Neuroscience Research最新文献_第2页

A novel quadrant spatial assay reveals environmental preference in mouse spontaneous and parental behaviors. 一种新型象限空间测定法揭示了小鼠自发行为和亲代行为中的环境偏好。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 Epub Date: 2024-08-10 DOI: 10.1016/j.neures.2024.08.002

Aito Narita, Hirofumi Asano, Hayato Kudo, Shigeo Miyata, Fumihiro Shutoh, Goichi Miyoshi

引用次数: 0

Lifespan differences in background functional connectivity of core cognitive large-scale brain networks. 核心认知大尺度大脑网络背景功能连接的寿命差异。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 Epub Date: 2022-09-16 DOI: 10.1016/j.neures.2022.09.005

Patrick J Pruitt, Lingfei Tang, Jessica M Hayes, Noa Ofen, Jessica S Damoiseaux

{"title":"Lifespan differences in background functional connectivity of core cognitive large-scale brain networks.","authors":"Patrick J Pruitt, Lingfei Tang, Jessica M Hayes, Noa Ofen, Jessica S Damoiseaux","doi":"10.1016/j.neures.2022.09.005","DOIUrl":"10.1016/j.neures.2022.09.005","url":null,"abstract":"Large-scale brain networks undergo functional reorganization over the course of the lifespan, with concurrent implications for cognition. Characterizing network connectivity during a task may provide complementary insight into cognitive development and aging, to that provided by resting-state. We assessed network background connectivity, which refers to connectivity that remains after task effects have been regressed out, during a visual memory-encoding task in a lifespan sample. More specifically we assessed the within- and between-network background connectivity of the default mode, salience, and frontoparietal networks. Within-network background connectivity of salience and frontoparietal networks differed between age groups, with late-life adults showing lower connectivity. We did not find an effect of age group in default mode network background connectivity, contrary to previous findings using resting-state. However, default mode between-network background connectivity with salience and frontoparietal networks was greater in mid-life and late-life adults than in younger age groups. Overall, our findings in a lifespan sample are in line with previous observations of age-related network de-differentiation. However, the lack of age effect in default mode network background connectivity suggests that background connectivity indeed represents a complementary measure to resting-state connectivity, providing a differential glance of network connectivity during a particular state.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9278233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human induced pluripotent stem cell-derived dopaminergic neurons release alpha-synuclein through neuronal activity.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-29 DOI: 10.1016/j.neures.2024.11.007

Maierdanjiang Nuermaimaiti, Kei-Ichi Ishikawa, Genko Oyama, Risa Nonaka, Takahiro Shiga, Takayuki Jo, Taiji Tsunemi, Ryota Nakamura, Rejko Krüger, Wado Akamatsu, Nobutaka Hattori

{"title":"Human induced pluripotent stem cell-derived dopaminergic neurons release alpha-synuclein through neuronal activity.","authors":"Maierdanjiang Nuermaimaiti, Kei-Ichi Ishikawa, Genko Oyama, Risa Nonaka, Takahiro Shiga, Takayuki Jo, Taiji Tsunemi, Ryota Nakamura, Rejko Krüger, Wado Akamatsu, Nobutaka Hattori","doi":"10.1016/j.neures.2024.11.007","DOIUrl":"10.1016/j.neures.2024.11.007","url":null,"abstract":"Lewy body diseases, including Parkinson's disease (PD), are characterized by the spread of alpha-synuclein (αSyn) between neurons across synapses, a process crucial for understanding their pathophysiology and developing effective treatments. In this study, we aimed to investigate the role of neuronal activity in releasing αSyn from human induced pluripotent stem cell-derived dopaminergic neurons. We examined human induced pluripotent stem cell-derived dopaminergic neurons, both healthy and those with the αSyn gene mutation associated with PD. We employed pharmacological agents and optogenetic techniques and demonstrated that increased neuronal activity, induced by bicuculline or optogenetic stimulation, significantly enhances αSyn release. However, suppression of neuronal activity with cyanquixaline reduces αSyn secretion. These findings underscore the pivotal role of neuronal activity in αSyn transmission between neurons, showing its potential impact on the spread of Lewy pathology in patients with neurodegenerative diseases like PD. Therefore, this study advances our understanding of PD and opens new avenues for therapeutic strategies to mitigate Lewy body disease progression.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Future projections for mammalian whole-brain simulations based on technological trends in related fields. 基于相关领域技术发展趋势的哺乳动物全脑模拟未来预测。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-19 DOI: 10.1016/j.neures.2024.11.005

Jun Igarashi

引用次数: 0

Editorial: Neuroscience of resilience for mental health. 社论：心理健康复原力的神经科学。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-16 DOI: 10.1016/j.neures.2024.11.006

Tomoyuki Furuyashiki, Scott J Russo

引用次数: 0

Neural substrates of choking under pressure: A 7T-fMRI study. 压力下窒息的神经基础：7T-fMRI 研究。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-14 DOI: 10.1016/j.neures.2024.11.004

Kanae Ogasawara, Takahiko Koike, Masaki Fukunaga, Ayumi Yoshioka, Tetsuya Yamamoto, Norihiro Sadato

