Neuroscience Research最新文献_第6页

Neurotransmitter receptor gene expression patterns associated with reward-related neural representations 神经递质受体基因表达模式与奖励相关的神经表征。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-11-01 Epub Date: 2025-09-17 DOI: 10.1016/j.neures.2025.104957

Kaosu Matsumori , Kana Matsuyanagi , Kenji Matsumoto

{"title":"Neurotransmitter receptor gene expression patterns associated with reward-related neural representations","authors":"Kaosu Matsumori , Kana Matsuyanagi , Kenji Matsumoto","doi":"10.1016/j.neures.2025.104957","DOIUrl":"10.1016/j.neures.2025.104957","url":null,"abstract":"<div><div>The neural representation of reward is underpinned by neurotransmitter systems; however, current human neuroimaging techniques cannot assess the receptor-specific contributions to reward processing. We investigated the relationships between reward-related neural representations and the expression patterns of 30 neurotransmitter receptor genes by combining meta-analytic functional neuroimaging maps with gene expression data from the Allen Human Brain Atlas. Clustering analysis revealed that serotonin receptor 2 A was co-expressed with other reward-related receptors, whereas the nociceptin (NOP) receptor exhibited a distinct expression pattern. Using elastic net regression with spatial null models, we observed that monetary reward maps showed significant positive spatial correlations with serotonin receptor 2 A expression and negative correlations with NOP receptor expression. Similar positive correlations with serotonin receptor 2 A were observed in the craving maps. Principal component regression provided complementary evidence, with both monetary reward and craving maps showing significant associations with components characterized by NOP receptor loadings. These findings from multiple analytical approaches suggest that reward processing involves both coordinated receptor networks and specialized receptor systems, particularly highlighting the opposing roles of the serotonin receptor 2 A and NOP systems. Our results provide insights into the molecular mechanisms underlying reward processing in the human brain, potentially informing targeted interventions for reward-related disorders.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"220 ","pages":"Article 104957"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling natural neural networks of decision making with artificial neural networks 用人工神经网络建模自然神经网络的决策。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-11-01 Epub Date: 2025-09-26 DOI: 10.1016/j.neures.2025.104961

Akihiro Funamizu , Ryo Karakida

{"title":"Modeling natural neural networks of decision making with artificial neural networks","authors":"Akihiro Funamizu , Ryo Karakida","doi":"10.1016/j.neures.2025.104961","DOIUrl":"10.1016/j.neures.2025.104961","url":null,"abstract":"<div><div>One main focus in neuroscience is to understand the relationship between decision making and various brain regions. Researchers use machine learning approaches to model the neural circuits of cerebral cortices, cerebellum, and basal ganglia. This review focuses on artificial neural networks (ANNs), particularly recurrent neural networks (RNNs), to model cortical functions for decision making. We first introduce the basic architecture of RNNs and explain how researchers compare the activity and circuits between artificial and biological networks. We also summarize how RNNs model the prefrontal and posterior parietal cortical in tasks involving short-term memory, perceptual decision making, and value-based decision making. We then show our recent challenges to develop a real-cyber hybrid network, that integrates neuronal activity in mice with RNN-based artificial units to better generate continuous-time body movements, compared to conventional RNNs that only use artificial units. The hybrid network tries to develop RNNs which have similar activity to the brain by using real neurons, rather than developing artificial RNNs and comparing their functions with biological brain. We propose that such integrative approaches in neuroscience and AI will further our understanding of both natural and artificial intelligence in the field of neuro-AI.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"220 ","pages":"Article 104961"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Animal models of tau propagation in Alzheimer's disease 阿尔茨海默病中tau蛋白繁殖的动物模型。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-11-01 Epub Date: 2025-09-23 DOI: 10.1016/j.neures.2025.104960

