Neuroscience Research最新文献_第8页

Revisiting the blind mind: Still no evidence for sensory visual imagery in individuals with aphantasia 重温盲人思维：仍无证据表明幻觉症患者存在感官视觉意象。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-04-01 DOI: 10.1016/j.neures.2024.01.008

Rebecca Keogh , Joel Pearson

引用次数: 0

Neural circuits for retrospective and prospective introspection for the past, present and future in macaque monkeys and humans 猕猴和人类对过去、现在和未来进行回溯和前瞻性反省的神经回路。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-04-01 DOI: 10.1016/j.neures.2024.02.003

Kentaro Miyamoto

引用次数: 0

Neuronal subtype-specific transcriptomic changes in the cerebral neocortex associated with sleep pressure 与睡眠压力相关的大脑新皮层神经元亚型特异性转录组变化

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-03-25 DOI: 10.1016/j.neures.2024.03.004

{"title":"Neuronal subtype-specific transcriptomic changes in the cerebral neocortex associated with sleep pressure","authors":"","doi":"10.1016/j.neures.2024.03.004","DOIUrl":"10.1016/j.neures.2024.03.004","url":null,"abstract":"<div><div>Sleep is homeostatically regulated by sleep pressure, which increases during wakefulness and dissipates during sleep. Recent studies have suggested that the cerebral neocortex, a six-layered structure composed of various layer- and projection-specific neuronal subtypes, is involved in the representation of sleep pressure governed by transcriptional regulation. Here, we examined the transcriptomic changes in neuronal subtypes in the neocortex upon increased sleep pressure using single-nucleus RNA sequencing datasets and predicted the putative intracellular and intercellular molecules involved in transcriptome alterations. We revealed that sleep deprivation (SD) had the greatest effect on the transcriptome of layer 2 and 3 intratelencephalic (L2/3 IT) neurons among the neocortical glutamatergic neuronal subtypes. The expression of mutant SIK3 (SLP), which is known to increase sleep pressure, also induced profound changes in the transcriptome of L2/3 IT neurons. We identified <em>Junb</em> as a candidate transcription factor involved in the alteration of the L2/3 IT neuronal transcriptome by SD and SIK3 (SLP) expression. Finally, we inferred putative intercellular ligands, including BDNF, LSAMP, and PRNP, which may be involved in SD-induced alteration of the transcriptome of L2/3 IT neurons. We suggest that the transcriptome of L2/3 IT neurons is most impacted by increased sleep pressure among neocortical glutamatergic neuronal subtypes and identify putative molecules involved in such transcriptional alterations.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"207 ","pages":"Pages 13-25"},"PeriodicalIF":2.4,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal vascular pathology in a mouse model of Lafora progressive myoclonus epilepsy 拉弗拉进行性肌阵挛癫痫小鼠模型的视网膜血管病理学。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-03-06 DOI: 10.1016/j.neures.2024.02.004

Ruchira Pranay Patil , Nitin Kumar , Arveen Kaur , Rajendra Kumar Munian , Bishakh Bhattacharya , Subramaniam Ganesh , Rashmi Parihar

引用次数: 0

Decision-making ability limitations and brain neural activity changes in healthcare workers after mild COVID-19 医护人员在轻度 COVID-19 后的决策能力限制和脑神经活动变化。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-02-12 DOI: 10.1016/j.neures.2024.02.001

Yaotian Gao , Keyi Lin , Bangyue Wang , Wei Ji , Jia Liu , Mengcheng Du , Wei Wang , Yan Li , Xiaowen Du , Yuyang Wang , Tao Jiang

