Neuroscience Research最新文献_第2页

The effect of L-alanine on sleep through taste properties in Drosophila melanogaster l -丙氨酸通过果蝇味觉特性对睡眠的影响。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-14 DOI: 10.1016/j.neures.2025.104924

Rabia Garibağaoğlu, Riho Kobayashi , Victoria Hanashiro, Jun Tomita, Kazuhiko Kume

引用次数: 0

Alteration of perineuronal nets and parvalbumin interneurons in prefrontal cortex and hippocampus, and correlation with blood corticosterone in activity-based anorexia model mice 活动性厌食症模型小鼠前额皮质和海马神经元周围网和小白蛋白中间神经元的改变及其与血皮质酮的相关性。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-14 DOI: 10.1016/j.neures.2025.104922

Hoang Duy Nguyen , Haruko Miyazaki , Hiroki Kawai , Ziyi Wang , Shinji Sakamoto , Manabu Takaki , Toshitaka Oohashi

{"title":"Alteration of perineuronal nets and parvalbumin interneurons in prefrontal cortex and hippocampus, and correlation with blood corticosterone in activity-based anorexia model mice","authors":"Hoang Duy Nguyen , Haruko Miyazaki , Hiroki Kawai , Ziyi Wang , Shinji Sakamoto , Manabu Takaki , Toshitaka Oohashi","doi":"10.1016/j.neures.2025.104922","DOIUrl":"10.1016/j.neures.2025.104922","url":null,"abstract":"<div><div>Anorexia nervosa (AN) is an eating disorder characterized by restricted energy intake, severely underweight status, and frequent hyperactivity. Previous research has shown structural and functional alterations in the medial prefrontal cortex (mPFC) and hippocampus of AN patients. To investigate the pathological mechanism of AN, we analyzed the expression and distribution of parvalbumin (PV) interneurons and perineuronal nets (PNNs), which are implicated in the pathology of neuropsychiatric disorders, in the mPFC and hippocampus dorsal (HPCd) and ventral (HPCv) using an activity-based anorexia (ABA) mouse model. We found that PNN expression and density increased in the mPFC, with minor alterations in the HPCd and HPCv of ABA mice. The expression and distribution of PV neurons were unchanged in the brains of ABA mice, except for a regional decrease in PV-expressing neuron density in the HPCd. Co-localization analysis showed an increased number of PNNs enwrapping PV-negative neurons in the mPFC of ABA mice. Furthermore, the upregulation of PNN expression in the mPFC was positively correlated with elevated blood corticosterone levels, a well-known stress indicator, in ABA mice. Our findings suggest that the increased expression and distribution of PNNs surrounding PV-negative neurons in the mPFC may indicate the pathological mechanisms of AN.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"218 ","pages":"Article 104922"},"PeriodicalIF":2.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of endogenous NT-3 in neuronal activity and neurogenesis in the hippocampal dentate gyrus 内源性NT-3在海马齿状回神经元活动和神经发生中的作用。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-13 DOI: 10.1016/j.neures.2025.104923

Nanami Kasakura, Yuka Murata, Kanzo Suzuki, Eri Segi-Nishida

{"title":"Role of endogenous NT-3 in neuronal activity and neurogenesis in the hippocampal dentate gyrus","authors":"Nanami Kasakura, Yuka Murata, Kanzo Suzuki, Eri Segi-Nishida","doi":"10.1016/j.neures.2025.104923","DOIUrl":"10.1016/j.neures.2025.104923","url":null,"abstract":"<div><div>Neurotrophin-3 (NT-3) is a neurotrophic factor that regulates neuronal differentiation and synaptic plasticity. In the adult central nervous system, NT-3 is predominantly expressed in the hippocampal dentate gyrus (DG). Chronic antidepressant treatment suppresses <em>Ntf3</em> expression in the DG; however, its functional significance remains unclear. To investigate the role of NT-3 in the adult DG, an adeno-associated virus (AAV)-mediated knockdown system was employed in mice. Immunohistochemical analysis revealed that TrkC, the high-affinity receptor for NT-3, was highly expressed in the DG. Under basal conditions, NT-3 knockdown significantly reduced the expression of FosB, an activity-dependent marker. Gene expression analysis showed that <em>Arc</em>, <em>Egr1</em>, and <em>Fosb</em> expressions were also significantly decreased. Although NT-3 knockdown did not affect cell proliferation in the DG, it impaired dendritic elongation in immature neurons. Additionally, NT-3 knockdown significantly reduced <em>Npy</em> expression. These findings suggest that endogenous NT-3 in the adult DG regulates both basal neuronal activity and newborn neuronal differentiation, contributing to hippocampal homeostasis. Further research is required to determine whether NT-3 downregulation induced by chronic antidepressant treatment influences neuronal activity and hippocampal plasticity in neuropsychiatric conditions.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"218 ","pages":"Article 104923"},"PeriodicalIF":2.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synaptic plasticity induced by CA1 synaptic input with bursts superimposed on low-frequency rhythms 低频节奏叠加CA1脉冲突触输入诱导的突触可塑性

