Neuroradiology最新文献

{"title":"Evaluating a clinically available artificial intelligence model for intracranial aneurysm detection: a multi-reader study and algorithmic audit.","authors":"Bin Hu, Haitao He, Zhao Shi, Li Wang, Quanhui Liu, Zhiyuan Sun, Longjiang Zhang","doi":"10.1007/s00234-024-03536-3","DOIUrl":"10.1007/s00234-024-03536-3","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to validate a clinically available artificial intelligence (AI) model to assist general radiologists in the detection of intracranial aneurysm (IA) in a multi-reader multi-case (MRMC) study, and to explore its performance in routine clinical settings.</p><p><strong>Methods: </strong>Two distinct cohorts of head CT angiography (CTA) data were assembled to validate an AI model. Cohort 1, comprising gold-standard consecutive CTA cases, was used in an MRMC study involving six board-certified general radiologists. Cohort 2, representing clinical CTA cases, was used to simulate a routine clinical setting. Following these evaluations, an algorithmic audit was conducted to identify any unusual or unexpected behaviors exhibited by the model.</p><p><strong>Results: </strong>Cohort 1 consisted of 131 CTA cases, while Cohort 2 included 515 CTA cases. In the MRMC study, the AI-assisted strategy demonstrated a significant improvement in aneurysm diagnostic performance, with the area under the receiver operating characteristic curve increasing from 0.815 (95%CI: 0.754-0.875) to 0.875 (95%CI: 0.831-0.921; p = 0.008). In the AI-based first-reader study, 60.4% of the CTA cases were identified as negative by the AI, with a high negative predictive value of 0.994 (95%CI: 0.977-0.999). The algorithmic audit highlighted two issues for improvement: the accurate detection of tiny aneurysms and the effective exclusion of false-positive lesions.</p><p><strong>Conclusion: </strong>This study highlights the clinical utility of a high-performance AI model in detecting IAs, significantly improving general radiologists' diagnostic performance with the potential to reduce their workload in routine clinical practice. The algorithmic audit offers insights to guide the development and validation of future AI models.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"855-864"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal changes and implications of diffusion tensor imaging metrics and cerebral white matter volume in patients undergoing carotid endarterectomy - a prospective study.","authors":"Andrea Varga, Csongor Péter, Milán Vecsey-Nagy, Gyula Gyebnár, Sarolta Borzsák, Bálint Szilveszter, Zsuzsanna Mihály, Zsófia Czinege, Péter Sótonyi","doi":"10.1007/s00234-024-03527-4","DOIUrl":"10.1007/s00234-024-03527-4","url":null,"abstract":"<p><strong>Aims: </strong>To test utility of diffusion MRI-derived indices in carotid endarterectomy (CEA), change of diffusion tensor imaging (DTI) metrics, cerebral white matter (WM) volumes were evaluated and predictors of overall mortality determined.</p><p><strong>Methods: </strong>Prospectively enrolled participants had preoperative, immediate and late postoperative DTI after CEA. WM volumes, DTI metrics (fractional anisotropy, FA; axial, radial, mean diffusivities; AD, RD, MD, respectively) were calculated for the index/contralateral hemispheres at all time points. Temporal changes, predictors of log₂-transformed WM volumes, DTI values were analyzed using linear mixed model. Uni- and multivariable Cox proportional hazards models were used to identify predictors of mortality.</p><p><strong>Results: </strong>60 subjects (57% male, 69.5 ± 7.2years) were included. Significantly increased AD and MD was observed in both hemispheres comparing the preoperative and immediate postoperative DTI metrics (index AD: β = 0.02 [95%CI:0.01,0.02], p < 0.001; index MD: β = 0.02 [95%CI:0.01,0.03], p < 0.001; contralateral AD: β = 0.01 [95%CI:0.01,0.02], p = 0.001; contralateral MD: β = 0.02 [95%CI:0.01,0.03], p = 0.003). The index MD decreased (β = 0.01 [95%CI:0.01,0.001], p = 0.04), bilateral WM volumes (index WM: β = 0.04 [95%CI:0.02,0.07], p < 0.001; contralateral WM: β = 0.05 [95%CI:0.03,0.07], p < 0.001) decreased significantly between the immediate and late postoperative scans. Postoperative contralateral FA correlated significantly with lower mortality (HR = 0.001 [95%CI:0.001,0.19], p = 0.02); postoperative contralateral RD (HR = 3.74 × 10⁴ [95%CI:1.62,8.60 × 10⁸], p = 0.04) and MD (HR = 1.19 × 10⁵ [95%CI:1.03,1.37 × 10¹⁰], p = 0.049) were significant predictors of mortality.