Neuroscience Research最新文献_第9页

Characterization of pathological stages in a mouse model of progressive multiple sclerosis 渐进性多发性硬化症小鼠模型的病理阶段特征

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-02-01 DOI: 10.1016/j.neures.2024.01.009

Satoshi Hamano , Toshiki Yoshimizu , Mutsuki Mori , Akio Iida , Toshihide Yamashita

{"title":"Characterization of pathological stages in a mouse model of progressive multiple sclerosis","authors":"Satoshi Hamano , Toshiki Yoshimizu , Mutsuki Mori , Akio Iida , Toshihide Yamashita","doi":"10.1016/j.neures.2024.01.009","DOIUrl":"10.1016/j.neures.2024.01.009","url":null,"abstract":"<div><p>The purpose of this study was to analyze and elucidate the mechanisms of non-obese diabetes-experimental autoimmune encephalomyelitis (NOD-EAE), an animal model of progressive multiple sclerosis (MS), and to compare the pathological features with those observed in human progressive MS. Pathological analysis, flow cytometry analysis, immunohistochemical staining, and transcriptome analysis were performed at each pathological stage of the NOD-EAE mice to characterize each pathological stage in the lesion. The NOD-EAE mice showed a biphasic pattern of disease progression once in remission. The longitudinal profile of demyelination and inflammatory cell infiltration in the spinal cord was consistent with the pathological score. In the chronic phase of the disease, fibrosis and lymph follicle formation, characteristic of progressive human MS, were observed. Here we describe the pathological profile and transcriptome analysis of the NOD-EAE mice and verify that this model has similar features to those of human progressive MS. Our findings suggest that this model recapitulates lymph follicle formation, a disease hallmark of progressive MS, and fibrosis, a feature complicating the pathogenesis of MS in the chronic phase. This model may be useful for evaluating the efficacy of therapeutic agents and for mechanistic analysis.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"204 ","pages":"Pages 46-57"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000233/pdfft?md5=a57978a2bd0a6a011a8ad8cd6222f835&pid=1-s2.0-S0168010224000233-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels 一种新型硫化氢供体通过激活 ATP 敏感性钾通道减轻神经炎症和癫痫发作

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-02-01 DOI: 10.1016/j.neures.2023.07.004

Qiyun Kang , Ziting Zhu , Zhongrui Liu , Fei Li , Yan He , Yaru Yang , Xutao Wang , Shuisheng Lei , Zishu Yuan , Xiaoqin Zhu

{"title":"A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels","authors":"Qiyun Kang , Ziting Zhu , Zhongrui Liu , Fei Li , Yan He , Yaru Yang , Xutao Wang , Shuisheng Lei , Zishu Yuan , Xiaoqin Zhu","doi":"10.1016/j.neures.2023.07.004","DOIUrl":"10.1016/j.neures.2023.07.004","url":null,"abstract":"<div><p>Epilepsy is a common neurological disorder worldwide. Hydrogen sulfide (H<sub>2</sub>S) has been found to have anti-seizure effects. However, its mechanism remains to be explored. In the present study, we showed that a novel H<sub>2</sub>S donor attenuated neuroinflammation by up-regulating ATP-sensitive potassium channel (K<sub>ATP</sub>) expression to reduce seizures. The novel H<sub>2</sub>S donor significantly reduced the expression of TNF-α and increased the expression of IL-10 in LPS-treated BV2 cells and the hippocampus of pilocarpine-induced epileptic mice. The modulatory effects of the H<sub>2</sub>S donor on inflammatory cytokines were prevented by glibenclamide, a common K<sub>ATP</sub> channels blocker. The H<sub>2</sub>S donor promoted the expression of K<sub>ATP</sub> channel subunits SUR2 and Kir6.1 in LPS-treated BV2 cells and the hippocampus of pilocarpine-induced epileptic mice. In addition, the H<sub>2</sub>S donor reduced the electroencephalography amplitude of hippocampal epileptic waves and reduced seizures in pilocarpine-induced epileptic mice, which were also attenuated by glibenclamide. These results indicated that the novel H<sub>2</sub>S donor reduced seizures and regulated microglial inflammatory cytokines by activating K<sub>ATP</sub> channels, which may provide a prospective therapeutic strategy for the anti-seizure effects of H<sub>2</sub>S donor.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"199 ","pages":"Pages 21-29"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001396/pdfft?md5=24b63cd4d3dd97e0a616c261cc5db443&pid=1-s2.0-S0168010223001396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9857208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pro-neuroinflammatory and neurotoxic potential of extracellular histones H1 and H3 细胞外组蛋白 H1 和 H3 的促神经炎症和神经毒性潜力

