{"title":"Uptake patterns of Adult-type Non-Enhanced diffuse gliomas on [<sup>11</sup>C] methionine positron emission tomography : Previous presentations: none.","authors":"Shoji Yasuda, Naoya Imai, Hirohito Yano, Yuka Ikegame, Soko Ikuta, Takashi Maruyama, Noriyuki Nakayama, Morio Kumagai, Yoshihiro Muragaki, Jun Shinoda, Tsuyoshi Izumo","doi":"10.1007/s00234-025-03746-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To assess the uptake patterns of adult-type non-enhanced gliomas in the pre-angiogenic phase on [<sup>11</sup>C] methionine (MET) PET.</p><p><strong>Methods: </strong>We included 52 astrocytoma (Group A), 34 oligodendroglioma (Group O), and 21 glioblastoma (Group G) cases. Regions of interest (ROIs) were defined based on T2-weighted images of high-intensity lesions encompassing tumor volume. The maximum tumor-to-brain ratios (TBR<sub>max</sub>) were calculated from PET data. ROIs were internally layered at 5-mm intervals from the tumor surface to assess MET uptake distribution. Moderate (TBR<sub>max</sub> ≥1.3) and high (TBR<sub>max</sub> ≥2.0) uptakes were classified into three patterns based on the extent and distribution.</p><p><strong>Results: </strong>TBR<sub>max</sub> was significantly lower in Group A than in Groups O and G. TBR<sub>max</sub> was more frequently observed in the outermost 0-5 mm layer in all groups. Seventy-three cases with TBR<sub>max</sub> ≥1.3 exhibited the whole pattern in 13 (17.8%) and partial or spot patterns in 60 (82.2%) cases; partial or spot pattern cases were most frequently identified as surface/outside patterns (60.3%). Twenty-seven cases with TBR<sub>max</sub> ≥2.0 exhibited the whole pattern in 5 (18.5%) and partial or spot patterns in 22 (81.5%) cases; partial or spot pattern cases were identified as central or surface/outside patterns, and none of the cases showed surface/inside patterns, indicating a high-uptake area in the deeper part of the brain.</p><p><strong>Conclusion: </strong>In non-enhanced gliomas, MET accumulation was concentrated at the periphery of the tumor. Although some cases showed MET uptake throughout the tumor, none showed focal high uptake deep in the brain.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00234-025-03746-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: To assess the uptake patterns of adult-type non-enhanced gliomas in the pre-angiogenic phase on [11C] methionine (MET) PET.
Methods: We included 52 astrocytoma (Group A), 34 oligodendroglioma (Group O), and 21 glioblastoma (Group G) cases. Regions of interest (ROIs) were defined based on T2-weighted images of high-intensity lesions encompassing tumor volume. The maximum tumor-to-brain ratios (TBRmax) were calculated from PET data. ROIs were internally layered at 5-mm intervals from the tumor surface to assess MET uptake distribution. Moderate (TBRmax ≥1.3) and high (TBRmax ≥2.0) uptakes were classified into three patterns based on the extent and distribution.
Results: TBRmax was significantly lower in Group A than in Groups O and G. TBRmax was more frequently observed in the outermost 0-5 mm layer in all groups. Seventy-three cases with TBRmax ≥1.3 exhibited the whole pattern in 13 (17.8%) and partial or spot patterns in 60 (82.2%) cases; partial or spot pattern cases were most frequently identified as surface/outside patterns (60.3%). Twenty-seven cases with TBRmax ≥2.0 exhibited the whole pattern in 5 (18.5%) and partial or spot patterns in 22 (81.5%) cases; partial or spot pattern cases were identified as central or surface/outside patterns, and none of the cases showed surface/inside patterns, indicating a high-uptake area in the deeper part of the brain.
Conclusion: In non-enhanced gliomas, MET accumulation was concentrated at the periphery of the tumor. Although some cases showed MET uptake throughout the tumor, none showed focal high uptake deep in the brain.
期刊介绍：
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
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