Neuroradiology最新文献

{"title":"Tumor location, genomic alterations, and radiomic features as predictors of survival in glioblastoma: a Multi-Modal analysis.","authors":"Kavita Kundal, K Venkateswara Rao, Sandeep Kumar Dhanda, Neeraj Kumar, Rahul Kumar","doi":"10.1007/s00234-025-03742-7","DOIUrl":"https://doi.org/10.1007/s00234-025-03742-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to identify the impact of tumor location on the survival of glioblastoma (GBM) patients and the associated genetic alterations, using MRI scans from The Cancer Imaging Archive (TCIA) and genomic data from The Cancer Genome Atlas (TCGA). It also seeks to uncover non-invasive radiomic markers related to poor survival outcome for improved prognosis and treatment planning.</p><p><strong>Methods: </strong>We analysed pre-operative MRI scans and genomic data from 123 GBM patients (TCIA and TCGA). Tumor locations were determined using our in-house tool, \"tumorVQ\", followed by Kaplan-Meier survival analysis based on tumor position. Genomic analysis included somatic mutations, copy number variations, fusion genes, and differential gene expression to identify factors linked to poor survival. We extracted radiomic features from T1ce MRI scans using pyRadiomics to analyse their relationship with survival outcomes.</p><p><strong>Results: </strong>Kaplan-Meier analysis showed worse survival for tumors in the parietal lobe compared to other lobes, especially frontal lobe tumors. Genomic analysis revealed high prevalence of PTEN mutations, and exclusive fusion genes FGFR3-TACC3 and EGFR-SEPT14 in parietal lobe tumors. Differential gene expression showed upregulation of PITX2, HOXB13, and DTHD1, linked to tumor progression, while ALOX15 downregulation increased relapse risk. Copy number alterations, like LINC00290 deletions, were associated with aggressive parietal lobe tumors. Radiomic features, lower GLDM DependanceEntropy (LLL) and higher FirstOrder Mean (HLL), were strongly linked to increase risk.</p><p><strong>Conclusion: </strong>This study highlights poor survival outcomes in GBM patients with parietal lobe tumors. Key genetic alterations, such as PTEN mutations and fusion genes, drive tumor progression and chemoresistance in parietal lobe tumors. The association between radiomic features and survival indicates their potential as non-invasive prognostic biomarkers, which could aid in personalized treatment and improved patient management.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of brainstem hematoma volume evaluation techniques with a novel quantitative approach.","authors":"Xiangdong Wan, Yan Chen, Xueke Zhen, Ziqian Yan, Ziyi Liu, Tianxu Pang, Erwei Zhang, Zhenzeng Fan, Lijun Yang","doi":"10.1007/s00234-025-03729-4","DOIUrl":"https://doi.org/10.1007/s00234-025-03729-4","url":null,"abstract":"<p><p>This study systematically compares various methods for calculating brainstem hematoma volume, and introduces a novel estimation method based on the maximum cross-sectional area. First, we assessed the accuracy of the Tada formula and 3D Slicer software for quantifying brainstem hematomas of different sizes and morphologies. The results revealed significant differences among methods, with the traditional Tada formula frequently overestimating hematoma volumes. We therefore propose an improved algorithm that substantially increases both the accuracy and reliability of hematoma volume assessment. Experimental results demonstrate that this new method provides greater precision and consistency when measuring the volume of irregular hematomas. These findings not only contribute to improved diagnosis and treatment of brainstem hemorrhage but also provide valuable support for future research and practical applications.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of p48 flow diverters in the treatment of intracranial aneurysms: A systematic review and Meta-Analysis.","authors":"Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Salem M Tos, Mohammad Amin Habibi, Rana Hashemi, Arman Hasanzade, Azin Ebrahimi, Kimia Didehvar, Mahdi Hooshmand, Sara Bana","doi":"10.1007/s00234-025-03737-4","DOIUrl":"https://doi.org/10.1007/s00234-025-03737-4","url":null,"abstract":"<p><strong>Background: </strong>The p48 movable wire (MW) flow modulation devices are a group of novel low-profile flow diverters (FDs) that have recently been introduced for the management of small intracranial aneurysms (IAs). This study evaluates the current literature regarding the efficacy and safety of p48 in treating IAs.</p><p><strong>Methods: </strong>A literature search was conducted using the PubMed, Embase, Scopus, and Web of Science databases. Studies evaluating the role of p48 FDs in IAs were included.