carotid Wallstent for elective carotid artery stenting: a retrospective multicenter study.","authors":"Yves Leonard Voss, Mousa Zidan, Alexander Radbruch, Igor Fischer, Franziska Dorn, Hannes Nordmeyer","doi":"10.1007/s00234-025-03764-1","DOIUrl":"https://doi.org/10.1007/s00234-025-03764-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the safety and efficacy of the CGuard dual-layer stent with its mesh embolic protection system (EPS) in elective cases for treatment of internal carotid artery stenosis and compares it to the Carotid Wallstent as benchmark.</p><p><strong>Methods: </strong>In this retrospective, multicenter study, we analyzed data from consecutive patients who underwent carotid artery stenting with CGuard at two high-volume neurointerventional centers and compared them with prior consecutive patients treated with Carotid Wallstent (CWS), with and without a balloon guiding catheter (BGC) as protection, at the same institutions. Patient demographics, procedural details, clinical complications, early in-stent thrombosis and occlusion rates, and late follow-up restenosis rates were assessed.</p><p><strong>Results: </strong>A total of 428 patients were treated, 144 with the CGuard stent, 203 with CWS + BGC and 83 with CWS-BGC, the majority of patients for symptomatic stenoses. Technical success was achieved in 98.6% of CGuard patients. No clinical complications were observed in CGuard patients, however the clinical complication rate was 2.96% (6/203) for CWS + BGC and 4.94% (4/83) for CWS-BGC patients (p = 0.052). The in-hospital stent occlusion rate was 0.69% (1/144) for CGuard and 2.1% (6/286) in CWS ± BGC patients (p = 0.49). On long-term follow-up (mean 9.9 months) the CGuard demonstrated a comparatively low rate of restenosis (6.25%) and retreatment (2.1%).</p><p><strong>Conclusion: </strong>The CGuard dual-layer stent was safe and effective for carotid artery stenting in our series. Its design appears to contribute to a low risk of periprocedural complications, high technical success rate, while maintaining restenosis rates comparable to the Carotid Wallstent.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}