</p><p><strong>Conclusion: </strong>The increase of various DTI metrics from pre-to-postoperative may be indicative of microstructural deterioration following CEA. Temporal changes between the immediate and late postoperative scans suggest, however, reversal of detrimental WM changes and clearance of presumed subclinical WM edema. Our results also imply, that preserved cerebral properties are protective after CEA.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"943-959"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of MELD and MAP18 in patients with structural temporal lobe epilepsy.","authors":"Francesca De Luca, Jose Carlos Pariente, Sofia González-Ortiz, Estefanía Conde-Blanco, Mar Carreño, Xavier Setoain, Nuria Bargalló","doi":"10.1007/s00234-025-03549-6","DOIUrl":"10.1007/s00234-025-03549-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study compared two image post-processing toolboxes primarily designed for focal cortical dysplasia (FCD): Multi-Centre Epilepsy Lesion Detection (MELD) and Morphometric Analysis Program (MAP18), in identifying temporal lobe epilepsy (TLE) structural lesions on MRI.</p><p><strong>Methods: </strong>This retrospective study examined 79 adults, 58 patients with confirmed TLE, and 21 healthy controls. All participants underwent an elective brain MRI between June 2007 - May 2023 at Hospital Clinic, Barcelona, Spain. All the 3D T1-weighted images were processed using MELD and MAP18 to detect potential epileptogenic lesions. The location (lateral or mesial) and laterality of the reference TLE structural lesion (refTLE) were determined through histopathology or multidisciplinary consensus based on clinical data. Toolboxes' performance was evaluated using descriptive statistics, specificity, and diagnostic accuracy. Additionally, a second-look MRI was conducted for cases where abnormalities detected by MELD and MAP18 did not match the refTLE.</p><p><strong>Results: </strong>MELD and MAP18 demonstrated variability in specificity and diagnostic accuracy. Specificity ranged from 48% to 86%, with ProbMAP (MAP18) achieving the highest values. Global diagnostic accuracy ranged from 7% to 42%, with MELD showing the highest performance. In four patients with visible epileptogenic lesions on MRI, MELD and MAP18 identified additional abnormalities that were previously overlooked. Moreover, MELD detected one TLE lesion in one patient initially classified as MRI-negative (nonlesional).</p><p><strong>Conclusion: </strong>Incorporating tools like MELD and MAP18 into the diagnostic workflow can enhance the detection of TLE-related abnormalities on MRI, potentially improving patient outcomes and aiding in clinical decision-making.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"865-874"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased parietal operculum functional connectivity following vestibular rehabilitation in benign paroxysmal positional vertigo patients with residual dizziness: a randomized controlled resting-state fMRI study.","authors":"Zhengwei Chen, Yueji Liu, Yang Sun, Xiue Wei, Haiyan Liu, You Lv, Junjun Shan, Shanshan Dong, Lijie Xiao, Liangqun Rong","doi":"10.1007/s00234-024-03535-4","DOIUrl":"10.1007/s00234-024-03535-4","url":null,"abstract":"<p><strong>Introduction: </strong>Residual dizziness (RD) is common in patients with benign paroxysmal positional vertigo (BPPV) after successful canalith repositioning procedures. This study aimed to investigate the therapeutic effects of vestibular rehabilitation (VR) on BPPV patients experiencing RD, and to explore the impact of VR on functional connectivity (FC), specifically focusing on the bilateral parietal operculum (OP) cortex.</p><p><strong>Methods: </strong>Seventy patients with RD were randomly assigned to either a four-week VR group or a control group that received no treatment. Assessments included the dizziness Visual Analog Scale (VAS), Dizziness Handicap Inventory (DHI), Hamilton Anxiety/Depression Scale (HAMA/HAMD), and resting-state functional magnetic resonance imaging.</p><p><strong>Results: </strong>The VR group exhibited a significant decline in scores on VAS, DHI, HAMA and HAMD following training (all p < 0.05). Furthermore, the VR group demonstrated increased FC between the left OP and both the left precuneus and left middle frontal gyrus (MFG), and between the right OP and the right MFG (voxel-level p < 0.001; cluster-level p < 0.05, FDR corrected). Additionally, these changes in FC were found to correlate with clinical features, including scores on HAMA (p = 0.012, r =  - 0.513) and DHI (p = 0.022, r =  - 0.475) after the intervention.