Neuroscience Research最新文献

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Editorial: Neuroscience of Resilience for Mental Health. 社论:心理健康复原力的神经科学。
IF 2.4 4区 医学
Neuroscience Research Pub Date : 2024-11-16 DOI: 10.1016/j.neures.2024.11.006
Tomoyuki Furuyashiki, Scott J Russo
{"title":"Editorial: Neuroscience of Resilience for Mental Health.","authors":"Tomoyuki Furuyashiki, Scott J Russo","doi":"10.1016/j.neures.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.neures.2024.11.006","url":null,"abstract":"","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular, neural, and tissue circuits underlying physiological temperature responses in Caenorhabditis elegans. 草履虫生理温度反应的分子、神经和组织回路。
IF 2.4 4区 医学
Neuroscience Research Pub Date : 2024-11-13 DOI: 10.1016/j.neures.2024.11.001
Yukina Mori, Akane Ohta, Atsushi Kuhara
{"title":"Molecular, neural, and tissue circuits underlying physiological temperature responses in Caenorhabditis elegans.","authors":"Yukina Mori, Akane Ohta, Atsushi Kuhara","doi":"10.1016/j.neures.2024.11.001","DOIUrl":"10.1016/j.neures.2024.11.001","url":null,"abstract":"<p><p>Temperature is a constant environmental factor on Earth, acting as a continuous stimulus that organisms must constantly perceive to survive. Organisms possess neural systems that receive various types of environmental information, including temperature, and mechanisms for adapting to their surroundings. This paper provides insights into the neural circuits and intertissue networks involved in physiological temperature responses, specifically the mechanisms of \"cold tolerance\" and \"temperature acclimation,\" based on an analysis of the nematode Caenorhabditis elegans as an experimental system for neural and intertissue information processing.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural substrates of choking under pressure: A 7T-fMRI study. 压力下窒息的神经基础:7T-fMRI 研究。
IF 2.4 4区 医学
Neuroscience Research Pub Date : 2024-11-13 DOI: 10.1016/j.neures.2024.11.004
Kanae Ogasawara, Takahiko Koike, Masaki Fukunaga, Ayumi Yoshioka, Tetsuya Yamamoto, Norihiro Sadato
{"title":"Neural substrates of choking under pressure: A 7T-fMRI study.","authors":"Kanae Ogasawara, Takahiko Koike, Masaki Fukunaga, Ayumi Yoshioka, Tetsuya Yamamoto, Norihiro Sadato","doi":"10.1016/j.neures.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.neures.2024.11.004","url":null,"abstract":"<p><p>Perform ance decrement under excessive psychological pressure is known as \"choking,\" yet its mechanisms and neural foundations remain underexplored. Hypothesizing that changes in the internal model could induce choking, we conducted a 7T functional MRI introducing excessive pressure through a rare Jackpot condition that offers high rewards for successful performance. Twenty-nine volunteers underwent a visual reaching task. We monitored practice and main sessions to map the task's internal model through learning. Participants were pre-informed of four potential reward conditions upon success at the beginning of the main session task. The success rates in the Jackpot condition were significantly lower than in other conditions, indicative of choking. During the preparation phase, activations in the cerebellum and the middle temporal visual area (hMT+) were associated with Jackpot-specific failures. The cluster in the cerebellar hemisphere overlapped with the internal model regions identified by a learning-related decrease in activation during the practice session. We observed task-specific functional connectivity between the cerebellum and hMT+. These findings suggest a lack of sensory attenuation when an internal model predicting the outcome of one's actions is preloaded during motor preparation. Within the active inference framework of motor control, choking stems from the cerebellum's internal model modulation by psychological pressure, manifested through improper sensory attenuation.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A chemogenetic technology using insect Ionotropic Receptors to stimulate target cell populations in the mammalian brain. 利用昆虫离子受体刺激哺乳动物大脑目标细胞群的化学遗传技术。
IF 2.4 4区 医学
Neuroscience Research Pub Date : 2024-11-10 DOI: 10.1016/j.neures.2024.11.003
Yoshio Iguchi, Richard Benton, Kazuto Kobayashi
{"title":"A chemogenetic technology using insect Ionotropic Receptors to stimulate target cell populations in the mammalian brain.","authors":"Yoshio Iguchi, Richard Benton, Kazuto Kobayashi","doi":"10.1016/j.neures.2024.11.003","DOIUrl":"10.1016/j.neures.2024.11.003","url":null,"abstract":"<p><p>Chemogenetics uses artificially-engineered proteins to modify the activity of cells, notably neurons, in response to small molecules. Although a common set of chemogenetic tools are the G protein-coupled receptor-based DREADDs, there has been great hope for ligand-gated, ion channel-type chemogenetic tools that directly impact neuronal excitability. We have devised such a technology by exploiting insect Ionotropic Receptors (IRs), a highly divergent subfamily of ionotropic glutamate receptors that evolved to detect diverse environmental chemicals. Here, we review a series of studies developing and applying this \"IR-mediated neuronal activation\" (IRNA) technology with the Drosophila melanogaster IR84a/IR8a complex, which detects phenyl-containing ligands. We also discuss how variants of IRNA could be produced by modifying the composition of the IR complex, using natural or engineered subunits, which would enable artificial activation of different cell populations in the brain in response to distinct chemicals.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice. 在小鼠的经典条件反射过程中,纹状体中多巴胺的释放是对奖励和厌恶结果的反应。
IF 2.4 4区 医学
Neuroscience Research Pub Date : 2024-11-07 DOI: 10.1016/j.neures.2024.11.002
Tomohiko Yoshizawa, Makoto Funahashi
{"title":"Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice.","authors":"Tomohiko Yoshizawa, Makoto Funahashi","doi":"10.1016/j.neures.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.neures.2024.11.002","url":null,"abstract":"<p><p>The striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. Striosomes comprise approximately 15 % of the striatum by volume and are distributed mosaically. Therefore, it is difficult to selectively record dopamine dynamics in striosomes using traditional neurochemical measurements in behaving animals, and it is unclear whether distinct dynamics play a role in associative learning. In this study, we used transgenic mice selectively expressing Cre in striosomal neurons, combined with a fiber photometry technique, to selectively record dopamine release in striosomes during classical conditioning. Water-restricted mice could distinguish the conditioned stimulus (CS) associated with saccharin water from the air-puff-associated CS. The air-puff-associated CS evoked phasic dopamine release only in striosomes. Furthermore, air puff presentation induced dopamine release to striosomal neurons but suppressed release to striatal neurons non-selectively recorded. These findings suggest that dopamine is released in a differential manner in striosomes and the matrix in behaving animals and that dopamine release in striosomes is preferentially induced by the air-puff-associated CS and air puff presentation. These findings support the hypothesis that striosomal neurons play a dominant role in aversive stimuli prediction.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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