Neuroscience Research最新文献_第6页

Estimation of firing rate from instantaneous interspike intervals. 从瞬时间隔估算发射率

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-06-24 DOI: 10.1016/j.neures.2024.06.006

Lubomir Kostal, Kristyna Kovacova

引用次数: 0

Volume electron microscopy for genetically and molecularly defined neural circuits. 用于基因和分子定义神经回路的体电子显微镜。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-06-22 DOI: 10.1016/j.neures.2024.06.002

Nobuhiko Ohno, Fuyuki Karube, Fumino Fujiyama

{"title":"Volume electron microscopy for genetically and molecularly defined neural circuits.","authors":"Nobuhiko Ohno, Fuyuki Karube, Fumino Fujiyama","doi":"10.1016/j.neures.2024.06.002","DOIUrl":"10.1016/j.neures.2024.06.002","url":null,"abstract":"<p><p>The brain networks responsible for adaptive behavioral changes are based on the physical connections between neurons. Light and electron microscopy have long been used to study neural projections and the physical connections between neurons. Volume electron microscopy has recently expanded its scale of analysis due to methodological advances, resulting in complete wiring maps of neurites in a large volume of brain tissues and even entire nervous systems in a growing number of species. However, structural approaches frequently suffer from inherent limitations in which elements in images are identified solely by morphological criteria. Recently, an increasing number of tools and technologies have been developed to characterize cells and cellular components in the context of molecules and gene expression. These advancements include newly developed probes for visualization in electron microscopic images as well as correlative integration methods for the same elements across multiple microscopic modalities. Such approaches advance our understanding of interactions between specific neurons and circuits and may help to elucidate novel aspects of the basal ganglia network involving dopamine neurons. These advancements are expected to reveal mechanisms for processing adaptive changes in specific neural circuits that modulate brain functions.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-scale foundation models and generative AI for BigData neuroscience. 用于大数据神经科学的大规模基础模型和生成式人工智能。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-06-17 DOI: 10.1016/j.neures.2024.06.003

Ran Wang, Zhe Sage Chen

引用次数: 0

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-06-12 DOI: 10.1016/j.neures.2024.06.001

{"title":"Event-related brain potentials to typing errors in transparent and intransparent German words","authors":"","doi":"10.1016/j.neures.2024.06.001","DOIUrl":"10.1016/j.neures.2024.06.001","url":null,"abstract":"<div><div>Error detection in typing is crucial for assessing the adequacy of ongoing actions, leveraging both predictive mechanisms for early detection and sensory feedback for late detection. Neurophysiological studies have supported the anticipation of errors through predictive models. This research extends the understanding of error detection in typing, focusing on the neurocognitive mechanisms underlying errors in transparent and intransparent German words. Thirty-six volunteer students typed out aurally presented words, classified as either orthographically transparent or intransparent, on a computer keyboard without the possibility of correction. Because of poor spelling or excessive artifacts, the final sample comprised 27 participants. Event-related potentials (ERPs) were obtained time-locked to key presses, and behavioral data on typing correctness and speed were collected. A higher error rate and longer latency for intransparent words compared to transparent ones were found, suggesting the complexity of spelling impacts typing correctness. Post-error slowing was observed, aligning with increased cognitive control following errors. ERPs revealed a negative component akin to the error-related negativity (ERN) for typing errors, with a pronounced ERN-like negativity preceding erroneous key-presses, particularly for intransparent words. The study provides evidence of the cognitive and neural mechanisms underlying typing errors, highlighting the impact of orthographic transparency. The detection of an ERN-like negativity before erroneous key-presses, especially in typing intransparent words, underscores the brain's use of predictive mechanisms for error detection.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"207 ","pages":"Pages 37-44"},"PeriodicalIF":2.4,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric oxygen preconditioning rescues prolonged underwater exercise-induced hippocampal dysfunction by regulating microglia activation and polarization 高压氧预处理通过调节小胶质细胞的活化和极化，挽救长时间水下运动诱发的海马功能障碍

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-06-05 DOI: 10.1016/j.neures.2024.05.004

