Neuroscience Research最新文献

Stress and Parental Behaviors.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-12 DOI: 10.1016/j.neures.2024.12.004

Yifan Wang, Dayu Lin

引用次数: 0

LRP1-mediated p-tau propagation contributes to cognitive impairment after chronic neuropathic pain in rats. LRP1 介导的 p-tau 传播导致大鼠慢性神经病理性疼痛后出现认知障碍。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-12 DOI: 10.1016/j.neures.2024.12.005

Youzhi Ning, Yue Zhang, Tao Jiang, Jianguo Feng, Jian Zhan, Cehua Ou, Lu Wang

{"title":"LRP1-mediated p-tau propagation contributes to cognitive impairment after chronic neuropathic pain in rats.","authors":"Youzhi Ning, Yue Zhang, Tao Jiang, Jianguo Feng, Jian Zhan, Cehua Ou, Lu Wang","doi":"10.1016/j.neures.2024.12.005","DOIUrl":"10.1016/j.neures.2024.12.005","url":null,"abstract":"Trigeminal neuralgia (TN) is a prevalent chronic neuropathic pain syndrome characterized by severe pain, often accompanied by cognitive dysfunction and cerebral degeneration. However, its mechanisms remain poorly understood. Hyperphosphorylation of tau protein (p-tau) is often seen in neurodegenerative disorders such as Alzheimer's disease (AD). LRP1 expression on brain neurons and microglial cells is believed to facilitate the propagation of p-tau. We established a TN rat model via infraorbital nerve chronic constrictive injury (ION-CCI). Once the model was established, we investigated the association between p-tau and cognitive impairment in TN rats by evaluating behavioral and degenerative markers. During the initial phase, we noted an increase in p-tau level in the prefrontal cortex and hippocampal tissues of TN rats. The accompanied impaired learning and memory abilities suggested cognitive dysfunction. Blocking p-tau synthesis by orally administering a protein phosphatase and by injecting adenoviral vectors targeting LRP1 into the lateral ventricle of rats ameliorated cognitive impairment. This suggests that cognitive decline in TN rats is linked to elevated p-tau levels. Our findings show that LRP1-mediated p-tau propagation may drive cognitive impairment associated with neuropathic pain in TN rats.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial dynamics of spontaneous activity in the developing and adult cortices.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-07 DOI: 10.1016/j.neures.2024.12.002

Tomonari Murakami

{"title":"Spatial dynamics of spontaneous activity in the developing and adult cortices.","authors":"Tomonari Murakami","doi":"10.1016/j.neures.2024.12.002","DOIUrl":"10.1016/j.neures.2024.12.002","url":null,"abstract":"Even in the absence of external stimuli, the brain remains remarkably active, with neurons continuously firing and communicating with each other. It is not merely random firing of individual neurons but rather orchestrated patterns of activity that propagate throughout the intricate network. Over two decades, advancements in neuroscience observation tools for hemodynamics, membrane potential, and neural calcium signals, have allowed researchers to analyze the dynamics of spontaneous activity across different spatial scales, from individual neurons to macroscale brain networks. One of the remarkable findings from these studies is that the spatial patterns of spontaneous activity in the developing brain are vastly different from those in the mature adult brain. Spatial patterns of spontaneous activity during development are essential for connection refinement between brain regions, whereas the functional role in the adult brain is still controversial. In this paper, I review the differences in spatial dynamics of spontaneous activity between developing and adult cortices. Then, I delve into the cellular mechanisms underlying spontaneous activity, especially its generation and propagation manner, to contribute to a deeper understanding of brain function and its development.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detailed analysis of drift diffusion model parameters estimated for the ultimatum game.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-06 DOI: 10.1016/j.neures.2024.12.003

