Neuroradiology最新文献

{"title":"Correction to: Association of T1-weighted hyperintensity with timing of peak bilirubin levels in neonates with hyperbilirubinemia.","authors":"Rongrong Wang, Hongzhe Tian, Zhuanqin Ren, Xingxing Zheng, Tianbo Shen, Kun Zhang, Xianjun Li","doi":"10.1007/s00234-025-03731-w","DOIUrl":"10.1007/s00234-025-03731-w","url":null,"abstract":"","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2589"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral vasospasm following aneurysmal subarachnoid hemorrhage: the impact of cocaine use, Hunt-Hess grade, and other risk factors.","authors":"Aliana Rao, Samuel Ricci, Theodore Hannah, Erin Graves, Eric Quach, Kadir Erkmen, Rami Almefty","doi":"10.1007/s00234-025-03713-y","DOIUrl":"10.1007/s00234-025-03713-y","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral vasospasm (CV) is a common complication following aneurysmal subarachnoid hemorrhage (aSAH) that contributes to significant morbidity and mortality. While numerous identified CV risk factors exist, illicit substance use's influence, particularly cocaine, remains controversial. This study aims to elucidate relationships between known risk factors and CV's incidence, severity, and refractoriness.</p><p><strong>Methods: </strong>A retrospective chart review was conducted on all aSAH patients between 2014 and 2023 with inclusion criteria of confirmed aneurysms on digital subtraction angiography (DSA) and available urine drug screens (UDS). Demographic data, Hunt-Hess (HH), modified Fisher Scale (mFS), comorbidities, and vasospasm grades were collected. Outcomes, including vasospasm treatment counts, length of stay (LOS), and 3-month modified Rankin Scale (mRS) scores, were recorded.</p><p><strong>Results: </strong>Of 88 patients, 43% experienced CV. Cocaine use was significantly more prevalent in the CV group (26% vs. 8%, p = 0.04) and increased CV risk (OR = 4.11, 95% CI: 1.25-16.13, p = 0.03), independent of other factors. Higher HH grades were associated with increased CV incidence (OR = 1.75, p = 0.01), severity (β = 0.271, p = 0.02), and 3-month mRS scores (β = 0.81, p < 0.001). Female sex also predicted vasospasm incidence (OR = 4.78, p = 0.01). Older age was associated with worse long-term outcomes (β = 0.05, p = 0.004). In the multivariable analysis, cocaine revealed a significant increased risk of CV incidence (OR = 5.79, p = 0.02). Higher HH grades significantly impacted CV severity (OR = 0.30, p = 0.01) and worse long-term outcomes (OR = 0.957, p < 0.01) in the multivariable analysis.</p><p><strong>Conclusions: </strong>Females, those with positive cocaine use on UDS, and a history of T2DM were at an increased risk of CV with no impact on severity, recurrence, or 3-month outcomes. Older age was associated with worse long-term outcomes. HH grade was significantly associated with increased vasospasm severity, refractoriness to treatment, and worse long-term outcomes as per mRS scores.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2337-2347"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12546373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting periprocedural complications risk in intracranial angioplasty and stenting from integrated high-resolution vessel wall imaging radiomics and clinical characteristics.","authors":"Yu Guo, Chengxiu Yuan, Yuwen Su, Zhe Wang, Songchuan Li, Bao Wang, Chunhong Hu","doi":"10.1007/s00234-025-03757-0","DOIUrl":"10.1007/s00234-025-03757-0","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and validate an integrated model based on MR high-resolution vessel wall imaging (HR-VWI) radiomics and clinical features to preoperatively assess periprocedural complications (PC) risk in patients with intracranial atherosclerotic disease (ICAD) undergoing percutaneous transluminal angioplasty and stenting (PTAS).</p><p><strong>Methods: </strong>This multicenter retrospective study enrolled 601 PTAS patients (PC+, n = 84; PC -, n = 517) from three centers. Patients were divided into training (n = 336), validation (n = 144), and test (n = 121) cohorts. All patients underwent preoperative HR-VWI (precontrast T1-weighted [T1] and postcontrast T1-weighted [T1CE] sequences). We extracted 2,396 radiomic features and selected clinical variables via multivariate logistic regression. Radiomics, clinical and integrated model were developed. Model performance was evaluated using areas under the curve (AUC) and DeLong test. Decision Curve Analysis (DCA) was used to evaluate the net benefit of each model.