Neuroscience Research最新文献_第10页

Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency 经颅交流电刺激对感觉运动皮层本体感觉刺激诱发的β反弹的增强。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-03-28 DOI: 10.1016/j.neures.2025.03.008

Mayu Akaiwa , Ryo Kurokawa , Yuya Matsuda , Yasushi Sugawara , Rin Kosuge , Hidekazu Saito , Eriko Shibata , Takeshi Sasaki , Kazuhiro Sugawara

{"title":"Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency","authors":"Mayu Akaiwa , Ryo Kurokawa , Yuya Matsuda , Yasushi Sugawara , Rin Kosuge , Hidekazu Saito , Eriko Shibata , Takeshi Sasaki , Kazuhiro Sugawara","doi":"10.1016/j.neures.2025.03.008","DOIUrl":"10.1016/j.neures.2025.03.008","url":null,"abstract":"<div><div>Transcranial alternating current stimulation (tACS) can modulate endogenous brain oscillations in a frequency-specific manner. Previous studies have reported that beta tACS modulates the excitability of primary motor cortex and improves task performance. Tactile and proprioceptive stimuli also elicit event-related synchronization of the beta rhythm in contralateral sensorimotor cortex, termed beta rebound, and a strong correlation was reported between proprioception-induced rebound strength and clinical recovery in stroke patients. We investigated the effects of tACS matched to the dominant beta frequency on the strength of proprioception-induced beta rebound.We recorded the beta rebound from 14 healthy young adults in response to passive index finger movement by electroencephalography to determine individual peak beta frequency. Electroencephalograms (EEG) were recorded during passive movements before and after active or sham tACS. We recorded beta rebound of all participants to determine their individual peak frequency of beta rebound prior to this experiment. Active tACS at individually matched frequencies increased beta rebound strength during subsequent passive movement compared to sham tACS in the majority of participants, while the remaining participants demonstrated no significant change or a decrease. These findings on healthy participants provide an essential foundation for further studies on the effects of beta frequency-matched tACS for stroke patient rehabilitation.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104896"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications 突触核蛋白病的原纤维种子动物模型：病理机制，疾病建模和治疗意义。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-04-30 DOI: 10.1016/j.neures.2025.04.008

Norihito Uemura

{"title":"Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications","authors":"Norihito Uemura","doi":"10.1016/j.neures.2025.04.008","DOIUrl":"10.1016/j.neures.2025.04.008","url":null,"abstract":"<div><div>Accumulating evidence suggests that prion-like spread of misfolded α-Synuclein (αSyn) underlies the pathological progression of Lewy body diseases (LBD). Animal models injected with αSyn preformed fibrils (PFFs) have provided strong evidence for the prion hypothesis in LBD. Moreover, αSyn PFFs can be administered to various hosts and regions, contributing to the elucidation of pathological mechanisms and disease modeling. These models have also been used to identify biomarkers and develop new disease-modifying therapies for LBD. In contrast, it remains unknown how the prion-like properties of αSyn contribute to the pathogenesis of multiple system atrophy (MSA). Recent studies indicate that conformationally distinct αSyn fibrils induce different pathological features in animals, supporting the strain hypothesis, which suggests that conformational variations in αSyn fibrils contribute to the clinicopathological heterogeneity in synucleinopathies. However, the study of disease-specific αSyn fibrils in pathological mechanisms and disease modeling is still in its early stages. This review aims to highlight recent advances in αSyn fibril-seeded animal models with an emphasis on their unique features and utility in exploring pathological mechanisms and identifying novel disease-modifying therapies. In addition, I discuss future directions for refining these models in light of the emerging strain hypothesis in synucleinopathies.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104905"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress and parental behaviors 压力和父母行为。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2024-12-12 DOI: 10.1016/j.neures.2024.12.004

Yifan Wang , Dayu Lin

引用次数: 0

Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task 直接伸臂任务中人类杏仁核的β波段功率调制。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-05-11 DOI: 10.1016/j.neures.2025.05.001

Jonathon Cavaleri , Shivani Sundaram , Roberto Martin Del Campo-Vera , Xiecheng Shao , Ryan S. Chung , Miguel Parra , Adith Swarup , Selena Zhang , Alexandra Kammen , Angad Gogia , Xenos Mason , Ryan McGinn , Christi Heck , Charles Y. Liu , Spencer S. Kellis , Brian Lee