</p><p><strong>Conclusion: </strong>This study demonstrated the therapeutic effects of VR in alleviating RD and emotional disorders, as well as in improving overall quality of life. Notably, these positive outcomes might be associated with increased FC between brain regions involved in mood regulation and vestibular processing. Our findings offer novel neuroimaging evidence that supports the hypothesis that VR facilitates dynamic vestibular compensation.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"931-942"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of frailty with outcomes in patients with large vessel occlusion stroke undergoing mechanical thrombectomy.","authors":"Abdul Rasheed Bahar, Yasemin Bahar, George Kidess, Paawanjot Kaur, Vaishnavi Sirekulam, Mohamed S Alrayyashi, Ali Al-Ramadan, Mohammad Hazique, M Chadi Alraies","doi":"10.1007/s00234-025-03562-9","DOIUrl":"10.1007/s00234-025-03562-9","url":null,"abstract":"<p><strong>Purpose: </strong>Frailty is a clinical syndrome characterized by reduced physiological reserve and increased vulnerability to adverse health outcomes, potentially impacting patients undergoing mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion (LVO). This study aimed to evaluate the influence of frailty on in-hospital outcomes in these high-risk patients.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of the National Inpatient Sample (2016-2021), identifying patients with large vessel occlusion stroke undergoing mechanical thrombectomy. Frailty was defined using the Johns Hopkins Adjusted Clinical Groups (ACG) frailty-defining diagnoses. Propensity score matching (PSM) was applied to create balanced cohorts for primary analysis.</p><p><strong>Results: </strong>In propensity-matched analysis, frail patients had higher in-hospital mortality (12.06% vs. 9.90%, P = 0.004), seizures (2.35% vs. 1.65%, P = 0.048), major adverse cardiac events (MACE) (15.29% vs. 13.51%, P = 0.044), pulmonary embolism (2.38% vs. 1.62%, P = 0.031), and hospital-acquired pneumonia (6.10% vs. 4.80%, P = 0.023). Sensitivity analysis using multivariable logistic regression confirmed similar trends, with frailty remaining an independent predictor of mortality (aOR 1.24, 95% CI: 1.04-2.23, P = 0.04).</p><p><strong>Conclusion: </strong>Frailty is associated with significantly worse outcomes, including higher mortality, MACE, and pneumonia in patients undergoing mechanical thrombectomy for LVO. These findings emphasize the need for frailty screening as part of pre-procedural risk stratification and tailored management strategies to improve patient outcomes.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"845-854"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging the artery of Percheron: a pictorial review of associated pathology with important mimics of bithalamic abnormalities.","authors":"Mansi Jantre, David C Howlett","doi":"10.1007/s00234-025-03585-2","DOIUrl":"10.1007/s00234-025-03585-2","url":null,"abstract":"<p><strong>Background and purpose: </strong>The Artery of Percheron (AoP) supplying bilateral paramedian thalami and rostral midbrain is a rare anatomical variant. In the event of occlusion of AoP, a characteristic pattern of ischaemia is seen, presenting as bithalamic signal abnormality on magnetic resonance imaging (MRI). However, this particular imaging finding has significant radiological and clinical overlap with other conditions, necessitating a comprehensive understanding of the imaging characteristics and potential differential diagnosis. The aim of this pictorial essay is to provide a visual documentation of varying appearances of AoP infarction on imaging and highlighting other important pathologies that may cause similar appearance.</p><p><strong>Methods: </strong>Retrospective collection and review of imaging from patients with confirmed AoP infarction and other pathologies causing bithalamic signal abnormalities and identify crucial imaging caveats for differentiation.</p><p><strong>Results: </strong>We present a comprehensive visual spectrum of AoP infarction patterns, including bithalamic involvement (paramedian thalamic lesions) with or without midbrain involvement. Additionally, the \"V\" sign, observed on FLAIR and DWI sequences, is fairly characteristic of AoP infarction. Other important vascular causes seen include top of basilar artery syndrome, internal cerebral vein thrombosis as well as neoplastic lesions including diffuse midline glioma (DMG) H3 K27-altered. Additionally various inflammatory, metabolic and infective etiologies including viral encephalitis like Japanese encephalitis can cause a similar appearance.</p><p><strong>Conclusions: </strong>This pictorial essay demonstrates the diverse patterns of AoP infarction and emphasizes the significance of recognizing important mimics of this condition, highlighting the need for a meticulous evaluation. Improved awareness and understanding of these imaging characteristics will contribute to more effective management of patients with thalamic strokes.