Neuroradiology最新文献

{"title":"MRI follow-up of embolized intracranial dural arteriovenous fistulas using 3D time-of-flight and contrast-enhanced 3D T1-weighted GRE imaging.","authors":"Déesse Dji'ala, Fabrice Vallée, Vittorio Civelli, Jérôme Cartailler, Francesco Arpaia, Matteo Fantoni, Emmanuel Houdart, Alexis Guédon","doi":"10.1007/s00234-026-04160-z","DOIUrl":"10.1007/s00234-026-04160-z","url":null,"abstract":"<p><strong>Background: </strong>Although digital subtraction angiography (DSA) remains the reference standard for post-treatment follow-up of intracranial dural arteriovenous fistulas (DAVFs), it is an invasive procedure associated with procedural risks and may not be justified for the follow-up of all DAVFs.</p><p><strong>Purpose: </strong>This study aimed to evaluate the diagnostic performance of 3D time-of-flight (3D TOF) and contrast-enhanced 3D T1-weighted gradient-echo (3D T1 Gd) magnetic resonance imaging (MRI) sequences for monitoring embolized intracranial DAVFs.</p><p><strong>Materials and methods: </strong>In this retrospective single-center study, consecutive patients with embolized DAVFs between 2004 and 2023, who underwent MRI and arteriography during follow-up, were evaluated. 3D TOF sequence images were independently reviewed by two readers to assess treatment completeness. In cases of residual fistula, cortical venous drainage (CVD) was evaluated. Patency of the fistulous or proximal venous sinus was assessed on contrast-enhanced 3D T1-weighted GRE imaging. The median follow-up duration was 3.6 months (interquartile range [IQR], 3.0-8.4 months). Imaging findings were systematically compared with DSA as the reference standard.</p><p><strong>Results: </strong>Seventy-six patients (mean age, 56 ± 12,8 years; 46 men) with 78 embolized DAVFs were included. The positive predictive value, negative predictive value, and diagnostic accuracy of 3D TOF sequence for the detection of residual fistulas were 79% [54% - 94%], 93% [84% - 98%], 90% [81% - 95%], respectively. Inter-rater agreement was good (κ = 0.71; [0.52-0.90]). Intermodality agreement was good for the detection of residual fistulas (κ = 0.72; [0.54-0.90]) and moderate for the detection of cortical venous drainage (κ = 0.54; [0.22-0.85]). Additionally, agreement between 3D T1 Gd and DSA for assessing venous sinus patency was good (κ = 0.80; [0.58-1.00]).</p><p><strong>Conclusion: </strong>3D TOF and contrast-enhanced 3D T1-weighted GRE imaging are effective non-invasive tools for the follow-up of embolized DAVFs. 3D TOF provides high diagnostic performance for excluding clinically significant residual fistulas, whereas small residual microshunts or low-flow fistulas may remain occult and still require DSA confirmation in selected cases.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2697-2706"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra- and inter-rater agreement of the Menon, ASITN/SIR, and Calgary collateral grading systems using multiphase computed tomography angiography, and their association with clinical outcomes in acute stroke.","authors":"Esra Çıvgın, Gülsüm Kılıçkap, Elif Banu Güler Oklaz, Hasan Bayındır, İzzet Selçuk Parlak","doi":"10.1007/s00234-026-04184-5","DOIUrl":"10.1007/s00234-026-04184-5","url":null,"abstract":"<p><strong>Purpose: </strong>Cerebral collateral circulation is a key determinant of functional outcome in AIS with LVO. We aimed to compare intra- and interobserver agreement among the Menon, ASITN/SIR, and Calgary collateral grading systems on mCTA and to assess their association with clinical outcomes.</p><p><strong>Methods: </strong>In this retrospective study, mCTA images from 108 patients with anterior circulation LVO were independently assessed for collateral status by two radiologists using the Menon, ASITN/SIR, and Calgary systems; intra-observer agreement was assessed in 72 patients. The PCA-MCA component of the Calgary score was analyzed separately as Posterior-CS. All scores, except Calgary, were analyzed as 3-category versions. Agreement was assessed using weighted kappa, PABAK, and ICC. The association with mRS at 90-day was assessed using ordinal logistic regression and ROC analysis in 104 patients.