Neuroradiology最新文献

{"title":"Long-term outcome following vertebroplasty or bone cementoplasty in multiple myeloma patients.","authors":"Samer Soliman, Laurent Garderet, Kevin Premat, Julien Allard, Mehdi Drir, Mahmoud Elhorany, Nada Hamad, Armelle Lesaunier, Atika Talbi, Damien Roos-Weil, Marine Baron, Ines Boussen, Adrien Grenier, Nicolas Gauthier, Veronique Morel, Maya Ouzegdouh, Sylvain Choquet, Raphael Bonaccorsi, Pierre-Marie Chiaroni, Frederic Clarencon, Eimad Shotar","doi":"10.1007/s00234-025-03738-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03738-3","url":null,"abstract":"<p><strong>Objective: </strong>Evaluating long-term outcomes following cementoplasty in patients with multiple myeloma (MM).</p><p><strong>Methods: </strong>This is a single-center, retrospective study on all cementoplasties performed between January 2012 and December 2017. Patients with MM with a control MRI or CT scan beyond 5 years after the procedure were included. Images were reviewed blinded to the patients' clinical status.</p><p><strong>Results: </strong>During the inclusion period, 2085 patients underwent cementoplasty, including 154 patients with MM. Forty-seven patients (33 men (70%); median age 62.2 years [IQR 53.8;69.6]) were included. The patients underwent 74 procedures (142 cemented sites: 129 vertebrae, 11 pelvic girdle cementoplasties, and 2 other sites; 101 (71%) demineralized fractures and 41 (29%) osteolytic lacunae). No serious procedure-related adverse effects were observed. Only 2 (1.4%) recurrent fractures of the cemented bone were observed. At-risk adjacent vertebrae were defined as non-cemented vertebrae, adjacent to a cemented vertebra: 15/109 (14%) fractures of at-risk adjacent vertebrae were documented during follow-up (15/99 [15%] after excluding cervical at-risk vertebrae). Intervertebral disc cement leakage was significantly associated with the occurrence of vertebral fracture at the adjacent level (31% vs. 8.8%, p = 0.022). Fourteen patients (30%) developed a new vertebral fracture that was remote from the cemented site. These were more frequent in patients with higher bone marrow plasmacytosis (median 23% vs. 13%, p = 0.014), relapsed multiple myeloma (86% vs. 55%, p = 0.042) and bone demineralization fractures (93% vs. 48%, p < 0.01).</p><p><strong>Conclusion: </strong>Bone cementoplasty for MM is a durable treatment. At-risk adjacent vertebra fracture is a frequent event, prompting a discussion on prophylactic adjacent-level cementoplasty.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stent-Assisted Coil Embolization Versus Flow Diversion in Intracranial Vertebral Artery Dissecting Aneurysms: A Systematic Review and Meta-Analysis.","authors":"Ocílio Ribeiro Gonçalves, Anderson Matheus Pereira da SIlva, Mariana Lee Han, Filipe Virgilio Ribeiro, Mariana Oliveira, Rafael Reis de Oliveira, Milene Vitória Sampaio Sobral, Ahmet Gunkan, Marcio Yuri Ferreira, Jhon E Bocanegra-Becerra, Christian Ferreira, David Gordon, Yafell Serulle, David Langer","doi":"10.1007/s00234-025-03739-2","DOIUrl":"https://doi.org/10.1007/s00234-025-03739-2","url":null,"abstract":"<p><strong>Introduction: </strong>Intracranial vertebral artery dissecting aneurysms (IVADAs) represent a rare but challenging condition associated with high morbidity and mortality. In the therapeutic landscape, endovascular interventions such as Flow Diversion (FD) and Stent-Assisted Coiling (SAC) are widely used for the management of IVADAs. The aim of this systematic review and meta-analysis is to compare the clinical outcomes and complications associated with FD and SAC techniques in the endovascular management of IVADAs.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, Web of Science and Scopus from inception to December 2024. This meta-analysis included retrospective cohort studies comparing flow diverters versus stent-assisted coiling in patients with IVADAs. The primary outcomes included in-stent stenosis, complete occlusion rates, and modified Rankin Scale (mRS) scores. Risk of bias was assessed using the ROBINS-I tool for non-randomized studies. Statistical analyses were conducted using R software (version 4.4.0), with risk ratios (RR) and 95% confidence intervals (CI) calculated using the Mantel-Haenszel method. Heterogeneity was assessed using Cochran's Q test and I² statistics, with an I² > 40% considered significant. A leave-one-out analysis was performed to evaluate the influence of individual studies on the pooled estimates.