血栓性颅内动脉瘤血流动力学与放射学特征的相关性。

IF 2.6 3区 医学 Q2 CLINICAL NEUROLOGY
Zonghan Lyu, Andres Gudino, Navami Shenoy, Carlos Dier, Elena Sagues, Jingfeng Jiang, Edgar A Samaniego
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引用次数: 0

摘要

目的:评估颅内动脉瘤(IA)破裂风险对指导治疗至关重要。虽然囊内血栓形成(IST)不太常见,但它可以促进动脉瘤生长,肿块效应和破裂。高分辨率MRI (HR-MRI)的动脉瘤壁增强(AWE)为IST和IA的进展提供了有价值的见解。利用放射组学,我们提取了动脉瘤壁的空间信息来表征AWE。该研究旨在探索基于放射组学的AWE剖面与总体血流动力学参数之间的相关性,将成像和血流动力学结合起来,以更好地了解IST。方法:对IA合并IST的3T HR-MRI扫描队列进行放射组学分析。通过三维血管重建和CFD模拟来量化血流动力学参数。采用Spearman相关性分析动脉瘤形态、AWE模式和动脉瘤血流动力学特征。结果:共纳入37例血栓性动脉瘤,其中梭状动脉瘤22例(59.5%),囊状动脉瘤15例(40.5%)。6个AWE RFs显示与动脉瘤体积和表面积有很强的相关性(两者的ρ >.7)。10个AWE rf与流动涡参数(ρ > 0.7)高度相关,1个与壁面剪切应力(WSS)相关指标(ρ > 0.7)相关性强。在囊状IAs子集中,20个AWE rf与wss相关指标密切相关。与此相反,梭状涡的涡流强度与涡核特征的相关性更强。这些发现表明,AWE升高与高振荡剪切指数和不稳定流涡区域密切相关,表明壁增强与动脉瘤内血流动力学紊乱之间存在潜在联系。结论血流停滞可促进动脉瘤壁及IST的退行性重构。结合血流动力学参数和AWE模式的时空分析提供了IAs潜在生物学过程的信息,包括IST的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlations between hemodynamics and radiomic features in thrombosed intracranial aneurysms.

Purpose: Evaluating intracranial aneurysm (IA) rupture risk is essential for guiding management. Although intrasaccular thrombosis (IST) is less common, it can contribute to aneurysm growth, mass effect, and rupture. Aneurysm wall enhancement (AWE) on high-resolution MRI (HR-MRI) offers valuable insight into IST and IA progression. Using radiomics, we extracted spatial information of the aneurysm wall to characterize AWE. This study aimed to explore correlations between radiomics-based AWE profiles and gross hemodynamic parameters, integrating imaging and flow dynamics to better understand IST.

Methods: Radiomic analysis was conducted on a cohort of 3T HR-MRI scans from IA with IST. Three-dimensional vascular reconstructions and CFD simulations were conducted to quantify hemodynamic parameters. Spearman's correlation was performed to correlate aneurysm morphology, AWE patterns, and aneurysmal hemodynamic characteristics.

Results: A total of 37 thrombosed IAs were included in the analysis, comprising 22 fusiform (59.5%) and 15 saccular (40.5%) aneurysms. Six AWE RFs demonstrated strong correlations with aneurysm volume and surface area (ρ > 0.7 for both). Ten AWE RFs were highly correlated with flow vortex parameters (ρ > 0.7), and one showed a strong correlation with wall shear stress (WSS)-related metrics (ρ > 0.7). In the subset of saccular IAs, 20 AWE RFs were strongly associated with WSS-related metrics. In contrast, fusiform IAs showed stronger correlations between AWE RFs and vortex core characteristics. These findings suggest that elevated AWE is closely associated with regions of high oscillatory shear index and unstable flow vortices, indicating a potential link between wall enhancement and disturbed intra-aneurysmal hemodynamics. Conclusions Stagnant flow may promote degenerative remodeling of the aneurysm wall and IST. A combined spatiotemporal analysis of hemodynamic parameters and AWE patterns provide information about underlying biological processes of IAs, including the development of IST.

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来源期刊
Neuroradiology
Neuroradiology 医学-核医学
CiteScore
5.30
自引率
3.60%
发文量
214
审稿时长
4-8 weeks
期刊介绍: Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
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