Arterial wall enhancement indicates higher reperfusion rates in non-ruptured aneurysms after endovascular treatment with stent-assisted coiling.

IF 2.6 3区医学 Q2 CLINICAL NEUROLOGY

Neuroradiology Pub Date : 2025-09-01 Epub Date: 2025-07-10 DOI:10.1007/s00234-025-03709-8

Valentin Ladenhauf, Malik Galijasevic, Milovan Regodic, Verena Rass, Christian Freyschlag, Johannes Deeg, Leonhard Gruber, Michael Swoboda, Jakub Bochnicka, Stephanie Mangesius, Lukas Lenhart, Elke Ruth Gizewski, Astrid Ellen Grams

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引用次数: 0

Abstract

Background and purpose: There are differing results in recent literature concerning aneurysmal wall enhancement (AWE) after endovascular treatment (ET) of intracranial aneurysms (IAs). The aim of this retrospective study is to investigate if the presence of AWE of unruptured treated IAs via stent-assisted coiling (SAC) is associated with higher reperfusion rates.

Materials and methods: The clinical courses of 58 patients with IAs after ET via SAC were examined over the timespan of up to 5 years, assessing for AWE in T1 SPACE FS and T1 SE FS blood suppression sequences after contrast administration, events of reperfusion and need for retreatment.

Results: 58 patients were included (23 with AWE, 35 without). 18 of 23 patients (78.3%) with AWE showed reperfusion after treatment, compared to 15 of 35 patients (42.9%) without AWE. Reperfusion rates were significantly higher in patients with AWE, compared to those without AWE (p = 0.0139) also after propensity score matching (p = 0.0456).

Conclusions: In patients with unruptured IAs treated exclusively with SAC, AWE on follow-up MRI was significantly associated with higher reperfusion rates. AWE may serve as an early imaging biomarker of post-treatment instability.

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动脉壁增强表明在血管内支架辅助盘绕治疗后，未破裂动脉瘤的再灌注率更高。

背景与目的：近期关于颅内动脉瘤（IAs）血管内治疗（ET）后动脉瘤壁增强（AWE）的研究结果不一。本回顾性研究的目的是调查通过支架辅助卷绕（SAC）治疗的未破裂的IAs是否存在AWE与更高的再灌注率相关。材料和方法：研究了58例经SAC行ET后IAs患者长达5年的临床病程，评估了对比剂给药后T1 SPACE FS和T1 SE FS抑血序列的AWE、再灌注事件和再治疗的需要。结果：纳入58例患者（23例有AWE， 35例无AWE）。23例AWE患者中18例（78.3%）治疗后出现再灌注，35例无AWE患者中15例（42.9%）出现再灌注。在倾向评分匹配（p = 0.0456）后，AWE患者的再灌注率明显高于无AWE患者（p = 0.0139）。结论：在仅接受SAC治疗的未破裂IAs患者中，随访MRI上的AWE与更高的再灌注率显著相关。AWE可作为治疗后不稳定性的早期成像生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.