Masami Masuda-Suzukake, Shotaro Shimonaka, Takashi Nonaka, Masato Hasegawa

{"title":"Animal models of tau propagation in Alzheimer's disease","authors":"Masami Masuda-Suzukake, Shotaro Shimonaka, Takashi Nonaka, Masato Hasegawa","doi":"10.1016/j.neures.2025.104960","DOIUrl":"10.1016/j.neures.2025.104960","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is characterized by extracellular amyloid plaques composed of amyloid-β and intracellular neurofibrillary tangles composed of aggregated tau protein. In sporadic AD, the distribution of pathological tau progresses in a stereotypical manner and correlates with clinical staging, whereas the distribution of amyloid-β plaques does not. This suggests that the spread of tau pathology is a critical process that plays a key role in neurodegeneration and disease progression. Accurate models of tau propagation are therefore necessary to develop disease-modifying drugs for AD. The prion-like propagation hypothesis is a potential mechanism for the progressive distribution of tau pathology in the brain. In 2009, it was experimentally demonstrated that the intracerebral injection of brain extracts from transgenic mice that overexpress a mutated form of human tau protein into other tau transgenic mice induced the spread of pathological tau <em>in vivo</em>. Since then, this approach has been widely used to model tau propagation. More recently, newer models that more closely replicate the pathology of AD have been developed. This review summarizes the latest developments in animal models of tau propagation in sporadic AD.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"220 ","pages":"Article 104960"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphologic changes in striatonigral neurons in a rat model of levodopa-induced dyskinesia 左旋多巴诱导运动障碍大鼠纹状体神经元形态学改变

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI: 10.1016/j.neures.2025.104953

Masako Fujita , Haruo Nishijima , Tomonori Furukawa , Fumiaki Mori , Aogi Kobayashi , Chieko Suzuki , Koichi Wakabayashi , Masahiko Tomiyama

{"title":"Morphologic changes in striatonigral neurons in a rat model of levodopa-induced dyskinesia","authors":"Masako Fujita , Haruo Nishijima , Tomonori Furukawa , Fumiaki Mori , Aogi Kobayashi , Chieko Suzuki , Koichi Wakabayashi , Masahiko Tomiyama","doi":"10.1016/j.neures.2025.104953","DOIUrl":"10.1016/j.neures.2025.104953","url":null,"abstract":"<div><div>We aimed to elucidate morphological changes in striatonigral projection neurons in a rat model of levodopa-induced dyskinesia (LID). Male Wistar rats underwent unilateral 6-hydroxydopamine lesioning to establish a hemiparkinsonian model. At 8 weeks postoperatively, the rats were allocated to either the levodopa-treated group or the saline-treated control group. Behavioral abnormalities were quantified using the Abnormal Involuntary Movement (AIM) scores. We identified direct pathway neurons projecting to substantia nigra pars reticulata (SNr) by retrograde tracer injection. Dendritic spine morphology and the ultrastructure of synaptic terminals in SNr were assessed. The AIM scores increased along with levodopa treatment. Compared to control rats and the intact side of the LID model, the dendritic spine heads of striatonigral projection neurons were significantly enlarged, while spine density was reduced in the dopamine-denervated side of the LID model. Electron microscopic analysis revealed enlarged axon terminals and an increased number of synaptic vesicles in the dopamine-denervated side of SNr in levodopa-treated rats compared with those of the controls. Repeated levodopa administration induces morphological plasticity in striatonigral neurons, characterized by enlarged dendritic spine heads, reduced spine density, and enlarged synaptic terminals. These structural alterations likely contribute to enhanced GABAergic transmission in SNr and a reduced threshold for dyskinesia.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"219 ","pages":"Article 104953"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural mechanisms for the control of thirst and salt appetite in response to body fluid conditions and intake behavior 根据体液状况和摄入行为控制口渴和盐的食欲的神经机制。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-10-01 Epub Date: 2025-07-23 DOI: 10.1016/j.neures.2025.104941