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-01-24 DOI: 10.1016/j.neures.2024.01.004

Seamus A. McRae , Christy M. Richards , Dylan E. Da Silva, Ishvin Riar, Sijie (Shirley) Yang, Noah E. Zurfluh, Julien Gibon, Andis Klegeris

{"title":"Pro-neuroinflammatory and neurotoxic potential of extracellular histones H1 and H3","authors":"Seamus A. McRae , Christy M. Richards , Dylan E. Da Silva, Ishvin Riar, Sijie (Shirley) Yang, Noah E. Zurfluh, Julien Gibon, Andis Klegeris","doi":"10.1016/j.neures.2024.01.004","DOIUrl":"10.1016/j.neures.2024.01.004","url":null,"abstract":"<div><p>Histones organize DNA within cellular nuclei, but they can be released from damaged cells. In peripheral tissues extracellular histones act as damage-associated molecular patterns (DAMPs) inducing pro-inflammatory activation of immune cells. Limited studies have considered DAMP-like activity of histones in the central nervous system (CNS); therefore, we studied the effects of extracellular histones on microglia, the CNS immunocytes, and on neuronal cells. Both the linker histone H1 and the core histone H3 induced pro-inflammatory activation of microglia-like cells by upregulating their secretion of NO and cytokines, including interferon-γ-inducible protein 10 (IP-10) and tumor necrosis factor-α (TNF). The selective inhibitors MMG-11 and TAK-242 were used to demonstrate involvement of toll-like receptors (TLR) 2 and 4, respectively, in H1-induced NO secretion by BV-2 microglia. H1, but not H3, downregulated the phagocytic activity of BV-2 microglia. H1 was also directly toxic to all neuronal cell types studied. We conclude that H1, and to a lesser extent H3, when released extracellularly, have the potential to act as a CNS DAMPs. Inhibition of the DAMP-like effects of extracellular histones on microglia and their neurotoxic activity represents a potential strategy for combating neurodegenerative diseases that are characterized by the adverse activation of microglia and neuronal death.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"204 ","pages":"Pages 34-45"},"PeriodicalIF":2.4,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000087/pdfft?md5=a0f020e724e7e3d8ac93459e30a6ea40&pid=1-s2.0-S0168010224000087-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139558912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary somatosensory cortex organization for engineering artificial somatosensation 用于人工体感工程的初级体感皮层组织

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-01-24 DOI: 10.1016/j.neures.2024.01.005

Krista Lamorie-Foote , Daniel R. Kramer , Shivani Sundaram , Jonathon Cavaleri , Zachary D. Gilbert , Austin M. Tang , Luke Bashford , Charles Y. Liu , Spencer Kellis , Brian Lee