{"title":"Decision-making ability limitations and brain neural activity changes in healthcare workers after mild COVID-19","authors":"Yaotian Gao , Keyi Lin , Bangyue Wang , Wei Ji , Jia Liu , Mengcheng Du , Wei Wang , Yan Li , Xiaowen Du , Yuyang Wang , Tao Jiang","doi":"10.1016/j.neures.2024.02.001","DOIUrl":"10.1016/j.neures.2024.02.001","url":null,"abstract":"<div><p>Studies have demonstrated that the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) extensively affects brain function. Although cognitive dysfunction is considered a common manifestation in COVID-19 patients during the recovery period, the potential changes in decision-making ability, are not yet clear. Decision-making functions are essential to the work of healthcare workers. However, there is a lack of a multidimensional assessment of its functioning in COVID-19 cases. Here, we used tests combined with the resting-state functional magnetic resonance imaging (rs-fMRI) stabilization feature amplitude of low-frequency fluctuations (ALFF) to explore decision-making behavior and brain neural activity changes in healthcare workers after mild COVID-19. Participants were divided into the SARS-CoV-2 infected group (SI, n = 41) and healthy controls (HC, n = 42). All participants underwent a series of neuropsychological tests. They performed the Iowa Gambling Task (IGT) and the Game of Dice Task (GDT), followed by fMRI (n = 20) to assess their decision-making ability under ambiguous and risky conditions and changes in brain neural activity. The SI group performed worse in verbal memory than the HC group. Furthermore, the SI group performed worse in the IGT, whereas no significant difference was observed in the GDT. In addition, rs-fMRI showed enhanced spontaneous neural activity in the postcentral gyrus and inferior parietal lobe in the SI group compared to the HC group.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"204 ","pages":"Pages 14-21"},"PeriodicalIF":2.4,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000257/pdfft?md5=c0809c974ebf76a3f63a1d6354789192&pid=1-s2.0-S0168010224000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exendin-4 increases the firing activity of hippocampal CA1 neurons through TRPC4/5 channels Exendin-4 通过 TRPC4/5 通道增加海马 CA1 神经元的发射活动

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-02-01 DOI: 10.1016/j.neures.2023.08.001

Hui-Zhe Sun , Fang-Shuai Shen , Xiao-Xue Li , Cui Liu , Yan Xue , Xiao-Hua Han , Xin-Yi Chen , Lei Chen

{"title":"Exendin-4 increases the firing activity of hippocampal CA1 neurons through TRPC4/5 channels","authors":"Hui-Zhe Sun , Fang-Shuai Shen , Xiao-Xue Li , Cui Liu , Yan Xue , Xiao-Hua Han , Xin-Yi Chen , Lei Chen","doi":"10.1016/j.neures.2023.08.001","DOIUrl":"10.1016/j.neures.2023.08.001","url":null,"abstract":"<div><p>The central neuropeptide GLP-1 is synthesized by preproglucagon (PPG) neurons in the brain. GLP-1 receptors are widely distributed in central nervous system. Hippocampus is a key component of the limbic system which is involved in learning, memory, and cognition. Previous studies have shown that overexpression of GLP-1 receptors in the hippocampus could improve the process of learning and memory. However, up to now, the direct electrophysiological effects and possible molecular mechanisms of GLP-1 in hippocampal CAl neurons remain unexplored. The present study aims to evaluate the effects and mechanisms of GLP-1 on the spontaneous firing activity of hippocampal CAl neurons. Employing multibarrel single-unit extracellular recordings, the present study showed that micro-pressure administration of GLP-1 receptor agonist, exendin-4, significantly increased the spontaneous firing rate of hippocampal CA1 neurons in rats. Furthermore, application of the specific GLP-1 receptor antagonist, exendin(9−39), alone significantly decreased the firing rate of CA1 neurons, suggesting that endogenous GLP-1 modulates the firing activity of CA1 neurons. Co-application of exendin(9−39) completely blocked exendin-4-induced excitation of hippocampal CA1 neurons. Finally, the present study demonstrated for the first time that the transient receptor potential canonical 4 (TRPC4)/TRPC5 channels may be involved in exendin-4-induced excitation. The present studies may provide a rationale for further investigation of the modulation of GLP-1 on learning and memory as well as its possible involvement in Alzheimer's disease.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"199 ","pages":"Pages 48-56"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001529/pdfft?md5=3c032f77878b6ebabdc16cc54b988986&pid=1-s2.0-S0168010223001529-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Super-resolution imaging reveals the relationship between CaMKIIβ and drebrin within dendritic spines 超分辨率成像揭示树突棘内 CaMKIIβ 与 drebrin 之间的关系