{"title":"Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task","authors":"Jonathon Cavaleri , Shivani Sundaram , Roberto Martin Del Campo-Vera , Xiecheng Shao , Ryan S. Chung , Miguel Parra , Adith Swarup , Selena Zhang , Alexandra Kammen , Angad Gogia , Xenos Mason , Ryan McGinn , Christi Heck , Charles Y. Liu , Spencer S. Kellis , Brian Lee","doi":"10.1016/j.neures.2025.05.001","DOIUrl":"10.1016/j.neures.2025.05.001","url":null,"abstract":"<div><div>The human amygdala is primarily known for its involvement in processing emotional and fearful responses, but newer evidence has identified a role for this structure in motor processing. Our lab previously utilized an arm-reaching task and observed significant beta-band (13–30 Hz) modulation in the hippocampus. Given these results, we sought to characterize the role of beta-band modulation in the amygdala during movement execution in participants with stereoelectroencephalography (SEEG) depth electrodes in the amygdala for seizure localization. We show that 9 of 13 participants (69.2 %) showed decreased beta-band power in the amygdala during the Response (movement execution) phase of an arm-reaching task when compared to Fixation (baseline). Secondary analyses show that there are no statistically significant differences in beta-band modulation between ipsilateral and contralateral implanted electrodes, but there is a small difference between male and female participants. The decrease in beta-band power in the amygdala during the Response phase of a Direct Reach task is consistent with our previous findings in the hippocampus. Our study is the first to report beta-band modulation in the amygdala during motor processing and sets the stage for further studies into the involvement of the amygdala in motor control.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104906"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral competition between infant care and sexual behavior in male but not female common marmosets 雄性而非雌性普通狨猴的育婴和性行为之间的行为竞争。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1016/j.neures.2025.04.003

Takuma Kurachi , Kazutaka Shinozuka , Chihiro Yoshihara , Saori Yano-Nashimoto , Ayako Y. Murayama , Junichi Hata , Hideyuki Okano , Atsuko Saito , Kumi O. Kuroda

{"title":"Behavioral competition between infant care and sexual behavior in male but not female common marmosets","authors":"Takuma Kurachi , Kazutaka Shinozuka , Chihiro Yoshihara , Saori Yano-Nashimoto , Ayako Y. Murayama , Junichi Hata , Hideyuki Okano , Atsuko Saito , Kumi O. Kuroda","doi":"10.1016/j.neures.2025.04.003","DOIUrl":"10.1016/j.neures.2025.04.003","url":null,"abstract":"<div><div>Sexual desire and parenthood sometimes compete in a sexually dimorphic manner, but the neural mechanism for this remains to be clarified. Here we show that, in the family-living primate common marmoset, fathers temporarily reduce infant care during the postpartum mating period leading to conception, whereas mothers do not. Functional suppression of the calcitonin receptor-expressing MPOA subregion (cMPOA) scalably disrupts infant care in both sexes and abolishes sexual behavior in males. The neuronal activation pattern induced by infant care is not identical to, but overlaps with that induced by male mating in the medial preoptic area (MPOA) of the forebrain. These data suggest that the commonality of the neural mechanism required for infant care and sexual behavior in the MPOA may lead to competition between these behaviors in fathers. Further studies are needed to identify the precise neuronal mechanism regulating this phenomenon in marmosets.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104900"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo recording from calcitonin receptor-expressing neurons in the medial preoptic area during affiliative social behaviors 在亲和的社会行为中，来自内侧视前区表达降钙素受体的神经元的体内记录。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-01-31 DOI: 10.1016/j.neures.2025.01.007

Kansai Fukumitsu , Chihiro Yoshihara , Arthur J. Huang , Thomas J. McHugh , Kumi O. Kuroda

