Neuroscience Research最新文献_第7页

Disrupted interoceptive awareness by auditory distractor: Difficulty inferring the internal bodily states? 听觉干扰物干扰的内感受意识：难以推断身体内部状态？

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-05-01 DOI: 10.1016/j.neures.2023.11.002

Yusuke Haruki , Kenji Ogawa

{"title":"Disrupted interoceptive awareness by auditory distractor: Difficulty inferring the internal bodily states?","authors":"Yusuke Haruki , Kenji Ogawa","doi":"10.1016/j.neures.2023.11.002","DOIUrl":"10.1016/j.neures.2023.11.002","url":null,"abstract":"<div><p>Recent studies have associated interoceptive awareness, the perception of internal bodily sensations, with a predictive mechanism of perception across all sensory modalities. According to the framework, volitional attention plays a pivotal role in interoceptive awareness by prioritizing interoceptive sensations over exteroceptive ones. Consequently, it is hypothesized that the presence of irrelevant stimuli would disrupt the attentional modulation and interoceptive awareness, which remains untested. In this study, we investigated if interoceptive awareness is diminished by unrelated auditory distractors to validate the proposed perceptual framework. A total of 30 healthy human volunteers performed the heartbeat counting task both with and without auditory distractors. Additionally, we measured participant’s psychophysiological traits related to interoception, including the high-frequency component of heart rate variability (HF-HRV) and trait interoceptive sensibility. The results showed that interoceptive accuracy, confidence, and heartbeat intensity decreased in the presence of distractor sound. Moreover, individuals with higher HF-HRV and a greater tendency to worry about bodily states experienced a more pronounced distractor effect on interoceptive awareness. These results provide support for the perceptual mechanism of interoceptive awareness in terms of the predictive process, highlighting the impact of relative precision across interoceptive and exteroceptive signals on perceptual experiences.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"202 ","pages":"Pages 30-38"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001979/pdfft?md5=4424a10c2205b5e185a9f19ffaee4e40&pid=1-s2.0-S0168010223001979-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71484243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of the retrosplenial cortex to route selection in a complex maze 脾后皮层对复杂迷宫路径选择的贡献。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-05-01 DOI: 10.1016/j.neures.2023.11.011

Tomohiro Hayashi , Nobuya Sato

{"title":"Contribution of the retrosplenial cortex to route selection in a complex maze","authors":"Tomohiro Hayashi , Nobuya Sato","doi":"10.1016/j.neures.2023.11.011","DOIUrl":"10.1016/j.neures.2023.11.011","url":null,"abstract":"<div><p>The retrosplenial cortex (RSC) is a region involved in navigation. In this study, we investigated the role of the RSC in navigation in a large-scale environment where the destination is not visible from the current location. We used a large maze where the routes could be freely designed by inserting and removing plates. In Experiment 1, rats learned a specific route in the maze and then were tested with a shortcut route in addition to the learned route. The rats with RSC lesions utilized the shortcut faster than those in the control group. In Experiment 2, rats were initially trained to follow a specific route, and subsequently, we tested the effects of a small change in the environment on their route-following behavior. In the test, the rats with RSC lesions demonstrated more errors than those in the control group. This suggests that lesions in the RSC make navigation to a goal unstable. These findings suggest that the RSC may be involved in the ability to perform appropriate behavior at a segment on a learned route in a large-scale environment, which drives habitually following the learned route.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"202 ","pages":"Pages 52-59"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223002067/pdfft?md5=7e40db166e66e1440e362b4d905bccab&pid=1-s2.0-S0168010223002067-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138478215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative overview of DSCAM and its multifunctional roles in Drosophila and vertebrates DSCAM 及其在果蝇和脊椎动物中的多功能作用比较概述

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-05-01 DOI: 10.1016/j.neures.2023.12.005