{"title":"Neural substrates of choking under pressure: A 7T-fMRI study.","authors":"Kanae Ogasawara, Takahiko Koike, Masaki Fukunaga, Ayumi Yoshioka, Tetsuya Yamamoto, Norihiro Sadato","doi":"10.1016/j.neures.2024.11.004","DOIUrl":"10.1016/j.neures.2024.11.004","url":null,"abstract":"Performance decrement under excessive psychological pressure is known as \"choking,\" yet its mechanisms and neural foundations remain underexplored. Hypothesizing that changes in the internal model could induce choking, we conducted a 7 T functional MRI introducing excessive pressure through a rare Jackpot condition that offers high rewards for successful performance. Twenty-nine volunteers underwent a visual reaching task. We monitored practice and main sessions to map the task's internal model through learning. Participants were pre-informed of four potential reward conditions upon success at the beginning of the main session task. The success rates in the Jackpot condition were significantly lower than in other conditions, indicative of choking. During the preparation phase, activations in the cerebellum and the middle temporal visual area (hMT+) were associated with Jackpot-specific failures. The cluster in the cerebellar hemisphere overlapped with the internal model regions identified by a learning-related decrease in activation during the practice session. We observed task-specific functional connectivity between the cerebellum and hMT+. These findings suggest a lack of sensory attenuation when an internal model predicting the outcome of one's actions is preloaded during motor preparation. Within the active inference framework of motor control, choking stems from the cerebellum's internal model modulation by psychological pressure, manifested through improper sensory attenuation.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular, neural, and tissue circuits underlying physiological temperature responses in Caenorhabditis elegans. 草履虫生理温度反应的分子、神经和组织回路。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-13 DOI: 10.1016/j.neures.2024.11.001

Yukina Mori, Akane Ohta, Atsushi Kuhara

引用次数: 0

A chemogenetic technology using insect Ionotropic Receptors to stimulate target cell populations in the mammalian brain. 利用昆虫离子受体刺激哺乳动物大脑目标细胞群的化学遗传技术。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-10 DOI: 10.1016/j.neures.2024.11.003

Yoshio Iguchi, Richard Benton, Kazuto Kobayashi

引用次数: 0

Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice. 在小鼠的经典条件反射过程中，纹状体中多巴胺的释放是对奖励和厌恶结果的反应。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-07 DOI: 10.1016/j.neures.2024.11.002

Tomohiko Yoshizawa, Makoto Funahashi

{"title":"Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice.","authors":"Tomohiko Yoshizawa, Makoto Funahashi","doi":"10.1016/j.neures.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.neures.2024.11.002","url":null,"abstract":"The striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. Striosomes comprise approximately 15 % of the striatum by volume and are distributed mosaically. Therefore, it is difficult to selectively record dopamine dynamics in striosomes using traditional neurochemical measurements in behaving animals, and it is unclear whether distinct dynamics play a role in associative learning. In this study, we used transgenic mice selectively expressing Cre in striosomal neurons, combined with a fiber photometry technique, to selectively record dopamine release in striosomes during classical conditioning. Water-restricted mice could distinguish the conditioned stimulus (CS) associated with saccharin water from the air-puff-associated CS. The air-puff-associated CS evoked phasic dopamine release only in striosomes. Furthermore, air puff presentation induced dopamine release to striosomal neurons but suppressed release to striatal neurons non-selectively recorded. These findings suggest that dopamine is released in a differential manner in striosomes and the matrix in behaving animals and that dopamine release in striosomes is preferentially induced by the air-puff-associated CS and air puff presentation. These findings support the hypothesis that striosomal neurons play a dominant role in aversive stimuli prediction.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanisms linking loss of TDP-43 function to amyotrophic lateral sclerosis/frontotemporal dementia-related genes TDP-43 功能丧失与肌萎缩侧索硬化症/颞前痴呆症相关基因的分子机制。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.05.001

{"title":"Molecular mechanisms linking loss of TDP-43 function to amyotrophic lateral sclerosis/frontotemporal dementia-related genes","authors":"","doi":"10.1016/j.neures.2024.05.001","DOIUrl":"10.1016/j.neures.2024.05.001","url":null,"abstract":"<div><div>Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by nuclear depletion and cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43). TDP-43 plays a key role in regulating the splicing of numerous genes, including TARDBP. This review aims to delineate two aspects of ALS/FTD pathogenesis associated with TDP-43 function. First, we described novel mechanistic insights into the splicing of UNC13A, a TDP-43 target gene. Single nucleotide polymorphisms (SNPs) in UNC13A are the most common risk factors for ALS/FTD. We found that TDP-43 represses “cryptic exon” inclusion during UNC13A RNA splicing. A risk-associated SNP in this exon results in increased RNA levels of UNC13A retaining the cryptic exon. Second, we described the perturbation of the TDP-43 autoregulatory mechanism caused by age-related DNA demethylation. Aging is a major risk factor for sporadic ALS/FTD. Typically, TDP-43 levels are regulated via alternative splicing of TARDBP mRNA. This review focused on that TARDBP methylation is altered by aging, thereby disrupting TDP-43 autoregulation. It was found that demethylation reduces the efficiency of alternative splicing and increases TARDBP mRNA levels. Moreover, we demonstrated that, with aging, this region is demethylated in the human motor cortex and is associated with the early onset of ALS.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"208 ","pages":"Pages 1-7"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0