大鼠皮质下行信号的功能分隔和动态整合

IF 2.4 4区 医学 Q3 NEUROSCIENCES
Hikaru Sugino, Sho Tanno, Tatsumi Yoshida, Yoshikazu Isomura, Riichiro Hira
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引用次数: 0

摘要

上丘(SC)以层特异性和径向亚区特异性的方式接收来自不同脑区的输入,但上丘是否表现出亚区特异性动态仍不清楚。为了解决这个问题,我们在光激活清醒的头固定 Thy1-ChR2 大鼠的皮层区域时记录了单个 SC 神经元的尖峰活动。根据反应动力学,我们将有明显反应的 309 个神经元分为 8 个群组。其中,具有单相兴奋反应(7-12 毫秒潜伏期)且在 20 毫秒内恢复基线的神经元通常出现在中内侧和中外侧 SC 的视灰层和中间灰层。与此相反,在前外侧 SC 的深层常见到具有复杂多相反应的神经元。交叉相关分析表明,深灰层的内部回路只能部分解释这种复杂模式。我们的研究结果表明,SC 内侧到外侧的神经元只是简单地传递大脑皮层的活动,而SC 前外侧深层的神经元则动态地整合了来自大脑皮层、SNr、CN 和局部回路的输入。这些研究结果表明,SC 整合存在空间梯度,简单的中继回路和复杂的动态整合回路之间存在分工。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional segregation and dynamic integration of the corticotectal descending signal in rat.

The superior colliculus (SC) receives inputs from various brain regions in a layer- and radial subregion-specific manner, but whether the SC exhibits subregion-specific dynamics remains unclear. To address this issue, we recorded the spiking activity of single SC neurons while photoactivating cortical areas in awake head-fixed Thy1-ChR2 rats. We classified 309 neurons that responded significantly into 8 clusters according to the response dynamics. Among them, neurons with monophasic excitatory responses (7-12 ms latency) that returned to baseline within 20 ms were commonly observed in the optic and intermediate gray layers of centromedial and centrolateral SC. In contrast, neurons with complex polyphasic responses were commonly observed in the deep layers of the anterolateral SC. Cross-correlation analysis suggested that the complex pattern could be only partly explained by an internal circuit of the deep gray layer. Our results indicate that medial to centrolateral SC neurons simply relay cortical activity, whereas neurons in the deep layers of the anterolateral SC dynamically integrate inputs from the cortex, SNr, CN, and local circuits. These findings suggest a spatial gradient in SC integration, with a division of labor between simple relay circuits and those integrating complex dynamics.

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来源期刊
Neuroscience Research
Neuroscience Research 医学-神经科学
CiteScore
5.60
自引率
3.40%
发文量
136
审稿时长
28 days
期刊介绍: The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.
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