{"title":"Primary somatosensory cortex organization for engineering artificial somatosensation","authors":"Krista Lamorie-Foote , Daniel R. Kramer , Shivani Sundaram , Jonathon Cavaleri , Zachary D. Gilbert , Austin M. Tang , Luke Bashford , Charles Y. Liu , Spencer Kellis , Brian Lee","doi":"10.1016/j.neures.2024.01.005","DOIUrl":"10.1016/j.neures.2024.01.005","url":null,"abstract":"<div><p>Somatosensory deficits from stroke, spinal cord injury, or other neurologic damage can lead to a significant degree of functional impairment. The primary (SI) and secondary (SII) somatosensory cortices encode information in a medial to lateral organization. SI is generally organized topographically, with more discrete cortical representations of specific body regions. SII regions corresponding to anatomical areas are less discrete and may represent a more functional rather than topographic organization. Human somatosensory research continues to map cortical areas of sensory processing with efforts primarily focused on hand and upper extremity information in SI. However, research into SII and other body regions is lacking. In this review, we synthesize the current state of knowledge regarding the cortical organization of human somatosensation and discuss potential applications for brain computer interface. In addition to accurate individualized mapping of cortical somatosensation, further research is required to uncover the neurophysiological mechanisms of how somatosensory information is encoded in the cortex.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"204 ","pages":"Pages 1-13"},"PeriodicalIF":2.4,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000099/pdfft?md5=821c8c8b48aba3469537ea6defa1ba1d&pid=1-s2.0-S0168010224000099-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139559089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort CFAS 群体衍生神经病理学队列中大脑胆固醇和胆固醇生物合成酶与阿尔茨海默氏症病理和痴呆症的关系

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-01-24 DOI: 10.1016/j.neures.2024.01.003

Hemant Mistry , Connor D. Richardson , Adrian Higginbottom , Bridget Ashford , Saif U. Ahamed , Zoe Moore , Fiona E. Matthews , Carol Brayne , Julie E. Simpson , Stephen B. Wharton , on behalf of the Cognitive Function and Ageing Study

{"title":"Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort","authors":"Hemant Mistry , Connor D. Richardson , Adrian Higginbottom , Bridget Ashford , Saif U. Ahamed , Zoe Moore , Fiona E. Matthews , Carol Brayne , Julie E. Simpson , Stephen B. Wharton , on behalf of the Cognitive Function and Ageing Study","doi":"10.1016/j.neures.2024.01.003","DOIUrl":"10.1016/j.neures.2024.01.003","url":null,"abstract":"<div><p>Altered cholesterol metabolism is implicated in brain ageing and Alzheimer’s disease. We examined whether key genes regulating cholesterol metabolism and levels of brain cholesterol are altered in dementia and Alzheimer’s disease neuropathological change (ADNC). Temporal cortex (n = 99) was obtained from the Cognitive Function and Ageing Study. Expression of the cholesterol biosynthesis rate-limiting enzyme HMG-CoA reductase (HMGCR) and its regulator, SREBP2, were detected using immunohistochemistry. Expression of <em>HMGCR</em>, <em>SREBP2</em>, <em>CYP46A1</em> and <em>ABCA1</em> were quantified by qPCR in samples enriched for astrocyte and neuronal RNA following laser-capture microdissection. Total cortical cholesterol was measured using the Amplex Red assay. HMGCR and SREBP2 proteins were predominantly expressed in pyramidal neurones, and in glia. Neuronal HMGCR did not vary with ADNC, oxidative stress, neuroinflammation or dementia status. Expression of <em>HMGCR</em> neuronal mRNA decreased with ADNC (p = 0.022) and increased with neuronal DNA damage (p = 0.049), whilst <em>SREBP2</em> increased with ADNC (p = 0.005). High or moderate tertiles for cholesterol levels were associated with increased dementia risk (OR 1.44, 1.58). <em>APOE ε4</em> allele was not associated with cortical cholesterol levels. ADNC is associated with gene expression changes that may impair cholesterol biosynthesis in neurones but not astrocytes, whilst levels of cortical cholesterol show a weak relationship to dementia status.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"204 ","pages":"Pages 22-33"},"PeriodicalIF":2.4,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000075/pdfft?md5=7c5961e67841a136e90068c4d3e1f62c&pid=1-s2.0-S0168010224000075-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139559090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural activity related to productive vocabulary knowledge effects during second language comprehension 第二语言理解过程中与生产性词汇知识效应相关的神经活动

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-01-18 DOI: 10.1016/j.neures.2024.01.002

