Neuroscience Research最新文献_第2页

The neurobiology of ticklishness 挠痒的神经生物学。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-16 DOI: 10.1016/j.neures.2025.05.002

Shimpei Ishiyama

{"title":"The neurobiology of ticklishness","authors":"Shimpei Ishiyama","doi":"10.1016/j.neures.2025.05.002","DOIUrl":"10.1016/j.neures.2025.05.002","url":null,"abstract":"<div><div>Ticklishness is an idiosyncratic form of touch observed in multiple animal species, including humans. Although commonly regarded as trivial, it involves complex neurobiological mechanisms and diverse behavioral phenomena observed across species. Two distinct forms exist: knismesis, a mild tingling sensation elicited by gentle touch, and gargalesis, an intense sensation associated with involuntary laughter. Advocating the importance of clearly distinguishing these two types of ticklishness, this review synthesizes current knowledge on their neuronal underpinnings. Topics include somatosensory processing, self-tickling and sensory attenuation, emotional modulation, sociosexual dimensions, and evolutionary perspectives, among others. Special attention is given to the ambivalent nature of gargalesis, challenging conventional single-dimensional models of emotional valence. Ultimately, studying ticklishness provides a valuable opportunity to investigate playful emotional experiences from a naturalistic perspective, addressing fundamental yet underrepresented questions in contemporary neuroscience. Far from trivial, ticklishness thus provides valuable insights into the neural mechanisms underlying complex, context-dependent emotional and social experiences.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104907"},"PeriodicalIF":2.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projection-specific and reversible functional blockage in the association cortex of macaque monkeys 猕猴联合皮层投射特异性和可逆性功能阻滞。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-15 DOI: 10.1016/j.neures.2025.05.004

Seiichirou Yokoo , Takayasu Higo , Florian Gerard-Mercier , Mineki Oguchi , Masamichi Sakagami , Haruhiko Bito , Masayuki Sakamoto , Noritake Ichinohe , Keiji Tanaka

{"title":"Projection-specific and reversible functional blockage in the association cortex of macaque monkeys","authors":"Seiichirou Yokoo , Takayasu Higo , Florian Gerard-Mercier , Mineki Oguchi , Masamichi Sakagami , Haruhiko Bito , Masayuki Sakamoto , Noritake Ichinohe , Keiji Tanaka","doi":"10.1016/j.neures.2025.05.004","DOIUrl":"10.1016/j.neures.2025.05.004","url":null,"abstract":"<div><div>The functional manipulation techniques based on optogenetics have been widely and effectively utilized in the rodent brain. However, the applications of these techniques to the macaque cerebral cortex, particularly those to the prefrontal cortex, have been limited due to the extensive size and complex functional organization of each prefrontal area. In this study, we developed projection-specific and reversible functional blockade methods applicable to areas of the macaque prefrontal cortex, based on chemogenetic techniques. In chemogenetics, once a pair of viral vectors has been injected into the regions of projection source and target, the projection-specific functional blockage can be initiated through the oral, intravenous, or intramuscular administration of an appropriate pharmaceutical agent. Two methods were developed using two different effector proteins, an inhibitory DREADD, hM4Di, and tetanus toxin, given the substantial discrepancy in the on-off time course of functional blockade between the two. The Cre-DIO system was combined with hM4Di, and the Tet-On system with tetanus toxin. The effectiveness of these methods was evaluated by developing an electrophysiological assay using photic stimulation and field potential recordings.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104909"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task 直接伸臂任务中人类杏仁核的β波段功率调制。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-11 DOI: 10.1016/j.neures.2025.05.001

Jonathon Cavaleri , Shivani Sundaram , Roberto Martin Del Campo-Vera , Xiecheng Shao , Ryan S. Chung , Miguel Parra , Adith Swarup , Selena Zhang , Alexandra Kammen , Angad Gogia , Xenos Mason , Ryan McGinn , Christi Heck , Charles Y. Liu , Spencer S. Kellis , Brian Lee

{"title":"Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task","authors":"Jonathon Cavaleri , Shivani Sundaram , Roberto Martin Del Campo-Vera , Xiecheng Shao , Ryan S. Chung , Miguel Parra , Adith Swarup , Selena Zhang , Alexandra Kammen , Angad Gogia , Xenos Mason , Ryan McGinn , Christi Heck , Charles Y. Liu , Spencer S. Kellis , Brian Lee","doi":"10.1016/j.neures.2025.05.001","DOIUrl":"10.1016/j.neures.2025.05.001","url":null,"abstract":"<div><div>The human amygdala is primarily known for its involvement in processing emotional and fearful responses, but newer evidence has identified a role for this structure in motor processing. Our lab previously utilized an arm-reaching task and observed significant beta-band (13–30 Hz) modulation in the hippocampus. Given these results, we sought to characterize the role of beta-band modulation in the amygdala during movement execution in participants with stereoelectroencephalography (SEEG) depth electrodes in the amygdala for seizure localization. We show that 9 of 13 participants (69.2 %) showed decreased beta-band power in the amygdala during the Response (movement execution) phase of an arm-reaching task when compared to Fixation (baseline). Secondary analyses show that there are no statistically significant differences in beta-band modulation between ipsilateral and contralateral implanted electrodes, but there is a small difference between male and female participants. The decrease in beta-band power in the amygdala during the Response phase of a Direct Reach task is consistent with our previous findings in the hippocampus. Our study is the first to report beta-band modulation in the amygdala during motor processing and sets the stage for further studies into the involvement of the amygdala in motor control.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104906"},"PeriodicalIF":2.4,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Young fecal microbiota transplantation improves working memory in aged recipient rats by increasing interleukin-4 and interleukin-17 levels 年轻粪便微生物群移植通过增加白细胞介素-4和白细胞介素-17水平改善老年受体大鼠的工作记忆。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-30 DOI: 10.1016/j.neures.2025.04.005