</p><p><strong>Results: </strong>Intra-observer agreement was substantial to almost perfect for the Menon (κ = 0.636-0.914) and ASITN/SIR scores (κ = 0.727-0.943), and excellent for Calgary (ICC = 0.931). Inter-observer agreement was moderate to almost perfect for the Menon (κ = 0.462-0.815) and ASITN/SIR (κ = 0.469-0.813), and good for Calgary (ICC = 0.865). Posterior-CS demonstrated moderate intra-observer (κ = 0.474) and poor inter-observer agreement (κ = 0.187). All collateral scores were significantly associated with 90-day mRS (p ≤ 0.039), except 3-category Posterior-CS (p = 0.073). Higher scores predicted favorable outcome (mRS 0-2) and decreased mortality (mRS 6).</p><p><strong>Conclusion: </strong>The Menon and ASITN/SIR systems demonstrated substantial to almost perfect intra-observer and moderate to almost perfect inter-observer agreement, while Calgary demonstrated excellent intra-observer and good inter-observer agreement. All three systems demonstrated comparable prognostic performance in AIS with LVO. Higher collateral scores predicted favorable outcomes and decreased mortality.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"3101-3111"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline imaging for determining infarct core in patients with acute ischemic stroke: noncontrast computed tomography vs computed tomography perfusion.","authors":"Yue Chu, Qiang Zhang, Gao Ma, Guang-Chen Shen, Shan-Shan Lu, Fei-Yun Wu, Sheng Liu, Xiao-Quan Xu","doi":"10.1007/s00234-026-04021-9","DOIUrl":"10.1007/s00234-026-04021-9","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the value of noncontrast computed tomography (NCCT) and computed tomography perfusion (CTP) in determining the infarct core in patients with acute ischemic stroke (AIS).</p><p><strong>Methods: </strong>Four hundred and forty-nine AIS patients who underwent baseline NCCT and CTP assessment, endovascular thrombectomy (EVT) and follow-up imaging evaluation from October 2019 to August 2023 were retrospectively enrolled. Alberta Stroke Program Early Computed Tomography Score (ASPECTS) were assessed on baseline NCCT, cerebral blood flow (CBF) colored map and follow-up imaging. Baseline infarct core volume was calculated as regions with reduction in the relative CBF < 30% of that in contralateral normal tissue. \"NCCT-CTP mismatch\" was defined as low ASPECTS (< 6) with small infarct core (< 70 ml) (LASC), or high ASPECTS (≥ 6) with large infarct core (≥ 70 ml) (HALC).</p><p><strong>Results: </strong>\"NCCT-CTP mismatch\" was found in 145 (32.3%) patients, and 35.9% of them achieved good outcomes after EVT. IVT using before CTP imaging (OR, 1.833; P = 0.005) and higher admission NIHSS (OR, 1.055; P < 0.001) were independently associated with \"NCCT-CTP mismatch\". LASC patients exhibited longer stroke onset time [median, 306 min vs. 125 min; P = 0.004] and higher rate of hemorrhagic infarction (33.1% vs. 8.3%, P = 0.077) after EVT than HALC patients. Compared with CBF map, stronger correlations of deep basal ganglia regional infarct were found between baseline NCCT and follow-up imaging for both early and late presenters (all P < 0.05).</p><p><strong>Conclusions: </strong>About 30% patients showed \"NCCT-CTP mismatch\", and 35.9% of them achieved good outcome. Despite NCCT showing stronger correlations, CTP could provide complementary information to NCCT, therefore both were suggested in future practice.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2601-2611"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147875147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioarchitectural characterization of transdural supply in brain arteriovenous malformations: a multicenter retrospective study.","authors":"Yasuyuki Kaku, Tetsu Satow, Shuichi Tanoue, Masafumi Hiramatsu, Tomohiko Ozaki, Wataro Tsuruta, Yushin Takemoto, Timo Krings, Hiro Kiyosue","doi":"10.1007/s00234-026-04161-y","DOIUrl":"10.1007/s00234-026-04161-y","url":null,"abstract":"<p><strong>Purpose: </strong>Transdural supply (TDS) is a recognized angioarchitectural feature of brain arteriovenous malformations (bAVMs). We aimed to systematically characterize the angioarchitecture of TDS in bAVMs, focusing on whether transdural feeders terminated within the nidus or connected directly to the draining vein. TDS prevalence and its associated clinical features were also investigated.