Neuroscience Research最新文献

Asfotase alfa restores PLP-dependent GABA, cystathionine, and amino acid metabolism in a mouse model of hypophosphatasia 在低磷酸症小鼠模型中，Asfotase α恢复plp依赖的GABA、胱胱甘氨酸和氨基酸代谢。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-11 DOI: 10.1016/j.neures.2025.104940

Kathryn N. Phoenix , Andre Marozsan , Susan Liu-Chen , Lizhong Zhang , Amit Mogha , Yan Wong , Catherine A. Brownstein , Raja Padidela

引用次数: 0

Functional analysis of periaqueductal gray neurons projecting to the medulla in active and passive defensive behaviors 主动和被动防御行为中投射到延髓的导水管周围灰色神经元的功能分析

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-07 DOI: 10.1016/j.neures.2025.104939

Yuki Honshuku , Yuki Yamaguchi , Koki Kawazoe , Yuki Nishida , Yuki Kurauchi , Masabumi Minami , Hiroshi Katsuki , Natsuko Hitora-Imamura

{"title":"Functional analysis of periaqueductal gray neurons projecting to the medulla in active and passive defensive behaviors","authors":"Yuki Honshuku , Yuki Yamaguchi , Koki Kawazoe , Yuki Nishida , Yuki Kurauchi , Masabumi Minami , Hiroshi Katsuki , Natsuko Hitora-Imamura","doi":"10.1016/j.neures.2025.104939","DOIUrl":"10.1016/j.neures.2025.104939","url":null,"abstract":"<div><div>Fear responses and defensive behaviors are essential for survival. Fear responses are mediated by neural circuits that detect threatening stimuli and classify them as “unpleasant” or “aversive”. These circuits coordinate the selection of defensive behaviors, such as freezing or flight, depending on the perceived imminence of the threat. Activation of excitatory neurons in the lateral/ventrolateral periaqueductal gray (l/vlPAG) induces diverse fear responses, depending on the subregions, projection targets, and stimulation intensity. Some l/vlPAG neurons project to the magnocellular nucleus of the medulla (Mc). However, it remains unclear which of the diverse behaviors arising from different intensities of l/vlPAG stimulation are mediated via the l/vlPAG-Mc pathway. Additionally, the role of the l/vlPAG-Mc pathway activation in driving negative or positive valence-related behavior is unknown. To address these questions, we used optogenetics to stimulate Mc-projecting l/vlPAG neurons at two levels of light intensity and analyzed the resulting behavioral changes. Strong stimulation of Mc-projecting l/vlPAG neurons induced flight behavior, whereas weak stimulation elicited a freezing response. Real-time and conditioned place aversion tests indicated that strong stimulation was aversive. These findings suggest that strong stimulation of Mc-projecting l/vlPAG neurons induces active defensive behavior and behavioral aversion, while weak stimulation induces passive defensive behavior.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"218 ","pages":"Article 104939"},"PeriodicalIF":2.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formyl peptide receptor 2 antagonist WRW4 ameliorates diabetes-induced cognitive decline in mice 甲酰基肽受体2拮抗剂WRW4改善糖尿病诱导的小鼠认知能力下降。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-05 DOI: 10.1016/j.neures.2025.104932

Hiroki Uno , Takahide Itokazu , Toshihide Yamashita

{"title":"Formyl peptide receptor 2 antagonist WRW4 ameliorates diabetes-induced cognitive decline in mice","authors":"Hiroki Uno , Takahide Itokazu , Toshihide Yamashita","doi":"10.1016/j.neures.2025.104932","DOIUrl":"10.1016/j.neures.2025.104932","url":null,"abstract":"<div><div>Cognitive impairment is a significant complication of diabetes. Although the detailed mechanism remains unclear, prolonged neuroinflammation mediated by microglia is recognized as a key contributor to neural dysfunction. Recent studies have shown that Formyl peptide receptor 1 (FPR1), a G protein-coupled chemoattractant receptor, plays a role in microglial activation and brain pathology. However, the involvement of FPR2, another isoform within the FPR family, in microglial activation and cognitive decline has not yet been explored. In this study, we observed an increased expression of FPR2 in microglia within the hippocampus of type 2 diabetes (db/db) mice. Furthermore, we demonstrated that intracerebroventricular administration of WRW4, a selective FPR2 antagonist, alleviates diabetes-related cognitive decline. Histological analysis revealed that WRW4 treatment mitigates morphological alteration and upregulation of a phagocytic marker (CD68) of the microglia in the hippocampus of db/db mice. These results indicate that FPR2 plays a critical role in inducing diabetes-related microglial phenotype. These findings highlight the therapeutic potential of FPR2 signal inhibition as a novel strategy to mitigate cognitive decline associated with diabetes.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"218 ","pages":"Article 104932"},"PeriodicalIF":2.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biased thalamic innervation onto the distinct subregion where dopamine receptor 1 is dominantly expressed in the caudal striatum 偏置丘脑神经支配到多巴胺受体1在尾状体中主要表达的独特亚区。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-30 DOI: 10.1016/j.neures.2025.104930

