Manxi Xu, Bing Liu, Aocai Yang, Jixin Luan, Shijun Li, Li Zhu, Ni Shu, Gaoxiang Ouyang, Yuli Wang, Yao Wang, Guolin Ma
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Effects of hyperprolactinemia and bromocriptine treatment on cerebral blood flow and functional brain States.
Purpose: Hyperprolactinemia (HPRL) affects both reproductive function and the central nervous system. However, its specific effects on brain function and blood flow remain unclear.
Methods: This study used multimodal magnetic resonance imaging to examine cerebral blood flow (CBF) and functional network characteristics in 32 HPRL patients, including those undergoing bromocriptine treatment, and 40 healthy controls.
Results: Results revealed a significant reduction in global mean CBF in HPRL patients, particularly in the right inferior frontal gyrus, left middle temporal gyrus, and bilateral rectus gyrus. In contrast, the right middle frontal gyrus exhibited increased CBF. Following bromocriptine treatment, global CBF showed an upward trend. Additionally, the hierarchical structure of functional networks in HPRL patients was diminished and negatively correlated with serum prolactin levels, potentially related to reduced connectivity between the default mode and sensorimotor networks.
Conclusion: These findings provide new insights into how HPRL and bromocriptine influence brain function, enhancing the understanding of the underlying neurophysiological mechanisms.
期刊介绍：
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
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