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-03 DOI: 10.1016/j.neures.2025.104913

Satoshi Fujii , Yoshihiko Yamazaki , Hiroki Fujiwara , Jun-Ichi Goto , Takeo Watanabe , Katsuhiko Mikoshiba

{"title":"Synaptic plasticity induced by CA1 synaptic input with bursts superimposed on low-frequency rhythms","authors":"Satoshi Fujii , Yoshihiko Yamazaki , Hiroki Fujiwara , Jun-Ichi Goto , Takeo Watanabe , Katsuhiko Mikoshiba","doi":"10.1016/j.neures.2025.104913","DOIUrl":"10.1016/j.neures.2025.104913","url":null,"abstract":"<div><div>Hippocampal neurons fire synchronously in a population at low frequencies and burst individually at high frequencies, with synaptic plasticity thought to depend on the interplay of these firing patterns. This study investigated synaptic plasticity in the hippocampal CA1 region induced by synaptic input with bursts superimposed on low-frequency rhythms. Low-frequency stimulation (LFS) was varied from 0.5 to 5 Hz, and various numbers of bursts (3–1000) consisting of 2–4 pulses at 100 Hz were superimposed on LFS. The patterned stimuli with 1-Hz LFS effectively induced synaptic plasticity. The direction and magnitude of plasticity depended on the number of bursts. We identified key roles for adenosine A<sub>1</sub> receptors and GABAergic signaling in regulating synaptic plasticity. The blockade of adenosine A<sub>1</sub> receptors increased the magnitude of long-term potentiation induced by specific burst patterns and differentially affected synaptic plasticity induced by 1-Hz LFS. Through its interactions with hippocampal rhythms and inhibitory circuits, adenosine elevated extracellularly during conditioning stimuli regulated the magnitude and direction of synaptic plasticity. This study proposes hypotheses for the role of adenosine in the modulation of synaptic plasticity, which maintains the balance between potentiation and depression in hippocampal circuits.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104913"},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-brain long-range connectivity of glutamatergic, GABAergic, parvalbumin-expressing and somatostatin-expressing neurons in mouse somatosensory cortex 小鼠体感觉皮层谷氨酸能、gaba能、小蛋白表达和生长抑素表达神经元的全脑远程连通性

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-26 DOI: 10.1016/j.neures.2025.104912

Zhaoxin Zhu , Tao Jiang , Xueyan Jia , Xiaojun Wang , Miao Ren

{"title":"Whole-brain long-range connectivity of glutamatergic, GABAergic, parvalbumin-expressing and somatostatin-expressing neurons in mouse somatosensory cortex","authors":"Zhaoxin Zhu , Tao Jiang , Xueyan Jia , Xiaojun Wang , Miao Ren","doi":"10.1016/j.neures.2025.104912","DOIUrl":"10.1016/j.neures.2025.104912","url":null,"abstract":"<div><div>Understanding the composition of cortical circuits at the whole-brain scale is crucial. However, the specific ways in which particular neuronal types in the primary somatosensory cortex (SSp) establish connections with upstream and downstream brain regions remain unclear. In this study, we used whole-brain imaging technology with submicron resolution to systematically reveal the long-range connectivity patterns of glutamatergic, GABAergic, parvalbumin-expressing (PV+), and somatostatin-expressing (SOM+) neurons in the SSp. Our results show that while glutamatergic, GABAergic, PV+ , and SOM+ neurons receive similar upstream afferent, specific thalamic subregions showed numerically stronger afferent to GABAergic, PV+ , and SOM+ neurons compared to glutamatergic neurons. Additionally, glutamatergic neurons exhibit a more complex collateral projection pattern in subcortical axonal pathways compared to PV+ neurons. These findings elucidate the long-range connectivity patterns of specific neuronal types in the SSp, offering new insights into the cell-type-specific mechanisms of sensory information processing.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104912"},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible role of mosaic mutations of neurodevelopmental disorder-related genes in bipolar disorder: Lessons from Kmt2c chimeric heterozygous knockout mice 神经发育障碍相关基因镶嵌突变在双相情感障碍中的可能作用：来自Kmt2c嵌合敲除小鼠的经验教训。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-23 DOI: 10.1016/j.neures.2025.05.005

