Marie-Julie D K Lemmens, R H G J van Lanen, D Uher, A J Colon, M C Hoeberigs, G Hoogland, A Roebroeck, D Ivanov, B A Poser, R P W Rouhl, P A M Hofman, I Gijselhart, G S Drenthen, J F A Jansen, W H Backes, K Rijkers, O E M G Schijns
{"title":"主要来自颞叶的人类致痫标本的体外超高场磁共振成像：系统综述。","authors":"Marie-Julie D K Lemmens, R H G J van Lanen, D Uher, A J Colon, M C Hoeberigs, G Hoogland, A Roebroeck, D Ivanov, B A Poser, R P W Rouhl, P A M Hofman, I Gijselhart, G S Drenthen, J F A Jansen, W H Backes, K Rijkers, O E M G Schijns","doi":"10.1007/s00234-024-03474-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Magnetic resonance imaging (MRI) is the preferred diagnostic tool for the detection of structural cerebral lesions in patients with epilepsy. Ultra-high field (UHF) MRI with field strengths ≥7 Tesla has been reported to improve the visualization and delineation of epileptogenic lesions. The use of ex vivo UHF MRI may expand our knowledge on the detection and detailed micromorphology of subtle epileptogenic lesions by bridging the gap between in vivo MRI and histopathology.</p><p><strong>Methods: </strong>A systematic review of available literature was conducted following PRISMA guidelines. A descriptive analysis of included articles was performed, focusing on (I) the ability of ex vivo UHF MRI to detect subtle abnormalities related to epilepsy, (II) different post-processing methods, and (III) concordance between UHF MRI and histopathology.</p><p><strong>Results: </strong>Eleven studies with focus on the depiction of focal cortical dysplasia (n = 4) or hippocampal sclerosis (n = 7) as causative lesion of drug-resistant epilepsy were included. Ex vivo UHF MRI proved its ability to visualize the anatomy of cortical and hippocampal structures in greater detail when compared to ex vivo conventional field strengths. Different MRI post-processing methods enabled differentiation between lesional subtypes and provided novel insights into (peri)lesional characteristics. Concordance between ex vivo UHF MRI findings and histopathology was high.</p><p><strong>Conclusion: </strong>Acquisition of ex vivo UHF MRI and its image processing has the potential to depict epileptogenic abnormalities in greater detail with a spatial resolution approximating histological images. The translation of ex vivo UHF MRI features to in vivo clinical settings remains challenging and urges further exploration.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"875-893"},"PeriodicalIF":2.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041060/pdf/","citationCount":"0","resultStr":"{\"title\":\"Ex vivo ultra-high field magnetic resonance imaging of human epileptogenic specimens from primarily the temporal lobe: A systematic review.\",\"authors\":\"Marie-Julie D K Lemmens, R H G J van Lanen, D Uher, A J Colon, M C Hoeberigs, G Hoogland, A Roebroeck, D Ivanov, B A Poser, R P W Rouhl, P A M Hofman, I Gijselhart, G S Drenthen, J F A Jansen, W H Backes, K Rijkers, O E M G Schijns\",\"doi\":\"10.1007/s00234-024-03474-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Magnetic resonance imaging (MRI) is the preferred diagnostic tool for the detection of structural cerebral lesions in patients with epilepsy. Ultra-high field (UHF) MRI with field strengths ≥7 Tesla has been reported to improve the visualization and delineation of epileptogenic lesions. The use of ex vivo UHF MRI may expand our knowledge on the detection and detailed micromorphology of subtle epileptogenic lesions by bridging the gap between in vivo MRI and histopathology.</p><p><strong>Methods: </strong>A systematic review of available literature was conducted following PRISMA guidelines. A descriptive analysis of included articles was performed, focusing on (I) the ability of ex vivo UHF MRI to detect subtle abnormalities related to epilepsy, (II) different post-processing methods, and (III) concordance between UHF MRI and histopathology.</p><p><strong>Results: </strong>Eleven studies with focus on the depiction of focal cortical dysplasia (n = 4) or hippocampal sclerosis (n = 7) as causative lesion of drug-resistant epilepsy were included. Ex vivo UHF MRI proved its ability to visualize the anatomy of cortical and hippocampal structures in greater detail when compared to ex vivo conventional field strengths. Different MRI post-processing methods enabled differentiation between lesional subtypes and provided novel insights into (peri)lesional characteristics. Concordance between ex vivo UHF MRI findings and histopathology was high.</p><p><strong>Conclusion: </strong>Acquisition of ex vivo UHF MRI and its image processing has the potential to depict epileptogenic abnormalities in greater detail with a spatial resolution approximating histological images. The translation of ex vivo UHF MRI features to in vivo clinical settings remains challenging and urges further exploration.</p>\",\"PeriodicalId\":19422,\"journal\":{\"name\":\"Neuroradiology\",\"volume\":\" \",\"pages\":\"875-893\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041060/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroradiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00234-024-03474-0\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00234-024-03474-0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/8 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Ex vivo ultra-high field magnetic resonance imaging of human epileptogenic specimens from primarily the temporal lobe: A systematic review.
Purpose: Magnetic resonance imaging (MRI) is the preferred diagnostic tool for the detection of structural cerebral lesions in patients with epilepsy. Ultra-high field (UHF) MRI with field strengths ≥7 Tesla has been reported to improve the visualization and delineation of epileptogenic lesions. The use of ex vivo UHF MRI may expand our knowledge on the detection and detailed micromorphology of subtle epileptogenic lesions by bridging the gap between in vivo MRI and histopathology.
Methods: A systematic review of available literature was conducted following PRISMA guidelines. A descriptive analysis of included articles was performed, focusing on (I) the ability of ex vivo UHF MRI to detect subtle abnormalities related to epilepsy, (II) different post-processing methods, and (III) concordance between UHF MRI and histopathology.
Results: Eleven studies with focus on the depiction of focal cortical dysplasia (n = 4) or hippocampal sclerosis (n = 7) as causative lesion of drug-resistant epilepsy were included. Ex vivo UHF MRI proved its ability to visualize the anatomy of cortical and hippocampal structures in greater detail when compared to ex vivo conventional field strengths. Different MRI post-processing methods enabled differentiation between lesional subtypes and provided novel insights into (peri)lesional characteristics. Concordance between ex vivo UHF MRI findings and histopathology was high.
Conclusion: Acquisition of ex vivo UHF MRI and its image processing has the potential to depict epileptogenic abnormalities in greater detail with a spatial resolution approximating histological images. The translation of ex vivo UHF MRI features to in vivo clinical settings remains challenging and urges further exploration.
期刊介绍：
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
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