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"785-798"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced targeted microsphere embolization for arteriovenous malformations: state-of-the-art and future directions.","authors":"Ali Mortezaei, Khaled M Taghlabi, Nadir Al-Saidi, Saketh Amasa, Rachael E Whitehead, Alex Hoang, Kurt Yaeger, Amir H Faraji, Ramanathan Kadirvel, Sherief Ghozy","doi":"10.1007/s00234-025-03584-3","DOIUrl":"10.1007/s00234-025-03584-3","url":null,"abstract":"<p><strong>Background: </strong>Arteriovenous malformations (AVMs) present a significant therapeutic challenge, as current treatment modalities frequently fail to achieve complete and rapid obliteration and are associated with substantial morbidity in both the short and long term. This underscores the critical need for innovative therapeutic strategies that enable efficient AVM obliteration while minimizing patient risk. The current review aims to comprehensively assess the role of ATME in AVM management, examining its clinical efficacy, associated risks and benefits, and the economic and ethical implications to provide valuable foundation for future studies and guiding development in treatment strategies for AVMs.</p><p><strong>Results: </strong>Advanced targeted microsphere embolization (ATME) has emerged as a promising therapeutic option, initially developed for the localized treatment of AVMs and unresectable tumors, including liver cancer. By providing targeted delivery, ATME offers potential advantages over conventional approaches in achieving effective local control.</p><p><strong>Conclusions: </strong>ATME are safe and effective for vascular disease and cancer. Although evidence for microspheres in AVMs is scarce, results are promising. Future research could refine eligibility criteria, evaluate treatment techniques, and optimize ATME.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"1009-1022"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The probability of cerebral amyloid angiopathy according to the Simplified Edinburgh CT criteria in a large, unselected lobar intracerebral hemorrhage population.","authors":"Amir Hillal, Trine Apostolaki-Hansson, Birgitta Ramgren, Björn Hansen, Bo Norrving, Johan Wassélius, Teresa Ullberg","doi":"10.1007/s00234-025-03555-8","DOIUrl":"10.1007/s00234-025-03555-8","url":null,"abstract":"<p><strong>Purpose: </strong>Early identification of the underlying cause of intracerebral hemorrhage (ICH) is important for treatment and prognosis. This study aims to investigate the association of hematoma volume and other clinical parameters on the distribution of cerebral amyloid angiopathy (CAA) probability according to the simplified Edinburgh CT criteria in a large, unselected intracerebral hemorrhage (ICH) population.</p><p><strong>Method: </strong>Patients with spontaneous ICH residing in Skane county registered with clinical data in the Swedish Stroke Register 2016-2020 were included. Radiological parameters were evaluated using baseline non-contrast CT (NCCT) for categorization according to the simplified Edinburgh CT criteria by the presence of subarachnoid hemorrhage (SAH) and fingerlike-projections (FLP). Multivariable logistic regression analysis was used to determine factors associated with an increased (intermediate/high) CAA probability.</p><p><strong>Results: </strong>Of 666 patients with lobar ICH, 190 (29%) had high, 92 (14%) had intermediate, and 384 (58%) had low CAA probability. Patients with increased CAA probability presented more often with decreased level of consciousness, larger hematoma volumes, and higher 90-day mortality. Baseline hematoma volume [10-30 ml (OR = 4.03;95%CI: 2.26-7.19); 30-80 ml (OR = 12.00;95%CI:7.26-22.53); >80 ml (OR = 30.00;95%CI:15.94-59.09)], female sex (OR = 1.58;95%CI:1.08-2.32) and age (OR = 1.04;95%CI:1.02-1.06) were associated with an increased odds of having an increased CAA probability.</p><p><strong>Conclusion: </strong>We identified a strong association between baseline hematoma volume and an increased probability of CAA in lobar ICH patients on NCCT, indicating that large hematoma volumes alone may contribute to the occurrence of FLP and SAH, and act as a confounder for the simplified Edinburgh CT criteria. Validation against MRI is warranted.