Neuroscience Research最新文献_第10页

Gait rhythm analysis as a new continuous scale for cerebellar ataxia: Power law and lognormal components represent the ataxic gait quantity 步态节律分析是小脑共济失调的一种新的连续量表：幂律和对数正态成分代表共济失调步态量。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.07.001

引用次数: 0

Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity 海马沃伯格效应介导硫化氢改善糖尿病相关认知功能障碍：涉及促进海马突触可塑性。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.07.002

Run-Qi Li , Wei-Wen Zhu , Cheng Li , Ke-Bin Zhan , Ping Zhang , Fan Xiao , Jia-Mei Jiang , Wei Zou

{"title":"Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity","authors":"Run-Qi Li , Wei-Wen Zhu , Cheng Li , Ke-Bin Zhan , Ping Zhang , Fan Xiao , Jia-Mei Jiang , Wei Zou","doi":"10.1016/j.neures.2024.07.002","DOIUrl":"10.1016/j.neures.2024.07.002","url":null,"abstract":"<div><div>Our previous studies have reported that hydrogen sulfide (H<sub>2</sub>S) has ability to improve diabetes-associated cognitive dysfunction (DACD), but the exact mechanisms remain unknown. Recent research reveals that Warburg effect is associated with synaptic plasticity which plays a key role in cognition promotion. Herein, the present study was aimed to demonstrate whether hippocampal Warburg effect contributes to H<sub>2</sub>S-ameliorated DACD and further explore its potential mechanism. We found that H<sub>2</sub>S promoted the hippocampal Warburg effect and inhibited the OxPhos in the hippocampus of STZ-induced diabetic rats. It also improved the hippocampal synaptic plasticity in STZ-induced diabetic rats, as evidenced by the change of microstructures and the expression of different key-enzymes. Furthermore, inhibited hippocampal Warburg effect induced by DCA markedly abolished the improvement of H<sub>2</sub>S on synaptic plasticity in the hippocampus of STZ-induced diabetic rats. DCA blocked H<sub>2</sub>S-attenuated the cognitive dysfunction in STZ-induced diabetic rats, according to the Y-maze, Novel Objective Recognition, and Morris Water Maze tests. Collectively, these findings indicated that the hippocampal Warburg effect mediates H<sub>2</sub>S-ameliorated DACD by improving hippocampal synaptic plasticity.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"208 ","pages":"Pages 15-28"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REELIN ameliorates Alzheimer's disease, but how? REELIN 可改善阿尔茨海默病，但如何改善？

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.07.004

Yu Katsuyama , Mitsuharu Hattori

{"title":"REELIN ameliorates Alzheimer's disease, but how?","authors":"Yu Katsuyama , Mitsuharu Hattori","doi":"10.1016/j.neures.2024.07.004","DOIUrl":"10.1016/j.neures.2024.07.004","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is the most prevalent type of dementia; therefore, there is a high demand for therapeutic medication targeting it. In this context, extensive research has been conducted to identify molecular targets for drugs. AD manifests through two primary pathological signs: senile plaques and neurofibrillary tangles, caused by accumulations of amyloid-beta (Aβ) and phosphorylated tau, respectively. Thus, studies concerning the molecular mechanisms underlying AD etiology have primarily focused on Aβ generation and tau phosphorylation, with the anticipation of uncovering a signaling pathway impacting these molecular processes. Over the past two decades, studies using not only experimental model systems but also examining human brains have accumulated fragmentary evidences suggesting that REELIN signaling pathway is deeply involved in AD. Here, we explore REELIN signaling pathway and its involvement in memory function within the brain and review studies investigating molecular connections between REELIN signaling pathway and AD etiology. This review aims to understand how the manipulation (activation) of this pathway might ameliorate the disease’s etiology.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"208 ","pages":"Pages 8-14"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models 新型胆固醇 24- 羟化酶抑制剂索替列司他在急性和慢性神经变性模型中的特性分析