Yiru Yin , Meiqi Guan , Shufen Wu , Chenlong Cui , Rui Wang , Xin Zhao , Xiaorong Yang , Lingran Qiao , Yanli Li , Ce Zhang

{"title":"Young fecal microbiota transplantation improves working memory in aged recipient rats by increasing interleukin-4 and interleukin-17 levels","authors":"Yiru Yin , Meiqi Guan , Shufen Wu , Chenlong Cui , Rui Wang , Xin Zhao , Xiaorong Yang , Lingran Qiao , Yanli Li , Ce Zhang","doi":"10.1016/j.neures.2025.04.005","DOIUrl":"10.1016/j.neures.2025.04.005","url":null,"abstract":"<div><div>While transplanting the fecal microbiota from young to aged rodents has been extensively studied (that is, young FMT [yFMT]), its mechanism of alleviating working memory decline has not been fully elucidated. In this report, we aimed to investigate the effect of yFMT on the working memory of aged recipient rats performing delayed match-to-position (DMTP) tasks and the associated cellular and molecular mechanisms. The results revealed that yFMT mitigated the decline in DMTP task performance of aged recipients. This improvement was associated with a reshaped gut microbiota and increased levels of brain-derived neurotrophic factor, N-methyl-D-aspartate receptor subunit 1, and synaptophysin, enhancing synaptic formation and transmission. The remodeling of the gut microbiome influenced peripheral circulation and the hippocampus and medial prefrontal cortex by regulating the Th17/Treg ratio and microglial polarization. Ultimately, interleukin-4 and interleukin-17 emerged as potential key molecules driving the beneficial effects of FMT. These observations provide new insights into the gut<img>brain axis, emphasizing the connection between the gut and brain through the circulation system, and suggest an immunological mechanism that may help reverse age-related declines in the gut microbiota.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104902"},"PeriodicalIF":2.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications 突触核蛋白病的原纤维种子动物模型：病理机制，疾病建模和治疗意义。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-30 DOI: 10.1016/j.neures.2025.04.008

Norihito Uemura

{"title":"Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications","authors":"Norihito Uemura","doi":"10.1016/j.neures.2025.04.008","DOIUrl":"10.1016/j.neures.2025.04.008","url":null,"abstract":"<div><div>Accumulating evidence suggests that prion-like spread of misfolded α-Synuclein (αSyn) underlies the pathological progression of Lewy body diseases (LBD). Animal models injected with αSyn preformed fibrils (PFFs) have provided strong evidence for the prion hypothesis in LBD. Moreover, αSyn PFFs can be administered to various hosts and regions, contributing to the elucidation of pathological mechanisms and disease modeling. These models have also been used to identify biomarkers and develop new disease-modifying therapies for LBD. In contrast, it remains unknown how the prion-like properties of αSyn contribute to the pathogenesis of multiple system atrophy (MSA). Recent studies indicate that conformationally distinct αSyn fibrils induce different pathological features in animals, supporting the strain hypothesis, which suggests that conformational variations in αSyn fibrils contribute to the clinicopathological heterogeneity in synucleinopathies. However, the study of disease-specific αSyn fibrils in pathological mechanisms and disease modeling is still in its early stages. This review aims to highlight recent advances in αSyn fibril-seeded animal models with an emphasis on their unique features and utility in exploring pathological mechanisms and identifying novel disease-modifying therapies. In addition, I discuss future directions for refining these models in light of the emerging strain hypothesis in synucleinopathies.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104905"},"PeriodicalIF":2.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglial colonization routes and their impacts on cellular diversity 小胶质细胞定植途径及其对细胞多样性的影响。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.004