</p><p><strong>Results: </strong>Age was the sole independent clinical predictor (OR = 1.06, p = 0.001). The integrated model demonstrated favorable predictive performance in the training cohort (AUC: 0.93, 95% CI [0.88, 0.96]), validation cohort (AUC: 0.87, 95% CI [0.74, 0.99]), and test cohort (AUC: 0.87, 95% CI [0.78, 0.95]). It significantly outperformed all clinical models (AUC range: 0.59-0.73; all p < 0.05) and showed performance comparable to the optimal radiomics model (T1-T1CE model; AUC range: 0.80-0.91; all p > 0.05).Notably, the DCA curve indicated that the integrated model achieved the optimal clinical net benefit across the 0-90% threshold range in the test cohort.</p><p><strong>Conclusion: </strong>The integrated model demonstrates clinical utility for preoperative PC risk stratification in PTAS patients.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2459-2469"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between hemodynamics and radiomic features in thrombosed intracranial aneurysms.","authors":"Zonghan Lyu, Andres Gudino, Navami Shenoy, Carlos Dier, Elena Sagues, Jingfeng Jiang, Edgar A Samaniego","doi":"10.1007/s00234-025-03730-x","DOIUrl":"10.1007/s00234-025-03730-x","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluating intracranial aneurysm (IA) rupture risk is essential for guiding management. Although intrasaccular thrombosis (IST) is less common, it can contribute to aneurysm growth, mass effect, and rupture. Aneurysm wall enhancement (AWE) on high-resolution MRI (HR-MRI) offers valuable insight into IST and IA progression. Using radiomics, we extracted spatial information of the aneurysm wall to characterize AWE. This study aimed to explore correlations between radiomics-based AWE profiles and gross hemodynamic parameters, integrating imaging and flow dynamics to better understand IST.</p><p><strong>Methods: </strong>Radiomic analysis was conducted on a cohort of 3T HR-MRI scans from IA with IST. Three-dimensional vascular reconstructions and CFD simulations were conducted to quantify hemodynamic parameters. Spearman's correlation was performed to correlate aneurysm morphology, AWE patterns, and aneurysmal hemodynamic characteristics.</p><p><strong>Results: </strong>A total of 37 thrombosed IAs were included in the analysis, comprising 22 fusiform (59.5%) and 15 saccular (40.5%) aneurysms. Six AWE RFs demonstrated strong correlations with aneurysm volume and surface area (ρ > 0.7 for both). Ten AWE RFs were highly correlated with flow vortex parameters (ρ > 0.7), and one showed a strong correlation with wall shear stress (WSS)-related metrics (ρ > 0.7). In the subset of saccular IAs, 20 AWE RFs were strongly associated with WSS-related metrics. In contrast, fusiform IAs showed stronger correlations between AWE RFs and vortex core characteristics. These findings suggest that elevated AWE is closely associated with regions of high oscillatory shear index and unstable flow vortices, indicating a potential link between wall enhancement and disturbed intra-aneurysmal hemodynamics. Conclusions Stagnant flow may promote degenerative remodeling of the aneurysm wall and IST. A combined spatiotemporal analysis of hemodynamic parameters and AWE patterns provide information about underlying biological processes of IAs, including the development of IST.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2447-2458"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12546522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESNR 2025.","authors":"","doi":"10.1007/s00234-025-03726-7","DOIUrl":"10.1007/s00234-025-03726-7","url":null,"abstract":"","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"1-368"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative plaque characteristics based on 3D high-resolution vessel wall imaging predict long-term recurrence in intracranial atherosclerotic stroke.","authors":"Ying Zhao, Jiajia Yang, Yao Dai, Yuzhu Ma, Ziyang Song, Chunhong Hu, Yu Zhang","doi":"10.1007/s00234-025-03642-w","DOIUrl":"10.1007/s00234-025-03642-w","url":null,"abstract":"","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2309-2319"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical venous opacification score predicts outcomes after thrombectomy in large vessel occlusion stroke: a systematic review and meta-analysis.","authors":"Rafaela Correia Maciel, Wei Jun Lee, Beatriz Aguiar de Macedo, Davi Barbosa Pereira da Silva, Amanda Boutrik, Maria Clara Merighi, Henrique Alexsander Ferreira Neves, Luisa Braga Salles Machado, Bernard Giancristoforo Campos","doi":"10.1007/s00234-025-03701-2","DOIUrl":"10.1007/s00234-025-03701-2","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess whether the Cortical Vein Opacification Score (COVES), a visual scoring system based on single-phase Computed Tomography Angiography (CTA), is associated with clinical and radiological outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO) after endovascular treatment (EVT).</p><p><strong>Methods and materials: </strong>A systematic review and meta-analysis were conducted according to PRISMA guidelines. PubMed, EMBASE, and Cochrane Library were searched from inception to early June 2025, identifying 572 articles, of which 6 were included. Post-hoc analyses of randomized controlled trials (RCTs) and observational studies, with patients stratified by venous outflow (VO) status, were included. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed using I² statistic. Sensitivity analyses were performed in outcomes that presented high heterogeneity.</p><p><strong>Results: </strong>The six studies included 2,709 patients. VO + was associated with higher excellent (RR 1.34; p < 0.001) and successful reperfusion (RR 1.05; p = 0.001). Functional independence at 90 days (modified Rankin Scale [mRS] 0-2) was higher in the VO + group (RR 2.67; p = 0.002). VO + was associated with lower rates of symptomatic intracranial hemorrhage (sICH), parenchymal hematoma (PH), and mortality at 90 days.</p><p><strong>Conclusion: </strong>VO + is associated with better reperfusion and functional independence, as well as reduced hemorrhagic complications and mortality. These findings support the potential prognostic value of VO in AIS-LVO patients undergoing EVT. Heterogeneity and limited number of studies warrant cautious interpretation. Standardized imaging protocols and prospective validation are needed.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2483-2496"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of resolve DWI and DCE MRI in differentiating benign and malignant skull base lesions.","authors":"Pradeep Mohanasundaram, Jyoti Kumar, Gaurav Shanker Pradhan, Daljit Singh, Ishwar Singh","doi":"10.1007/s00234-025-03760-5","DOIUrl":"10.1007/s00234-025-03760-5","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the utility of RESOLVE Diffusion-Weighted Imaging (DWI) and Dynamic Contrast-Enhanced (DCE) MRI in differentiating benign and malignant skull base lesions using qualitative and quantitative imaging parameters.</p><p><strong>Methods: </strong>This prospective study included 44 patients with 45 skull base lesions who underwent MRI with RESOLVE DWI and DCE-MRI. Apparent diffusion coefficient (ADC) values and lesion-to-medulla ADC ratios were calculated from DWI. Perfusion parameters (Ktrans, Kep, Ve) and time-intensity curve (TIC) were derived from DCE-MRI. Benign and malignant lesions were statistically compared, and receiver operating characteristic analysis was performed to evaluate diagnostic capability.</p><p><strong>Results: </strong>Malignant lesions had significantly lower mean ADC values (0.88 × 10⁻³ mm²/s) than benign lesions (1.05 × 10⁻³ mm²/s, p = 0.033). The lesion-to-medulla ADC ratio was also significantly lower in malignant lesions (1.03 vs. 1.25, p = 0.029), yielding 89% sensitivity and 44% specificity at a cutoff ≤ 1.167 (AUC = 0.695). Among DCE-MRI parameters, both Kep and the distribution of time-intensity curve (TIC) showed significant differences between benign and malignant lesions (p = 0.037 and p < 0.001, respectively). Kep was higher in malignant lesions (0.98 vs. 0.78), with an AUC of 0.689, 94% sensitivity, and 52% specificity at a cutoff of ≥ 0.581. Ktrans and Ve did not show significant statistical difference.</p><p><strong>Conclusion: </strong>RESOLVE DWI and DCE-MRI are effective non-invasive tools for differentiating benign and malignant skull base lesions. The ADC ratio and Kep are valuable quantitative markers, while TIC pattern analysis offers complementary qualitative insights, enhancing diagnostic confidence.