Kento Hizawa , Takuya Sasaki , Nariko Arimura

{"title":"A comparative overview of DSCAM and its multifunctional roles in Drosophila and vertebrates","authors":"Kento Hizawa , Takuya Sasaki , Nariko Arimura","doi":"10.1016/j.neures.2023.12.005","DOIUrl":"10.1016/j.neures.2023.12.005","url":null,"abstract":"<div><p>DSCAM (Down syndrome cell adhesion molecule) is a unique neuronal adhesion protein with extensively documented multifaceted functionalities. DSCAM also has interesting properties in vertebrates and invertebrates, respectively. In Drosophila species, particularly, <em>Dscam</em> exhibits remarkable genetic diversity, with tens of thousands of splicing isoforms that modulate the specificity of neuronal wiring. Interestingly, this splice variant diversity of <em>Dscam</em> is absent in vertebrates. DSCAM plays a pivotal role in mitigating excessive adhesion between identical cell types, thereby maintaining the structural and functional coherence of neural networks. DSCAM contributes to the oversight of selective intercellular interactions such as synaptogenesis; however, the precise regulatory mechanisms underlying the promotion and inhibition of cell adhesion involved remain unclear. In this review, we aim to delineate the distinct molecules that interact with DSCAM and their specific roles within the biological landscapes of Drosophila and vertebrates. By integrating these comparative insights, we aim to elucidate the multifunctional nature of DSCAM, particularly its capacity to facilitate or deter intercellular adhesion.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"202 ","pages":"Pages 1-7"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223002225/pdfft?md5=b36a7ed3816645d58c3626ed9f392b7a&pid=1-s2.0-S0168010223002225-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139028191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobiological mechanisms underlying oxytocin-mediated parental behavior in rodents 啮齿动物催产素介导的亲子行为的神经生物学机制

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-04-18 DOI: 10.1016/j.neures.2024.04.001

{"title":"Neurobiological mechanisms underlying oxytocin-mediated parental behavior in rodents","authors":"","doi":"10.1016/j.neures.2024.04.001","DOIUrl":"10.1016/j.neures.2024.04.001","url":null,"abstract":"<div><div>Parental behavior is essential for mammalian offspring to survive. Because of this significance, elucidating the neurobiological mechanisms that facilitate parental behavior has received strong interest. Decades of studies utilizing pharmacology and molecular biology have revealed that in addition to its facilitatory effects on parturition and lactation, oxytocin (OT) promotes the expression of parental behavior in rodents. Recent studies have also described the modulation of sensory processing by OT and the interaction of the OT system with other brain regions associated with parental behavior. However, the precise neurobiological mechanisms underlying the facilitation of caregiving behaviors by OT remain unclear. In this <em>Review</em>, I summarize the findings from rats and mice with a view toward integrating past and recent progress. I then review recent advances in the understanding of the molecular, cellular, and circuit mechanisms of OT-mediated parental behavior. Based on these observations, I propose a hypothetical model that would explain the mechanisms underlying OT-mediated parental behavior. Finally, I conclude by discussing some major remaining questions and propose potential future research directions.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"207 ","pages":"Pages 1-12"},"PeriodicalIF":2.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140767386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cognitive reality monitoring network and theories of consciousness 认知现实监测网络与意识理论

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-04-01 DOI: 10.1016/j.neures.2024.01.007

Aurelio Cortese , Mitsuo Kawato

{"title":"The cognitive reality monitoring network and theories of consciousness","authors":"Aurelio Cortese , Mitsuo Kawato","doi":"10.1016/j.neures.2024.01.007","DOIUrl":"10.1016/j.neures.2024.01.007","url":null,"abstract":"<div><p>Theories of consciousness abound. However, it is difficult to arbitrate reliably among competing theories because they target different levels of neural and cognitive processing or anatomical loci, and only some were developed with computational models in mind. In particular, theories of consciousness need to fully address the three levels of understanding of the brain proposed by David Marr: computational theory, algorithms and hardware. Most major theories refer to only one or two levels, often indirectly. The cognitive reality monitoring network (CRMN) model is derived from computational theories of mixture-of-experts architecture, hierarchical reinforcement learning and generative/inference computing modules, addressing all three levels of understanding. A central feature of the CRMN is the mapping of a gating network onto the prefrontal cortex, making it a prime coding circuit involved in monitoring the accuracy of one's mental states and distinguishing them from external reality. Because the CRMN builds on the hierarchical and layer structure of the cerebral cortex, it may connect research and findings across species, further enabling concrete computational models of consciousness with new, explicitly testable hypotheses. In sum, we discuss how the CRMN model can help further our understanding of the nature and function of consciousness.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"201 ","pages":"Pages 31-38"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000117/pdfft?md5=12810d5de6d57dd3f2583b44dc8d2538&pid=1-s2.0-S0168010224000117-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139683273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New ways of studying subjective experience 研究主观体验的新方法

