Neuroscience Research最新文献

Whole-brain long-range connectivity of glutamatergic, GABAergic, parvalbumin-expressing and somatostatin-expressing neurons in mouse somatosensory cortex 小鼠体感觉皮层谷氨酸能、gaba能、小蛋白表达和生长抑素表达神经元的全脑远程连通性

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-26 DOI: 10.1016/j.neures.2025.104912

Zhaoxin Zhu , Tao Jiang , Xueyan Jia , Xiaojun Wang , Miao Ren

{"title":"Whole-brain long-range connectivity of glutamatergic, GABAergic, parvalbumin-expressing and somatostatin-expressing neurons in mouse somatosensory cortex","authors":"Zhaoxin Zhu , Tao Jiang , Xueyan Jia , Xiaojun Wang , Miao Ren","doi":"10.1016/j.neures.2025.104912","DOIUrl":"10.1016/j.neures.2025.104912","url":null,"abstract":"<div><div>Understanding the composition of cortical circuits at the whole-brain scale is crucial. However, the specific ways in which particular neuronal types in the primary somatosensory cortex (SSp) establish connections with upstream and downstream brain regions remain unclear. In this study, we used whole-brain imaging technology with submicron resolution to systematically reveal the long-range connectivity patterns of glutamatergic, GABAergic, parvalbumin-expressing (PV+), and somatostatin-expressing (SOM+) neurons in the SSp. Our results show that while glutamatergic, GABAergic, PV+ , and SOM+ neurons receive similar upstream afferent, specific thalamic subregions showed numerically stronger afferent to GABAergic, PV+ , and SOM+ neurons compared to glutamatergic neurons. Additionally, glutamatergic neurons exhibit a more complex collateral projection pattern in subcortical axonal pathways compared to PV+ neurons. These findings elucidate the long-range connectivity patterns of specific neuronal types in the SSp, offering new insights into the cell-type-specific mechanisms of sensory information processing.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104912"},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible role of mosaic mutations of neurodevelopmental disorder-related genes in bipolar disorder: Lessons from Kmt2c chimeric heterozygous knockout mice 神经发育障碍相关基因镶嵌突变在双相情感障碍中的可能作用：来自Kmt2c嵌合敲除小鼠的经验教训。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-23 DOI: 10.1016/j.neures.2025.05.005

Takumi Nakamura , Kazuo Nakajima , Noriko Fujimori-Tonou , Takaoki Kasahara , Takashi Tsuboi , Tadafumi Kato

{"title":"Possible role of mosaic mutations of neurodevelopmental disorder-related genes in bipolar disorder: Lessons from Kmt2c chimeric heterozygous knockout mice","authors":"Takumi Nakamura , Kazuo Nakajima , Noriko Fujimori-Tonou , Takaoki Kasahara , Takashi Tsuboi , Tadafumi Kato","doi":"10.1016/j.neures.2025.05.005","DOIUrl":"10.1016/j.neures.2025.05.005","url":null,"abstract":"<div><div>We recently found a loss of function mosaic mutation of <em>KMT2C</em>, a causative gene for autism spectrum disorder and Kleefstra syndrome, in a patient with bipolar disorder and reported that somatic mutations in neurodevelopmental disorder-related genes are increased in bipolar disorder by deep exome sequencing analysis. However, causal roles of neurodevelopmental disorder-related mutations in bipolar disorder, a qualitatively different mental disorder, are not known. In this study, we focused on a loss of function mutation of <em>Kmt2c</em>, that causes autism-like phenotypes in mice. To simulate a mosaic mutation found in the patient, we generated mosaic <em>Kmt2c</em> knockout mice using conventional chimera mice technology. We showed that the mosaic <em>Kmt2c</em> knockout mice did not show autism-like behavior but presented anxiety disorder-like symptom, which is avoidance to a corner where the mice previously experienced air puff. The rate of depression-like episodes measured by wheel running recording did not differ from control mosaic mice. These results suggest that mosaic mutations of neurodevelopmental disorder-related genes can cause qualitatively different anxiety disorder-like phenotypes. Because anxiety is one of symptomatic spectrum of bipolar disorder, these findings support the role of mosaic mutations of neurodevelopmental disorder-related genes as a component of the genetic architecture of bipolar disorder.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104910"},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-lasting expression of FosB/ΔFosB immunoreactivity following acute stress in the paraventricular and supraoptic nuclei of the rat hypothalamus. 急性应激后大鼠下丘脑室旁核和视上核中FosB/ΔFosB免疫反应性的长期表达。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-22 DOI: 10.1016/j.neures.2025.104911