Takashi Matsuda

{"title":"Neural mechanisms for the control of thirst and salt appetite in response to body fluid conditions and intake behavior","authors":"Takashi Matsuda","doi":"10.1016/j.neures.2025.104941","DOIUrl":"10.1016/j.neures.2025.104941","url":null,"abstract":"<div><div>Terrestrial animals, including humans, seek out and consume adequate amounts of water and salt on a daily basis to maintain body fluid homeostasis. To initiate water and salt intake behaviors, the brain anticipates and senses fluid imbalances, i.e., changes in [Na<sup>+</sup> ] and relevant circulating hormones, including angiotensin II and aldosterone. Circumventricular organs, such as the organum vasculosum lamina terminalis and subfornical organ, continuously detect information about body fluids and convert it into neuronal signals that drive or quench thirst and salt appetite. On the other hand, signals for water and salt intake are detected in peripheral organs and sent back to the control center for the transient suppression of thirst and salt appetite through specific neural circuits. Some brain regions integrate this information to maintain the harmony of body fluid balance. This review discusses the neural mechanisms responsible for monitoring fluid imbalances, driving the motivation for thirst and salt appetite, and then quenching this motivation after the ingestion of water and salt. Based on our findings and those of other studies, the mechanisms by which the brain integrates multiple sources of information to flexibly control thirst and salt appetite are also highlighted.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"219 ","pages":"Article 104941"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative comparison of uncrossed corticospinal tracts arising from different cortical areas in humans 人类不同皮质区产生的未交叉皮质脊髓束的定量比较。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-10-01 Epub Date: 2025-09-01 DOI: 10.1016/j.neures.2025.104954

Noboru Usuda, Sho K. Sugawara, Toshiki Tazoe, Yukio Nishimura

{"title":"Quantitative comparison of uncrossed corticospinal tracts arising from different cortical areas in humans","authors":"Noboru Usuda, Sho K. Sugawara, Toshiki Tazoe, Yukio Nishimura","doi":"10.1016/j.neures.2025.104954","DOIUrl":"10.1016/j.neures.2025.104954","url":null,"abstract":"<div><div>The uncrossed corticospinal tract (CST) has garnered interest as a potential compensatory neural pathway for recovering motor function after stroke-induced damage to the crossed CST. However, the area of origin of the uncrossed CST in humans remain unclear. This study aimed to identify the area of origin of the uncrossed CST in healthy adults via fibre tractography and diffusion-weighted magnetic resonance imaging. We identified uncrossed corticospinal (CS) streamlines arising from seven cortical areas: the primary motor cortex (M1: mean ± SE = 71.55 ± 2.19 %), primary somatosensory cortex (13.77 ± 2.18 %), supplementary motor area (SMA: 8.02 ± 1.49 %), dorsal (2.51 ± 0.52 %), and ventral (1.39 ± 0.31 %) aspects of the premotor cortex, preSMA (1.50 ± 0.42), and Brodmann area 5 (1.26 ± 0.21 %). Even though there was a fair amount of individual variation (min - max: 17.98–99.73 %), on average, 74.04 % of the CS streamlines passed through the dorsolateral funiculus of the spinal cord. Our findings enhance the anatomical understanding of the uncrossed CST and may inform neurorehabilitation strategies aimed at optimizing motor recovery following neurological injury.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"219 ","pages":"Article 104954"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural responses to male and female voices: An event-related potential study on listener and speaker differences 对男性和女性声音的神经反应：听者和说话者差异的事件相关电位研究。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-10-01 Epub Date: 2025-07-30 DOI: 10.1016/j.neures.2025.104942

Eunbi Park , Misato Kasuya , Fumitaka Homae

{"title":"Neural responses to male and female voices: An event-related potential study on listener and speaker differences","authors":"Eunbi Park , Misato Kasuya , Fumitaka Homae","doi":"10.1016/j.neures.2025.104942","DOIUrl":"10.1016/j.neures.2025.104942","url":null,"abstract":"<div><div>This study investigated sex-based differences in the temporal dynamics of brain responses to male and female voices using electroencephalography (EEG). We examined whether the sex of the speaker and listener influenced the early and late event-related potential (ERP) components. The participants (14 females and 15 males) listened to voice stimuli and identified the speaker’s sex. The results showed a trend toward lower recognition accuracy for female voices. EEG revealed distinct differences in responses; both male and female participants exhibited stronger positivity for female voices, whereas late-stage components showed pronounced responses to female voices in male participants. These findings suggest that voice-based sex identification relies on both basic acoustic feature processing and advanced cognitive stages with sex-specific dynamics in brain responses. This study provides insight into the neural mechanisms of voice perception and highlights the influence of the interaction between voice gender and listener’s sex, thereby contributing to a deeper understanding of social communication.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"219 ","pages":"Article 104942"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A supplemental receiver coil recovers frontal and subcortical functional magnetic resonance imaging signals under half-volume head coil configuration 在半体积头线圈配置下，补充接收线圈恢复额叶和皮层下功能磁共振成像信号。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.neures.2025.104943