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-02-01 DOI: 10.1016/j.neures.2023.08.002

Hiroyuki Yamazaki , Noriko Koganezawa , Hideaki Yokoo , Yuko Sekino , Tomoaki Shirao

{"title":"Super-resolution imaging reveals the relationship between CaMKIIβ and drebrin within dendritic spines","authors":"Hiroyuki Yamazaki , Noriko Koganezawa , Hideaki Yokoo , Yuko Sekino , Tomoaki Shirao","doi":"10.1016/j.neures.2023.08.002","DOIUrl":"10.1016/j.neures.2023.08.002","url":null,"abstract":"<div><p>Dendritic spines are unique postsynaptic structures that emerge from the dendrites of neurons. They undergo activity-dependent morphological changes known as structural plasticity. The changes involve actin cytoskeletal remodeling, which is regulated by actin-binding proteins. CaMKII is a crucial molecule in synaptic plasticity. Notably, CaMKIIβ subtype is known to bind to filamentous-actin and is closely involved in structural plasticity. We have shown that CaMKIIβ binds to drebrin, and is localized in spines as both drebrin-dependent and drebrin-independent pools. However, the nanoscale relationship between drebrin and CaMKIIβ within dendritic spines has not been clarified. In this study, we used stochastic optical reconstruction microscopy (STORM) to examine the detailed localization of these proteins. STORM imaging showed that CaMKIIβ co-localized with drebrin in the core region of spines, and localized in the submembrane region of spines without drebrin. Interestingly, the dissociation of CaMKIIβ and drebrin in the core region was induced by NMDA receptor activation. In drebrin knockdown neurons, CaMKIIβ was decreased in the core region but not in the submembrane region. Together it indicates that the clustering of CaMKIIβ in the spine core region is dependent on drebrin. These findings suggest that drebrin-dependent CaMKIIβ is in a standby state before its activation.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"199 ","pages":"Pages 30-35"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001657/pdfft?md5=2a20c32e129d8dbc687c0c957f8f56c2&pid=1-s2.0-S0168010223001657-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10177251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BMSC-derived exosomal miR-148b-3p attenuates OGD/R-induced HMC3 cell activation by targeting DLL4 and Notch1 BMSC衍生的外泌体miR-148b-3p通过靶向DLL4和Notch1来减弱OGD/R诱导的HMC3细胞活化。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-02-01 DOI: 10.1016/j.neures.2023.09.005

Fang Yi , Hui Xiao , Mingyu Song , Lei Huang , Qianyi Huang , Jun Deng , Han Yang , Lan Zheng , Hong Wang , Wenping Gu