</p><p><strong>Methods: </strong>This retrospective study enrolled 521 patients (524 bAVMs) from 16 centers who underwent systematic six-vessel digital subtraction angiography. bAVMs were classified as nidus- or fistula-dominant. Angiography was evaluated with specific focus on the presence of TDS and the termination site of transdural feeders. TDS was classified as TDS-Nidus (fistulous point within the nidus) or TDS-DV (fistulous point at the draining vein wall).</p><p><strong>Results: </strong>TDS was identified in 88 bAVMs (16.8%). The fistula-dominant type was more frequent in bAVMs with TDS (P < 0.01). Among TDS cases, 25 (28.4%) demonstrated TDS-DV. Fistula-dominant morphology was the only independent predictor of TDS-DV (P < 0.01). No significant differences in complete occlusion rates or modified Rankin Scale score after treatment were observed between the TDS-Nidus and TDS-DV groups. Older age (odds ratio [OR]: 1.04; 95% confidence interval [CI]: 1.02-1.06), larger nidus size (OR: 1.95; 95% CI: 1.60-2.42), occipital location (OR: 3.12; 95% CI: 1.28-7.62), eloquent area involvement (OR: 3.23; 95% CI: 1.61-6.50), and headache (OR: 2.85; 95% CI: 1.26-6.44) were independently associated with TDS.</p><p><strong>Conclusion: </strong>TDS-DV was identified in 28% of bAVMs with TDS and was strongly associated with fistula-dominant morphology. Recognition of this angioarchitectural pattern may facilitate angiographic characterization of bAVMs with TDS.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2719-2728"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning for contrast-enhanced MRI in pediatric brain imaging.","authors":"Anna Macula, Giovanni Morana, Fiorenza Coppola, Andrea Garnero, Andrea Rossi, Alberto Fringuello Mingo, Stefano Tambalo, Giovanni Valbusa, Fabio Tedoldi, Sonia Colombo Serra, Angelo Bifone","doi":"10.1007/s00234-026-04073-x","DOIUrl":"10.1007/s00234-026-04073-x","url":null,"abstract":"<p><strong>Purpose: </strong>A deep learning algorithm for contrast amplification in brain MRI, trained exclusively on adult data, was tested for cross-population generalization to pediatric patients, including subjects aged 0-2 years.</p><p><strong>Methods: </strong>A retrospective monocentric dataset (n = 22 cases) comprising pediatric patients (0-17 years old) diagnosed with various brain tumors was used to evaluate the algorithm, which takes T1-weighted pre- and standard post-contrast images as input and generates an output image with amplified contrast, further post-processed with an HDR algorithm. Quantitative comparisons between standard and amplified images were performed using contrast-to-noise ratio (CNR), contrast enhancement percentage (CEP), and lesion-to-background ratio (LBR). Three neuroradiologists performed qualitative assessment using a 4-point Likert scale, focusing on lesion contrast and delineation. Anatomical similarity was assessed using SSIM and log-Jacobian range. Statistical significance was evaluated using two-tailed paired t-tests.</p><p><strong>Results: </strong>Compared to standard-dose images, contrast-amplified images showed significantly higher values for CNR (+ 186.5%), LBR (+ 61.9%), and CEP (+ 110.4%). Qualitative assessments demonstrated comparable lesion visualization, with improvements observed in selected cases. Reader 1 preferred the contrast-amplified image in 12 of 22 cases (54.5%), reader 2 favored it in 18 of 22 cases (81.8%) and reader 3 in 13/22 cases (59.1%). One reader reported improved overall image quality (mean score: 3.95 vs. 3.73). The average SSIM between amplified and standard-dose images was 0.98, and any significant anatomical differences were highlighted by the log-Jacobian range (p-value = 0.556).