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.06.005

{"title":"Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models","authors":"","doi":"10.1016/j.neures.2024.06.005","DOIUrl":"10.1016/j.neures.2024.06.005","url":null,"abstract":"<div><div>We investigated whether soticlestat (TAK-935), a newly discovered cholesterol 24-hydroxylase (CH24H) inhibitor now in phase 3 clinical trials for Dravet and Lennox-Gastaut syndromes, has effects on neurodegeneration in both chronic and acute animal models associated with glutamate hyperexcitation. Soticlestat was administered at doses that approximately halve 24S-hydroxycholesterol in both experiments. In the kainic acid (KA)-induced acute hippocampal degeneration model, soticlestat ameliorated inflammatory cytokine expression, hippocampal degeneration, and memory impairment. We ruled out the possibility that soticlestat directly interferes with KA binding to the KA receptor, or that 24S-hydroxycholesterol modulates KA receptor signaling, by conducting receptor binding and cell death assays. In the PS19 chronic degeneration model of tauopathy, treatment effects were observed in neurodegeneration markers. Notably, there was a significant correlation between the levels of brain 24S-hydroxycholesterol and a proinflammatory cytokine, tumor necrosis factor-α, which is implicated in cognitive decline and lowering of seizure threshold. This is the first study demonstrating that CH24H inhibition can alleviate neurodegeneration concomitant with neuroinflammation. Herein, we discuss the interplay among 24S-hydroxycholesterol production, neuroinflammation, and excitotoxicity. Effects on neurodegeneration and neuroinflammation demonstrated in two preclinical models suggest that soticlestat is effective in ameliorating seizures and addressing cognitive dysfunction in seizure disorders.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"208 ","pages":"Pages 29-38"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Medaka approach to evolutionary social neuroscience 社会神经科学进化的青鳉方法。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-10-30 DOI: 10.1016/j.neures.2024.10.005

Satoshi Ansai , Towako Hiraki-Kajiyama , Ryutaro Ueda , Takahide Seki , Saori Yokoi , Takafumi Katsumura , Hideaki Takeuchi

{"title":"The Medaka approach to evolutionary social neuroscience","authors":"Satoshi Ansai , Towako Hiraki-Kajiyama , Ryutaro Ueda , Takahide Seki , Saori Yokoi , Takafumi Katsumura , Hideaki Takeuchi","doi":"10.1016/j.neures.2024.10.005","DOIUrl":"10.1016/j.neures.2024.10.005","url":null,"abstract":"<div><div>Previously, the integration of comparative biological and neuroscientific approaches has led to significant advancements in social neuroscience. This review highlights the potential and future directions of evolutionary social neuroscience research utilizing medaka fishes (the family Adrianichthyidae) including Japanese medaka (<em>Oryzias latipes</em>). We focus on medaka social cognitive capabilities and mate choice behavior, particularly emphasizing mate preference using visual cues. Medaka fishes are also advantageous due to their abundant genetic resources, extensive genomic information, and the relative ease of laboratory breeding and genetic manipulation. Here we present some research examples of both the conventional neuroscience approach and evolutionary approach involving medaka fishes and other species. We also discuss the prospects of uncovering the molecular and cellular mechanisms underlying the diversity of visual mate preference among species. Especially, we introduce that the single-cell transcriptome technology, particularly in conjunction with 'Adaptive Circuitry Census', is an innovative tool that bridges comparative biological methods and neuroscientific approaches. Evolutionary social neuroscience research using medaka has the potential to unveil fundamental principles in neuroscience and elucidate the mechanisms responsible for generating diversity in mating strategies.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"214 ","pages":"Pages 32-41"},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bayesian estimation of trunk-leg coordination during walking using phase oscillator models 利用相位振荡器模型对行走过程中躯干-腿协调性进行贝叶斯估计。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-10-22 DOI: 10.1016/j.neures.2024.10.002

Haruma Furukawa , Takahiro Arai , Tetsuro Funato , Shinya Aoi , Toshio Aoyagi

引用次数: 0

Adaptive circuits for action and value information in rodent operant learning 啮齿动物操作学习中的行动和价值信息适应回路

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-26 DOI: 10.1016/j.neures.2024.09.003