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"823-831"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards clinical implementation of automated segmentation of vestibular schwannomas: a reliability study comparing AI and human performance.","authors":"Stefan Cornelissen, Sammy M Schouten, Patrick P J H Langenhuizen, Henricus P M Kunst, Jeroen B Verheul, Peter H N De With","doi":"10.1007/s00234-025-03611-3","DOIUrl":"10.1007/s00234-025-03611-3","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinimetric reliability of automated vestibular schwannoma (VS) segmentations by a comparison with human inter-observer variability on T1-weighted contrast-enhanced MRI scans.</p><p><strong>Methods: </strong>This retrospective study employed MR images, including follow-up, from 1,015 patients (median age: 59, 511 men), resulting in 1,856 unique scans. Two nnU-Net models were trained using fivefold cross-validation to create a single-center segmentation model, along with a multi-center model using additional publicly available data. Geometric-based segmentation metrics (e.g. the Dice score) were used to evaluate model performance. To quantitatively assess the clinimetric reliability of the models, automated tumor volumes from a separate test set were compared to human inter-observer variability using the limits of agreement with the mean (LOAM) procedure. Additionally, new agreement limits that include automated annotations are calculated.</p><p><strong>Results: </strong>Both models performed comparable to current state-of-the-art VS segmentation models, with median Dice scores of 91.6% and 91.9% for the single and multi-center models, respectively. There is a stark difference in clinimetric performance between both models: automated tumor volumes of the multi-center model fell within human agreement limits in 73% of the cases, compared to 44% for the single-center model. Newly calculated agreement limits including the single-center model, resulted in very high and wide limits. For the multi-center model, the new agreement limits were comparable to human inter-observer variability.</p><p><strong>Conclusion: </strong>Models with excellent geometric-based metrics do not necessarily imply high clinimetric reliability, demonstrating the need to clinimetrically evaluate models as part of the clinical implementation process. The multi-center model displayed high reliability, warranting its possible future use in clinical practice. However, caution should be exercised when employing the model for small tumors, as the reliability was found to be volume-dependent.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"1049-1059"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thalamic changes in patients with chronic facial pain.","authors":"Anton Pashkov, Elena Filimonova, Boris Zaitsev, Azniv Martirosyan, Galina Moysak, Jamil Rzaev","doi":"10.1007/s00234-024-03508-7","DOIUrl":"10.1007/s00234-024-03508-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate structural alterations in the thalamus in patients with primary trigeminal neuralgia and provide a detailed perspective on thalamic remodeling in response to chronic pain at the level of individual thalamic nuclei.  METHODS: We analyzed a sample of 62 patients with primary trigeminal neuralgia who underwent surgical treatment, along with 28 healthy participants. Magnetic resonance imaging (MRI) data were acquired using a 3T system equipped with a 16-channel receiver head coil. Segmentation of the thalamic nuclei was performed using FreeSurfer 7.2.0. We divided the group of patients with trigeminal neuralgia into two subgroups: those with right-sided pain and those with left-sided pain. Each subgroup was compared to a control group by means of one-way ANOVA. Associations between morphometric and clinical variables were assessed with Spearman correlation coefficient.</p><p><strong>Results: </strong>Our results revealed significant gray matter volume changes in thalamic nuclei among patients with trigeminal neuralgia. Notably, the intralaminar nuclei (centromedian/parafascicular) and nuclei associated with visual and auditory signal processing (lateral and medial geniculate bodies) exhibited significant alterations, contrasting with the ventral group nuclei involved in nociceptive processing. Additionally, we found no substantial volume increase in any of the studied nuclei following successful surgical intervention 6 months later. The volumes of thalamic nuclei were negatively correlated with pain intensity and disease duration.</p><p><strong>Conclusion: </strong>The results of this study, although preliminary, hold promise for clinical applications as they reveal previously unknown structural alterations in the thalamus that occur in patients with chronic trigeminal neuralgia.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"895-908"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}