</p><p><strong>Results: </strong>A total of seven non-randomized studies were included in the meta-analysis comprising 649 patients with IVADAs. Long-term complete occlusion rates were similar between FD and SAC (RR 0.99; 95% CI 0.89-1.10; I² = 0%). Favorable functional outcomes were marginally higher with FD (RR 1.04; 95% CI 1.00-1.10; I² = 0%). Recurrence (RR 0.36; 95% CI 0.13-1.01; I² = 0%) and retreatment rates (RR 0.44; 95% CI 0.16-1.17; I² = 0%) were not significantly different between groups. In terms of safety outcomes, in-stent stenosis rates (RR 1.17; 95% CI 0.47-2.91; I² = 0%) and complication rates (RR 0.74; 95% CI 0.40-1.35; I² = 0%) were not statistically significantly different. Risk of bias assessment indicated an overall moderate risk across studies, with no study classified as having a serious risk of bias.</p><p><strong>Conclusion: </strong>In this meta-analysis, FD and SAC demonstrated comparable efficacy and safety profiles in the treatment of IVADAs, with no significant differences in long-term complete occlusion, recurrence, retreatment, in-stent stenosis, or complication rates. In this context, FD is a promising technique to treat IVADAs.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Velocity-Selective arterial spin labeling (VSASL) for cerebral blood volume assessment in gliomas: comparison with VSASL based cerebral blood flow and dynamic susceptibility contrast MRI.","authors":"Yaoming Qu, Andong Ma, Xinran Yan, Xiaochan Ou, Xia Zou, Qihong Rui, Haitao Wen, Xianlong Wang, Dan Zhu, Qin Qin, Zhibo Wen","doi":"10.1007/s00234-025-03751-6","DOIUrl":"https://doi.org/10.1007/s00234-025-03751-6","url":null,"abstract":"<p><strong>Purpose: </strong>Cerebral blood volume (CBV) maps created using dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) are valuable but may be limited by gadolinium contraindications in certain clinical scenarios. A noninvasive perfusion method for CBV assessment based on velocity-selective (VS) ASL has emerged. This study is to evaluate the performance of VSASL-derived CBV among glioma patients in clinical practice, comparing with the VSASL-based cerebral blood flow (CBF) and DSC-PWI.</p><p><strong>Methods: </strong>Forty-eight patients with pathologically confirmed gliomas (mean age: 45 ± 13 years; 25 males; 25 in low-grade) underwent preoperative VSASL-CBV MRI. Lesion conspicuity on VSASL-CBV maps was visually scored (1-3) relative to surrounding parenchyma by two neuroradiologists. Relative maximum tumor blood volume (rTBV) and flow (rTBF) from VSASL and DSC-PWI were compared between low- and high-grade gliomas. Correlation and agreement between VSASL- and DSC-PWI-derived rTBV were assessed via linear regression and Bland-Altman analysis. Diagnostic performance for glioma grading was evaluated using ROC curves.</p><p><strong>Results: </strong>VSASL-CBV maps demonstrated good lesion conspicuity (mean score: 2.26 ± 0.76; inter-reader weighted κ = 0.8). VSASL-rTBV strongly correlated with DSC-PWI-rTBV (R²=0.83, p < 0.001). Both VSASL and DSC-PWI metrics significantly distinguished low- from high-grade gliomas (p < 0.001). ROC analysis revealed that VSASL-rTBV achieved excellent diagnostic accuracy in glioma grading (AUC = 0.94), outperforming VSASL-rTBF (AUC = 0.89) and matching DSC-PWI-rTBV (AUC = 0.93). Sensitivity, predictive values, and accuracy of VSASL-rTBV were superior to VSASL-rTBF.</p><p><strong>Conclusion: </strong>VSASL provides accurate, noninvasive CBV quantification for glioma stratification, demonstrating diagnostic performance comparable to DSC-PWI. It offers a viable alternative in clinical settings where gadolinium contrast is contraindicated.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of large vessel occlusion using artificial intelligence tools: A systematic review and meta-analysis.","authors":"Julyana Dantas, Giovana Barros, Antonio Mutarelli, Caroline Dagostin, Pedro Romeiro, Giulia Almirón, Nicole Felix, Agostinho Pinheiro, Matheus A Bannach","doi":"10.1007/s00234-025-03716-9","DOIUrl":"10.1007/s00234-025-03716-9","url":null,"abstract":"<p><strong>Background and purpose: </strong>Large vessel occlusion (LVO) accounts for a third of all ischemic strokes. Artificial intelligence (AI) has shown good accuracy in identifying LVOs on computed tomography angiograms (CTA). We sought to analyze whether AI-adjudicated CTA improves workflow times and clinical outcomes in patients with confirmed LVOs.</p><p><strong>Materials and methods: </strong>We systematically searched PubMed, Embase, and Web of Science for studies comparing initial radiological assessment assisted by AI softwares versus standard assessment of patients with acute LVO strokes. Results were pooled using a random-effects model as mean differences for continuous outcomes or odds ratio (OR) for dichotomous outcomes, along with 95% confidence intervals (CI).