Neuroradiology最新文献

{"title":"Ex vivo ultra-high field magnetic resonance imaging of human epileptogenic specimens from primarily the temporal lobe: A systematic review.","authors":"Marie-Julie D K Lemmens, R H G J van Lanen, D Uher, A J Colon, M C Hoeberigs, G Hoogland, A Roebroeck, D Ivanov, B A Poser, R P W Rouhl, P A M Hofman, I Gijselhart, G S Drenthen, J F A Jansen, W H Backes, K Rijkers, O E M G Schijns","doi":"10.1007/s00234-024-03474-0","DOIUrl":"10.1007/s00234-024-03474-0","url":null,"abstract":"<p><strong>Purpose: </strong>Magnetic resonance imaging (MRI) is the preferred diagnostic tool for the detection of structural cerebral lesions in patients with epilepsy. Ultra-high field (UHF) MRI with field strengths ≥7 Tesla has been reported to improve the visualization and delineation of epileptogenic lesions. The use of ex vivo UHF MRI may expand our knowledge on the detection and detailed micromorphology of subtle epileptogenic lesions by bridging the gap between in vivo MRI and histopathology.</p><p><strong>Methods: </strong>A systematic review of available literature was conducted following PRISMA guidelines. A descriptive analysis of included articles was performed, focusing on (I) the ability of ex vivo UHF MRI to detect subtle abnormalities related to epilepsy, (II) different post-processing methods, and (III) concordance between UHF MRI and histopathology.</p><p><strong>Results: </strong>Eleven studies with focus on the depiction of focal cortical dysplasia (n = 4) or hippocampal sclerosis (n = 7) as causative lesion of drug-resistant epilepsy were included. Ex vivo UHF MRI proved its ability to visualize the anatomy of cortical and hippocampal structures in greater detail when compared to ex vivo conventional field strengths. Different MRI post-processing methods enabled differentiation between lesional subtypes and provided novel insights into (peri)lesional characteristics. Concordance between ex vivo UHF MRI findings and histopathology was high.</p><p><strong>Conclusion: </strong>Acquisition of ex vivo UHF MRI and its image processing has the potential to depict epileptogenic abnormalities in greater detail with a spatial resolution approximating histological images. The translation of ex vivo UHF MRI features to in vivo clinical settings remains challenging and urges further exploration.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"875-893"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A semantic segmentation model for automatic precise identification of pituitary microadenomas with preoperative MRI.","authors":"ChenGang Yuan, Hang Qu, HuMing Dai, HaiXiao Jiang, DeMao Cao, LiYing Shao, LiangXue Zhou, AiJun Peng","doi":"10.1007/s00234-025-03599-w","DOIUrl":"10.1007/s00234-025-03599-w","url":null,"abstract":"<p><strong>Purpose: </strong>Magnetic resonance imaging (MRI) is an essential technique for diagnosing pituitary adenomas; however, it is also challenging for neurosurgeons to use it to precisely identify some types of microadenomas. A novel neural network model was developed using preoperative MRI to assist clinicians in diagnosing pituitary microadenomas.</p><p><strong>Method: </strong>Sixty patients with pathologically diagnosed pituitary microadenomas, including hyperprolactinemia (n = 19), growth hormone microadenomas (n = 17), and adrenocorticotropin microadenomas (n = 24), were enrolled. An image edge-supervised same receptive field semantic segmentation network was developed based on T1-weighted, T2-weighted, and contrast-enhanced T1-weighted images.</p><p><strong>Results: </strong>The mean Intersection over Unions of our neural network model were 0.7013 ± 0.3400, 0.7295 ± 0.321, and 0.8053 ± 0.3052 for the test sets of T1-weighted, T2-weighted, and contrast-enhanced T1-weighted sequences, respectively, while the Dice Similarity Coefficient values were 0.8075 ± 0.3895, 0.8192 ± 0.3733, and 0.8860 ± 0.3443 for the corresponding sequences. The performance on contrast-enhanced T1-weighted images was better than that of the other two MR sequences.</p><p><strong>Conclusions: </strong>The image edge-supervised same receptive field segmentation network can potentially be used to precisely identify pituitary microadenomas automatically with preoperative MRI. The developed model exhibited good performance with contrast-enhanced T1-weighted images and could help neurosurgeons accurately determine the locations of pituitary microadenomas.