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2573-2583"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved CTA imaging for stroke evaluation - deep learning and iterative reconstruction comparative study.","authors":"Michal Pula, Emilia Kucharczyk, Marcin Piersiak, Maciej Ziomek, Agata Zdanowicz-Ratajczyk, Maciej Guzinski","doi":"10.1007/s00234-025-03733-8","DOIUrl":"10.1007/s00234-025-03733-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study compares a novel reconstruction algorithm deep learning-based image reconstruction (DLIR) and adaptive statistical iterative reconstruction-Veo (ASIR-V) for CTA in acute ischemic stroke (AIS) patients, emphasizing DLIR's potential to improve diagnostic accuracy and visualization of large vessel occlusion.</p><p><strong>Methods: </strong>This study retrospectively assessed 108 consecutive AIS-suspected emergency department patients (mean age 72.3 years +/- 17) who underwent head and neck CTA with DLIR and ASIR-V reconstructions. The analysis compared the impact of DLIR versus ASIR-V on image quality, assessing signal-to-noise (SNR), contrast-to-noise ratios (CNR), and contrast-enhanced arteries homogeneity computed on mean HU values and SD in six regions of interest located in head and neck including three arteries.</p><p><strong>Results: </strong>The DLIR reconstruction allowed for significant SNR and CNR improvement, with the largest SNR distinction obtained in the common carotid artery (52.29% increased SNR) and white matter of the pons (63.98% increased SNR). Among the three regions subject to CNR evaluation DLIR yielded superiority in the neck and posterior cerebral fossa while ASIR-V accounted for higher CNR in the medial cerebral fossa (MCF). Additionally, DLIR-reconstructed images achieved a 21.10% improvement in arterial homogeneity, enhancing the visualization of potential occlusion.</p><p><strong>Conclusion: </strong>DLIR yields superior image quality of the contrast-enhanced head and neck structures in CTA, providing artery images with increased homogeneity and potentially allowing for more proficient occlusion evaluation specifically in the area of the posterior cerebral fossa. However, this technique faces challenges in the visualization of MCF.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2437-2445"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial wall enhancement indicates higher reperfusion rates in non-ruptured aneurysms after endovascular treatment with stent-assisted coiling.","authors":"Valentin Ladenhauf, Malik Galijasevic, Milovan Regodic, Verena Rass, Christian Freyschlag, Johannes Deeg, Leonhard Gruber, Michael Swoboda, Jakub Bochnicka, Stephanie Mangesius, Lukas Lenhart, Elke Ruth Gizewski, Astrid Ellen Grams","doi":"10.1007/s00234-025-03709-8","DOIUrl":"10.1007/s00234-025-03709-8","url":null,"abstract":"<p><strong>Background and purpose: </strong>There are differing results in recent literature concerning aneurysmal wall enhancement (AWE) after endovascular treatment (ET) of intracranial aneurysms (IAs). The aim of this retrospective study is to investigate if the presence of AWE of unruptured treated IAs via stent-assisted coiling (SAC) is associated with higher reperfusion rates.</p><p><strong>Materials and methods: </strong>The clinical courses of 58 patients with IAs after ET via SAC were examined over the timespan of up to 5 years, assessing for AWE in T1 SPACE FS and T1 SE FS blood suppression sequences after contrast administration, events of reperfusion and need for retreatment.</p><p><strong>Results: </strong>58 patients were included (23 with AWE, 35 without). 18 of 23 patients (78.3%) with AWE showed reperfusion after treatment, compared to 15 of 35 patients (42.9%) without AWE. Reperfusion rates were significantly higher in patients with AWE, compared to those without AWE (p = 0.0139) also after propensity score matching (p = 0.0456).</p><p><strong>Conclusions: </strong>In patients with unruptured IAs treated exclusively with SAC, AWE on follow-up MRI was significantly associated with higher reperfusion rates. AWE may serve as an early imaging biomarker of post-treatment instability.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2327-2335"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12546472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}