Katsuya Uchida, Gopal Das, Ashraf H Talukder, Kazunori Kageyama, Keiichi Itoi

{"title":"Long-lasting expression of FosB/ΔFosB immunoreactivity following acute stress in the paraventricular and supraoptic nuclei of the rat hypothalamus.","authors":"Katsuya Uchida, Gopal Das, Ashraf H Talukder, Kazunori Kageyama, Keiichi Itoi","doi":"10.1016/j.neures.2025.104911","DOIUrl":"https://doi.org/10.1016/j.neures.2025.104911","url":null,"abstract":"<p><p>We examined expression profiles of FosB/∆FosB immunoreactivity and fosB gene transcripts in the paraventricular nucleus of the hypothalamus (PVH) and the supraoptic nucleus (SON) of rats following acute surgical stress (SS) and restraint stress (RS) and compared them with those of c-Fos immunoreactivity and c-fos mRNA. Following SS, the number of FosB/ΔFosB-ir cells markedly increased, the time course of which was slow-onset and long-lasting, in contrast with rapid-onset and short-lived c-Fos expression. Characteristically long-lasting FosB/ΔFosB expression was also observed following RS. On the other hand, fosB mRNA was short-lived, and its time course not much different from that of c-fos mRNA; thus, the long-lasting expression of FosB/∆FosB immunoreactivity may be attributed to the longer half-life of FosB proteins, and not to the persistent expression of fosB gene transcripts. Following SS, FosB/ΔFosB immunoreactivity was present mainly in PVH corticotropin-releasing factor (CRF) neurons and SON vasopressin (AVP) neurons, while c-Fos immunoreactivity in either PVH CRF neurons, or AVP and oxytocin neurons in PVH and SON. Following RS, FosB/ΔfosB- and c-Fos expression was almost restricted to PVH CRF neurons. The present study raises the possibility that FosB proteins in discrete populations of hypothalamic neuroendocrine neurons may play roles in forming adaptability to and/or resilience against stress, which takes longer than the acute phase response.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":"104911"},"PeriodicalIF":2.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenously generated patterns of neural activity sculpt axon connectivity. 内源性产生的神经活动模式塑造轴突连通性。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-17 DOI: 10.1016/j.neures.2025.05.003

Naoyuki Matsumoto

引用次数: 0

The neurobiology of ticklishness 挠痒的神经生物学。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-16 DOI: 10.1016/j.neures.2025.05.002

Shimpei Ishiyama

{"title":"The neurobiology of ticklishness","authors":"Shimpei Ishiyama","doi":"10.1016/j.neures.2025.05.002","DOIUrl":"10.1016/j.neures.2025.05.002","url":null,"abstract":"<div><div>Ticklishness is an idiosyncratic form of touch observed in multiple animal species, including humans. Although commonly regarded as trivial, it involves complex neurobiological mechanisms and diverse behavioral phenomena observed across species. Two distinct forms exist: knismesis, a mild tingling sensation elicited by gentle touch, and gargalesis, an intense sensation associated with involuntary laughter. Advocating the importance of clearly distinguishing these two types of ticklishness, this review synthesizes current knowledge on their neuronal underpinnings. Topics include somatosensory processing, self-tickling and sensory attenuation, emotional modulation, sociosexual dimensions, and evolutionary perspectives, among others. Special attention is given to the ambivalent nature of gargalesis, challenging conventional single-dimensional models of emotional valence. Ultimately, studying ticklishness provides a valuable opportunity to investigate playful emotional experiences from a naturalistic perspective, addressing fundamental yet underrepresented questions in contemporary neuroscience. Far from trivial, ticklishness thus provides valuable insights into the neural mechanisms underlying complex, context-dependent emotional and social experiences.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104907"},"PeriodicalIF":2.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projection-specific and reversible functional blockage in the association cortex of macaque monkeys 猕猴联合皮层投射特异性和可逆性功能阻滞。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-15 DOI: 10.1016/j.neures.2025.05.004

Seiichirou Yokoo , Takayasu Higo , Florian Gerard-Mercier , Mineki Oguchi , Masamichi Sakagami , Haruhiko Bito , Masayuki Sakamoto , Noritake Ichinohe , Keiji Tanaka