Yuki Hattori

{"title":"Microglial colonization routes and their impacts on cellular diversity","authors":"Yuki Hattori","doi":"10.1016/j.neures.2025.04.004","DOIUrl":"10.1016/j.neures.2025.04.004","url":null,"abstract":"<div><div>Microglia are the resident immune cells of the central nervous system. Unlike other glial cells—such as astrocytes and oligodendrocytes—which originate from neural stem cells alongside neurons, microglia derive from erythromyeloid progenitors that emerge in the yolk sac during early embryonic development. Once they reach the brain, microglia expand their population through proliferation during development. A growing body of research has revealed that microglia play diverse roles throughout life, both in physiological and pathological contexts. With recent advancements in single-cell transcriptomics, it has become increasingly evident that microglia exhibit substantial heterogeneity in their gene expression patterns. While various functions and subtypes of microglia are being uncovered, the mechanisms underlying their diversity remain largely unknown. Two key hypotheses may explain how microglial diversity arises. One possibility is that their diversity is influenced by the different colonization routes they take before settling in the brain. Alternatively, microglia may acquire distinct properties in response to their local environment. This review explores both possibilities, with a particular focus on the first hypothesis, drawing on recent findings that highlight the multiple routes microglia utilize to colonize the brain. It discusses how these processes contribute to the establishment of microglial diversity during brain development.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104901"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Does big data change neuroscience? 社论：大数据会改变神经科学吗？

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.007

Ryota Kobayashi , Ken Nakae

引用次数: 0

Behavioral competition between infant care and sexual behavior in male but not female common marmosets 雄性而非雌性普通狨猴的育婴和性行为之间的行为竞争。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.003

Takuma Kurachi , Kazutaka Shinozuka , Chihiro Yoshihara , Saori Yano-Nashimoto , Ayako Y. Murayama , Junichi Hata , Hideyuki Okano , Atsuko Saito , Kumi O. Kuroda

{"title":"Behavioral competition between infant care and sexual behavior in male but not female common marmosets","authors":"Takuma Kurachi , Kazutaka Shinozuka , Chihiro Yoshihara , Saori Yano-Nashimoto , Ayako Y. Murayama , Junichi Hata , Hideyuki Okano , Atsuko Saito , Kumi O. Kuroda","doi":"10.1016/j.neures.2025.04.003","DOIUrl":"10.1016/j.neures.2025.04.003","url":null,"abstract":"<div><div>Sexual desire and parenthood sometimes compete in a sexually dimorphic manner, but the neural mechanism for this remains to be clarified. Here we show that, in the family-living primate common marmoset, fathers temporarily reduce infant care during the postpartum mating period leading to conception, whereas mothers do not. Functional suppression of the calcitonin receptor-expressing MPOA subregion (cMPOA) scalably disrupts infant care in both sexes and abolishes sexual behavior in males. The neuronal activation pattern induced by infant care is not identical to, but overlaps with that induced by male mating in the medial preoptic area (MPOA) of the forebrain. These data suggest that the commonality of the neural mechanism required for infant care and sexual behavior in the MPOA may lead to competition between these behaviors in fathers. Further studies are needed to identify the precise neuronal mechanism regulating this phenomenon in marmosets.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104900"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) 急性给药α -甲基色胺（AMT）、5-甲氧基- α -甲基色胺（5-MeO-AMT）和5-甲氧基- n， n -二异丙基色胺（5-MeO-DiPT）后大鼠脑内单胺类神经递质变化的系统研究

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.006

Kaixi Li , Nan Li , Yuanyuan Chen , Xiangyu Li , Yanling Qiao , Dan Wang , Bin Di , Peng Xu

{"title":"A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT)","authors":"Kaixi Li , Nan Li , Yuanyuan Chen , Xiangyu Li , Yanling Qiao , Dan Wang , Bin Di , Peng Xu","doi":"10.1016/j.neures.2025.04.006","DOIUrl":"10.1016/j.neures.2025.04.006","url":null,"abstract":"<div><div>Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are three synthetic tryptamines with hallucinogenic properties that are widely abused worldwide. The hallucinogenic effects of tryptamines are primarily related to activation of the 5-HT receptor, and among the many subtypes of 5-HT receptors, the 5-HT<sub>2A</sub> receptor is the key receptor for hallucinogenic effects. In the present study, the monoamine neurotransmitters DA and its metabolites 3,4-Dihydroxyphenylacetic Acid (DOPAC) and homovanillic acid (HVA), 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were systematically investigated in the prefrontal cortex (PFC), nucleus accumbent (NAc), dorsolateral striatum (DLS) and hippocampus (HIP) using a validated HPLC-ECD analytical method after administration of the three tryptamines at different doses. The results showed that the three tryptamines had certain effects and the effects were different in different brain regions and showed that AMT, 5-MeO-AMT and 5-MeO-DiPT had significant effects on monoaminergic neurotransmitters in rat brains. Among them, DAergic and serotonergic play important roles, and this study provides valuable information for further research on the neurochemical effects of tryptamine hallucinogens in the brain.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104903"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus 代谢综合征和2型糖尿病鼠模型周围神经的炎症和自噬。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-17 DOI: 10.1016/j.neures.2025.04.002

Petra Baum , Thomas Ebert , Nora Klöting , Sontje Krupka , Matthias König , Sabine Paeschke , Peggy Stock , Michal Bulc , Matthias Blüher , Katarzyna Palus , Marcin Nowicki , Joanna Kosacka

引用次数: 0