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"1061-1070"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis into the haemorrhage rate during follow-up of asymptomatic high-grade intracranial dural arterio-venous fistulas (dAVF) - results from a single centre study.","authors":"Kaustubha Ghate, Matthew Page, Shane Lee, James Caldwell, Ben McGuinness","doi":"10.1007/s00234-025-03572-7","DOIUrl":"10.1007/s00234-025-03572-7","url":null,"abstract":"","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"987-993"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pretreatment and early treatment with statins on safety and efficacy outcomes in patients after acute ischemic stroke undergoing endovascular thrombectomy: a systematic review and meta-analysis.","authors":"Ocílio Ribeiro Gonçalves, Gabriel de Almeida Monteiro, Ana B Santos, Anthony Hong, Maria Antonia Oliveira Machado Pereira, Christian Ken Fukunaga, Hilária Saugo Faria, Luis Otávio Nogueira, Filipe Virgilio Ribeiro, Márcio Yuri Ferreira, João Victor Araújo de Oliveira, Kelson James Almeida","doi":"10.1007/s00234-025-03583-4","DOIUrl":"10.1007/s00234-025-03583-4","url":null,"abstract":"<p><strong>Introduction: </strong>It remains unclear whether early statin treatment and statin pre-treatment could change prognosis in patients after ischemic stroke undergoing endovascular thrombectomy (EVT).</p><p><strong>Objectives: </strong>This study aims to assess whether both statins pretreatment and early statins in-hospital treatment impact the outcomes of patients with acute ischemic stroke (AIS) undergoing EVT.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, and Cochrane Central Register of Controlled Trials from inception to June 2024. The early statin use was defined as in-hospital administration of statins post-stroke onset. The statin pre-treatment was defined as the regular use of statins because of any previous indication. The efficacy outcomes were favorable functional outcomes at 90 days, reduced neurological deterioration, and NIHSS improvement greater or equal to 4 points from baseline. We defined a favorable functional outcome as a mRS of 0-2 points. The safety outcomes included symptomatic intracranial hemorrhage (sICH), any ICH, and all-cause death. All statistical analyses were performed using R version 4.4.0.</p><p><strong>Results: </strong>Seven observational studies comprising 2,440 patients were included. The incidence of favorable functional outcomes (mRS 0-2) in 90 days(RR 1.74; 95% CI 1.38-2.20; p < 0.001; I² = 52.4%) was significantly increased in the early statins group compared with the non-statins group. In addition, sICH (RR 0.48; 95% CI 0.29-0.80; p = 0.005; I² = 45.2%), any ICH (RR 0.65; 95% CI 0.52-0.81; p < 0.001; I² = 0.0%), neurological deterioration (RR 0.36; 95% CI 0.26-0.49; p < 0.001; I² = 0%), and death in 90 days (RR 0.38; 95% CI 0.28-0.53; p < 0.001; I² = 15%) was significantly lower in the early statins group compared with the non-statins group. No difference between groups in neurological improvement was identified (RR 1.32; 95% CI 0.98-1.78; p = 0.065; I² = 66%). In the statins pre-treatment analysis there was no difference between groups in the incidence of successful recanalization (OR 2.62; 95% CI 0.80-8.53; p = 0.11; I² = 69%), the incidence of favorable functional outcomes (mRS 0-2) in 90 days (OR 1.53; 95% CI 0.82-2.83; p = 0.18; I² = 35%) and neurological improvement (OR 1.35; 95% CI 0.69-2.65; p = 0.38; I² = 0%).</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis identified that early statin treatment is correlated with significant improvement in efficacy and safety outcomes of endovascular thrombectomy. On the other hand, statins pretreatment had no considerable positive impact on outcomes of endovascular thrombectomy.. Large randomized controlled trials are needed to confirm our findings.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"995-1007"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease.","authors":"Wenwen Wang, Jing Huang, Runtian Cheng, Xiaoshuang Liu, Tianyou Luo","doi":"10.1007/s00234-025-03557-6","DOIUrl":"10.1007/s00234-025-03557-6","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease (CSVD).