</p><p><strong>Results: </strong>Twelve studies encompassing 312 individuals with 330 IAs were included. The meta-analysis revealed a pooled complete occlusion rate of 58% (95% CI: 40%-75%), a favorable outcome rate of 96% (95% CI: 86%-100%), and a morbidity rate of 1% (95% CI: 0%-3%). Regarding the complications, our findings showed a pooled intraprocedural rate of 7% (95% CI: 1%-16%), a postprocedural rate of 9% (95% CI: 6%-13%), an ischemic complication rate of 8% (95% CI: 5%-12%), a hemorrhagic complication rate of 3% (95% CI: 1%-5%), and an in-stent stenosis rate of 1% (95% CI: 0%-3%). The subgroup analysis comparing p48 MW and p48 MW with a hydrophilic coating (HPC) did not demonstrate significant differences between groups in outcomes and complications, except for hemorrhagic complications, which were higher in p48 MW than in p48 MW HPC devices (p48: 3% vs. p48 HPC: 0%, P = 0.04).</p><p><strong>Conclusion: </strong>The p48 FDs represent novel therapeutic options in the management of IAs, associated with promising outcomes and low complication rates.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound assessment of peripheral nerve size in Guillain-Barré syndrome: A systematic review and Meta-Analysis.","authors":"Omar Alomari, Bassel Alrabadi, Tarek A Hussein, Sanaa Shtayat, Rania A Hussein, Reem Alnahdi, Ragad Tawalbeh, Mahmoud Sayed Ahmed, Anas Elgenidy","doi":"10.1007/s00234-025-03728-5","DOIUrl":"https://doi.org/10.1007/s00234-025-03728-5","url":null,"abstract":"<p><strong>Purpose: </strong>Guillain-Barré Syndrome (GBS) is an autoimmune disorder causing acute inflammatory polyneuropathy, resulting in muscle weakness. Timely diagnosis is critical to prevent complications such as respiratory failure and long-term disability. Ultrasound imaging of peripheral nerves, specifically assessing nerve cross-sectional area (CSA), has been suggested as a diagnostic tool for GBS. This systematic review aims to evaluate the utility of nerve ultrasound in diagnosing and monitoring GBS.</p><p><strong>Methods: </strong>A systematic review was conducted following PRISMA guidelines, searching databases including PubMed, Scopus, Web of Science, and Cochrane Library up to December 2024. Studies that used ultrasound to assess peripheral nerve size in GBS patients compared to healthy controls or other neuropathy patients were included. Statistical analysis was conducted using Review Manager 5.4 software.</p><p><strong>Results: </strong>Out of 848 studies, 25 met the inclusion criteria, with 12 included in the meta-analysis. A total of 528 patients with GBS were included. Ultrasound revealed significant increases in the CSA of cervical, peroneal, median, ulnar, and tibial nerves in GBS patients. Specifically, cervical nerve enlargement (MD: 1.45, P = 0.0008) and peroneal nerve enlargement (Mean Difference (MD): 2.09, P < 0.00001) were notable. Subgroup analysis revealed significant enlargement of the ulnar and tibial nerves across different anatomical regions.</p><p><strong>Conclusion: </strong>Ultrasound imaging of peripheral nerves, particularly changes in CSA, provides valuable diagnostic insight for GBS, may be helpful in early recognition and intervention. Further studies are needed to establish consistent CSA patterns and improve diagnostic accuracy across various GBS subtypes.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning diagnostic model for amyotrophic lateral sclerosis analysis using MRI-derived features.","authors":"Pablo Gil Chong, Miguel Mazon, Leonor Cerdá-Alberich, Maria Beser Robles, José Miguel Carot, Juan Francisco Vázquez-Costa, Luis Martí-Bonmatí","doi":"10.1007/s00234-025-03732-9","DOIUrl":"https://doi.org/10.1007/s00234-025-03732-9","url":null,"abstract":"<p><strong>Purpose: </strong>Amyotrophic Lateral Sclerosis is a devastating motor neuron disease characterized by its diagnostic difficulty. Currently, no reliable biomarkers exist in the diagnosis process. In this scenario, our purpose is the application of machine learning algorithms to imaging MRI-derived variables for the development of diagnostic models that facilitate and shorten the process.</p><p><strong>Methods: </strong>A dataset of 211 patients (114 ALS, 45 mimic, 22 genetic carriers and 30 control) with MRI-derived features of volumetry, cortical thickness and local iron (via T2* mapping, and visual assessment of susceptibility imaging). A binary classification task approach has been taken to classify patients with and without ALS. A sequential modeling methodology, understood from an iterative improvement perspective, has been followed, analyzing each group's performance separately to adequately improve modelling. Feature filtering techniques, dimensionality reduction techniques (PCA, kernel PCA), oversampling techniques (SMOTE, ADASYN) and classification techniques (logistic regression, LASSO, Ridge, ElasticNet, Support Vector Classifier, K-neighbors, random forest) were included. Three subsets of available data have been used for each proposed architecture: a subset containing automatic retrieval MRI-derived data, a subset containing the variables from the visual analysis of the susceptibility imaging and a subset containing all features.