{"title":"BMSC-derived exosomal miR-148b-3p attenuates OGD/R-induced HMC3 cell activation by targeting DLL4 and Notch1","authors":"Fang Yi , Hui Xiao , Mingyu Song , Lei Huang , Qianyi Huang , Jun Deng , Han Yang , Lan Zheng , Hong Wang , Wenping Gu","doi":"10.1016/j.neures.2023.09.005","DOIUrl":"10.1016/j.neures.2023.09.005","url":null,"abstract":"<div><p>Bone mesenchymal stem cell (BMSC)-derived exosome (BMSC-Exo) could be a treatment method for ischemic injury. In ischemic cerebrovascular disease (IC), microglia is pivotal in neuronal damage and remodeling. This study explores the mechanisms of BMSC-Exo miR-148b-3p in regulating oxygen-glucose deprivation/reoxygenation (OGD/R)-induced human microglial clone 3 (HMC3) cell activation. Transmission electron microscopy (TEM) and qNano were used to assess BMSC-Exo features. The functions of BMSC-Exo miR-148 b-3p in OGD/R-induced HMC3 cell activation were explored via MTT assay, flow cytometry, scratch, transwell, and enzyme-linked immunosorbent assay (ELISA) assays. A dual-luciferase reporter assay was performed to determine the relationship between miR-148b-3p and Delta-like ligand 4(DDL4) or neurogenic locus notch homolog protein 1 (Notch1). OGD/R decreased miR-148b-3p expression in HMC3 cells. After BMSC-Exo treatment, miR-148b-3p expression was upregulated, cell viability and migration were inhibited, cell cycles remained in the G0/G1 phase, and proinflammatory cytokines were decreased in OGD/R-induced HMC3 cells. More importantly, BMSC-Exo miR-148b-3p could further strengthen BMSC-Exo effects. DDL4 and Notch1 are direct targets of miR-148b-3p, respectively. Moreover, the knockdown of DLL4 or Notch1 could inhibit OGD/R-induced HMC3 cell activation. BMSC-Exo miR-148b-3p inhibited OGD/R-induced HMC3 cell activation via inhibiting DLL4 and Notch1 expression, which provided a new strategy for treating cerebral ischemia.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"199 ","pages":"Pages 36-47"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001876/pdfft?md5=7cdd09557d5e69256f5b730a2c6f8a06&pid=1-s2.0-S0168010223001876-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction error in dopamine neurons during associative learning 多巴胺神经元在联想学习过程中的预测误差

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-02-01 DOI: 10.1016/j.neures.2023.07.003

Ryunosuke Amo

引用次数: 0

SUMOylation effects on neural stem cells self-renewal, differentiation, and survival SUMO对神经干细胞自我更新、分化和存活的影响。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-02-01 DOI: 10.1016/j.neures.2023.09.006

Letícia Yoshitome Queiroz , Ryoichiro Kageyama , Helena I. Cimarosti

{"title":"SUMOylation effects on neural stem cells self-renewal, differentiation, and survival","authors":"Letícia Yoshitome Queiroz , Ryoichiro Kageyama , Helena I. Cimarosti","doi":"10.1016/j.neures.2023.09.006","DOIUrl":"10.1016/j.neures.2023.09.006","url":null,"abstract":"<div><p>SUMO (small ubiquitin-like modifier) conjugation or SUMOylation, a post-translational modification, is a crucial regulator of protein function and cellular processes. In the context of neural stem cells (NSCs), SUMOylation has emerged as a key player, affecting their proliferation, differentiation, and survival. By modifying transcription factors, such as SOX1, SOX2, SOX3, SOX6, Bmi1, and Nanog, SUMOylation can either enhance or impair their transcriptional activity, thus impacting on NSCs self-renewal. Moreover, SUMOylation regulates neurogenesis and neuronal differentiation by modulating key proteins, such as Foxp1, Mecp2, MEF2A, and SOX10. SUMOylation is also crucial for the survival and proliferation of NSCs in both developing and adult brains. By regulating the activity of transcription factors, coactivators, and corepressors, SUMOylation acts as a molecular switch, inducing cofactor recruitment and function during development. Importantly, dysregulation of NSCs SUMOylation has been implicated in various disorders, including embryonic defects, ischemic cerebrovascular disease, glioma, and the harmful effects of benzophenone-3 exposure. Here we review the main findings on SUMOylation-mediated regulation of NSCs self-renewal, differentiation and survival. Better understanding NSCs SUMOylation mechanisms and its functional consequences might provide new strategies to promote neuronal differentiation that could contribute for the development of novel therapies targeting neurodegenerative diseases.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"199 ","pages":"Pages 1-11"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001888/pdfft?md5=13947c72fb42f896cd9219dfdfc061cf&pid=1-s2.0-S0168010223001888-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41147339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0