</p><p><strong>Methods: </strong>Thirty normal controls and 65 CSVD patients, including 33 patients with mild cognitive impairment and 32 patients with no cognitive impairment were included. Structural and resting-state functional MRI measures, including gray matter volume (GMV) and white matter volume (WMV) using voxel-based morphometry (VBM) analysis and amplitude of low-frequency fluctuation (ALFF), were obtained and compared among the three groups. Associations between cognitive scores and ALFF/VBM coupling in the co-altered regions were investigated in CSVD groups.</p><p><strong>Results: </strong>Multiple brain regions showed significant differences in GMV and WMV among the three groups (P < 0.01). Abnormal ALFF among the three groups was identified in the left putamen, Rolandic operculum, fusiform gyrus, caudate, parahippocampal gyrus, insula, middle cingulum, bilateral lingual gyrus, and right frontal lobe (P < 0.01). Importantly, a decrease in VBM and increase in ALFF in the left parahippocampal gyrus, caudate and Rolandic operculum, a reduction of the WMV and ALFF in the right superior frontal lobe, and a united rise of GMV and ALFF in the left caudate were detected in CSVD groups. In addition, abnormal ALFF/VBM coupling was significantly related to multiple cognitive assessments.</p><p><strong>Conclusion: </strong>The study indicated a reversed pattern of the brain structural deficits and functional activation in the left parahippocampal gyrus, caudate, and Rolandic operculum, suggesting structure-function decoupling in CSVD groups. These might help further understand the pathophysiological mechanism of CSVD.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"833-844"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based assessment of morphometric abnormalities distinguishes bipolar disorder and major depressive disorder.","authors":"Kewei He, Jingbo Zhang, Yang Huang, Xue Mo, Renqiang Yu, Jing Min, Tong Zhu, Yunfeng Ma, Xiangqian He, Fajin Lv, Jianguang Zeng, Chao Li, Robert K McNamara, Du Lei, Mengqi Liu","doi":"10.1007/s00234-025-03544-x","DOIUrl":"10.1007/s00234-025-03544-x","url":null,"abstract":"<p><strong>Introduction: </strong>Bipolar disorder (BD) and major depressive disorder (MDD) have overlapping clinical presentations which may make it difficult for clinicians to distinguish them potentially resulting in misdiagnosis. This study combined structural MRI and machine learning techniques to determine whether regional morphological differences could distinguish patients with BD and MDD.</p><p><strong>Methods: </strong>A total of 123 participants, including BD (n = 31), MDD (n = 48), and healthy controls (HC, n = 44), underwent high-resolution 3D T1-weighted imaging. Cortical thickness, surface area, and subcortical volumes were measured using FreeSurfer software. Common and classic machine learning models were utilized to identify distinct morphometric alterations between BD and MDD.</p><p><strong>Results: </strong>Significant morphological differences were observed in both common and distinct brain regions between BD, MDD, and HC. Specifically, abnormalities in the amygdala, thalamus, medial orbitofrontal cortex and fusiform were observed in both BD and MDD compared with HC. Relative to HC, unique differences in BD were identified in the lateral occipital and inferior/middle temporal regions, whereas MDD exhibited differences in nucleus accumbens and middle temporal regions. BD exhibited larger surface area in right middle temporal gyrus and greater right nucleus accumbens volume compared to MDD. The integration of two-stage models, including deep neural network (DNN) and support vector machine (SVM), achieved an accuracy rate of 91.2% in discriminating individuals with BD from MDD.</p><p><strong>Conclusion: </strong>These findings demonstrate that structural MRI combined with machine learning techniques can accurately discriminate individuals with BD from MDD, and provide a foundation supporting the potential of this approach to improve diagnostic accuracy.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"921-930"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal cord cross sign: a potential marker for hereditary spastic paraplegia type 5.","authors":"Fan Zhang, Jianping Hu, Zebin Xiao, Chenlin Lin, Zhuoting Huang, Ning Wang, Ying Liu","doi":"10.1007/s00234-025-03543-y","DOIUrl":"10.1007/s00234-025-03543-y","url":null,"abstract":"<p><strong>Purpose: </strong>Spastic paraplegia type 5 (SPG5) is a rare neurodegenerative disease diagnosed primarily through genetic testing.We identified a specific spinal cord sign on conventional MR imaging to help narrow the scope of genetic screening.