Neuroscience Research最新文献_第9页

Lateralized local circuit tuning in female mouse auditory cortex 雌性小鼠听觉皮层的局部偏侧电路调谐。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-04-04 DOI: 10.1016/j.neures.2025.03.009

Soomin C. Song , Robert C. Froemke

{"title":"Lateralized local circuit tuning in female mouse auditory cortex","authors":"Soomin C. Song , Robert C. Froemke","doi":"10.1016/j.neures.2025.03.009","DOIUrl":"10.1016/j.neures.2025.03.009","url":null,"abstract":"<div><div>Most offspring are born helpless, requiring intense caregiving from parents especially during the first few days of neonatal life. For many species, infant cries are a primary signal used by parents to provide caregiving. Previously we and others documented how maternal left auditory cortex rapidly becomes sensitized to pup calls over hours of parental experience, enabled by oxytocin. The speed and robustness of this maternal plasticity suggests cortical pre-tuning or initial bias for pup call stimulus features. Here we examine the circuit basis of left-lateralized tuning to vocalization features with whole-cell recordings in brain slices. We found that layer 2/3 pyramidal cells of female left auditory cortex show selective suppression of inhibitory inputs with repeated stimulation at the fundamental pup call rate (inter-stimulus interval ∼150 msec) in pup-naïve females and expanded with maternal experience. However, optogenetic stimulation of cortical inhibitory cells showed that inputs from somatostatin-positive and oxytocin-receptor-expressing interneurons were less suppressed at these rates. This suggested that disynaptic inhibition rather than monosynaptic depression was a major mechanism underlying pre-tuning of cortical excitatory neurons, confirmed with simulations. Thus cortical interneuron specializations can augment neuroplasticity mechanisms to ensure fast appropriate caregiving in response to infant cries.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104897"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxytocin and neuroscience of lactation: Insights from the molecular genetic approach 催产素和哺乳期神经科学：来自分子遗传方法的见解。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-01-15 DOI: 10.1016/j.neures.2025.01.002

Hiroko Yukinaga , Kazunari Miyamichi

{"title":"Oxytocin and neuroscience of lactation: Insights from the molecular genetic approach","authors":"Hiroko Yukinaga , Kazunari Miyamichi","doi":"10.1016/j.neures.2025.01.002","DOIUrl":"10.1016/j.neures.2025.01.002","url":null,"abstract":"<div><div>In mammals, lactation is essential for the health and growth of infants and supports the formation of the mother–infant bond. Breastfeeding is mediated by the neurohormone oxytocin (OT), which is released into the bloodstream in a pulsatile manner from OT neurons in the hypothalamus to promote milk ejection into mammary ducts. While classical studies using anesthetized rats have illuminated the activity patterns of putative OT neurons during breastfeeding, the molecular, cellular, and neural circuit mechanisms driving the synchronous pulsatile bursts of OT neurons in response to nipple stimulation remain largely elusive. Only recently have molecular neuroscience techniques for imaging and manipulating specific genetically defined cells been applied to lactating mice. For instance, fiber photometry has revealed the temporal dynamics of the population pulsatile activity of OT neurons in freely moving dams across various lactation stages, while microendoscopy has provided single-cell level insights. In this review, we introduce the neuroscience of lactation with respect to OT neuron activity, discuss findings from molecular neuroscience approaches, and highlight key unresolved questions.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104873"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglial colonization routes and their impacts on cellular diversity 小胶质细胞定植途径及其对细胞多样性的影响。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1016/j.neures.2025.04.004

Yuki Hattori

{"title":"Microglial colonization routes and their impacts on cellular diversity","authors":"Yuki Hattori","doi":"10.1016/j.neures.2025.04.004","DOIUrl":"10.1016/j.neures.2025.04.004","url":null,"abstract":"<div><div>Microglia are the resident immune cells of the central nervous system. Unlike other glial cells—such as astrocytes and oligodendrocytes—which originate from neural stem cells alongside neurons, microglia derive from erythromyeloid progenitors that emerge in the yolk sac during early embryonic development. Once they reach the brain, microglia expand their population through proliferation during development. A growing body of research has revealed that microglia play diverse roles throughout life, both in physiological and pathological contexts. With recent advancements in single-cell transcriptomics, it has become increasingly evident that microglia exhibit substantial heterogeneity in their gene expression patterns. While various functions and subtypes of microglia are being uncovered, the mechanisms underlying their diversity remain largely unknown. Two key hypotheses may explain how microglial diversity arises. One possibility is that their diversity is influenced by the different colonization routes they take before settling in the brain. Alternatively, microglia may acquire distinct properties in response to their local environment. This review explores both possibilities, with a particular focus on the first hypothesis, drawing on recent findings that highlight the multiple routes microglia utilize to colonize the brain. It discusses how these processes contribute to the establishment of microglial diversity during brain development.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104901"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression 尽管自噬上调和TDP-43表达异常，optinineurin敲除形成TDP-43聚集体来调节TDP-43蛋白水平。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-03-22 DOI: 10.1016/j.neures.2025.03.005