</p><p><strong>Conclusion: </strong>An algorithm for contrast amplification based on deep learning, trained with adult data, significantly enhances quantitative contrast metrics in images from pediatric patients. It is preferred over standard-dose images in the majority of cases when used for pediatric brain MRI, indicating its promising application for cross-population applicability.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"3059-3069"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"System-specific reductions of resting-state BOLD signal entropy in disorders of consciousness.","authors":"Shanshan Chen, Haoran Chen, Nan Zhang, Yituo Wang","doi":"10.1007/s00234-026-04054-0","DOIUrl":"10.1007/s00234-026-04054-0","url":null,"abstract":"<p><strong>Objective: </strong>Disorders of consciousness (DoC) are associated with large-scale abnormalities in brain function, but system-specific alterations in regional resting-state BOLD signal entropy remain poorly understood. Here, we examined regional entropy of resting-state fMRI signals in patients with minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS).</p><p><strong>Methods: </strong>Resting-state fMRI was acquired in 23 MCS patients, 31 UWS patients, and 20 age-matched healthy controls. Regional entropy was estimated from voxel-wise BOLD signals within anatomically defined brain regions using a PCA-based framework, allowing quantification of covariance-based regional BOLD signal variability across the whole brain. Pairwise group comparisons were performed at both the ROI level and in grouped functionally relevant regional sets.</p><p><strong>Results: </strong>Relative to healthy controls, MCS patients showed reduced regional entropy mainly in sensory- and memory-related regions, whereas UWS patients showed widespread reductions across sensory, memory-related, and high-order cognitive regions. In grouped regional-set analyses, entropy in sensory and memory systems showed a graded decrease from healthy controls to MCS and from MCS to UWS. In contrast, entropy in high-order cognitive systems remained relatively preserved in MCS and was significantly reduced only in UWS, with the exception of the posterior cingulate cortex and precuneus.</p><p><strong>Conclusion: </strong>These findings demonstrate system-specific reductions in resting-state BOLD signal entropy in DoC and reveal distinct patterns of altered regional BOLD signal variability across sensory, memory-related, and high-order cognitive systems in MCS and UWS. Regional BOLD signal entropy may provide a quantitative regional description of altered brain dynamics in DoC and complement existing work on large-scale communication and network dysfunction.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2805-2815"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal of a champagne bottle neck sign grading system reflecting advanced Suzuki stage and hemodynamic compromise in patients with Moyamoya disease.","authors":"Ryosuke Tashiro, Atsushi Kanoke, Hiroyuki Sakata, Hiroki Uchida, Shunsuke Omodaka, Miki Fujimura, Hidenori Endo","doi":"10.1007/s00234-026-04182-7","DOIUrl":"10.1007/s00234-026-04182-7","url":null,"abstract":"<p><strong>Purpose: </strong>The champagne bottle neck sign (CBNS) is regarded as a characteristic finding of the cervical internal carotid artery in patients with moyamoya disease (MMD). However, there is no universal definition, and its clinical significance remains unclear. Here, we aimed to propose a novel CBNS grading system using catheter angiography.</p><p><strong>Methods: </strong>First, we proposed a novel grading system for CBNS using the lateral view of common carotid artery angiograms. Three grades were defined (grades 0,1, and 2). CBNS grade was defined as a ratio of the internal carotid artery diameter to the common carotid artery diameter of < 0.5 on the lateral view of the common carotid artery angiogram. CBNS grade 2 additionally required plump enlargement of the bulbous portion of the cervical internal carotid artery. We then conducted a retrospective case-control study including 134 patients (247 sides) with MMD and 94 patients (98 sides) with non-MMD intracranial large artery stenosis/occlusion. Finally, we analyzed the association between CBNS grade and clinical features, including Suzuki stage and hemodynamic impairment.