{"title":"In vivo recording from calcitonin receptor-expressing neurons in the medial preoptic area during affiliative social behaviors","authors":"Kansai Fukumitsu , Chihiro Yoshihara , Arthur J. Huang , Thomas J. McHugh , Kumi O. Kuroda","doi":"10.1016/j.neures.2025.01.007","DOIUrl":"10.1016/j.neures.2025.01.007","url":null,"abstract":"<div><div>Social animals, including mice, are motivated to seek social contact and avoid being alone due to the benefit of the group living in survival and reproductive values. We have previously reported that pup exposure and co-housing with adult female mice can induce the expression of c-Fos in calcitonin receptor (Calcr) neurons located in the medial preoptic area (MPOA) of female mice. These neurons mediate maternal and social contact behaviors among adult virgin females. However, the correlation of the activity of MPOA<sup>Calcr+</sup> neurons with specific social behaviors remains unclear. In this study, we used in vivo fiber photometry to study MPOA<sup>Calcr+</sup> neuron activity during affiliative social behaviors. We found that MPOA<sup>Calcr+</sup> neurons are activated during proactive contact with adult female mice but not during passive contact, suggesting that motivation to seek social contacts is associated with the activation of these neurons. MPOA<sup>Calcr+</sup> neurons are not activated during contact with non-social objects, such as novel foods and nesting materials, supporting their specific involvement in social behavior. Furthermore, these neurons are more robustly activated during alloparental behaviors such as pup retrieval. Overall, this study demonstrates the involvement of MPOA<sup>Calcr+</sup> neurons in motivated social interactions with pups and peer females.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104878"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus 代谢综合征和2型糖尿病鼠模型周围神经的炎症和自噬。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-04-17 DOI: 10.1016/j.neures.2025.04.002

Petra Baum , Thomas Ebert , Nora Klöting , Sontje Krupka , Matthias König , Sabine Paeschke , Peggy Stock , Michal Bulc , Matthias Blüher , Katarzyna Palus , Marcin Nowicki , Joanna Kosacka

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A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) 急性给药α -甲基色胺（AMT）、5-甲氧基- α -甲基色胺（5-MeO-AMT）和5-甲氧基- n， n -二异丙基色胺（5-MeO-DiPT）后大鼠脑内单胺类神经递质变化的系统研究

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1016/j.neures.2025.04.006

Kaixi Li , Nan Li , Yuanyuan Chen , Xiangyu Li , Yanling Qiao , Dan Wang , Bin Di , Peng Xu

{"title":"A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT)","authors":"Kaixi Li , Nan Li , Yuanyuan Chen , Xiangyu Li , Yanling Qiao , Dan Wang , Bin Di , Peng Xu","doi":"10.1016/j.neures.2025.04.006","DOIUrl":"10.1016/j.neures.2025.04.006","url":null,"abstract":"<div><div>Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are three synthetic tryptamines with hallucinogenic properties that are widely abused worldwide. The hallucinogenic effects of tryptamines are primarily related to activation of the 5-HT receptor, and among the many subtypes of 5-HT receptors, the 5-HT<sub>2A</sub> receptor is the key receptor for hallucinogenic effects. In the present study, the monoamine neurotransmitters DA and its metabolites 3,4-Dihydroxyphenylacetic Acid (DOPAC) and homovanillic acid (HVA), 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were systematically investigated in the prefrontal cortex (PFC), nucleus accumbent (NAc), dorsolateral striatum (DLS) and hippocampus (HIP) using a validated HPLC-ECD analytical method after administration of the three tryptamines at different doses. The results showed that the three tryptamines had certain effects and the effects were different in different brain regions and showed that AMT, 5-MeO-AMT and 5-MeO-DiPT had significant effects on monoaminergic neurotransmitters in rat brains. Among them, DAergic and serotonergic play important roles, and this study provides valuable information for further research on the neurochemical effects of tryptamine hallucinogens in the brain.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104903"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-scale foundation models and generative AI for BigData neuroscience 用于大数据神经科学的大规模基础模型和生成式人工智能。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-01 Epub Date: 2024-06-17 DOI: 10.1016/j.neures.2024.06.003

Ran Wang , Zhe Sage Chen

引用次数: 0

Probing neuronal activity with genetically encoded calcium and voltage fluorescent indicators 利用基因编码的钙离子和电压荧光指示剂探测神经元活动

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-06-01 Epub Date: 2024-06-15 DOI: 10.1016/j.neures.2024.06.004

Masayuki Sakamoto, Tatsushi Yokoyama

引用次数: 0