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-04-01 DOI: 10.1016/j.neures.2024.01.010

Rebecca Keogh, Hakwan Lau

引用次数: 0

Reality monitoring and metacognitive judgments in a false-memory paradigm 错误记忆范式下的现实监测与元认知判断。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-04-01 DOI: 10.1016/j.neures.2023.11.007

Saurabh Ranjan , Brian Odegaard

{"title":"Reality monitoring and metacognitive judgments in a false-memory paradigm","authors":"Saurabh Ranjan , Brian Odegaard","doi":"10.1016/j.neures.2023.11.007","DOIUrl":"10.1016/j.neures.2023.11.007","url":null,"abstract":"<div><p>How well do we distinguish between different memory sources when the information from imagination and perception is similar? And how do metacognitive (confidence) judgments differ across different sources of experiences? To study these questions, we developed a reality monitoring task using semantically related words from the Deese-Roediger-McDermott (DRM) paradigm of false memories. In an orientation phase, participants either perceived word pairs or had to voluntarily imagine the second word of a word pair. In a test phase, participants viewed words and had to judge whether the paired word was previously perceived, imagined, or new. Results revealed an interaction between memory source and judgment type on both response rates and confidence judgments: reality monitoring was better for new and perceived (compared to imagined) sources, and participants often incorrectly reported imagined experiences to be perceived. Individuals exhibited similar confidence between correct imagined source judgments and incorrect imagined sources reported to be perceived. Modeling results indicated that the observed judgments were likely due to an externalizing bias (i.e., a bias to judge the memory source as perceived). Additionally, we found that overall metacognitive ability was best in the perceived source. Together, these results reveal a source-dependent effect on response rates and confidence ratings, and provide evidence that observers are surprisingly prone to externalizing biases when monitoring their own memories.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"201 ","pages":"Pages 3-17"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S016801022300202X/pdfft?md5=a6263d018753c6a7c41cde1f021d5476&pid=1-s2.0-S016801022300202X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisensory subtypes of aphantasia: Mental imagery as supramodal perception in reverse 幻觉的多感觉亚型:心理意象作为超模态知觉的反向。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-04-01 DOI: 10.1016/j.neures.2023.11.009

Alexei Joel Dawes , Rebecca Keogh , Joel Pearson

{"title":"Multisensory subtypes of aphantasia: Mental imagery as supramodal perception in reverse","authors":"Alexei Joel Dawes , Rebecca Keogh , Joel Pearson","doi":"10.1016/j.neures.2023.11.009","DOIUrl":"10.1016/j.neures.2023.11.009","url":null,"abstract":"<div><p>Cognitive neuroscience research on mental imagery has largely focused on the visual imagery modality in unimodal task contexts. Recent studies have uncovered striking individual differences in visual imagery capacity, with some individuals reporting a subjective absence of conscious visual imagery ability altogether (“aphantasia”). However, naturalistic mental imagery is often multi-sensory, and preliminary findings suggest that many individuals with aphantasia also report a subjective lack of mental imagery in other sensory domains (such as auditory or olfactory imagery). In this paper, we perform a series of cluster analyses on the multi-sensory imagery questionnaire scores of two large groups of aphantasic subjects, defining latent sub-groups in this sample population. We demonstrate that aphantasia is a heterogenous phenomenon characterised by dominant sub-groups of individuals with visual aphantasia (those who report selective visual imagery absence) and multi-sensory aphantasia (those who report an inability to generate conscious mental imagery in any sensory modality). We replicate our findings in a second large sample and show that more unique aphantasia sub-types also exist, such as individuals with selectively preserved mental imagery in only one sensory modality (e.g. intact auditory imagery). We outline the implications of our findings for network theories of mental imagery, discussing how unique aphantasia aetiologies with distinct self-report patterns might reveal alterations to various levels of the sensory processing hierarchy implicated in mental imagery.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"201 ","pages":"Pages 50-59"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223002043/pdfft?md5=ba224bf1cfa96381c036551b1cdea95c&pid=1-s2.0-S0168010223002043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138461275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral vision is mainly for looking rather than seeing 周边视觉主要是看而不是看。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-04-01 DOI: 10.1016/j.neures.2023.11.006