Takumi Nakamura , Kazuo Nakajima , Noriko Fujimori-Tonou , Takaoki Kasahara , Takashi Tsuboi , Tadafumi Kato

{"title":"Possible role of mosaic mutations of neurodevelopmental disorder-related genes in bipolar disorder: Lessons from Kmt2c chimeric heterozygous knockout mice","authors":"Takumi Nakamura , Kazuo Nakajima , Noriko Fujimori-Tonou , Takaoki Kasahara , Takashi Tsuboi , Tadafumi Kato","doi":"10.1016/j.neures.2025.05.005","DOIUrl":"10.1016/j.neures.2025.05.005","url":null,"abstract":"<div><div>We recently found a loss of function mosaic mutation of <em>KMT2C</em>, a causative gene for autism spectrum disorder and Kleefstra syndrome, in a patient with bipolar disorder and reported that somatic mutations in neurodevelopmental disorder-related genes are increased in bipolar disorder by deep exome sequencing analysis. However, causal roles of neurodevelopmental disorder-related mutations in bipolar disorder, a qualitatively different mental disorder, are not known. In this study, we focused on a loss of function mutation of <em>Kmt2c</em>, that causes autism-like phenotypes in mice. To simulate a mosaic mutation found in the patient, we generated mosaic <em>Kmt2c</em> knockout mice using conventional chimera mice technology. We showed that the mosaic <em>Kmt2c</em> knockout mice did not show autism-like behavior but presented anxiety disorder-like symptom, which is avoidance to a corner where the mice previously experienced air puff. The rate of depression-like episodes measured by wheel running recording did not differ from control mosaic mice. These results suggest that mosaic mutations of neurodevelopmental disorder-related genes can cause qualitatively different anxiety disorder-like phenotypes. Because anxiety is one of symptomatic spectrum of bipolar disorder, these findings support the role of mosaic mutations of neurodevelopmental disorder-related genes as a component of the genetic architecture of bipolar disorder.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104910"},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-lasting expression of FosB/ΔFosB immunoreactivity following acute stress in the paraventricular and supraoptic nuclei of the rat hypothalamus 急性应激后大鼠下丘脑室旁核和视上核中FosB/ΔFosB免疫反应性的长期表达。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-22 DOI: 10.1016/j.neures.2025.104911

Katsuya Uchida , Gopal Das , Ashraf H. Talukder , Kazunori Kageyama , Keiichi Itoi

{"title":"Long-lasting expression of FosB/ΔFosB immunoreactivity following acute stress in the paraventricular and supraoptic nuclei of the rat hypothalamus","authors":"Katsuya Uchida , Gopal Das , Ashraf H. Talukder , Kazunori Kageyama , Keiichi Itoi","doi":"10.1016/j.neures.2025.104911","DOIUrl":"10.1016/j.neures.2025.104911","url":null,"abstract":"<div><div>We examined expression profiles of FosB/∆FosB immunoreactivity and <em>fosB</em> gene transcripts in the paraventricular nucleus of the hypothalamus (PVH) and the supraoptic nucleus (SON) of rats following acute surgical stress (SS) and restraint stress (RS) and compared them with those of c-Fos immunoreactivity and <em>c-fos</em> mRNA. Following SS, the number of FosB/ΔFosB-ir cells markedly increased, the time course of which was slow-onset and long-lasting, in contrast with rapid-onset and short-lived c-Fos expression. Characteristically long-lasting FosB/ΔFosB expression was also observed following RS. On the other hand, <em>fosB</em> mRNA was short-lived, and its time course not much different from that of <em>c-fos</em> mRNA; thus, the long-lasting expression of FosB/∆FosB immunoreactivity may be attributed to the longer half-life of FosB proteins, and not to the persistent expression of <em>fosB</em> gene transcripts. Following SS, FosB/ΔFosB immunoreactivity was present mainly in PVH corticotropin-releasing factor (CRF) neurons and SON vasopressin (AVP) neurons, while c-Fos immunoreactivity in either PVH CRF neurons, or AVP and oxytocin neurons in PVH and SON. Following RS, FosB/ΔfosB- and c-Fos expression was almost restricted to PVH CRF neurons. The present study raises the possibility that FosB proteins in discrete populations of hypothalamic neuroendocrine neurons may play roles in forming adaptability to and/or resilience against stress, which takes longer than the acute phase response.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104911"},"PeriodicalIF":2.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenously generated patterns of neural activity sculpt axon connectivity 内源性产生的神经活动模式塑造轴突连通性。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-17 DOI: 10.1016/j.neures.2025.05.003