</p><p><strong>Results: </strong>We included 9 studies comprising 1,270 patients, of whom 671 (52.8%) had AI-assisted radiological assessment. AI consistently improved treatment times when compared to standard assessment, as evidenced by a mean reduction of 20.55 minutes in door-to-groin time (95% CI -36.69 to -4.42 minutes; p<0.01) and a reduction of 14.99 minutes in CTA to reperfusion (95% CI -28.45 to -1.53 minutes; p=0.03). Functional independence, defined as a modified Rankin scale 0-2, occurred at similar rates in the AI-supported group and with the standard workflow (OR 1.27; 95% CI 0.92 to 1.76; p=0.14), as did mortality (OR 0.71; 95% CI 0.27 to 1.88; p=0.49).</p><p><strong>Conclusions: </strong>The incorporation of AI softwares for LVO detection in acute ischemic stroke enhanced workflow efficiency and was associated with decreased time to treatment. However, AI did not improve clinical outcomes as compared with standard assessment.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2399-2407"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular management of a ruptured complex ACoM aneurysm in a 9-month-old infant: a rare case report and literature review.","authors":"Vinayagamani Selvadasan, Arunkumar Natarajan, Arunkumar M J, Uday S Limaye","doi":"10.1007/s00234-025-03743-6","DOIUrl":"10.1007/s00234-025-03743-6","url":null,"abstract":"<p><p>Ruptured intracranial aneurysms in infants are exceptionally rare, particularly saccular aneurysms of the anterior communicating artery (ACoM). We report a 9-month-old infant presenting with subarachnoid and intraventricular hemorrhage due to a ruptured complex ACoM aneurysm, along with two small right A2 saccular aneurysms. The child underwent successful balloon-assisted endovascular coiling, with clinically silent vasospasm and full neurological recovery. To our knowledge, this is the first reported case of a ruptured infantile saccular ACoM aneurysm treated with endovascular coiling resulting in a good functional outcome. This case supports the feasibility of endovascular treatment in selected pediatric aneurysm cases.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2527-2532"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of computational fluid dynamics indices of unruptured cerebral aneurysms with 3 T magnetic resonance angiography.","authors":"Futoshi Mori, Mikito Saito, Kentaro Fujimoto, Yoshitaka Kubo, Takahiro Koji, Yosuke Akamatsu, Kuniaki Ogasawara, Tsuyoshi Matsuda, Ikuko Uwano, Fumio Yamashita, Ryoichi Tanaka, Makoto Sasaki","doi":"10.1007/s00234-025-03667-1","DOIUrl":"10.1007/s00234-025-03667-1","url":null,"abstract":"","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2409-2418"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prominence of deep medullary veins associated with the risk of stroke in unilateral chronic internal carotid artery occlusion patients.","authors":"Na Liang, Wei Di, Zhiwei Li, Xiaoling Liu, Xiansong Cheng, Sheng Liu, Jun Hu","doi":"10.1007/s00234-025-03767-y","DOIUrl":"10.1007/s00234-025-03767-y","url":null,"abstract":"<p><strong>Purpose: </strong>To clarify the relationship between deep medullary veins (DMV) and risk of post-discharge stroke in chronic internal carotid artery occlusion (CICAO) patients.</p><p><strong>Methods: </strong>Hospitalized patients were divided into CICAO patients and control group without cerebral artery occlusion. SWI assessed DMV prominence in both cerebral hemispheres on a 0-3 scale. If the DMV scores of both hemispheres were consistent, DWV was not prominent (DMV-). Otherwise, DWV was prominent (DMV+) in the higher score hemisphere. In DMV + patients with CICAO, if the DMV score in the ipsilateral hemisphere of CICAO was higher than the contralateral hemisphere, DMV + was DMVi, otherwise, DMV + was DMVc.</p><p><strong>Results: </strong>110 unilateral CICAO patients and 75 control group patients were finally enrolled. 89CICAO patients and 5 control group patients were DMV+. In CICAO patients, 54 were DMVi patients and 35 were DMVc patients. Binary logistic regression analysis showed that CICAO was the independent risk factor of DMV+ (OR: 75.23; 95%CI :25.58-240.07; P < 0.001). Compared with DMVc patients, DMVi patients had a lower proportion of simultaneous primary and secondary collaterals activation(P = 0.034), decreased perfusion in the CICAO ipsilateral hemisphere (P < 0.001) and higher DMV scores in the prominent hemisphere (P = 0.012). Cox regression showed that the risk of stroke events post discharge in DMVi patients was higher than that in DMVc patients (HR: 4.68; 95%CI: 1.02-21.50; P = 0.047).