Li Zhaoping

{"title":"Peripheral vision is mainly for looking rather than seeing","authors":"Li Zhaoping","doi":"10.1016/j.neures.2023.11.006","DOIUrl":"10.1016/j.neures.2023.11.006","url":null,"abstract":"<div><p>Vision includes looking and seeing. Looking, mainly via gaze shifts, selects a fraction of visual input information for passage through the brain’s information bottleneck. The selected input is placed within the attentional spotlight, typically in the central visual field. Seeing decodes, i.e., recognizes and discriminates, the selected inputs. Hence, peripheral vision should be mainly devoted to looking, in particular, deciding where to shift the gaze. Looking is often guided exogenously by a saliency map created by the primary visual cortex (V1), and can be effective with no seeing and limited awareness. In seeing, peripheral vision not only suffers from poor spatial resolution, but is also subject to crowding and is more vulnerable to illusions by misleading, ambiguous, and impoverished visual inputs. Central vision, mainly for seeing, enjoys the top-down feedback that aids seeing in light of the bottleneck which is hypothesized to starts from V1 to higher areas. This feedback queries for additional information from lower visual cortical areas such as V1 for ongoing recognition. Peripheral vision is deficient in this feedback according to the Central-peripheral Dichotomy (CPD) theory. The saccades engendered by peripheral vision allows looking to combine with seeing to give human observers the impression of seeing the whole scene clearly despite inattentional blindness.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"201 ","pages":"Pages 18-26"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223002018/pdfft?md5=213070641053ee50011d4aa3ee5bcc67&pid=1-s2.0-S0168010223002018-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138434584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to study subjective experience in an animal model of blindsight? 如何在失明动物模型中研究主观体验？

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-04-01 DOI: 10.1016/j.neures.2023.09.001

Xiyao Yu , Reona Yamaguchi , Tadashi Isa

{"title":"How to study subjective experience in an animal model of blindsight?","authors":"Xiyao Yu , Reona Yamaguchi , Tadashi Isa","doi":"10.1016/j.neures.2023.09.001","DOIUrl":"10.1016/j.neures.2023.09.001","url":null,"abstract":"<div><p>The nature of subjective conscious experience, which accompanies us throughout our waking lives, and how it is generated, remain elusive<strong>.</strong> One of the challenges in studying subjective experience is disentangling the brain activity related to the sensory stimulus processing and stimulus-guided behavior from those associated with subjective perception. Blindsight, a phenomenon characterized by the retained visual discrimination performance but impaired visual consciousness due to damage to the primary visual cortex, becomes a special entry point to address this question. However, to fully understand the underlying neural mechanism, relying on studies involving human patients alone is insufficient. In this paper, we tried to address this issue, by first introducing the well-known cases of blindsight, especially the reports on subjective experience in both human and monkey subjects. And then we described how the impaired visual awareness of blindsight monkeys has been discovered and further studied by specifically designed tasks, as verbal reporting is not possible for these animals. Our previous studies also demonstrated that many complex visually guided cognitive processes were still retained despite the impairment of visual awareness. Further investigation needs to be conducted to explore the relationship between visually guided behavior, visual awareness and brain activity in blindsight subjects.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"201 ","pages":"Pages 39-45"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001669/pdfft?md5=97044e9fe35f8afa38bb9e98f9411480&pid=1-s2.0-S0168010223001669-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10579366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0