Neuroscience Research最新文献_第10页

Adaptive circuits for action and value information in rodent operant learning 啮齿动物操作学习中的行动和价值信息适应回路

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-26 DOI: 10.1016/j.neures.2024.09.003

Alain Rios , Kyohei Fujita , Yoshikazu Isomura , Nobuya Sato

{"title":"Adaptive circuits for action and value information in rodent operant learning","authors":"Alain Rios , Kyohei Fujita , Yoshikazu Isomura , Nobuya Sato","doi":"10.1016/j.neures.2024.09.003","DOIUrl":"10.1016/j.neures.2024.09.003","url":null,"abstract":"<div><div>Operant learning is a behavioral paradigm where animals learn to associate their actions with consequences, adapting their behavior accordingly. This review delves into the neural circuits that underpin operant learning in rodents, emphasizing the dynamic interplay between neural pathways, synaptic plasticity, and gene expression changes. We explore the cortico-basal ganglia circuits, highlighting the pivotal role of dopamine in modulating these pathways to reinforce behaviors that yield positive outcomes. We include insights from recent studies, which reveals the intricate roles of midbrain dopamine neurons in integrating action initiation and reward feedback, thereby enhancing movement-related activities in the dorsal striatum. Additionally, we discuss the molecular diversity of striatal neurons and their specific roles in reinforcement learning. The review also covers advances in transcriptome analysis techniques, such as single-cell RNA sequencing, which have provided deeper insights into the gene expression profiles associated with different neuronal populations during operant learning.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"214 ","pages":"Pages 62-68"},"PeriodicalIF":2.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automatic detection of foot-strike onsets in a rhythmic forelimb movement 自动检测有节奏的前肢运动中的击脚起始点

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.04.002

引用次数: 0

Elevation in body temperature may increase susceptibility to cortical spreading depression in a rat model 在大鼠模型中，体温升高可能会增加皮层扩散抑制的易感性

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.04.004

{"title":"Elevation in body temperature may increase susceptibility to cortical spreading depression in a rat model","authors":"","doi":"10.1016/j.neures.2024.04.004","DOIUrl":"10.1016/j.neures.2024.04.004","url":null,"abstract":"<div><p>One characteristic of migraine is recurrent headache attacks, which are known to be induced by changes in climatic variables such as atmospheric pressure, humidity, and outside temperature. However, the relationship between temperature changes and migraine remains unclear. Therefore, we investigated the relationship between body temperature changes and cortical spreading depression (CSD) using KCl-induced rat models of CSD. We initially induced CSD under controlled conditions at a room temperature of 28°C on an operating table maintained at 37°C. Subsequently, we controlled the operating table temperature to induce a second round of CSD under conditions of either a 10 ± 1% increase or decrease in body temperature. We ensured 1 h rest period between the first and second inductions of CSD. The results indicated that the number of CSDs significantly increased after body temperature elevation (before, 8.8 ± 1.2 times vs. after, 13.4 ± 1.3 times; p = 0.0003). The mean percentage change in cerebral blood flow decreased after body temperature increased (before, 33.1 ± 2.4% vs. after, 18.2 ± 1.4%; p = 0.006). There were no significant changes in CSD after body temperature decreased. The susceptibility of the cortex to CSD may increase under conditions of elevated body temperature.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"206 ","pages":"Pages 30-34"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000555/pdfft?md5=fb4552627cc27f3e7fc8c8301ab611b7&pid=1-s2.0-S0168010224000555-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140801170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the human conflict processing network: A review of the literature on direct neural recordings during performance of a modified stroop task 了解人类冲突处理网络：在执行修改后的 stroop 任务时进行直接神经记录的文献综述

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.03.006

{"title":"Understanding the human conflict processing network: A review of the literature on direct neural recordings during performance of a modified stroop task","authors":"","doi":"10.1016/j.neures.2024.03.006","DOIUrl":"10.1016/j.neures.2024.03.006","url":null,"abstract":"<div><p>The Stroop Task is a well-known neuropsychological task developed to investigate conflict processing in the human brain. Our group has utilized direct intracranial neural recordings in various brain regions during performance of a modified color-word Stroop Task to gain a mechanistic understanding of non-emotional human conflict processing. The purpose of this review article is to: 1) synthesize our own studies into a model of human conflict processing, 2) review the current literature on the Stroop Task and other conflict tasks to put our research in context, and 3) describe how these studies define a network in conflict processing. The figures presented are reprinted from our prior publications and key publications referenced in the manuscript. We summarize all studies to date that employ invasive intracranial recordings in humans during performance of conflict-inducing tasks. For our own studies, we analyzed local field potentials (LFPs) from patients with implanted stereotactic electroencephalography (SEEG) electrodes, and we observed intracortical oscillation patterns as well as intercortical temporal relationships in the hippocampus, amygdala, and orbitofrontal cortex (OFC) during the cue-processing phase of a modified Stroop Task. Our findings suggest that non-emotional human conflict processing involves modulation across multiple frequency bands within and between brain structures.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"206 ","pages":"Pages 1-19"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000518/pdfft?md5=456561bd46c338ddde0006f6ca04bfab&pid=1-s2.0-S0168010224000518-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recovery of node of ranvier structure in optic nerve under visual deprivation 视觉剥夺下视神经 Ranvier 节结构的恢复