Yuta Maetani , Takashi Kurashige , Yui Tada , Kodai Kume , Tomoaki Watanabe , Yusuke Sotomaru , Koji Yamanaka , Hirofumi Maruyama , Hideshi Kawakami

{"title":"Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression","authors":"Yuta Maetani , Takashi Kurashige , Yui Tada , Kodai Kume , Tomoaki Watanabe , Yusuke Sotomaru , Koji Yamanaka , Hirofumi Maruyama , Hideshi Kawakami","doi":"10.1016/j.neures.2025.03.005","DOIUrl":"10.1016/j.neures.2025.03.005","url":null,"abstract":"<div><div><em>Optineurin</em> is a causative gene of amyotrophic lateral sclerosis (ALS) and has many roles in processes such as autophagy and inflammation. However, it is unclear how optineurin causes ALS. <em>Optineurin</em> knock-out (<em>Optn</em>-KO) mice, which have been generated by several researchers, exhibit motor neuron degeneration and TDP-43 aggregates, but no motor deficits. Motor dysfunction in ALS model mice is associated with TDP-43 in the spinal cord. We bred <em>Optn</em>-KO mice with TDP-43 overexpression transgenic mice and evaluated whether increased TDP-43 protein causes motor deficits and whether <em>Optn</em>-KO affects TDP-43 protein level. <em>Optn</em>-KO mice had spinal TDP-43 protein levels and motor function comparable to wild-type mice, and TDP-43-transgenic (TDP-43-tg) mice resulted in motor dysfunction and early death. However, double-mutant TDP-43-tg / <em>Optn</em>-KO mice had lower TDP-43 protein levels than TDP-43-tg mice at 18 months age, and showed inhibition of the TBK1-optinerurin autophagic pathway with aging. Furthermore, <em>Optn</em>-KO caused TDP-43-positive cytoplasmic aggregates. TDP-43 overexpression by itself induced spinal microgliosis, but <em>Optn</em>-KO suppressed that microgliosis. Finally, we showed that <em>Optn</em>-KO mice could not exhibit behavioral dysfunction because TDP-43 protein levels were not elevated despite autophagy inhibition. Thus, downregulation of <em>Optn</em> may suppress TDP-43 toxicity by regulating its abundance through aggregate formation.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104893"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early postural adjustments in cats during a reaching task reflect strategies to predict the forthcoming target location 猫在到达任务中的早期姿势调整反映了预测即将到来的目标位置的策略。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-03-21 DOI: 10.1016/j.neures.2025.03.003

Toshi Nakajima , Mirai Takahashi , Kaoru Takakusaki

{"title":"Early postural adjustments in cats during a reaching task reflect strategies to predict the forthcoming target location","authors":"Toshi Nakajima , Mirai Takahashi , Kaoru Takakusaki","doi":"10.1016/j.neures.2025.03.003","DOIUrl":"10.1016/j.neures.2025.03.003","url":null,"abstract":"<div><div>Many types of voluntary movement depend on appropriate postural adjustments. In most situations, such postural adjustments are influenced by learning and are therefore subject to prediction strategies developed through learning. To address how these prediction strategies affect early postural adjustments (EPAs) that occur several hundred milliseconds before movement, we trained two cats in a reaching task where the location of the target was predictable through learning. At the beginning of each trial, the cat stood still with each paw on a force plate for several hundred milliseconds. A target then appeared on either side of a horizontal touch panel, prompting the cat to lift a forepaw. A food reward followed upon holding the target with the forepaw. Target location was alternated every three rewarded trials: one SWITCH followed by two STAY trials. In both cats, EPAs prior to target onset in STAY trials were significantly dependent on the predetermined target location, indicating that they anticipated the target location as a part of their strategy. In SWITCH trials, EPAs aligned with the subsequent STAY trials in both switch directions for one cat, but only in one direction for the other, suggesting that they developed different strategies to handle target location switches.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104891"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The parental brain: Anatomization of 75 years of neuroscience 1951–2024 父母的大脑：解剖75年的神经科学1951-2024。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-03-21 DOI: 10.1016/j.neures.2025.03.002