</p><p><strong>Results: </strong>The best results have been attained with all the available data through a voting classifier composed of five different classifiers: accuracy = 0.896, AUC = 0.929, sensitivity = 0.886, specificity = 0.929.</p><p><strong>Conclusion: </strong>These results confirm the potential of ML techniques applied to imaging variables of volumetry, cortical thickness, and local iron for the development of diagnostic model as a clinical tool for decision-making support.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute stroke risk prediction model based on dual-energy CTA-derived carotid plaque, perivascular adipose tissue characteristics, and serum lipid parameters: a dual-center study.","authors":"He Zhang, Xu Xu, Juan Long, Chenzi Wang, Xiaohan Liu, Wenbei Xu, Xiaonan Sun, Peipei Dou, Dexing Zhou, Wei Cao, Kai Xu, Yankai Meng","doi":"10.1007/s00234-025-03723-w","DOIUrl":"https://doi.org/10.1007/s00234-025-03723-w","url":null,"abstract":"<p><strong>Background: </strong>Acute stroke is a major global cause of mortality and disability. Accurate prediction of stroke risk is crucial for effective clinical management. This study aimed to develop a multidimensional prediction model for acute stroke using carotid plaque characteristics, lumen parameters, perivascular adipose tissue (PVAT) quantitative metrics derived from dual-energy computed tomography angiography (DE-CTA), and serum lipid biomarkers.</p><p><strong>Methods: </strong>This retrospective dual-center study enrolled 212 patients who underwent DE-CTA and MRI between January 2023 and October 2024, comprising a training cohort (137 patients) and an external validation cohort (75 patients). Quantitative parameters including carotid plaque features (composition and intraplaque parameters), lumen metrics, PVAT quantitative indices, and serum lipid levels were collected. Patients with ipsilateral acute anterior circulation infarcts identified on MRI were classified as symptomatic (STA), and those without infarcts as asymptomatic (ATA). Variables were selected via univariate analysis and LASSO regression to construct a multivariate logistic regression model. Model performance was evaluated by ROC analysis, confusion matrix, calibration curves, and clinical decision curves, followed by external validation.</p><p><strong>Results: </strong>External validation of the final model showed an area under the ROC curve (AUC) of 0.810, with a sensitivity of 80.8% and specificity of 65.3%, indicating robust predictive performance and good clinical applicability.</p><p><strong>Conclusions: </strong>The multidimensional predictive model integrating DE-CTA-derived carotid plaque features, PVAT metrics, and serum lipid parameters effectively predicts acute stroke risk, providing a reliable quantitative tool for early screening and clinical intervention.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic clival craniopharyngioma.","authors":"Golnaz Lotfian, Akram Al-Warqi, Santhosh Gaddikeri, Miral D Jhaveri, Surjith Vattoth","doi":"10.1007/s00234-025-03727-6","DOIUrl":"https://doi.org/10.1007/s00234-025-03727-6","url":null,"abstract":"<p><p>Craniopharyngiomas are rare, benign tumors with a bimodal age distribution, typically found in children and older adults. They arise along the craniopharyngeal tract, often in the intra- or suprasellar regions, and may compress adjacent structures, causing diverse symptoms. Diagnosis is primarily MRI-based, revealing heterogeneous mass with cystic and solid elements. Chordoma, another rare tumor, arises from notochordal remnants, often in the sacrum or clivus, and displays distinct imaging characteristics like T2 hyperintensity and bony destruction. This report discusses a rare ectopic clival craniopharyngioma in an 11-year-old- the youngest case reported in the literature to our knowledge -extending from the sellar to the clival region. Noteworthy imaging findings included T1 hyperintensity and a downward growth pattern along the expected Rathke pouch course, helping distinguish it from chordoma.