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.03.005

引用次数: 0

Structural MRI analysis of age-related changes and sex differences in marmoset brain volume 对狨猴脑容量与年龄有关的变化和性别差异的结构性核磁共振成像分析

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.04.003

{"title":"Structural MRI analysis of age-related changes and sex differences in marmoset brain volume","authors":"","doi":"10.1016/j.neures.2024.04.003","DOIUrl":"10.1016/j.neures.2024.04.003","url":null,"abstract":"<div><p>The field of aging biology, which aims to extend healthy lifespans and prevent age-related diseases, has turned its focus to the Callithrix jacchus (common marmoset) to understand the aging process better. This study utilized magnetic resonance imaging (MRI) to non-invasively analyze the brains of 216 marmosets, investigating age-related changes in brain structure; the relationship between body weight and brain volume; and potential differences between males and females. The key findings revealed that, similar to humans, Callithrix jacchus experiences a reduction in total intracranial volume, cortex, subcortex, thalamus, and cingulate volumes as they age, highlighting site-dependent changes in brain tissue. Notably, the study also uncovered sex differences in cerebellar volume. These insights into the structural connectivity and volumetric changes in the marmoset brain throughout aging contribute to accumulating valuable knowledge in the field, promising to inform future aging research and interventions for enhancing healthspan.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"206 ","pages":"Pages 20-29"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000531/pdfft?md5=c778303959df20403d55a45a215246a9&pid=1-s2.0-S0168010224000531-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140763283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic activity changes in transcription factors: Unlocking the mechanisms regulating physiological changes in the brain 转录因子的动态活性变化：揭开大脑生理变化的调节机制。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-10 DOI: 10.1016/j.neures.2024.08.001

Kentaro Abe

引用次数: 0

A data augmentation procedure to improve detection of spike ripples in brain voltage recordings 改进脑电压记录中尖峰波纹检测的数据增强程序。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-03 DOI: 10.1016/j.neures.2024.07.005

Emily D. Schlafly , Daniel Carbonero , Catherine J. Chu , Mark A. Kramer

{"title":"A data augmentation procedure to improve detection of spike ripples in brain voltage recordings","authors":"Emily D. Schlafly , Daniel Carbonero , Catherine J. Chu , Mark A. Kramer","doi":"10.1016/j.neures.2024.07.005","DOIUrl":"10.1016/j.neures.2024.07.005","url":null,"abstract":"<div><div>Epilepsy is a major neurological disorder characterized by recurrent, spontaneous seizures. For patients with drug-resistant epilepsy, treatments include neurostimulation or surgical removal of the epileptogenic zone (EZ), the brain region responsible for seizure generation. Precise targeting of the EZ requires reliable biomarkers. Spike ripples - high-frequency oscillations that co-occur with large amplitude epileptic discharges - have gained prominence as a candidate biomarker. However, spike ripple detection remains a challenge. The gold-standard approach requires an expert manually visualize and interpret brain voltage recordings, which limits reproducibility and high-throughput analysis. Addressing these limitations requires more objective, efficient, and automated methods for spike ripple detection, including approaches that utilize deep neural networks. Despite advancements, dataset heterogeneity and scarcity severely limit machine learning performance. Our study explores long-short term memory (LSTM) neural network architectures for spike ripple detection, leveraging data augmentation to improve classifier performance. We highlight the potential of combining training on augmented and <em>in vivo</em> data for enhanced spike ripple detection and ultimately improving diagnostic accuracy in epilepsy treatment.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"215 ","pages":"Pages 15-26"},"PeriodicalIF":2.4,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inference of monosynaptic connections from parallel spike trains: A review 从平行尖峰序列推断单突触连接：综述。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-02 DOI: 10.1016/j.neures.2024.07.006

Ryota Kobayashi , Shigeru Shinomoto

引用次数: 0

Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with sweetener consumption in mice 丘脑前室旁核的神经元活动与小鼠甜味剂摄入量呈正相关。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-01 DOI: 10.1016/j.neures.2024.02.002

{"title":"Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with sweetener consumption in mice","authors":"","doi":"10.1016/j.neures.2024.02.002","DOIUrl":"10.1016/j.neures.2024.02.002","url":null,"abstract":"<div><p>Although the brain can discriminate between various sweet substances, the underlying neural mechanisms of this complex behavior remain elusive. This study examines the role of the anterior paraventricular nucleus of the thalamus (aPVT) in governing sweet preference in mice. We fed the mice six different diets with equal sweetness for six weeks: control diet (CD), high sucrose diet (HSD), high stevioside diet (HSSD), high xylitol diet (HXD), high glycyrrhizin diet (HGD), and high mogroside diet (HMD). The mice exhibited a marked preference specifically for the HSD and HSSD. Following consumption of these diets, c-Fos expression levels in the aPVT were significantly higher in these two groups compared to the others. Utilizing fiber photometry calcium imaging, we observed rapid activation of aPVT neurons in response to sucrose and stevioside intake, but not to xylitol or water. Our findings suggest that aPVT activity aligns with sweet preference in mice, and notably, stevioside is the sole plant-based sweetener that elicits an aPVT response comparable to that of sucrose.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"205 ","pages":"Pages 16-26"},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000269/pdfft?md5=61234f8f1288f304b09f74dfdc1ff41f&pid=1-s2.0-S0168010224000269-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0