{"title":"Projection-specific and reversible functional blockage in the association cortex of macaque monkeys","authors":"Seiichirou Yokoo , Takayasu Higo , Florian Gerard-Mercier , Mineki Oguchi , Masamichi Sakagami , Haruhiko Bito , Masayuki Sakamoto , Noritake Ichinohe , Keiji Tanaka","doi":"10.1016/j.neures.2025.05.004","DOIUrl":"10.1016/j.neures.2025.05.004","url":null,"abstract":"<div><div>The functional manipulation techniques based on optogenetics have been widely and effectively utilized in the rodent brain. However, the applications of these techniques to the macaque cerebral cortex, particularly those to the prefrontal cortex, have been limited due to the extensive size and complex functional organization of each prefrontal area. In this study, we developed projection-specific and reversible functional blockade methods applicable to areas of the macaque prefrontal cortex, based on chemogenetic techniques. In chemogenetics, once a pair of viral vectors has been injected into the regions of projection source and target, the projection-specific functional blockage can be initiated through the oral, intravenous, or intramuscular administration of an appropriate pharmaceutical agent. Two methods were developed using two different effector proteins, an inhibitory DREADD, hM4Di, and tetanus toxin, given the substantial discrepancy in the on-off time course of functional blockade between the two. The Cre-DIO system was combined with hM4Di, and the Tet-On system with tetanus toxin. The effectiveness of these methods was evaluated by developing an electrophysiological assay using photic stimulation and field potential recordings.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"217 ","pages":"Article 104909"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task. 直接伸臂任务中人类杏仁核的β波段功率调制。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-11 DOI: 10.1016/j.neures.2025.05.001

Jonathon Cavaleri, Shivani Sundaram, Roberto Martin Del Campo-Vera, Xiecheng Shao, Ryan S Chung, Miguel Parra, Adith Swarup, Selena Zhang, Alexandra Kammen, Angad Gogia, Xenos Mason, Ryan McGinn, Christi Heck, Charles Y Liu, Spencer S Kellis, Brian Lee

{"title":"Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task.","authors":"Jonathon Cavaleri, Shivani Sundaram, Roberto Martin Del Campo-Vera, Xiecheng Shao, Ryan S Chung, Miguel Parra, Adith Swarup, Selena Zhang, Alexandra Kammen, Angad Gogia, Xenos Mason, Ryan McGinn, Christi Heck, Charles Y Liu, Spencer S Kellis, Brian Lee","doi":"10.1016/j.neures.2025.05.001","DOIUrl":"10.1016/j.neures.2025.05.001","url":null,"abstract":"<p><p>The human amygdala is primarily known for its involvement in processing emotional and fearful responses, but newer evidence has identified a role for this structure in motor processing. Our lab previously utilized an arm-reaching task and observed significant beta-band (13-30 Hz) modulation in the hippocampus. Given these results, we sought to characterize the role of beta-band modulation in the amygdala during movement execution in participants with stereoelectroencephalography (SEEG) depth electrodes in the amygdala for seizure localization. We show that 9 of 13 participants (69.2 %) showed decreased beta-band power in the amygdala during the Response (movement execution) phase of an arm-reaching task when compared to Fixation (baseline). Secondary analyses show that there are no statistically significant differences in beta-band modulation between ipsilateral and contralateral implanted electrodes, but there is a small difference between male and female participants. The decrease in beta-band power in the amygdala during the Response phase of a Direct Reach task is consistent with our previous findings in the hippocampus. Our study is the first to report beta-band modulation in the amygdala during motor processing and sets the stage for further studies into the involvement of the amygdala in motor control.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Young fecal microbiota transplantation improves working memory in aged recipient rats by increasing interleukin-4 and interleukin-17 levels. 年轻粪便微生物群移植通过增加白细胞介素-4和白细胞介素-17水平改善老年受体大鼠的工作记忆。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-30 DOI: 10.1016/j.neures.2025.04.005

Yiru Yin, Meiqi Guan, Shufen Wu, Chenlong Cui, Rui Wang, Xin Zhao, Xiaorong Yang, Lingran Qiao, Yanli Li, Ce Zhang