Takara Kenza Allal-Sumoto, Duygu Şahin, Hiroaki Mizuhara

{"title":"Neural activity related to productive vocabulary knowledge effects during second language comprehension","authors":"Takara Kenza Allal-Sumoto, Duygu Şahin, Hiroaki Mizuhara","doi":"10.1016/j.neures.2024.01.002","DOIUrl":"10.1016/j.neures.2024.01.002","url":null,"abstract":"<div><p>Second language learners and educators often believe that improving one’s listening ability hinges on acquiring an extensive vocabulary and engaging in thorough listening practice. Our previous study suggested that listening comprehension is also impacted by the ability to produce vocabulary. Nevertheless, it remained uncertain whether quick comprehension could be attributed to a simple acceleration of processing or to changes in neural activity. To identify neural activity changes during sentence listening comprehension according to different levels of lexical knowledge (productive, only comprehensive, uncomprehensive), we measured participants’ electrical activity in the brain via electroencephalography (EEG) and conducted a time-frequency-based EEG power analysis. Additionally, we employed a decoding model to verify the predictability of vocabulary knowledge levels based on neural activity. The decoding results showed that EEG activity could discriminate between listening to sentences containing phrases that include productive knowledge and ones without. The positive impact of productive vocabulary knowledge on sentence comprehension, driven by distinctive neural processing during sentence comprehension, was unequivocally evident. Our study emphasizes the importance of productive vocabulary knowledge acquisition to enhance the process of second language listening comprehension.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"203 ","pages":"Pages 8-17"},"PeriodicalIF":2.9,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000063/pdfft?md5=b13e9dc090628ae4bd51a55aab523094&pid=1-s2.0-S0168010224000063-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139495179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late-spiking retrosplenial cortical neurons are not synchronized with neocortical slow waves in anesthetized mice 麻醉小鼠的晚期尖峰后叶皮层神经元与新皮层慢波不同步

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-01-14 DOI: 10.1016/j.neures.2024.01.001

Hiroyuki Mizuno , Yuji Ikegaya

引用次数: 0

Increased nociceptive behaviors and spinal c-Fos expression in the formalin test in a rat repeated cold stress model 大鼠重复冷应激模型在福尔马林试验中的痛觉行为和脊髓 c-Fos 表达增加

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-01-01 DOI: 10.1016/j.neures.2023.06.010

Teruaki Nasu , Riku Kainuma , Hiroki Ota , Kazue Mizumura , Toru Taguchi

{"title":"Increased nociceptive behaviors and spinal c-Fos expression in the formalin test in a rat repeated cold stress model","authors":"Teruaki Nasu , Riku Kainuma , Hiroki Ota , Kazue Mizumura , Toru Taguchi","doi":"10.1016/j.neures.2023.06.010","DOIUrl":"10.1016/j.neures.2023.06.010","url":null,"abstract":"<div><p>Repeated cold stress (RCS) can trigger the development of fibromyalgia (FM)-like symptoms, including persistent deep-tissue pain, although nociceptive changes to the skin have not been fully characterized. Using a rat RCS model, we investigated nociceptive behaviors induced by noxious mechanical, thermal, and chemical stimuli applied to plantar skin. Neuronal activation in the spinal dorsal horn was examined using the formalin pain test. In rats exposed to RCS, nociceptive behavioral hypersensitivity was observed in all modalities of cutaneous noxious stimuli: the mechanical withdrawal threshold was decreased, and the heat withdrawal latency was shortened one day after the cessation of stress. The duration of nocifensive behaviors in the formalin test was prolonged in phase II but not in phase I. The number of c-Fos-positive neurons increased in the entire dorsal horn laminae I-VI, ipsilateral, but not contralateral, to formalin injection at the L3-L5 segments. The duration of nocifensive behavior in phase II was significantly and positively correlated with the number of c-Fos-positive neurons in laminae I-II. These results demonstrate that cutaneous nociception is facilitated in rats exposed to RCS for a short time and that the spinal dorsal horn neurons are hyperactivated by cutaneous formalin in the RCS model.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"198 ","pages":"Pages 30-38"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001347/pdfft?md5=a69e27e02001d550cb187e64b7c19505&pid=1-s2.0-S0168010223001347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Temporal and quantitative analysis of the functional expression of Ca2+-permeable AMPA receptors during LTP LTP 期间钙离子渗透性 AMPA 受体功能表达的时间和定量分析