Fuko Kadono , Jingqi Wang , Kenta Kobayashi , Fuyuki Karube , Fumino Fujiyama

{"title":"Biased thalamic innervation onto the distinct subregion where dopamine receptor 1 is dominantly expressed in the caudal striatum","authors":"Fuko Kadono , Jingqi Wang , Kenta Kobayashi , Fuyuki Karube , Fumino Fujiyama","doi":"10.1016/j.neures.2025.104930","DOIUrl":"10.1016/j.neures.2025.104930","url":null,"abstract":"<div><div>In the ventral part of the caudal striatum, the direct and indirect pathway neurons are unevenly distributed, forming zones with a paucity of neurons with dopamine receptor 1 (D1R) or dopamine receptor 2 (D2R), referred as D1R- or D2R-poor zone (D1pz or D2pz, respectively). This contrasts with their uniform distribution in other striatal regions. A key question is whether D1pz and D2pz function as a unit or independently. Since the striatum requires afferent excitatory inputs for activation, investigating biased excitatory inputs to the caudal striatum is essential. Our findings indicate that vesicular glutamate transporter 2 (VGluT2) was concentrated in D2pz, suggesting biased excitatory innervation. Retrograde tracer labeling identified potential sources of subcortical glutamatergic projections. Projection from the paraventricular nucleus of the thalamus (PVT) was visualized using VGluT2-Cre mice. PVT preferentially projected to the ventral caudal region in the striatum. Quantitative analysis of PVT axons revealed preferential localization in the D2pz, with fewer axons in the D1pz. The substantia nigra pars lateralis, innervated by the caudal striatum, did not project to the PVT, suggesting the caudal striatum and PVT may not form a part of the cortico-basal ganglia-thalamic loop. These results imply that D1pz and D2pz may be differentially activated by PVT inputs, selectively recruiting direct pathways.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"218 ","pages":"Article 104930"},"PeriodicalIF":2.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of MEK1/2 blocker U0126 on the medial preoptic synapse and behavioral selection of male mice MEK1/2阻滞剂U0126对雄性小鼠内侧视前突触和行为选择的影响。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-28 DOI: 10.1016/j.neures.2025.104929

Yumi Hamasaki, Masabumi Minami, Taiju Amano

{"title":"Effects of MEK1/2 blocker U0126 on the medial preoptic synapse and behavioral selection of male mice","authors":"Yumi Hamasaki, Masabumi Minami, Taiju Amano","doi":"10.1016/j.neures.2025.104929","DOIUrl":"10.1016/j.neures.2025.104929","url":null,"abstract":"<div><div>The central part of the mouse medial preoptic area (cMPOA) is involved in parental behavior because the neurotoxic lesion of the cMPOA disturbed parental behavior and switched to infanticidal behavior. The cMPOA receives projection from many brain regions, including the medial amygdala (Me). We have previously found that optogenetic inhibition of the projection pathway from the Me to the cMPOA in virgin male mice suppressed the infanticidal behavior of virgin mice toward pups. Furthermore, electrophysiological analysis has revealed that intracellular signaling-mediated disinhibition occurs in the cMPOA neurons during the transition from virgin to father in gestation experience (FGE) mice. However, the specific downstream signal transduction pathway remains unclear. In this study, we utilized U0126, a MEK1/2 inhibitor, because U0126 has been reported to modulate GABAergic currents. Therefore, we examined the contribution of U0126 at the synaptic and behavioral levels. Applying U0126 to the cMPOA neurons in FGE mice restored eIPSP as much as that in cMPOA neurons in virgin mice. Furthermore, microinfusion of U0126 into the cMPOA shifted the behavioral pattern of FGE mice toward infanticide. These changes were not observed in the mice that experienced parenting. The results suggest that MEK1/2 mediates neurotransmission in the cMPOA and contributes to the stage transition from virgin to FGE mice after mating with females.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"218 ","pages":"Article 104929"},"PeriodicalIF":2.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dopamine dynamics underlying maternal motivation and reward 母性动机和奖励背后的多巴胺动态。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-25 DOI: 10.1016/j.neures.2025.104928

Katherine R. Day, Stephen D. Shea

{"title":"Dopamine dynamics underlying maternal motivation and reward","authors":"Katherine R. Day, Stephen D. Shea","doi":"10.1016/j.neures.2025.104928","DOIUrl":"10.1016/j.neures.2025.104928","url":null,"abstract":"<div><div>Maternal behavior comprises a diverse set of caregiving actions essential for ensuring offspring survival and development. Shaped by evolutionary pressures, these behaviors range from goal-directed and coordinated overt motor actions such as nest building and pup retrieval to sustained akinetic states such as nursing and crouching. These can each be thought of as varying along two continua, one which captures the appetitive versus consummatory aspects of a given behavior, and the other describes the relative activity or passivity of the behavior. Since individual behaviors (1) vary substantially along these axes, and (2) evolve in time, we propose that motivated execution of them is likely accomplished through dynamic regulation by multiple circuits and neuromodulatory systems. One important regulator of maternal behaviors is dopamine (DA), a key neuromodulator that makes diverse contributions to behavior. Classically, dopamine is hypothesized to play a role in both the appetitive (e.g. pup retrieval) and consummatory (e.g. nursing, grooming) aspects of maternal behavior via distinct circuitry. Considering recent studies revealing the temporal dynamics of DA during maternal behavior, we examine the complexity of the concepts of appetitive and consummatory drive as maternal behavior unfolds in time. We propose that seemingly discrete behaviors, like pup retrieval, may be appreciated as evolving sequences of appetitive and consummatory components that reflect shifts in underlying neural dynamics at different timescales.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"218 ","pages":"Article 104928"},"PeriodicalIF":2.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of sleep on the Th17/Treg axis and cytokine levels in patients with major depressive disorder 睡眠对重度抑郁症患者Th17/Treg轴和细胞因子水平的影响