Shotaro Numano, Masahiko Haruno

{"title":"Detailed analysis of drift diffusion model parameters estimated for the ultimatum game.","authors":"Shotaro Numano, Masahiko Haruno","doi":"10.1016/j.neures.2024.12.003","DOIUrl":"10.1016/j.neures.2024.12.003","url":null,"abstract":"Bargaining is fundamental in human social interactions and often studied using the ultimatum game, where a proposer offers a division of resources, and the responder decides whether to accept or reject it. If accepted, the resources are divided as proposed, but neither party receives anything otherwise. While previous research has typically focused on either the choice or response time, a computational approach that integrates both can provide deeper insights into the cognitive and neural processes involved. Although the drift diffusion model (DDM) has been used for this purpose, few studies have tested it in the context of the ultimatum game. Here, we collected participants' behaviors as a responder during the ultimatum game (n = 71) and analyzed them using a Bayesian version of DDM. The best (estimated) model included parameters for non-decision time, boundary separation, bias, and drift, with drift expressed as a linear combination of self-reward, advantageous inequity, and disadvantageous inequity. This model accurately replicated participants' choices and response times. Our analysis revealed that the drift parameter represents trial-by-trial choices and response times, while other parameters represent average rejection rates and response times. We also found that boundary separation and bias exhibited a more complex interaction than previously recognized. Thus, this study provides important insights into the application of DDM to studies on neural analysis during human bargaining behavior.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell type census in cerebral cortex reveals species-specific brain function and connectivity.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-04 DOI: 10.1016/j.neures.2024.11.008

Kohei Onishi, Tomomi Shimogori

引用次数: 0

Systemic administrations of protamine heal subacute spinal cord injury in mice.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-03 DOI: 10.1016/j.neures.2024.12.001

Tomoya Ozaki, Takahiro Sugie, Yuji Suzuki, Kenji Uchimura, Masumi Suzui, Kazuma Sakamoto, Michiko Shirane, Kenji Kadomatsu

{"title":"Systemic administrations of protamine heal subacute spinal cord injury in mice.","authors":"Tomoya Ozaki, Takahiro Sugie, Yuji Suzuki, Kenji Uchimura, Masumi Suzui, Kazuma Sakamoto, Michiko Shirane, Kenji Kadomatsu","doi":"10.1016/j.neures.2024.12.001","DOIUrl":"10.1016/j.neures.2024.12.001","url":null,"abstract":"Spinal cord injury (SCI) results in damage to neural circuits that cause long-term locomotor and sensory disability. The objective of the present study is to evaluate whether a clinical drug, protamine, can be employed as a therapeutic agent for SCI. First, we examined the rescue effect of protamine on dystrophic endballs (DEs) cultured on a chondroitin sulfate (CS) gradient coating. Consequently, axons with DE, which are unable to grow through the CS barrier, resumed growth after protamine treatment and were able to pass through the barrier. In addition, we tested whether protamine resolves the DE phenotype, accumulation of autophagosomes. The results demonstrated that protamine has significantly reduced the density of LC3 in DEs. Subsequently, mice were administered 1 mg/kg protamine via the tail vein one week following a contusion injury to the thoracic spinal cord. The hindlimb movements of the mice were evaluated in order to assess the therapeutic effect of protamine. Eleven venous administrations of protamine improved the symptoms. The current study has demonstrated that protamine cancels the CS inhibitory effect on axonal regrowth. Administrations of protamine were observed to alleviate hindlimb motor dysfunction in SCI mice. Our results suggest an effective therapeutic agent for SCI and a possibility for drug repositioning. It would be of interest to see if protamine also exerts a therapeutic effect in brain injury.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Augmentation of intracranial self-stimulation induced by amphetamine-like drugs in Period circadian regulator 2 knockout mice is associated with intracellular Ca²⁺ levels. 安非他明类药物诱导的颅内自我刺激在昼夜节律调节器2基因敲除小鼠中的增强与细胞内Ca2+水平有关。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 Epub Date: 2024-07-31 DOI: 10.1016/j.neures.2024.07.007

Hyeokjun Kwon, Eunchong Hong, Yong Sup Lee, Jae Hoon Cheong, Hee Jin Kim, Soyoung Kim, Jaesuk Yun