</p><p><strong>Methods: </strong>In 25 patients with SPG5 and 21 healthy controls (HCs), the spinal cord cross sign was evaluated on T2*-weighted imaging. The morphological and signal characteristics of the dorsal column (DC), ventral funiculi (VF), dorsal horn (DH), ventral horn (VH), and intermediate zone (IMZ) were assessed. Differences in fractional anisotropy (FA) values within specific regions between HC and SPG5 were tested using Student's t-test. Spearman correlation was used to evaluate associations between cross-sign scores, FA values, and clinical indicators.</p><p><strong>Results: </strong>The cross sign was detected in the cervical spinal cord of all SPG5 patients. The occurrence of T2 hyperintensity in the DC, VF and IMZ was 100%,100% and 88%,respectively. Bilateral VH morphology was normal in 14.4% of cases, blurred in 49.6%, and absent in 36%.Bilateral DH morphology was normal in 13.6%, blurred in 56%, and absent in 30.4%. FA values were reduced in these spinal cord regions. Cross-sign scores were negatively correlated with FA values in both grey (r = -0.70~-0.37) and white matter (r = -0.78~-0.70). Cross-sign scores were positively correlated with Spastic Paraplegia Rating Scale (r = 0.57) and disease duration (r = 0.42).</p><p><strong>Conclusion: </strong>The spinal cord cross sign was a potential imaging marker for SPG5. Cross-sign scores were associated with disease duration and severity in SPG5 patients.</p><p><strong>Trial registration: </strong>A Registered Cohort Study on Spastic Paraplegia,NCT04006418 Registered 1 July 2019, https://clinicaltrials.gov/study/NCT04006418 .</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"1081-1090"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning radiomics for H3K27M mutation prediction in gliomas: A systematic review and meta-analysis.","authors":"Bardia Hajikarimloo, Salem M Tos, Alireza Kooshki, Mohammadamin Sabbagh Alvani, Mohammad Shahir Eftekhar, Arman Hasanzade, Roozbeh Tavanaei, Mohammadhosein Akhlaghpasand, Rana Hashemi, Mohammadreza Ghaffarzadeh-Esfahani, Ibrahim Mohammadzadeh, Mohammad Amin Habibi","doi":"10.1007/s00234-025-03597-y","DOIUrl":"https://doi.org/10.1007/s00234-025-03597-y","url":null,"abstract":"<p><strong>Purpose: </strong>Noninvasive prediction and identification of the H3K27M mutation play an important role in optimizing therapeutic strategies and improving outcomes in gliomas. In this systematic review and meta-analysis, we aimed to evaluate the performance of machine learning (ML)-based models in predicting H3K27M mutation in gliomas.</p><p><strong>Methods: </strong>Literature records were retrieved on September 16th, 2024, in PubMed, Embase, Scopus, and Web of Science. Records were screened according to the eligibility criteria, and the data from the included studies were extracted. The meta-analysis, sensitivity analysis, and meta-regression were conducted using R software.</p><p><strong>Results: </strong>A total of 15 studies were included in our study. Our meta-analysis demonstrated a pooled AUC, sensitivity, and specificity of 0.87 (95% CI: 0.77-0.97), 92% (95% CI: 83%-96%), and 89% (95% CI: 86%-91%)), respectively. The subgroup meta-analysis revealed that despite the higher sensitivity of the deep learning (DL) models, the sensitivity is not superior to ML (P = 0.6). In contrast, the ML-based pooled specificity was significantly higher (P < 0.01). The meta-analysis revealed a 78.1 (95% CI: 33.3 - 183.5). The SROC curve indicated an AUC of 0.921, and the estimated sensitivity is 0.898 concurrent with the false positive rate of 0.126, which indicates high sensitivity with a low false positive rate.</p><p><strong>Conclusion: </strong>Our systematic review and meta-analysis demonstrated that ML-based magnetic resonance imaging (MRI) radiomics models are associated with promising diagnostic performance in predicting H3K27M mutation in gliomas.