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-25 DOI: 10.1016/j.neures.2025.104927

Tiantian Fu , Wanting Zhang , Shengxiao Zhang , Feng Tian

{"title":"The impact of sleep on the Th17/Treg axis and cytokine levels in patients with major depressive disorder","authors":"Tiantian Fu , Wanting Zhang , Shengxiao Zhang , Feng Tian","doi":"10.1016/j.neures.2025.104927","DOIUrl":"10.1016/j.neures.2025.104927","url":null,"abstract":"<div><div>A cross-sectional study was designed to investigate the relationship between immune parameters and sleep quality in patients with depression, in which 65 depression patients and 63 healthy controls were enrolled between August 2021 and June 2024, with sleep assessments ultimately completed by 59 depression patients following exclusions. Th17/Treg cell ratios and cytokine levels were measured using flow cytometry and cytometric bead array (CBA), and correlation and regression analyses were performed to evaluate associations between sleep quality and inflammatory markers. Elevated Th17 cells, Th17/Treg imbalance, and increased IL-6 and IL-17 levels were observed in depression patients compared to controls (all <em>P</em> < 0.0167), while higher IL-4, IL-6, and IL-17 levels were found in patients with sleep disorders (all <em>P</em> < 0.0071). Th17/Treg ratios were positively correlated with sleep disturbance scores, whereas Treg levels showed an inverse correlation, and IL-6, IL-17, IFN-γ, and TNF-α levels were positively associated with sleep disturbances (all <em>P</em> < 0.05). Furthermore, IL-6 and IFN-γ were identified as significant predictors of poor sleep quality (all <em>P</em> < 0.05). These findings suggest that inflammatory dysregulation, particularly elevated IL-6 and IFN-γ, is associated with poorer sleep quality in depression patients, providing potential insights for enhanced clinical management.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"218 ","pages":"Article 104927"},"PeriodicalIF":2.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall” [Neurosci. Res. 212 (2025) 75–83] “记忆巩固和回忆过程中前扣带皮层离线长期增强的时间窗口”的勘误[神经科学]。Res. 212 (2025) 75-83]

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-21 DOI: 10.1016/j.neures.2025.104926

Junyu Liu , Akihiro Goto , Yasunori Hayashi

引用次数: 0

Parent brain responses to child facial and vocal communication: What different methodologies reveal about parenting cognitions and practices as well as their moderation by parental status, gender, and culture as well as child characteristics 父母对儿童面部和声音交流的大脑反应：不同的方法揭示了父母的认知和实践，以及父母地位、性别、文化和儿童特征的调节作用。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-20 DOI: 10.1016/j.neures.2025.104925

Marc H. Bornstein , Amir Gandjbakhche , Thien Nguyen , Gianluca Esposito

{"title":"Parent brain responses to child facial and vocal communication: What different methodologies reveal about parenting cognitions and practices as well as their moderation by parental status, gender, and culture as well as child characteristics","authors":"Marc H. Bornstein , Amir Gandjbakhche , Thien Nguyen , Gianluca Esposito","doi":"10.1016/j.neures.2025.104925","DOIUrl":"10.1016/j.neures.2025.104925","url":null,"abstract":"<div><div>Parenting is constituted of caregiving cognitions and practices, based in evolution and biology as well as culture and context, and lodged in nervous system structure and function. This narrative review first discusses parenting and an orientation toward caregiving in terms of its nature, constituents, and goals. Next, the review operationalizes parenting cognitions and practices that are expressed in response to facial and vocal cues of young offspring and revealed in naturalistic and experimental studies using behavioral preferences, attention tasks, and implicit association tests. Studies of autonomic and central nervous system structures and functions in the service of parenting are subsequently reviewed. Taken together, these investigations of the parent nervous system reveal associations with, and likely neuropsychological underpinnings of, parenting cognitions and practices and begin to unveil specific mechanisms and loci in the human nervous system that define a neuroscience of parenting.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"218 ","pages":"Article 104925"},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of L-alanine on sleep through taste properties in Drosophila melanogaster l -丙氨酸通过果蝇味觉特性对睡眠的影响。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-14 DOI: 10.1016/j.neures.2025.104924

Rabia Garibağaoğlu, Riho Kobayashi , Victoria Hanashiro, Jun Tomita, Kazuhiko Kume

引用次数: 0