Alessandro Carollo , Lucrezia Torre , Marc H. Bornstein , Gianluca Esposito

{"title":"The parental brain: Anatomization of 75 years of neuroscience 1951–2024","authors":"Alessandro Carollo , Lucrezia Torre , Marc H. Bornstein , Gianluca Esposito","doi":"10.1016/j.neures.2025.03.002","DOIUrl":"10.1016/j.neures.2025.03.002","url":null,"abstract":"<div><div>Studies of the parental brain have garnered significant attention, revealing neurobiological and psychological changes associated with caregiving. Here, we provide a comprehensive, data-driven overview of the scientific literature on the parental brain, analyzing a large dataset to map the field’s knowledge structure. Our objectives include identifying influential authors, contributing countries, publication sources, and commonly used keywords as well as highlighting the most impactful documents and primary thematic areas of research. We analyzed 656 documents (and their 39,302 cited references) from Scopus using CiteSpace software for document co-citation analysis. Our analysis identified 17 key documents, of which the most influential focused on neural correlates of maternal and romantic love and maternal brain responses to infant cues in relation to attachment style. Our analysis additionally identified 10 major thematic domains in the parental brain literature. Qualitative analysis of research clusters revealed a trajectory in the study of the parental brain, progressing from foundational studies on dendritic spine density and maternal memory to the exploration of shared mammalian and human-specific brain networks underlying parental behaviors. Our study points to a growing interest in understanding neurobiological changes in fathers, with parental involvement and exposure to infant cues as moderating factors. The parental brain is a plastic, dynamic network, with bio-behavioral synchrony playing a central role as an interpersonal mechanism that enhances specificity of attachments.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104890"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenously generated patterns of neural activity sculpt axon connectivity 内源性产生的神经活动模式塑造轴突连通性。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-05-17 DOI: 10.1016/j.neures.2025.05.003

Naoyuki Matsumoto

引用次数: 0

Young fecal microbiota transplantation improves working memory in aged recipient rats by increasing interleukin-4 and interleukin-17 levels 年轻粪便微生物群移植通过增加白细胞介素-4和白细胞介素-17水平改善老年受体大鼠的工作记忆。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-04-30 DOI: 10.1016/j.neures.2025.04.005

Yiru Yin , Meiqi Guan , Shufen Wu , Chenlong Cui , Rui Wang , Xin Zhao , Xiaorong Yang , Lingran Qiao , Yanli Li , Ce Zhang

{"title":"Young fecal microbiota transplantation improves working memory in aged recipient rats by increasing interleukin-4 and interleukin-17 levels","authors":"Yiru Yin , Meiqi Guan , Shufen Wu , Chenlong Cui , Rui Wang , Xin Zhao , Xiaorong Yang , Lingran Qiao , Yanli Li , Ce Zhang","doi":"10.1016/j.neures.2025.04.005","DOIUrl":"10.1016/j.neures.2025.04.005","url":null,"abstract":"<div><div>While transplanting the fecal microbiota from young to aged rodents has been extensively studied (that is, young FMT [yFMT]), its mechanism of alleviating working memory decline has not been fully elucidated. In this report, we aimed to investigate the effect of yFMT on the working memory of aged recipient rats performing delayed match-to-position (DMTP) tasks and the associated cellular and molecular mechanisms. The results revealed that yFMT mitigated the decline in DMTP task performance of aged recipients. This improvement was associated with a reshaped gut microbiota and increased levels of brain-derived neurotrophic factor, N-methyl-D-aspartate receptor subunit 1, and synaptophysin, enhancing synaptic formation and transmission. The remodeling of the gut microbiome influenced peripheral circulation and the hippocampus and medial prefrontal cortex by regulating the Th17/Treg ratio and microglial polarization. Ultimately, interleukin-4 and interleukin-17 emerged as potential key molecules driving the beneficial effects of FMT. These observations provide new insights into the gut<img>brain axis, emphasizing the connection between the gut and brain through the circulation system, and suggest an immunological mechanism that may help reverse age-related declines in the gut microbiota.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104902"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of brand longevity on consumers’ purchase intention: An ERP study 品牌寿命对消费者购买意愿的影响：一项ERP研究。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1016/j.neures.2025.04.001

Jianhua Liu

引用次数: 0

Neuronal stress-coping mechanisms in postpartum females 产后女性神经压力应对机制。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-07-01 Epub Date: 2025-02-18 DOI: 10.1016/j.neures.2025.02.006

Yoshikage Muroi, Toshiaki Ishii

{"title":"Neuronal stress-coping mechanisms in postpartum females","authors":"Yoshikage Muroi, Toshiaki Ishii","doi":"10.1016/j.neures.2025.02.006","DOIUrl":"10.1016/j.neures.2025.02.006","url":null,"abstract":"<div><div>Animals exhibit a wide range of stress responses aimed at restoring homeostasis and promoting adaptation. In response to stress, they employ coping mechanisms to maintain physiological balance. Dysregulated stress-coping strategies have been associated with mental disorders, including depression, anxiety, and post-traumatic stress disorder. Understanding the neuronal mechanisms that regulate stress-coping is critical for elucidating normal physiological responses and addressing the pathological processes underlying these disorders. Stress responses are influenced by sex and life stage, with notable variability in the prevalence and severity of mental disorders based on these factors. Stress-coping mechanisms are pivotal in determining the vulnerability or resilience of an individual to stress. Thus, identifying differences in stress-coping strategies between sexes and across life stages is essential for advancing prevention and treatment strategies for stress-related mental disorders. This review explores the neuronal mechanisms underlying stress responses, emphasizing the distinct stress-coping strategies utilized by postpartum females. Highlighting these differences underscores the need for targeted prevention and treatment approaches that consider sex- and life stage-specific variations in stress-coping mechanisms.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104885"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0