</p><p><strong>Results: </strong>CBNS grade 2 demonstrated a strong association with MMD, although grade 2 CBNS was infrequently observed among patients with non-MMD intracranial large-artery stenosis/occlusion (p < 0.001). Additionally, multivariate analysis demonstrated a significant association between CBNS grade 2 and hemodynamic impairment, which was present in 32.5% (13/40) and 55.9% (19/34) of MMD sides at CBNS grades 1 and 2, respectively (p < 0.001).</p><p><strong>Conclusion: </strong>We propose a CBNS grading system for MMD patients. CBNS grade 2, characterized by pronounced enlargement of the bulbous portion of the cervical internal carotid artery, may serve as an imaging marker of advanced Suzuki stage and hemodynamic impairment in MMD.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2729-2740"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can cervical spine axial GRE imaging replace FSE T2 axial imaging in the evaluation of central canal stenosis?","authors":"Jinyoung Choi, Hee Jin Park, Ji Na Kim, Myung Sub Kim","doi":"10.1007/s00234-026-03998-7","DOIUrl":"10.1007/s00234-026-03998-7","url":null,"abstract":"<p><strong>Background: </strong>Many hospitals perform both axial fast spin-echo T2-weighted image (FSE T2WI) and axial gradient recalled echo T2-weighted (GRE) imaging.</p><p><strong>Purpose: </strong>This study was performed to compare inter-reader agreement of cervical central spinal stenosis (CCSS) grading with the use of axial GRE imaging and axial FSE T2WI. We also compared the correlations between each radiologic grade and clinical manifestations.</p><p><strong>Methods: </strong>A total of 143 patients (M: F = 71:72; mean age, 52 years) who underwent magnetic resonance imaging of the cervical spine at our hospital were included. Two radiologists evaluated the degree of CCSS from the level of C2-3 to the level of C6-7 using axial GRE imaging, axial FSE T2WI, axial GRE imaging with sagittal T2WI, and axial FSE T2WI with sagittal T2WI. Kappa statistics were used to analyze the inter-reader agreement.</p><p><strong>Results: </strong>The existence of substantial agreement between GRE axial and FSE T2 axial images was reported by both readers (0.657 ≤ κ ≤ 0.665), who also reported almost-perfect agreement between GRE axial + T2 sagittal and T2 axial + T2 sagittal imaging (0.958 ≤ κ ≤ 0.979). The GRE axial, GRE axial + T2 sagittal, and T2 axial + T2 sagittal images showed superior correlation (moderate) compared to that of T2 axial images only (weak) in revealing the correlation between Kang grade and clinical manifestation.</p><p><strong>Conclusion: </strong>The agreement of CCSS grading with axial GRE imaging and axial FSE T2WI findings was substantial. Using axial GRE images led to a superior correlation between magnetic resonance sequence and clinical manifestations relative to using axial FSE T2WI.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"3093-3100"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Position-dependent white matter microstructural differences in amateur soccer players: a multi-shell diffusion MRI study.","authors":"Demet Küçük, Hamza Küçük, Barış Genç, Kerim Aslan, Hüseyin Akan","doi":"10.1007/s00234-026-04087-5","DOIUrl":"10.1007/s00234-026-04087-5","url":null,"abstract":"<p><strong>Purpose: </strong>To exploratorily evaluate whether long-term exposure to repetitive subconcussive head impacts is associated with position-related patterns of white matter microstructural variation in amateur soccer players using multi-shell diffusion MRI.