Neuroscience Research最新文献_第6页

Augmentation of intracranial self-stimulation induced by amphetamine-like drugs in Period circadian regulator 2 knockout mice is associated with intracellular Ca2+ levels 安非他明类药物诱导的颅内自我刺激在昼夜节律调节器2基因敲除小鼠中的增强与细胞内Ca2+水平有关。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 DOI: 10.1016/j.neures.2024.07.007

Hyeokjun Kwon , Eunchong Hong , Yong Sup Lee , Jae Hoon Cheong , Hee Jin Kim , Soyoung Kim , Jaesuk Yun

{"title":"Augmentation of intracranial self-stimulation induced by amphetamine-like drugs in Period circadian regulator 2 knockout mice is associated with intracellular Ca2+ levels","authors":"Hyeokjun Kwon , Eunchong Hong , Yong Sup Lee , Jae Hoon Cheong , Hee Jin Kim , Soyoung Kim , Jaesuk Yun","doi":"10.1016/j.neures.2024.07.007","DOIUrl":"10.1016/j.neures.2024.07.007","url":null,"abstract":"<div><div>Over the past decade, new psychoactive substances (NPS) have emerged in the illegal drug market and have continued to attract attention from the international community. Among these, amphetamine-like NPS, classified as stimulants, constitute a significant proportion. However, the pharmacological characteristics and mechanisms underlying addiction to amphetamine-like NPS remain poorly understood. Given that circadian rhythms are linked to the brain stimulation effects of methamphetamine (METH) and amphetamine, we investigated the effects of METH, 1-(4-methoxyphenyl)-N-methylpropan-2-amine (PMMA), and 1-(benzofuran-5-yl)-N-ethylpropan-2-amine (5-EAPB) on intracranial self-stimulation (ICSS) in wild-type (WT) or Period circadian regulator 2 knockout mice. Amphetamine-like drugs increase intracellular Ca<sup>2+</sup> levels to provoke dopamine release, so we examined the impact of <em>Per2</em> knockdown on intracellular Ca<sup>2+</sup> levels in PC12 cells to elucidate a potential mechanism underlying NPS-induced ICSS enhancement. Our ICSS results showed that METH and PMMA significantly increased brain stimulation in <em>Per2</em> knockout mice compared to WT mice. Similarly, METH and PMMA induced higher Ca<sup>2+</sup> fluorescence intensity in <em>Per2</em> knockdown PC12 cells than in control cells. In contrast, 5-EAPB did not produce significant changes in either ICSS or Ca<sup>2+</sup> signaling. These findings suggest that <em>Per2</em> plays a crucial role in the brain stimulation effects of amphetamine-like drugs through the regulation of intracellular Ca<sup>2+</sup>.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"209 ","pages":"Pages 34-41"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Correlations of brain structure with the social behavior of 15q11-13 duplication mice, an animal model of autism 自闭症动物模型 15q11-13 重复小鼠大脑结构与社交行为的相关性。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 DOI: 10.1016/j.neures.2024.07.009

Zhilei Zhao , Naohiro Okada , Sho Yagishita , Noriaki Yahata , Nobuhiro Nitta , Sayaka Shibata , Yoshifumi Abe , Susumu Morita , Eureka Kumagai , Kenji F. Tanaka , Tetsuya Suhara , Toru Takumi , Kiyoto Kasai , Seiichiro Jinde

{"title":"Correlations of brain structure with the social behavior of 15q11-13 duplication mice, an animal model of autism","authors":"Zhilei Zhao , Naohiro Okada , Sho Yagishita , Noriaki Yahata , Nobuhiro Nitta , Sayaka Shibata , Yoshifumi Abe , Susumu Morita , Eureka Kumagai , Kenji F. Tanaka , Tetsuya Suhara , Toru Takumi , Kiyoto Kasai , Seiichiro Jinde","doi":"10.1016/j.neures.2024.07.009","DOIUrl":"10.1016/j.neures.2024.07.009","url":null,"abstract":"<div><div>Duplication of chromosome 15q11–13 has been reported to be one of the most frequent cytogenetic copy number variations in autism spectrum disorder (ASD), and a mouse model of paternal 15q11–13 duplication was generated, termed <em>15q dup</em> mice. While previous studies have replicated some of the behavioral and brain structural phenotypes of ASD separately, the relationship between brain structure and behavior has rarely been examined. In this study, we performed behavioral experiments related to anxiety and social behaviors and magnetic resonance imaging (MRI) using the same set of <em>15q dup</em> and wild-type mice. <em>15q dup</em> mice showed increased anxiety and a tendency toward alterations in social behaviors, as reported previously, as well as variability in terms of sociability. MRI analysis revealed that a lower sociability index was correlated with a smaller gray matter volume in the right medial entorhinal cortex. These results may help to understand how variability in behavioral phenotypes of ASD arises even in individuals with the same genetic background and to determine the individual differences in neurodevelopmental trajectory correlated with specific brain structures that underlie these phenotypes.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"209 ","pages":"Pages 42-49"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Structural connectivity of the precuneus and its relation to resting-state networks 楔前肌的结构连接及其与静息态网络的关系

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 DOI: 10.1016/j.neures.2023.12.004