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The delayed spectral sign in Post-transfer CT imaging: an imaging marker of stroke severity and hemorrhagic risk.","authors":"Edwin Gulko, Sheldon Lerman, Eris Spirollari, Sabrina Zeller, Monica Mureb, John Wainwright, Akihiko Oishi, Anoosh Kouyoumdjian, Kevin Clare, Anna Rozenshtein, Fawaz Al-Mufti, Chirag Gandhi, Hasit Mehta","doi":"10.1007/s00234-025-03718-7","DOIUrl":"https://doi.org/10.1007/s00234-025-03718-7","url":null,"abstract":"<p><strong>Purpose: </strong>Acute stroke transfer patients often undergo repeat computed tomography (CT) imaging upon arrival at a thrombectomy-capable center. Often, there is residual intravenous (IV) \"contrast staining\" of acute infarcts on the initial post-transfer CT head exam, which we have detected utilizing dual-layer CT spectral virtual non-contrast images. We term this the delayed spectral sign (DSS). We sought to measure the incidence of the DSS on initial post-transfer CT head exams and evaluate for any associated clinical outcomes.</p><p><strong>Methods: </strong>We performed a retrospective study of acute stroke transfer patients with residual IV contrast on initial post-transfer CT spectral scanner head exams. Two neuroradiologists independently reviewed CT head exams and virtual non-contrast images to measure the incidence of the DSS. Data was analyzed to evaluate significant differences between DSS and non-DSS groups.</p><p><strong>Results: </strong>67 acute stroke transfer patients met inclusion criteria, of whom 8 (11.9%) demonstrated the DSS. Patients with the DSS were more likely to have a large vessel occlusion (100% vs. 64.4%, P = 0.049) and an M1 middle cerebral artery (MCA) occlusion (OR 4.9, P = 0.046). DSS patients had a greater prevalence of intracranial hemorrhage on follow-up CT or magnetic resonance imaging (MRI) exams (OR 9.259, P = 0.008). DSS patients had a higher average National Institute of Health Stroke Scale (NIHSS) upon discharge (22.25 ± 18.3), although this was not statistically significant (P = 0.079). In multivariate regression analyses, DSS was positively associated with intracranial hemorrhage on inpatient follow-up CT or MRI (OR 9.683, P = 0.012).</p><p><strong>Conclusion: </strong>The delayed spectral sign is associated with greater incidences of large vessel occlusions and intracranial hemorrhage on follow-up head imaging.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Association of T1-weighted hyperintensity with timing of peak bilirubin levels in neonates with hyperbilirubinemia.","authors":"Rongrong Wang, Hongzhe Tian, Zhuanqin Ren, Xingxing Zheng, Tianbo Shen, Kun Zhang, Xianjun Li","doi":"10.1007/s00234-025-03731-w","DOIUrl":"https://doi.org/10.1007/s00234-025-03731-w","url":null,"abstract":"","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the diagnosis and management of pudendal nerve entrapment: The role of neurophysiological studies and imaging-guided infiltrations.","authors":"Cláudia Fernandes, Vanessa Viegas, Manuel Saavedra, Javier Casado, Ana Sánchez, Clara Velasco, Lidia Cabañes, Cecilia Luque, Alberto Artiles, Luís San José, Luís Lopez-Fando Lavalle","doi":"10.1007/s00234-025-03645-7","DOIUrl":"10.1007/s00234-025-03645-7","url":null,"abstract":"<p><strong>Purpose: </strong>Pudendal nerve entrapment (PNE) diagnosis is not standardized. This leads to diagnosis delays, impacting quality of life and therapeutic outcomes. The main goal is to find the role of neurophysiological study (NFS) and Imaging-guided pudendal nerve infiltration (ImPNI) in PNE diagnosis and patient selection for surgery.</p><p><strong>Methods: </strong>A retrospective, multicentric study was conducted. Patients with PNE refractory to conservative treatment were included. Patient data, including NFS results, ImPNI, and surgical outcomes, were evaluated. A visual analogue scale was used to assess intervention response. Test performance metrics for NFS and ImPNI and binary logistic regression were used to determine their predictive value for postoperative improvement.</p><p><strong>Results: </strong>88 patients were diagnosed with PNE. All had NFS, and ImPNI was performed in 69 (78.4%), with 60 (68.2%) showing symptom improvement. Among the 40 patients (85%) who underwent pudendal nerve decompression surgery, 75% improved after surgery, and 20% did not. The combination of NFS and ImPNI showed a sensitivity of 79% and a specificity of 85.7%, with a Positive Predictive Value (PPV) of 98% and a Negative Predictive Value (NPV) of 30%. NFS and ImPNI were significant predictors of surgical success with p-values of 0.013 [ 95% CI: -23.6-19.9] and 0.003 [95% CI: -20.6 -18.5], respectively. Primary limitations: retrospective design and the absence of a control group.</p><p><strong>Conclusions: </strong>NFS and ImPNI are essential and highly reliable tools for diagnosing PNE. ImPNI is a valuable predictor of surgical outcomes. These findings enable precise patient selection for surgery, ensuring optimal surgical outcomes.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2239-2245"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}