{"title":"Augmentation of intracranial self-stimulation induced by amphetamine-like drugs in Period circadian regulator 2 knockout mice is associated with intracellular Ca2+ levels.","authors":"Hyeokjun Kwon, Eunchong Hong, Yong Sup Lee, Jae Hoon Cheong, Hee Jin Kim, Soyoung Kim, Jaesuk Yun","doi":"10.1016/j.neures.2024.07.007","DOIUrl":"10.1016/j.neures.2024.07.007","url":null,"abstract":"Over the past decade, new psychoactive substances (NPS) have emerged in the illegal drug market and have continued to attract attention from the international community. Among these, amphetamine-like NPS, classified as stimulants, constitute a significant proportion. However, the pharmacological characteristics and mechanisms underlying addiction to amphetamine-like NPS remain poorly understood. Given that circadian rhythms are linked to the brain stimulation effects of methamphetamine (METH) and amphetamine, we investigated the effects of METH, 1-(4-methoxyphenyl)-N-methylpropan-2-amine (PMMA), and 1-(benzofuran-5-yl)-N-ethylpropan-2-amine (5-EAPB) on intracranial self-stimulation (ICSS) in wild-type (WT) or Period circadian regulator 2 knockout mice. Amphetamine-like drugs increase intracellular Ca2+ levels to provoke dopamine release, so we examined the impact of Per2 knockdown on intracellular Ca2+ levels in PC12 cells to elucidate a potential mechanism underlying NPS-induced ICSS enhancement. Our ICSS results showed that METH and PMMA significantly increased brain stimulation in Per2 knockout mice compared to WT mice. Similarly, METH and PMMA induced higher Ca2+ fluorescence intensity in Per2 knockdown PC12 cells than in control cells. In contrast, 5-EAPB did not produce significant changes in either ICSS or Ca2+ signaling. These findings suggest that Per2 plays a crucial role in the brain stimulation effects of amphetamine-like drugs through the regulation of intracellular Ca2+.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":"34-41"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlations of brain structure with the social behavior of 15q11-13 duplication mice, an animal model of autism. 自闭症动物模型 15q11-13 重复小鼠大脑结构与社交行为的相关性。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 Epub Date: 2024-08-02 DOI: 10.1016/j.neures.2024.07.009

Zhilei Zhao, Naohiro Okada, Sho Yagishita, Noriaki Yahata, Nobuhiro Nitta, Sayaka Shibata, Yoshifumi Abe, Susumu Morita, Eureka Kumagai, Kenji F Tanaka, Tetsuya Suhara, Toru Takumi, Kiyoto Kasai, Seiichiro Jinde

{"title":"Correlations of brain structure with the social behavior of 15q11-13 duplication mice, an animal model of autism.","authors":"Zhilei Zhao, Naohiro Okada, Sho Yagishita, Noriaki Yahata, Nobuhiro Nitta, Sayaka Shibata, Yoshifumi Abe, Susumu Morita, Eureka Kumagai, Kenji F Tanaka, Tetsuya Suhara, Toru Takumi, Kiyoto Kasai, Seiichiro Jinde","doi":"10.1016/j.neures.2024.07.009","DOIUrl":"10.1016/j.neures.2024.07.009","url":null,"abstract":"Duplication of chromosome 15q11-13 has been reported to be one of the most frequent cytogenetic copy number variations in autism spectrum disorder (ASD), and a mouse model of paternal 15q11-13 duplication was generated, termed 15q dup mice. While previous studies have replicated some of the behavioral and brain structural phenotypes of ASD separately, the relationship between brain structure and behavior has rarely been examined. In this study, we performed behavioral experiments related to anxiety and social behaviors and magnetic resonance imaging (MRI) using the same set of 15q dup and wild-type mice. 15q dup mice showed increased anxiety and a tendency toward alterations in social behaviors, as reported previously, as well as variability in terms of sociability. MRI analysis revealed that a lower sociability index was correlated with a smaller gray matter volume in the right medial entorhinal cortex. These results may help to understand how variability in behavioral phenotypes of ASD arises even in individuals with the same genetic background and to determine the individual differences in neurodevelopmental trajectory correlated with specific brain structures that underlie these phenotypes.","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":"42-49"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation. 杏仁核簇间的双向情绪编码：动机的对手过程理论的神经基础

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 Epub Date: 2024-07-19 DOI: 10.1016/j.neures.2024.07.003

Kenta M Hagihara, Andreas Lüthi

引用次数: 0

Structural connectivity of the precuneus and its relation to resting-state networks. 楔前肌的结构连接及其与静息态网络的关系

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 Epub Date: 2023-12-30 DOI: 10.1016/j.neures.2023.12.004

Atsushi Yamaguchi, Tatsuya Jitsuishi

引用次数: 0