{"title":"Hyperbaric oxygen preconditioning rescues prolonged underwater exercise-induced hippocampal dysfunction by regulating microglia activation and polarization","authors":"","doi":"10.1016/j.neures.2024.05.004","DOIUrl":"10.1016/j.neures.2024.05.004","url":null,"abstract":"<div><div>Underwater exercise is becoming increasingly prevalent, during which brain function is necessary but is also at risk. However, no study has explored how prolonged exercise affect the brain in underwater environment. Previous studies have indicated that excessive exercise in common environment causes brain dysfunction but have failed to provide appropriate interventions. Numerous evidence has indicated the neuroprotective effect of hyperbaric oxygen preconditioning (HBO-PC). The objective of this study was to investigate the cognitive effect of prolonged underwater exercise (PUE) and to explore the potential neuroprotective effect of HBO-PC in underwater environment. Rats swimming for 3 h in a simulated hyperbaric chamber (2.0 ATA) was used to establish the PUE animal model and HBO-PC (2.5 ATA for 1, 3,5 times respectively) was administrated before PUE. The results demonstrated that PUE triggers anxiety-like behaviors, cognitive impairment accompanied by hippocampal dysfunction, microglia activation and neuroinflammation. Conversely, 3 HBO-PC rescued anxiety-like behaviors and cognitive impairment. Mechanistically, 3 HBO-PC reduced microglia activation and switched the activated microglia from a pro-inflammatory to neuroprotective phenotype. These findings illustrated that PUE induces anxiety-like behaviors and cognitive impairment and HBO-PC of proper frequency may provide an appropriate and less invasive intervention for protecting the brain in underwater exercise.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"207 ","pages":"Pages 26-36"},"PeriodicalIF":2.4,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141265522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating physiological and transcriptomic analyses at the single-neuron level. 在单神经元水平整合生理分析和转录组分析。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-05-29 DOI: 10.1016/j.neures.2024.05.003

Haruya Yagishita, Takuya Sasaki

引用次数: 0

Delayed gramicidin delivery through an intra-pipette capillary facilitates perforated patch recordings 通过移液管内毛细管延迟递送格列宁可促进穿孔贴片记录。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-05-11 DOI: 10.1016/j.neures.2024.05.002

引用次数: 0

Glial tone of aggression 攻击性的神经胶质。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-05-01 DOI: 10.1016/j.neures.2023.11.008

Yuki Asano, Daichi Sasaki, Yoko Ikoma, Ko Matsui

{"title":"Glial tone of aggression","authors":"Yuki Asano, Daichi Sasaki, Yoko Ikoma, Ko Matsui","doi":"10.1016/j.neures.2023.11.008","DOIUrl":"10.1016/j.neures.2023.11.008","url":null,"abstract":"<div><p>Anger transition is often abrupt. In this study, we investigated the mechanisms responsible for switching and modulating aggression levels. The cerebellum is considered a center for motor coordination and learning; however, its connection to social behavior has long been observed. Here, we used the resident-intruder paradigm in male mice and examined local field potential (LFP) changes, glial cytosolic ion fluctuations, and vascular dynamics in the cerebellar vermis throughout various phases of a combat sequence. Notably, we observed the emergence of theta band oscillations in the LFP and sustained elevations in glial Ca<sup>2+</sup> levels during combat breakups. When astrocytes, including Bergmann glial cells, were photoactivated using channelrhodopsin-2, the theta band emerged and an early combat breakup occurred. Within a single combat sequence, rapid alteration of offensive (fight) and passive (flight) responses were observed, which roughly correlated with decreases and increases in glial Ca<sup>2+</sup>, respectively. Neuron-glial interactions in the cerebellar vermis may play a role in adjusting Purkinje cell excitability and setting the tone of aggression. Future anger management strategies and clinical control of excessive aggression and violent behavior may be realized by developing a therapeutic strategy that adjusts glial activity in the cerebellum.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"202 ","pages":"Pages 39-51"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223002031/pdfft?md5=da1b1d0345915f94b857cb7c56d18017&pid=1-s2.0-S0168010223002031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of the descending pain-inhibiting serotonergic pathway on the antihyperalgesic effect of gabapentin in neuropathic pain model rats 下行疼痛抑制5-羟色胺能通路对加巴喷丁在神经病理性疼痛模型大鼠中抗镇痛作用的影响。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-05-01 DOI: 10.1016/j.neures.2023.11.003