</p><p><strong>Methods: </strong>This prospective observational study included 43 male amateur soccer players (defenders, n = 17; midfielders, n = 14; goalkeepers, n = 12), aged 18-27 years, each with ≥ 10 years of playing experience. Player position was defined as the primary registered position reported by the participant's club and confirmed by self-report as the predominant playing role over the preceding decade. Participants reporting frequent position switching or hybrid tactical roles were excluded to reduce positional overlap. Diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics were analyzed using tract-based spatial statistics. Given the modest sample size and the use of player position as an indirect proxy for repetitive head-impact exposure, the analytical framework was defined a priori as exploratory and hypothesis-generating.</p><p><strong>Results: </strong>Defenders demonstrated more widespread white matter microstructural differences compared with midfielders, characterized by reduced fractional anisotropy and neurite density index and increased radial and mean diffusivity across multiple association, projection, and commissural tracts (P < 0.05, TFCE-corrected). Comparisons involving goalkeepers revealed fewer and more spatially restricted alterations. No cerebral microhemorrhages were detected on susceptibility-weighted imaging. Neurocognitive performance did not differ significantly among groups.</p><p><strong>Conclusions: </strong>Within the constraints of an exploratory design and operational position definitions, multi-shell diffusion MRI identified position-associated patterns of white matter microstructural variation in amateur soccer players, with defenders showing more extensive alterations. These findings should be interpreted cautiously and primarily serve to inform future studies employing larger samples, objective exposure metrics, and longitudinal designs.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2783-2792"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between posterior cerebral artery involvement and arterial wall enhancement in moyamoya disease: a cross-sectional study with vessel wall imaging.","authors":"Takeshi Funaki, Hideo Chihara, Tomoki Sasagasako, Masakazu Okawa, Yohei Mineharu, Yasutaka Fushimi, Sachi Okuchi, Kentaro Ueno, John Grinstead, Sinyeob Ahn, Alto Stemmer, Taichi Ikedo, Hiroyuki Ikeda, Yoshiki Arakawa","doi":"10.1007/s00234-026-04037-1","DOIUrl":"10.1007/s00234-026-04037-1","url":null,"abstract":"<p><strong>Purpose: </strong>Early detection and activity assessment of posterior cerebral artery (PCA) involvement in moyamoya disease (MMD) are challenging. We aimed to assess the cross-sectional association between PCA involvement and PCA wall enhancement on vessel wall MRI (DANTE T1-SPACE).</p><p><strong>Methods: </strong>We analyzed consecutive patients with MMD who underwent both non-contrast-enhanced and contrast-enhanced DANTE T1-SPACE. Positive wall enhancement was defined as location-appropriate arterial wall enhancement with an enhancement ratio ≥ 1.5. PCA involvement was graded 0-2 on MRA obtained during the same period.</p><p><strong>Results: </strong>Of 368 hemispheres from 184 patients, 56 (15.2%) showed PCA involvement and 17 (4.6%) showed PCA wall enhancement. PCA involvement was present in 94.1% of enhancement-positive hemispheres versus 11.4% of enhancement-negative hemispheres (p < 0.001). The difference was consistent across age, Suzuki stage, and RNF213 genotype strata. Enhancement most often involved the P2A segment. Topographical correspondence between enhancement and the stenoocclusive lesion was excellent (overall percent agreement, 94.1%). PCA wall enhancement was observed in 0.3%, 61.5%, and 18.6% of hemispheres with grade 0, 1, and 2 PCA involvement, respectively. Positive enhancement was more frequent in grade 1 PCA involvement than in grade 2 (adjusted p = 0.02).</p><p><strong>Conclusions: </strong>Statistical and topographical findings suggest a strong cross-sectional association between PCA involvement and PCA wall enhancement. The enhancement may be associated with disease activity and may facilitate detection of early-stage PCA involvement with high specificity; these hypotheses require confirmation in longitudinal cohorts.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2613-2621"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147948727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}