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cangrelor, a newer P2Y12 inhibitor, in neuro-interventional procedures: a systematic review and updated meta-analysis.","authors":"Ocílio Ribeiro Gonçalves, Ana B Santos, Anthony Hong, Leonardo Januário Campos Cardoso, Márcio Yuri Ferreira, Christian Ken Fukunaga, Victor Arthur Ohannesian, Kelson James Almeida, Filipe Virgilio Ribeiro","doi":"10.1007/s00234-025-03573-6","DOIUrl":"https://doi.org/10.1007/s00234-025-03573-6","url":null,"abstract":"<p><strong>Background: </strong>Cangrelor, a reversible P2Y12 receptor inhibitor commonly utilized in cardiovascular interventions, is increasingly being investigated for its potential in cerebrovascular applications. This study presents a comprehensive evaluation of its safety and efficacy in neuro-interventional procedures, based on a systematic review and meta-analysis of recent evidence.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Cochrane, Web of Science, and Scopus for studies on endovascular therapy with cangrelor-based intravenous antiplatelet therapy for cerebrovascular pathologies. Endpoints included 90-day functional outcomes, successful reperfusion (mTICI 2b-3), mortality, symptomatic intracranial hemorrhage (sICH), hemorrhagic transformation, gastrointestinal bleeding, intraprocedural complications (in-stent thrombosis, thromboembolic events), and retroperitoneal hematoma. Single-proportion analysis with 95% CIs under a random-effects model was conducted.</p><p><strong>Results: </strong>Seventeen studies with 646 patients were included. Favorable 90-day functional outcomes occurred in 57.06% (44.37-69.76%), and successful recanalization in 98.74% (96.63-100.00%). Rates of hemorrhagic transformation, sICH, gastrointestinal bleeding, and retroperitoneal hematoma were 24.06%, 4.64%, 0.02%, and 0.07%, respectively. Intraprocedural in-stent thrombosis occurred in 0.28%, thromboembolic events in 0.48%, and 90-day all-cause mortality was 7.94%.</p><p><strong>Conclusion: </strong>The findings suggest that intravenous cangrelor, used as antiplatelet therapy following neuro-interventional procedures, is both safe and effective. This is reflected in high rates of favorable clinical outcomes, successful recanalization, and low complication rates.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated flat panel computed tomography for pre-operative temporal bone imaging: Image quality and dosimetry comparison to conventional high resolution multislice computed tomography.","authors":"Elie Diamandis, Sebastian Johannes Müller, Eya Khadhraoui, Stefan Klebingat, Eric Einspänner, Martin Durisin, Anne Albrecht, Daniel Behme","doi":"10.1007/s00234-025-03592-3","DOIUrl":"https://doi.org/10.1007/s00234-025-03592-3","url":null,"abstract":"<p><strong>Purpose: </strong>High-resolution multislice CT (HR-MSCT) and cone beam CT (CBCT) are commonly used for preoperative temporal bone imaging, with HR-MSCT often preferred due to its shorter scan duration and lower susceptibility to motion artifacts. However, recent advancements in accelerated flat panel CT (Acc-FPCT) available with the latest generation angiography systems have addressed traditional limitations of CBCT by significantly decreasing scan time. This cadaver-based study evaluates the diagnostic performance and radiation dose of Acc-FPCT compared to HR-MSCT in preoperative temporal bone imaging.</p><p><strong>Methods: </strong>Six different Acc-FPCT protocols were acquired on five whole-head cadaveric specimens (ten temporal bones). Three neuroradiologists experienced in temporal bone imaging assessed the image quality of Acc-FPCT protocols in comparison to that of HR-MSCT for the visualization of 31 landmarks of middle and inner ear using a 5-point Likert scale. We also compared radiation dose parameters (CT dose index and dose length product) among the protocols.</p><p><strong>Results: </strong>Two high-Resolution Acc-FPCT protocols were found to be superior to HR-MSCT by all raters (p < 0.001). There were no significant differences between the two HR-FPCT protocols (p = 0.25). The remaining Acc-FPCT protocols were rated significantly inferior to HR-MSCT. The inter-rater reliability was excellent (ICC (2,k) = 0.925; CI [0.92-0.93]). The dose length product was significantly lower in all Acc-FPCT protocols compared to HR-MSCT.</p><p><strong>Conclusion: </strong>The results of our cadaver-based study highlight the utility of certain Acc-FPCT protocols as a viable alternative to HR-MSCT in preoperative temporal bone imaging, improving the visualization of critical anatomical landmarks without increasing radiation exposure.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}