Yucong Yuan , Toshiko Tanaka , Daisuke Nishiyama , Yasuhiro Shimada , Ichiro Fujimoto , Tomoki Haji , Atsushi Wada , Masahiko Haruno

{"title":"A supplemental receiver coil recovers frontal and subcortical functional magnetic resonance imaging signals under half-volume head coil configuration","authors":"Yucong Yuan , Toshiko Tanaka , Daisuke Nishiyama , Yasuhiro Shimada , Ichiro Fujimoto , Tomoki Haji , Atsushi Wada , Masahiko Haruno","doi":"10.1016/j.neures.2025.104943","DOIUrl":"10.1016/j.neures.2025.104943","url":null,"abstract":"<div><div>The need for multisensory devices such as virtual reality and touch during functional magnetic resonance imaging (fMRI) is increasing. However, implementation of those devices requires a large presentation system, and the face-covering receiver coil obstructs their placement. To create more space, it has been proposed to remove the front half coil and place a small elliptical flex receiver coil on the participant's forehead. However, this coil configuration's signal intensity has not been evaluated quantitatively and needs validation for use in various fMRI experiments. In this study, we first compared signal-to-noise ratios of resting-state fMRI for different brain regions under full, posterior half only, and posterior half + flex coil conditions and found that the flex coil improved the fMRI signal in both frontal and subcortical regions significantly. Furthermore, we tested the flex coil during a facial expression discrimination task, finding it enabled the detection of task-related fMRI signals in areas related to emotional decision-making and perception such as the amygdala. Thus, this study demonstrated the usefulness of the flex configuration in various fMRI experiments requiring additional equipment in front of the face, expanding the range of fMRI studies.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"219 ","pages":"Article 104943"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of a transgenic strain for the whole brain calcium imaging in larval medaka fish (Oryzias latipes) medaka鱼幼鱼全脑钙显像转基因菌株的建立。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.neures.2025.104944

Takahide Seki , Kazuhiro Miyanari , Asuka Shiraishi , Sachiko Tsuda , Satoshi Ansai , Hideaki Takeuchi

引用次数: 0

Ethical, legal, social, and cultural implications of the non-clinical use of transcranial direct current stimulation (tDCS) in Korea and Japan 韩国和日本非临床使用经颅直流电刺激（tDCS）的伦理、法律、社会和文化影响。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1016/j.neures.2025.104951

Sinu Choi , Anita S. Jwa , Jiwon Shim , Soojin Kim , Juhee Eom , Yoshiyuki Takimoto , Eisuke Nakazawa , Young-Joon Ryu

{"title":"Ethical, legal, social, and cultural implications of the non-clinical use of transcranial direct current stimulation (tDCS) in Korea and Japan","authors":"Sinu Choi , Anita S. Jwa , Jiwon Shim , Soojin Kim , Juhee Eom , Yoshiyuki Takimoto , Eisuke Nakazawa , Young-Joon Ryu","doi":"10.1016/j.neures.2025.104951","DOIUrl":"10.1016/j.neures.2025.104951","url":null,"abstract":"<div><div>Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuroscience technique that modulates brain activity by applying a weak electric current to the scalp. tDCS is already used in hospitals to alleviate symptoms of neurological diseases and mental disorders. However, it can also be purchased over the Internet without medical authorization or oversight. In such cases, experts have raised concerns about potential health side effects and unforeseen social issues resulting from the misuse of tDCS and called for a thorough analysis of the broad societal implications of its non-clinical use. To address these concerns, this study explored the ethical, legal, social, and cultural issues related to the use of tDCS outside its authorized medical applications, focusing on South Korean and Japanese societies as case studies. We employed an Integration Workflow and XYZ approach specifically designed to analyze the implications of emerging neurotechnologies. Our findings highlighted several areas of concern: safety, effectiveness, fairness, lack of regulation in both sports and non-sports sectors, insufficient critical information from device manufacturers, hype and exaggerated claims, and use for enhancement in meritocratic competitions. We anticipate that our study’s findings will inform the future development of tDCS devices and encourage public engagement through discussions involving key stakeholders, including device manufacturers and policymakers.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"219 ","pages":"Article 104951"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0