Naoyuki Matsumoto

引用次数: 0

The neurobiology of ticklishness 挠痒的神经生物学。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-16 DOI: 10.1016/j.neures.2025.05.002

Shimpei Ishiyama

{"title":"The neurobiology of ticklishness","authors":"Shimpei Ishiyama","doi":"10.1016/j.neures.2025.05.002","DOIUrl":"10.1016/j.neures.2025.05.002","url":null,"abstract":"<div><div>Ticklishness is an idiosyncratic form of touch observed in multiple animal species, including humans. Although commonly regarded as trivial, it involves complex neurobiological mechanisms and diverse behavioral phenomena observed across species. Two distinct forms exist: knismesis, a mild tingling sensation elicited by gentle touch, and gargalesis, an intense sensation associated with involuntary laughter. Advocating the importance of clearly distinguishing these two types of ticklishness, this review synthesizes current knowledge on their neuronal underpinnings. Topics include somatosensory processing, self-tickling and sensory attenuation, emotional modulation, sociosexual dimensions, and evolutionary perspectives, among others. Special attention is given to the ambivalent nature of gargalesis, challenging conventional single-dimensional models of emotional valence. Ultimately, studying ticklishness provides a valuable opportunity to investigate playful emotional experiences from a naturalistic perspective, addressing fundamental yet underrepresented questions in contemporary neuroscience. Far from trivial, ticklishness thus provides valuable insights into the neural mechanisms underlying complex, context-dependent emotional and social experiences.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104907"},"PeriodicalIF":2.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projection-specific and reversible functional blockage in the association cortex of macaque monkeys 猕猴联合皮层投射特异性和可逆性功能阻滞。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-15 DOI: 10.1016/j.neures.2025.05.004

Seiichirou Yokoo , Takayasu Higo , Florian Gerard-Mercier , Mineki Oguchi , Masamichi Sakagami , Haruhiko Bito , Masayuki Sakamoto , Noritake Ichinohe , Keiji Tanaka

{"title":"Projection-specific and reversible functional blockage in the association cortex of macaque monkeys","authors":"Seiichirou Yokoo , Takayasu Higo , Florian Gerard-Mercier , Mineki Oguchi , Masamichi Sakagami , Haruhiko Bito , Masayuki Sakamoto , Noritake Ichinohe , Keiji Tanaka","doi":"10.1016/j.neures.2025.05.004","DOIUrl":"10.1016/j.neures.2025.05.004","url":null,"abstract":"<div><div>The functional manipulation techniques based on optogenetics have been widely and effectively utilized in the rodent brain. However, the applications of these techniques to the macaque cerebral cortex, particularly those to the prefrontal cortex, have been limited due to the extensive size and complex functional organization of each prefrontal area. In this study, we developed projection-specific and reversible functional blockade methods applicable to areas of the macaque prefrontal cortex, based on chemogenetic techniques. In chemogenetics, once a pair of viral vectors has been injected into the regions of projection source and target, the projection-specific functional blockage can be initiated through the oral, intravenous, or intramuscular administration of an appropriate pharmaceutical agent. Two methods were developed using two different effector proteins, an inhibitory DREADD, hM4Di, and tetanus toxin, given the substantial discrepancy in the on-off time course of functional blockade between the two. The Cre-DIO system was combined with hM4Di, and the Tet-On system with tetanus toxin. The effectiveness of these methods was evaluated by developing an electrophysiological assay using photic stimulation and field potential recordings.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104909"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0