{"title":"Young fecal microbiota transplantation improves working memory in aged recipient rats by increasing interleukin-4 and interleukin-17 levels.","authors":"Yiru Yin, Meiqi Guan, Shufen Wu, Chenlong Cui, Rui Wang, Xin Zhao, Xiaorong Yang, Lingran Qiao, Yanli Li, Ce Zhang","doi":"10.1016/j.neures.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.neures.2025.04.005","url":null,"abstract":"<p><p>While transplanting the fecal microbiota from young to aged rodents has been extensively studied (that is, young FMT [yFMT]), its mechanism of alleviating working memory decline has not been fully elucidated. In this report, we aimed to investigate the effect of yFMT on the working memory of aged recipient rats performing delayed match-to-position (DMTP) tasks and the associated cellular and molecular mechanisms. The results revealed that yFMT mitigated the decline in DMTP task performance of aged recipients. This improvement was associated with a reshaped gut microbiota and increased levels of brain-derived neurotrophic factor, N-methyl-D-aspartate receptor subunit 1, and synaptophysin, enhancing synaptic formation and transmission. The remodeling of the gut microbiome influenced peripheral circulation and the hippocampus and medial prefrontal cortex by regulating the Th17/Treg ratio and microglial polarization. Ultimately, interleukin-4 and interleukin-17 emerged as potential key molecules driving the beneficial effects of FMT. These observations provide new insights into the gutbrain axis, emphasizing the connection between the gut and brain through the circulation system, and suggest an immunological mechanism that may help reverse age-related declines in the gut microbiota.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications. 突触核蛋白病的原纤维种子动物模型：病理机制，疾病建模和治疗意义。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-30 DOI: 10.1016/j.neures.2025.04.008

Norihito Uemura

{"title":"Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications.","authors":"Norihito Uemura","doi":"10.1016/j.neures.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.neures.2025.04.008","url":null,"abstract":"<p><p>Accumulating evidence suggests that prion-like spread of misfolded α-Synuclein (αSyn) underlies the pathological progression of Lewy body diseases (LBD). Animal models injected with αSyn preformed fibrils (PFFs) have provided strong evidence for the prion hypothesis in LBD. Moreover, αSyn PFFs can be administered to various hosts and regions, contributing to the elucidation of pathological mechanisms and disease modeling. These models have also been used to identify biomarkers and develop new disease-modifying therapies for LBD. In contrast, it remains unknown how the prion-like properties of αSyn contribute to the pathogenesis of multiple system atrophy (MSA). Recent studies indicate that conformationally distinct αSyn fibrils induce different pathological features in animals, supporting the strain hypothesis, which suggests that conformational variations in αSyn fibrils contribute to the clinicopathological heterogeneity in synucleinopathies. However, the study of disease-specific αSyn fibrils in pathological mechanisms and disease modeling is still in its early stages. This review aims to highlight recent advances in αSyn fibril-seeded animal models with an emphasis on their unique features and utility in exploring pathological mechanisms and identifying novel disease-modifying therapies. In addition, I discuss future directions for refining these models in light of the emerging strain hypothesis in synucleinopathies.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglial colonization routes and their impacts on cellular diversity. 小胶质细胞定植途径及其对细胞多样性的影响。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.004

Yuki Hattori

{"title":"Microglial colonization routes and their impacts on cellular diversity.","authors":"Yuki Hattori","doi":"10.1016/j.neures.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.neures.2025.04.004","url":null,"abstract":"<p><p>Microglia are the resident immune cells of the central nervous system. Unlike other glial cells-such as astrocytes and oligodendrocytes-which originate from neural stem cells alongside neurons, microglia derive from erythromyeloid progenitors that emerge in the yolk sac during early embryonic development. Once they reach the brain, microglia expand their population through proliferation during development. A growing body of research has revealed that microglia play diverse roles throughout life, both in physiological and pathological contexts. With recent advancements in single-cell transcriptomics, it has become increasingly evident that microglia exhibit substantial heterogeneity in their gene expression patterns. While various functions and subtypes of microglia are being uncovered, the mechanisms underlying their diversity remain largely unknown. Two key hypotheses may explain how microglial diversity arises. One possibility is that their diversity is influenced by the different colonization routes they take before settling in the brain. Alternatively, microglia may acquire distinct properties in response to their local environment. This review explores both possibilities, with a particular focus on the first hypothesis, drawing on recent findings that highlight the multiple routes microglia utilize to colonize the brain. It discusses how these processes contribute to the establishment of microglial diversity during brain development.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0