Alain Rios , Kyohei Fujita , Yoshikazu Isomura , Nobuya Sato

{"title":"Adaptive circuits for action and value information in rodent operant learning","authors":"Alain Rios , Kyohei Fujita , Yoshikazu Isomura , Nobuya Sato","doi":"10.1016/j.neures.2024.09.003","DOIUrl":"10.1016/j.neures.2024.09.003","url":null,"abstract":"<div><div>Operant learning is a behavioral paradigm where animals learn to associate their actions with consequences, adapting their behavior accordingly. This review delves into the neural circuits that underpin operant learning in rodents, emphasizing the dynamic interplay between neural pathways, synaptic plasticity, and gene expression changes. We explore the cortico-basal ganglia circuits, highlighting the pivotal role of dopamine in modulating these pathways to reinforce behaviors that yield positive outcomes. We include insights from recent studies, which reveals the intricate roles of midbrain dopamine neurons in integrating action initiation and reward feedback, thereby enhancing movement-related activities in the dorsal striatum. Additionally, we discuss the molecular diversity of striatal neurons and their specific roles in reinforcement learning. The review also covers advances in transcriptome analysis techniques, such as single-cell RNA sequencing, which have provided deeper insights into the gene expression profiles associated with different neuronal populations during operant learning.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"214 ","pages":"Pages 62-68"},"PeriodicalIF":2.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automatic detection of foot-strike onsets in a rhythmic forelimb movement 自动检测有节奏的前肢运动中的击脚起始点

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.04.002

引用次数: 0

Elevation in body temperature may increase susceptibility to cortical spreading depression in a rat model 在大鼠模型中，体温升高可能会增加皮层扩散抑制的易感性

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.04.004

{"title":"Elevation in body temperature may increase susceptibility to cortical spreading depression in a rat model","authors":"","doi":"10.1016/j.neures.2024.04.004","DOIUrl":"10.1016/j.neures.2024.04.004","url":null,"abstract":"<div><p>One characteristic of migraine is recurrent headache attacks, which are known to be induced by changes in climatic variables such as atmospheric pressure, humidity, and outside temperature. However, the relationship between temperature changes and migraine remains unclear. Therefore, we investigated the relationship between body temperature changes and cortical spreading depression (CSD) using KCl-induced rat models of CSD. We initially induced CSD under controlled conditions at a room temperature of 28°C on an operating table maintained at 37°C. Subsequently, we controlled the operating table temperature to induce a second round of CSD under conditions of either a 10 ± 1% increase or decrease in body temperature. We ensured 1 h rest period between the first and second inductions of CSD. The results indicated that the number of CSDs significantly increased after body temperature elevation (before, 8.8 ± 1.2 times vs. after, 13.4 ± 1.3 times; p = 0.0003). The mean percentage change in cerebral blood flow decreased after body temperature increased (before, 33.1 ± 2.4% vs. after, 18.2 ± 1.4%; p = 0.006). There were no significant changes in CSD after body temperature decreased. The susceptibility of the cortex to CSD may increase under conditions of elevated body temperature.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"206 ","pages":"Pages 30-34"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000555/pdfft?md5=fb4552627cc27f3e7fc8c8301ab611b7&pid=1-s2.0-S0168010224000555-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140801170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the human conflict processing network: A review of the literature on direct neural recordings during performance of a modified stroop task 了解人类冲突处理网络：在执行修改后的 stroop 任务时进行直接神经记录的文献综述

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.03.006

{"title":"Understanding the human conflict processing network: A review of the literature on direct neural recordings during performance of a modified stroop task","authors":"","doi":"10.1016/j.neures.2024.03.006","DOIUrl":"10.1016/j.neures.2024.03.006","url":null,"abstract":"<div><p>The Stroop Task is a well-known neuropsychological task developed to investigate conflict processing in the human brain. Our group has utilized direct intracranial neural recordings in various brain regions during performance of a modified color-word Stroop Task to gain a mechanistic understanding of non-emotional human conflict processing. The purpose of this review article is to: 1) synthesize our own studies into a model of human conflict processing, 2) review the current literature on the Stroop Task and other conflict tasks to put our research in context, and 3) describe how these studies define a network in conflict processing. The figures presented are reprinted from our prior publications and key publications referenced in the manuscript. We summarize all studies to date that employ invasive intracranial recordings in humans during performance of conflict-inducing tasks. For our own studies, we analyzed local field potentials (LFPs) from patients with implanted stereotactic electroencephalography (SEEG) electrodes, and we observed intracortical oscillation patterns as well as intercortical temporal relationships in the hippocampus, amygdala, and orbitofrontal cortex (OFC) during the cue-processing phase of a modified Stroop Task. Our findings suggest that non-emotional human conflict processing involves modulation across multiple frequency bands within and between brain structures.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"206 ","pages":"Pages 1-19"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000518/pdfft?md5=456561bd46c338ddde0006f6ca04bfab&pid=1-s2.0-S0168010224000518-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0