</p><p><strong>Conclusion: </strong>CICAO is an independent risk factor for DMV. The collateral circulation and cerebral perfusion are related to DMVc. DMVc predictes a lower risk of stroke in CICAO patients post discharge.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2371-2378"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy related endocrinopathy of the pineal and pituitary gland that resolved following discontinuation of treatment: case report.","authors":"Anish Bhandari, Ilaria Vittoria De Martini, Samuel N Rogers, Aparna Nallagangula, Hasan Ozgur","doi":"10.1007/s00234-025-03687-x","DOIUrl":"10.1007/s00234-025-03687-x","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICI) have been integrated into various tumor treatment protocols, including melanoma. Endocrinopathies related to ICI have been well-documented, with most common sites of involvement being thyroid, pituitary, adrenal, and pancreas. We report a 65-year-old female with metastatic melanoma who developed endocrinopathy of the pineal gland and pituitary gland following treatment with ICI. Although metastatic disease was considered in the differential diagnosis, the MRI findings in conjunction with resolution upon discontinuation of immunotherapy was most consistent with inflammatory etiology. A comprehensive literature search yielded no reports of immunotherapy-induced endocrinopathy of the pineal gland, suggesting that this may be potentially the first reported case. Understanding the clinical and imaging findings of immune-related adverse events in patients undergoing immunotherapy is crucial to ensure proper diagnosis and subsequent treatment plans.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2585-2588"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12546547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histology of PFO-associated stroke thrombus compared to iliofemoral deep vein thrombus: an explorative study.","authors":"M H M Immens, M Stam, D W J Dippel, G J Lycklama À Nijeholt, H B van der Worp, S Jenniskens, M J van Rijn, F E de Leeuw, T J F Ten Cate, H M M van Beusekom, Anil M Tuladhar","doi":"10.1007/s00234-025-03693-z","DOIUrl":"10.1007/s00234-025-03693-z","url":null,"abstract":"","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2321-2326"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12546273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A low apparent diffusion coefficient value is associated with hemorrhagic transformation following endovascular treatment for a large ischemic core.","authors":"Takeru Umemura, Yuko Tanaka, Toru Kurokawa, Ryo Miyaoka, Masaru Idei, Hirotsugu Ohta, Junkoh Yamamoto","doi":"10.1007/s00234-025-03682-2","DOIUrl":"10.1007/s00234-025-03682-2","url":null,"abstract":"<p><strong>Purpose: </strong>Endovascular treatment (EVT) for large ischemic stroke is associated with a risk of hemorrhagic transformation (HT). The severity of ischemic stress can be assessed using the apparent diffusion coefficient (ADC), with a high ADC indicating viability. This study aimed to examine whether a low ADC is associated with HT following EVT, based on a low Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and diffusion-weighted imaging (DWI).</p><p><strong>Methods: </strong>This retrospective cohort study included consecutive patients with acute large ischemic stroke (ASPECTS-DWI ≤ 5) who underwent EVT with successful recanalization between April 2014 and March 2023. The most frequent ADC (peak ADC) in the ischemic core and DWI lesion volume were assessed. Patients with and without HT following EVT were compared to evaluate the associated between a low ADC and HT.</p><p><strong>Results: </strong>Seventy-eight patients were enrolled, 25 (32%) of whom experienced HT after EVT. Parenchymal hematomas were observed in 17 patients (22%). Statistically significant differences in peak ADC and onset-to-recanalization time were observed between patients with and without HT (p = 0.0036 and p = 0.0151, respectively). In multivariate analysis, a low peak ADC was associated with HT (odds ratio [OR], 0.839; p = 0.018), but onset-to-recanalization time was not. A threshold peak ADC resulting in HT was calculated as < 480 × 10^-6 mm²/s.</p><p><strong>Conclusions: </strong>A low peak ADC was associated with HT after EVT for a large ischemic core. The threshold of the peak ADC that resulted in HT was < 480 × 10^-6 mm²/s. These results suggest that evaluating the ischemic core is necessary to confirm EVT.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2497-2504"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}