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-01-01 DOI: 10.1016/j.neures.2023.07.002

Yoshihiko Wakazono , Ryosuke Midorikawa , Kogo Takamiya

{"title":"Temporal and quantitative analysis of the functional expression of Ca2+-permeable AMPA receptors during LTP","authors":"Yoshihiko Wakazono , Ryosuke Midorikawa , Kogo Takamiya","doi":"10.1016/j.neures.2023.07.002","DOIUrl":"10.1016/j.neures.2023.07.002","url":null,"abstract":"<div><p>In the present study, we attempted to temporally and quantitatively analyze the functional contributions of Ca<sup>2+</sup>-permeable (CP) α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) during long-term potentiation (LTP) expression using electrophysiological and pharmacological approaches. In hippocampal CA1 neurons, using 1-naphthyl acetyl spermine (NASPM), a CP-AMPAR antagonist, we began by demonstrating that NASPM-sensitive components, probably including the GluA1 homomer, functionally contributed to about 15% of AMPAR-mediated EPSC amplitude in basal conditions. Then, when NASPM was treated at different time points (3–30 min) after LTP induction, it was found that LTP was almost completely impaired at 3 or 10 min but maintained at 20 or 30 min, although its potentiation was reduced. Further temporal and quantitative analysis revealed that the functional expression of CP-AMPARs began increasing approximately 20 min after LTP induction and reached more than twice the basal level at 30 min. These results suggest that CP-AMPARs in the first 3–10 min of LTP might play an important role in LTP maintenance. Moreover, their decay time was also significantly increased at 30 min, suggesting that CP-AMPARs changed not only quantitatively in LTP but also qualitatively.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"198 ","pages":"Pages 21-29"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001372/pdfft?md5=d9e9ab9e97e810eab330371d04c4a8fc&pid=1-s2.0-S0168010223001372-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9773806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perinatal ethanol exposure affects cell populations in adult dorsal hippocampal neurogenic niche 围产期乙醇暴露影响成年背侧海马神经源龛的细胞群

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-01-01 DOI: 10.1016/j.neures.2023.07.001

Nerina M. Villalba , Catalina Madarnas , Julieta Bressano , Viviana Sanchez , Alicia Brusco

{"title":"Perinatal ethanol exposure affects cell populations in adult dorsal hippocampal neurogenic niche","authors":"Nerina M. Villalba , Catalina Madarnas , Julieta Bressano , Viviana Sanchez , Alicia Brusco","doi":"10.1016/j.neures.2023.07.001","DOIUrl":"10.1016/j.neures.2023.07.001","url":null,"abstract":"<div><p>Neurodevelopment is highly affected by perinatal ethanol exposure (PEE). In the adult brain, neurogenesis takes place in the dentate gyrus (DG) of the hippocampus and in the subventricular zone. This work aimed to analyze the effect of PEE on the cellular types involved in adult dorsal hippocampal neurogenesis phases using a murine model. For this purpose, primiparous female CD1 mice consumed only ethanol 6% v/v from 20 days prior to mating and along pregnancy and lactation to ensure that the pups were exposed to ethanol throughout pre- and early postnatal development. After weaning, pups had no further contact with ethanol. Cell types of the adult male dorsal DG were studied by immunofluorescence. A lower percentage of type 1 cells and immature neurons and a higher percentage of type 2 cells were observed in PEE animals. This decrease in type 1 cells suggests that PEE reduces the population of remnant progenitors of the dorsal DG present in adulthood. The increase in type 2 cells and the decrease in immature neurons indicate that, during neurodevelopment, ethanol alters the capacity of neuroblasts to become neurons in the adult neurogenic niche. These results suggest that pathways implicated in cell determination are affected by PEE and remain affected in adulthood.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"198 ","pages":"Pages 8-20"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001360/pdfft?md5=23c0522a6158e1b06e14e6129d2f3182&pid=1-s2.0-S0168010223001360-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9852141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0