Harue Yanagimura , Mika Sasaki , Hiroshi Baba , Yoshinori Kamiya

{"title":"Influence of the descending pain-inhibiting serotonergic pathway on the antihyperalgesic effect of gabapentin in neuropathic pain model rats","authors":"Harue Yanagimura , Mika Sasaki , Hiroshi Baba , Yoshinori Kamiya","doi":"10.1016/j.neures.2023.11.003","DOIUrl":"10.1016/j.neures.2023.11.003","url":null,"abstract":"<div><p>Gabapentinoids are used worldwide as first-line agents for the treatment of neuropathic pain. Accumulating evidence indicates that one of the antihyperalgesic mechanisms of gabapentinoids is through activation of the noradrenergic pathway of the descending pain inhibition system. However, the involvement of the serotonin pathway is unclear. We investigated the effects of gabapentin (GBP) on the serotonergic pathway of the descending inhibitory system using the spinal nerve ligation (SNL) rat model. As in previous reports, administration of GBP to SNL rats improved paw withdrawal thresholds (PWT). Intrathecally administered serotonin receptor antagonists abolished GBP's amelioration in PWT. GBP did not ameliorate PWT in noradrenaline-depleted SNL rats by DSP-4. However, GBP ameliorated PWT in serotonin-depleted SNL rats by para-chlorophenylalanine, which was not inhibited by intrathecal administration of a serotonin receptor antagonist. Immunohistochemical analysis of serotonin in the spinal dorsal horn revealed a slight, albeit statistically insignificant, increase in 5-HT levels in SNL rats compared to naive rats. However, no apparent changes were observed before or after GBP administration in naive and SNL rats. In conclusion, the involvement of the serotonergic pathway in the antihyperalgesic effects of GBP on the spinal cord is secondary, although it cooperates with the noradrenergic system to produce analgesia.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"202 ","pages":"Pages 20-29"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223001980/pdfft?md5=1b655b32e5b9ea4c5a9ff6b7a94aa3b3&pid=1-s2.0-S0168010223001980-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglia modulate sleep/wakefulness under baseline conditions and under acute social defeat stress in adult mice 小胶质细胞在基线条件下和急性社会失败应激下调节成年小鼠的睡眠/觉醒。

IF 2.9 4区医学

Neuroscience Research Pub Date : 2024-05-01 DOI: 10.1016/j.neures.2023.11.010

Kazuya Miyanishi , Noriko Hotta-Hirashima , Chika Miyoshi , Satsuki Hayakawa , Miyo Kakizaki , Satomi Kanno , Aya Ikkyu , Hiromasa Funato , Masashi Yanagisawa

{"title":"Microglia modulate sleep/wakefulness under baseline conditions and under acute social defeat stress in adult mice","authors":"Kazuya Miyanishi , Noriko Hotta-Hirashima , Chika Miyoshi , Satsuki Hayakawa , Miyo Kakizaki , Satomi Kanno , Aya Ikkyu , Hiromasa Funato , Masashi Yanagisawa","doi":"10.1016/j.neures.2023.11.010","DOIUrl":"10.1016/j.neures.2023.11.010","url":null,"abstract":"<div><p>Although sleep is tightly regulated by multiple neuronal circuits in the brain, nonneuronal cells such as glial cells have been increasingly recognized as crucial sleep regulators. Recent studies have shown that microglia may act to maintain wakefulness. Here, we investigated the possible involvement of microglia in the regulation of sleep quantity and quality under baseline and stress conditions through electroencephalography (EEG)/electromyography (EMG) recordings, and by employing pharmacological methods to eliminate microglial cells in the adult mouse brain. We found that severe microglial depletion induced by the colony-stimulating factor 1 receptor (CSF1R) antagonist PLX5622 (PLX) reversibly decreased the total wake time and the wake episode duration and increased the EEG slow-wave power during wakefulness under baseline conditions. To examine the role of microglia in sleep/wake regulation under mental stress, we used the acute social defeat stress (ASDS) paradigm, an ethological model for psychosocial stress. Sleep analysis under ASDS revealed that microglial depletion exacerbated the stress-induced decrease in the total wake time and increase in anxiety-like behaviors in the open field test. These results demonstrate that microglia actively modulate sleep quantity and architecture under both baseline and stress conditions. Our findings suggest that microglia may potentially provide resilience against acute psychosocial stress by regulating restorative sleep.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"202 ","pages":"Pages 8-19"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010223002055/pdfft?md5=2d16e777ff15eab9892c01c194793d1c&pid=1-s2.0-S0168010223002055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138461274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0