Atsushi Yamaguchi, Tatsuya Jitsuishi

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Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation 杏仁核簇间的双向情绪编码：动机的对手过程理论的神经基础

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 DOI: 10.1016/j.neures.2024.07.003

Kenta M. Hagihara , Andreas Lüthi

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A novel quadrant spatial assay reveals environmental preference in mouse spontaneous and parental behaviors 一种新型象限空间测定法揭示了小鼠自发行为和亲代行为中的环境偏好。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 DOI: 10.1016/j.neures.2024.08.002

Aito Narita , Hirofumi Asano , Hayato Kudo , Shigeo Miyata , Fumihiro Shutoh , Goichi Miyoshi

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Lifespan differences in background functional connectivity of core cognitive large-scale brain networks 核心认知大尺度大脑网络背景功能连接的寿命差异。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-12-01 DOI: 10.1016/j.neures.2022.09.005

Patrick J. Pruitt , Lingfei Tang , Jessica M. Hayes , Noa Ofen , Jessica S. Damoiseaux

{"title":"Lifespan differences in background functional connectivity of core cognitive large-scale brain networks","authors":"Patrick J. Pruitt , Lingfei Tang , Jessica M. Hayes , Noa Ofen , Jessica S. Damoiseaux","doi":"10.1016/j.neures.2022.09.005","DOIUrl":"10.1016/j.neures.2022.09.005","url":null,"abstract":"<div><div>Large-scale brain networks undergo functional reorganization over the course of the lifespan, with concurrent implications for cognition. Characterizing network connectivity during a task may provide complementary insight into cognitive development and aging, to that provided by resting-state. We assessed network background connectivity, which refers to connectivity that remains after task effects have been regressed out, during a visual memory-encoding task in a lifespan sample. More specifically we assessed the within- and between-network background connectivity of the default mode, salience, and frontoparietal networks. Within-network background connectivity of salience and frontoparietal networks differed between age groups, with late-life adults showing lower connectivity. We did not find an effect of age group in default mode network background connectivity, contrary to previous findings using resting-state. However, default mode between-network background connectivity with salience and frontoparietal networks was greater in mid-life and late-life adults than in younger age groups. Overall, our findings in a lifespan sample are in line with previous observations of age-related network de-differentiation. However, the lack of age effect in default mode network background connectivity suggests that background connectivity indeed represents a complementary measure to resting-state connectivity, providing a differential glance of network connectivity during a particular state.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"209 ","pages":"Pages 1-8"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9278233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Future projections for mammalian whole-brain simulations based on technological trends in related fields. 基于相关领域技术发展趋势的哺乳动物全脑模拟未来预测。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-19 DOI: 10.1016/j.neures.2024.11.005

Jun Igarashi

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Molecular, neural, and tissue circuits underlying physiological temperature responses in Caenorhabditis elegans. 草履虫生理温度反应的分子、神经和组织回路。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-13 DOI: 10.1016/j.neures.2024.11.001

Yukina Mori, Akane Ohta, Atsushi Kuhara

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A chemogenetic technology using insect Ionotropic Receptors to stimulate target cell populations in the mammalian brain. 利用昆虫离子受体刺激哺乳动物大脑目标细胞群的化学遗传技术。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-10 DOI: 10.1016/j.neures.2024.11.003

Yoshio Iguchi, Richard Benton, Kazuto Kobayashi

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Molecular mechanisms linking loss of TDP-43 function to amyotrophic lateral sclerosis/frontotemporal dementia-related genes TDP-43 功能丧失与肌萎缩侧索硬化症/颞前痴呆症相关基因的分子机制。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.05.001

{"title":"Molecular mechanisms linking loss of TDP-43 function to amyotrophic lateral sclerosis/frontotemporal dementia-related genes","authors":"","doi":"10.1016/j.neures.2024.05.001","DOIUrl":"10.1016/j.neures.2024.05.001","url":null,"abstract":"<div><div>Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by nuclear depletion and cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43). TDP-43 plays a key role in regulating the splicing of numerous genes, including <em>TARDBP</em>. This review aims to delineate two aspects of ALS/FTD pathogenesis associated with TDP-43 function. First, we described novel mechanistic insights into the splicing of <em>UNC13A</em>, a TDP-43 target gene. Single nucleotide polymorphisms (SNPs) in <em>UNC13A</em> are the most common risk factors for ALS/FTD. We found that TDP-43 represses “cryptic exon” inclusion during <em>UNC13A</em> RNA splicing. A risk-associated SNP in this exon results in increased RNA levels of <em>UNC13A</em> retaining the cryptic exon. Second, we described the perturbation of the TDP-43 autoregulatory mechanism caused by age-related DNA demethylation. Aging is a major risk factor for sporadic ALS/FTD. Typically, TDP-43 levels are regulated via alternative splicing of <em>TARDBP</em> mRNA. This review focused on that <em>TARDBP</em> methylation is altered by aging, thereby disrupting TDP-43 autoregulation. It was found that demethylation reduces the efficiency of alternative splicing and increases <em>TARDBP</em> mRNA levels. Moreover, we demonstrated that, with aging, this region is demethylated in the human motor cortex and is associated with the early onset of ALS.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"208 ","pages":"Pages 1-7"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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